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Toxicology and applied pharmacology, ISSN 0041-008X, 01/2014, Volume 274, Issue 2, pp. 328 - 338
Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to... 
Early onset of fibrosis | Precision-cut liver slices | Antifibrotic drugs | Liver fibrosis | Ex vivo model | ROSMARINIC ACID | ANGIOTENSIN-II | ANTI-FIBROTIC DRUGS | IN-VITRO | INHIBITS ACTIVATION | HEPATIC STELLATE CELLS | ENDOPLASMIC-RETICULUM | DERMAL FIBROBLASTS | GROWTH-FACTOR | IMATINIB MESYLATE | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Niacinamide - analogs & derivatives | Rats, Wistar | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | Male | Valproic Acid - pharmacology | Depsides - pharmacology | Perindopril - pharmacology | Collagen Type I - genetics | Liver - drug effects | Benzamides - pharmacology | Benzylisoquinolines - pharmacology | Organ Culture Techniques | Liver Cirrhosis - drug therapy | Gene Expression | Collagen Type I - metabolism | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Down-Regulation | Liver - metabolism | Rats | Becaplermin | Transforming Growth Factor beta1 - genetics | Pyrimidines - pharmacology | Cinnamates - pharmacology | HSP47 Heat-Shock Proteins - genetics | Imatinib Mesylate | Piperazines - pharmacology | Animals | Models, Biological | Sorafenib | HSP47 Heat-Shock Proteins - metabolism | Connective Tissue Growth Factor - genetics | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Connective Tissue Growth Factor - metabolism | Pyridones - pharmacology | Proto-Oncogene Proteins c-sis - antagonists & inhibitors | Drugs | Liver diseases | Analysis | Liver | Fibrosis | Gene expression | Growth factors | Index Medicus | FIBROSIS | DRUGS | GENES | LIVER | RATS | 60 APPLIED LIFE SCIENCES | ATP
Journal Article
Journal Article
Basic & clinical pharmacology & toxicology, ISSN 1742-7835, 05/2015, Volume 116, Issue 5, pp. 398 - 413
Rosmarinic acid is a polyphenolic compound and main constituent of Rosmarinus officinalis and has been shown to possess antioxidant and anti‐inflammatory... 
Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Reperfusion Injury - etiology | Rats, Wistar | Plant Extracts - pharmacology | Bronchoalveolar Lavage Fluid - immunology | Male | Inflammation - blood | Depsides - pharmacology | Reperfusion Injury - blood | Respiratory Burst - drug effects | Dose-Response Relationship, Drug | Time Factors | Anti-Inflammatory Agents - isolation & purification | Lung - metabolism | Phytotherapy | Neutrophils - metabolism | Disease Models, Animal | Edema - prevention & control | Edema - immunology | Anti-Inflammatory Agents - pharmacology | Neutrophils - drug effects | Inflammation Mediators - blood | Neutrophils - immunology | Plant Extracts - isolation & purification | Inflammation - immunology | Antioxidants - pharmacology | Biomarkers - blood | Cinnamates - pharmacology | Inflammation - etiology | Edema - blood | Animals | Reperfusion Injury - prevention & control | Lung - drug effects | Reperfusion Injury - immunology | Inflammation - prevention & control | Bronchoalveolar Lavage Fluid - chemistry | Carrageenan | Edema - chemically induced | Oxidative Stress - drug effects | Lung - immunology | Plants, Medicinal | Rosmarinus - chemistry | Anti-inflammatory diet | Models | Inflammation | Liver diseases | Anti-inflammatory drugs | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e60770 - e60770
Topoisomerase inhibitors are effective for antibacterial and anticancer therapy because they can lead to the accumulation of the intermediate DNA cleavage... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Depsides - isolation & purification | Small Molecule Libraries - pharmacology | Escherichia coli - drug effects | Humans | Ascomycota - chemistry | Biological Products - pharmacology | Depsides - pharmacology | Depsides - toxicity | Dose-Response Relationship, Drug | Topoisomerase Inhibitors - pharmacology | Hydroxybenzoates - pharmacology | Yersinia pestis - drug effects | Anti-Bacterial Agents - toxicity | Drug Evaluation, Preclinical | Cell Survival - drug effects | Detergents - pharmacology | Escherichia coli - enzymology | DNA Topoisomerases, Type I - metabolism | Topoisomerase Inhibitors - toxicity | Anti-Bacterial Agents - isolation & purification | Magnesium - pharmacology | Hydroxybenzoates - isolation & purification | Topoisomerase Inhibitors - isolation & purification | High-Throughput Screening Assays | Anti-Bacterial Agents - pharmacology | Hydroxybenzoates - toxicity | Yersinia pestis - enzymology | Biological products | Cell death | Antibacterial agents | Escherichia coli | High-throughput screening | Identification | Biochemistry | Assaying | Antibacterial materials | Accumulation | Anticancer properties | E coli | Antibacterial activity | Cleavage | Deoxyribonucleic acid--DNA | Library collections | DNA topoisomerase (ATP-hydrolysing) | Enzymes | Fractionation | DNA topoisomerase | Antimicrobial agents | Screening | Chemistry | Inhibitors | Acids | Natural products | Mutation | Molecular biology | Cancer | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Biogerontology (Dordrecht), ISSN 1573-6768, 04/2011, Volume 12, Issue 4, pp. 329 - 347
Journal Article
Journal of pharmaceutical and biomedical analysis, ISSN 0731-7085, 01/2019, Volume 162, pp. 225 - 233
•Biochemical fingerprints of Scrophularia lucida extracts were evaluated.•Antioxidant, enzyme inhibitory and anti-inflammatory effects were investigated.•In... 
S. lucida | Phenolic | Docking | Antioxidant | Anti-inflammatory | Tyrosinase | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Chemistry, Analytical | Life Sciences & Biomedicine | Science & Technology | Depsides - isolation & purification | Plant Extracts - chemistry | Antioxidants - chemistry | Plant Extracts - pharmacology | Scrophularia - classification | Solvents - chemistry | Glycoside Hydrolase Inhibitors - isolation & purification | Acetates - chemistry | Monophenol Monooxygenase - antagonists & inhibitors | Scrophularia - chemistry | Structure-Activity Relationship | Chromatography, High Pressure Liquid | Hesperidin - isolation & purification | Depsides - pharmacology | Monophenol Monooxygenase - metabolism | Amylases - metabolism | Cinnamates - isolation & purification | Computer Simulation | Enzyme Inhibitors - chemistry | Kaempferols - isolation & purification | Anti-Inflammatory Agents - isolation & purification | Cholinesterase Inhibitors - isolation & purification | Molecular Structure | Methanol - chemistry | Anti-Inflammatory Agents - pharmacology | Plant Components, Aerial - chemistry | Enzyme Inhibitors - pharmacology | Plant Extracts - isolation & purification | Antioxidants - pharmacology | Glycoside Hydrolase Inhibitors - pharmacology | Luteolin - pharmacology | Cinnamates - pharmacology | Molecular Dynamics Simulation | Enzyme Inhibitors - isolation & purification | Luteolin - isolation & purification | Macrophages - metabolism | Amylases - antagonists & inhibitors | Animals | Cholinesterase Inhibitors - pharmacology | Antioxidants - isolation & purification | Plant Roots - chemistry | Hesperidin - pharmacology | Macrophages - drug effects | RAW 264.7 Cells | Kaempferols - pharmacology | Mice | Molecular Docking Simulation | Nitric Oxide - metabolism | Antioxidants | Esters | Anti-inflammatory drugs | High performance liquid chromatography | Index Medicus
Journal Article