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Science, ISSN 0036-8075, 9/2007, Volume 317, Issue 5843, pp. 1390 - 1393
Tricyclic antidepressants exert their pharmacological effect--inhibiting the reuptake of serotonin, norepinephrine, and dopamine--by directly blocking... 
Molecules | Salts | Neurotransmitters | Antidepressants | Reuptake | Serotonin plasma membrane transport proteins | Neurotransmitter transport proteins | Reports | Pharmacology | Inhibitory concentration 50 | Crystal structure | SENSITIVE DOPAMINE TRANSPORTER | NOREPINEPHRINE TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | ION-BINDING | MONOAMINE TRANSPORTERS | SEROTONIN | INHIBITORS | Dopamine - chemistry | Antidepressive Agents, Tricyclic - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Bacterial Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Serotonin - chemistry | Dopamine Uptake Inhibitors - metabolism | Drosophila Proteins - metabolism | Antidepressive Agents, Tricyclic - chemistry | Neurotransmitter Uptake Inhibitors - metabolism | Desipramine - metabolism | Conserved Sequence | Binding Sites | Dopamine - metabolism | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Cell Line | Leucine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Models, Molecular | Serotonin Uptake Inhibitors - chemistry | Drosophila Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Leucine - chemistry | Sequence Homology, Amino Acid | Animals | Norepinephrine - metabolism | Desipramine - chemistry | Neurotransmitter Uptake Inhibitors - chemistry | Norepinephrine - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Protein Conformation | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Leucine | Structure | Desipramine | Health aspects | Antidepressants, Tricyclic | Inhibitor drugs | Psychiatry | Binding sites
Journal Article
European Neuropsychopharmacology, ISSN 0924-977X, 2017, Volume 27, Issue 6, pp. 554 - 559
Journal Article
Neuropharmacology, ISSN 0028-3908, 08/2016, Volume 107, pp. 111 - 121
Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of... 
SAHA | Antidepressants | CREB coactivator | BDNF | Mood disorders | HDAC inhibitor | Epigenetics | Animal model of depression | TRANSCRIPTION FACTORS | COACTIVATOR CRTC1 | ANTIDEPRESSANT ACTION | NEUROTROPHIC FACTOR | NUCLEAR RECEPTORS | ELEMENT-BINDING PROTEIN | SYNAPTIC PLASTICITY | NEUROSCIENCES | SENSITIVE COINCIDENCE DETECTOR | CORTICAL-NEURONS | PHARMACOLOGY & PHARMACY | HISTONE DEACETYLASE INHIBITORS | Receptors, Steroid - metabolism | Depressive Disorder, Major - metabolism | Transcription Factors - deficiency | Male | Hippocampus - drug effects | DNA-Binding Proteins - metabolism | Desipramine - pharmacology | Prefrontal Cortex - drug effects | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | Depressive Disorder, Treatment-Resistant - metabolism | Drug Evaluation, Preclinical | Hydroxamic Acids - pharmacology | Depressive Disorder, Major - drug therapy | Disease Models, Animal | Transcription Factors - genetics | Depressive Disorder, Treatment-Resistant - drug therapy | Mice, Knockout | Nerve Tissue Proteins - metabolism | Receptors, Thyroid Hormone - metabolism | Hippocampus - metabolism | Animals | Prefrontal Cortex - metabolism | Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism | Histone Deacetylase Inhibitors - pharmacology | Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism | Epigenetic inheritance | Gene expression | Depression, Mental | Neurophysiology | Analysis | mood disorders | animal model of depression | antidepressants | epigenetics
Journal Article
Journal Article
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 2006, Volume 1758, Issue 12, pp. 1957 - 1977
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 01/2014, Volume 55, Issue 12, pp. 2606 - 2619
Journal Article
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 04/2017, Volume 18, Issue 4, pp. 839 - 839
Cardiac dysfunction, in particular of the left ventricle, is a common and early event in sepsis, and is strongly associated with an increase in patients'... 
Ceramide | De novo synthesis | Sepsis | Desipramine | Cardiac dysfunction | Acid sphingomyelinase | BRAIN NATRIURETIC PEPTIDE | INDUCED APOPTOSIS | acid sphingomyelinase | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | CHEMISTRY, MULTIDISCIPLINARY | desipramine | NIEMANN-PICK-DISEASE | de novo synthesis | ceramide | SEPTIC SHOCK | cardiac dysfunction | CYSTIC-FIBROSIS | TNF-ALPHA | MYOCARDIAL DYSFUNCTION | sepsis | L-Lactate Dehydrogenase - metabolism | Sphingomyelin Phosphodiesterase - genetics | Heart Diseases - metabolism | Male | Sepsis - complications | Gene Expression Profiling | Desipramine - metabolism | Desipramine - pharmacology | Sepsis - metabolism | Myocardium - metabolism | Sphingomyelin Phosphodiesterase - metabolism | Female | Disease Models, Animal | Ceramides - metabolism | Heart Diseases - physiopathology | Cardiac Output - drug effects | Gene Expression Regulation | Lipid Metabolism | Mice, Transgenic | Sepsis - genetics | Mice, Knockout | Heart Diseases - etiology | Animals | Biomarkers | Heart Diseases - drug therapy | Mice | Oxidative Stress - drug effects | Troponin I - metabolism | Sepsis - microbiology | Oxidative stress | Animal models | Cardiomyopathy | Cardiac conditioning | Lipids | Metabolism | Sphingomyelin phosphodiesterase | Troponin | Troponin I | Calcium-binding protein | Ventricle | Heart diseases | Apoptosis
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 2017, Volume 58, Issue 3, pp. 563 - 577
Glucosylceramide (GlcCer) is the primary storage lipid in the lysosomes of Gaucher patients and a secondary one in Niemann-Pick disease types A, B, and C. The... 
Lysophospholipids | Gaucher disease | Anionic phospholipids | Cationic lipids | Electrostatic interaction | Sphingosine | Sphingomyelin | Acylglycerols | Fatty acids | Cholesterol | GH3 PITUITARY-CELLS | fatty acids | SPHINGOLIPID ACTIVATOR PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | anionic phospholipids | sphingosine | GAUCHER-DISEASE | CHOLESTEROL TRAFFICKING | SAPOSIN-C | NIEMANN-PICK-DISEASE | UNILAMELLAR VESICLES | TRICYCLIC ANTIDEPRESSANT DESIPRAMINE | lysophospholipids | cationic lipids | cholesterol | sphingomyelin | electrostatic interaction | ACID SPHINGOMYELINASE ACTIVITY | acylglycerols | EXTRACTION CAPACITY | Lysophospholipids - metabolism | Glucosylceramidase - genetics | Gaucher Disease - metabolism | Genetic Association Studies | Humans | Lysosomes - enzymology | Glucosylceramidase - metabolism | Gaucher Disease - pathology | Niemann-Pick Diseases - metabolism | Cholesterol - metabolism | Niemann-Pick Diseases - pathology | Monoglycerides - metabolism | Hydrolysis | Saposins - metabolism | Gaucher Disease - genetics | Lipid Metabolism - genetics | Glucosylceramides - metabolism | Niemann-Pick Diseases - genetics | Niemann-Pick disease | Diacylglycerol | Lysosomes | Lipids | Phospholipids | pH effects | Electrostatic properties | Sphinganine | Ceramide | Bone morphogenetic proteins | Glucosylceramidase | Genotypes
Journal Article
Psychopharmacology, ISSN 0033-3158, 7/2011, Volume 216, Issue 1, pp. 75 - 84
The pharmacological actions of most antidepressants are ascribed to the modulation of serotonergic and/or noradrenergic transmission in the brain. During... 
Neurosciences | Biomedicine | Serotonin | Lactate | Antidepressants | Glycogen | Pharmacology/Toxicology | Glia | Psychiatry | Growth factors | BEHAVIORAL ACTIONS | DENDRITIC GROWTH | PSYCHIATRY | TYROSINE KINASE | DRUG DISCOVERY | ANTIDEPRESSANT TREATMENT | NEUROSCIENCES | PREFRONTAL CORTEX | IN-VITRO | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | BRAIN | ENDOTHELIAL GROWTH-FACTOR | Animals, Newborn | Astrocytes - drug effects | Brain-Derived Neurotrophic Factor - genetics | Fluoxetine - pharmacology | Depressive Disorder, Major - metabolism | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Gene Expression Regulation - drug effects | Animals | Glucose - metabolism | Mice | Serotonin Uptake Inhibitors - pharmacology | Astrocytes - metabolism | Depressive Disorder, Major - drug therapy | Paroxetine | Brain | RNA | Fluoxetine | Depression, Mental | Glucose | Dextrose | Glucose metabolism | Imipramine | Analysis | Physiological aspects | Vascular endothelial growth factor | Health aspects | Mental depression | Psychopharmacology | Cells | Astrocytes | Desipramine | Neurons | imipramine | Data processing | Depression | Serotonin uptake inhibitors | Gene expression | Neurotrophic factors | Brain-derived neurotrophic factor | paroxetine | Norepinephrine | Lactic acid | Neurotransmission
Journal Article