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Journal Article
Cytokine, ISSN 1043-4666, 04/2016, Volume 80, p. 26
* Desipramine was given orally for 21days. * Desipramine inhibited the LPS-induced IL-1[beta] levels in the brain and plasma of rats. * The most important drug... 
Desipramine | Mitogens
Journal Article
Journal of Colloid And Interface Science, ISSN 0021-9797, 02/2016, Volume 463, pp. 279 - 287
Journal Article
Autonomic Neuroscience: Basic and Clinical, ISSN 1566-0702, 07/2017, Volume 205, p. 21
Desipramine (DMI) is a blocker of neuronal norepinephrine (NE) uptake transporter. Although intravenous DMI has been shown to cause centrally-mediated... 
Desipramine | Acetylcholine | Physiological aspects
Journal Article
International Clinical Psychopharmacology, ISSN 0268-1315, 03/2013, Volume 28, Issue 2, pp. 99 - 105
The results of two single-center, two-period, open-label trials that evaluated the effects of multiple doses of desvenlafaxine on the pharmacokinetics of... 
pharmacokinetics | desipramine | desvenlafaxine | SYSTEM | EFFICACY | DRUG-INTERACTIONS | SAFETY | PSYCHIATRY | REUPTAKE-INHIBITOR | CYTOCHROME-P450 2D6 | 100 MG/DAY | IN-VITRO | ANTIDEPRESSANTS | PHARMACOLOGY & PHARMACY | MAJOR DEPRESSIVE DISORDER | Cytochrome P-450 CYP2D6 Inhibitors | Cyclohexanols - adverse effects | Neurotransmitter Uptake Inhibitors - adverse effects | Antidepressive Agents, Tricyclic - pharmacokinetics | Humans | Middle Aged | Half-Life | Biological Availability | Male | Metabolic Clearance Rate | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Young Adult | Desipramine - adverse effects | Desipramine - urine | Drug Interactions | Neurotransmitter Uptake Inhibitors - administration & dosage | Desvenlafaxine Succinate | Adult | Female | Desipramine - analogs & derivatives | Enzyme Inhibitors - adverse effects | Cytochrome P-450 CYP2D6 - genetics | Desipramine - blood | Antidepressive Agents, Tricyclic - urine | Polymorphism, Genetic | Desipramine - pharmacokinetics | Antidepressive Agents, Tricyclic - blood | Metabolic Detoxication, Phase I | Adolescent | Antidepressive Agents, Tricyclic - adverse effects | Cytochrome P-450 CYP2D6 - metabolism | Antidepressive Agents - administration & dosage | Antidepressive Agents - adverse effects | Cyclohexanols - administration & dosage | Clinical trials | Enzymes | Pharmacokinetics | Desipramine | Cytochrome P450 | CYP2D6 protein
Journal Article
Journal of Pain and Symptom Management, ISSN 0885-3924, 07/2019, Volume 58, p. 171
Journal Article
American Journal of Psychiatry, ISSN 0002-953X, 12/2014, Volume 171, Issue 12, pp. 1297 - 1309
Objective:The authors compared the effectiveness of fluoxetine and desipramine treatment in a prospective double-blind pharmacogenetics study in... 
COST-EFFECTIVENESS | PRIMARY-CARE | METAANALYSIS | EFFICACY | PSYCHIATRY | TOLERABILITY | TREATMENT RESPONSE | HISPANICS | MAJOR DEPRESSIVE DISORDER | SCALE | ADHERENCE | Brain-Derived Neurotrophic Factor - genetics | Predictive Value of Tests | Prospective Studies | Epigenesis, Genetic | Humans | Middle Aged | Male | Antidepressive Agents, Second-Generation - therapeutic use | Desipramine - adverse effects | Psychiatric Status Rating Scales | Desipramine - therapeutic use | Adult | Female | Fluoxetine - therapeutic use | Fluoxetine - adverse effects | Depressive Disorder, Major - drug therapy | Genome-Wide Association Study | Mexican Americans | Pharmacogenetics | Adrenergic Uptake Inhibitors - therapeutic use | Double-Blind Method | Drug Administration Schedule | Serotonin Uptake Inhibitors - therapeutic use | Genotype | Treatment Outcome | Desipramine - administration & dosage | Antidepressive Agents - therapeutic use | Depressive Disorder, Major - psychology | Antidepressive Agents, Tricyclic - therapeutic use | Fluoxetine - administration & dosage | Antidepressive Agents - administration & dosage | Aged | Polymorphism, Single Nucleotide | Antidepressive Agents - adverse effects | Depressive Disorder, Major - diagnosis | Research Design | Brain | Epigenetic inheritance | Fluoxetine | Patient outcomes | Depression, Mental | Research | Pharmaceutical research | Genetic research | Genetic aspects | Dosage and administration | Methylation | Drug therapy | Health aspects | drug response | pharmacogenomics | fluoxetine | methylation sites | epigenetic | Mexican-American population | antidepressants | depression | desipramine
Journal Article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ISSN 0928-0987, 05/2019, Volume 133, pp. 264 - 274
Journal Article
Journal Article
Science, ISSN 0036-8075, 9/2007, Volume 317, Issue 5843, pp. 1390 - 1393
Tricyclic antidepressants exert their pharmacological effect--inhibiting the reuptake of serotonin, norepinephrine, and dopamine--by directly blocking... 
Molecules | Salts | Neurotransmitters | Antidepressants | Reuptake | Serotonin plasma membrane transport proteins | Neurotransmitter transport proteins | Reports | Pharmacology | Inhibitory concentration 50 | Crystal structure | SENSITIVE DOPAMINE TRANSPORTER | NOREPINEPHRINE TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | ION-BINDING | MONOAMINE TRANSPORTERS | SEROTONIN | INHIBITORS | Dopamine - chemistry | Antidepressive Agents, Tricyclic - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Bacterial Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Serotonin - chemistry | Dopamine Uptake Inhibitors - metabolism | Drosophila Proteins - metabolism | Antidepressive Agents, Tricyclic - chemistry | Neurotransmitter Uptake Inhibitors - metabolism | Desipramine - metabolism | Conserved Sequence | Binding Sites | Dopamine - metabolism | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Cell Line | Leucine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Models, Molecular | Serotonin Uptake Inhibitors - chemistry | Drosophila Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Leucine - chemistry | Sequence Homology, Amino Acid | Animals | Norepinephrine - metabolism | Desipramine - chemistry | Neurotransmitter Uptake Inhibitors - chemistry | Norepinephrine - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Protein Conformation | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Leucine | Structure | Desipramine | Health aspects | Antidepressants, Tricyclic | Inhibitor drugs | Psychiatry | Binding sites
Journal Article
Lancet, The, ISSN 0140-6736, 2016, Volume 388, Issue 10047, pp. 881 - 890
Summary Background Major depressive disorder is one of the most common mental disorders in children and adolescents. However, whether to use pharmacological... 
Internal Medicine | TRIALS | MEDICINE, GENERAL & INTERNAL | ACCEPTABILITY | MENTAL-HEALTH-CARE | TRENDS | GUIDELINES | Mianserin - adverse effects | Triazoles - administration & dosage | Triazoles - adverse effects | Humans | Citalopram - adverse effects | Sertraline - adverse effects | Venlafaxine Hydrochloride - adverse effects | Imipramine - administration & dosage | Paroxetine - adverse effects | Mianserin - analogs & derivatives | Paroxetine - administration & dosage | Desipramine - adverse effects | Nortriptyline - administration & dosage | Nortriptyline - adverse effects | Mianserin - administration & dosage | Child | Fluoxetine - adverse effects | Depressive Disorder, Major - drug therapy | Clomipramine - administration & dosage | Duloxetine Hydrochloride - adverse effects | Double-Blind Method | Drug Administration Schedule | Treatment Outcome | Clomipramine - adverse effects | Evidence-Based Medicine | Desipramine - administration & dosage | Randomized Controlled Trials as Topic | Venlafaxine Hydrochloride - administration & dosage | Citalopram - administration & dosage | Confounding Factors (Epidemiology) | Sertraline - administration & dosage | Adolescent | Amitriptyline - adverse effects | Bayes Theorem | Fluoxetine - administration & dosage | Duloxetine Hydrochloride - administration & dosage | Antidepressive Agents - administration & dosage | Antidepressive Agents - adverse effects | Research Design | Amitriptyline - administration & dosage | Imipramine - adverse effects | Psychological aspects | Medical colleges | Neurosciences | Drugs and youth | Rankings | Comparative analysis | Child psychopathology | Major depressive disorder | Antidepressants, Tricyclic | Pediatric pharmacology | Mental illness | Studies | Teenagers | Mental depression | Antidepressants | Meta-analysis | Children & youth
Journal Article
Cardiovascular Toxicology, ISSN 1530-7905, 06/2018, Volume 18, Issue 3, p. 252
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s12012-017-9435-x We... 
Medical colleges | Desipramine | Smooth muscle
Journal Article