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1. Full Text Cunninghamella blakesleeana-mediated biotransformation of a contraceptive drug, desogestrel, and anti-MDR-Staphylococcus aureus activity of its metabolites
by Atia-tul-Wahab and Siddiqui, Mahwish and Ibrahim, Iman and Hussain, Arifa and Ajandouz, El Hassan and Hijazi, Akram and Baydoun, Elias and Choudhary, M. Iqbal
Bioorganic Chemistry, ISSN 0045-2068, 04/2018, Volume 77, pp. 152 - 158
is one of the most infectious agents among staphylococcal bacteria. Currently many strains of have developed resistance against available antibiotics.... 
Desogestrel | Biotransformation | Cunninghamella blakesleeana | Cytotoxicity | Anti-bacterial | Drug resistant Staphylococcus aureus | 6β,15β-Dihydroxy-desogestrel | UNITED-STATES | INFECTIONS | FUNGI | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYDROXYLATION | CHEMISTRY, ORGANIC | MICROBIAL TRANSFORMATION | 6 beta,15 beta-Dihydroxy-desogestrel | Desogestrel - chemistry | Methicillin-Resistant Staphylococcus aureus - drug effects | Anti-Bacterial Agents - metabolism | Structure-Activity Relationship | Desogestrel - metabolism | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Contraceptive Agents - pharmacokinetics | Cunninghamella - metabolism | Anti-Bacterial Agents - chemistry | Desogestrel - pharmacokinetics | Anti-Bacterial Agents - pharmacokinetics | Molecular Structure | Contraceptive Agents - metabolism | Contraceptive Agents - chemistry | Drug resistance in microorganisms | Contraceptives | Metabolites | Antibacterial agents | Staphylococcus aureus | Staphylococcus aureus infections | Medicinal Chemistry | Life Sciences | Pharmacology | Chemical Sciences | Pharmaceutical sciences
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2. Full Text Plasma concentrations of etonogestrel in women using oral desogestrel before and after Roux‐en‐Y gastric bypass surgery: a pharmacokinetic study
by Ginstman, C and Frisk, J and Carlsson, B and Ärlemalm, A and Hägg, S and Brynhildsen, J and Medicinska fakulteten and Diagnostikcentrum and Barn- och kvinnocentrum and Centrum för kirurgi, ortopedi och cancervård and Avdelningen för barns och kvinnors hälsa and Region Östergötland and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Kirurgiska kliniken ViN and Klinisk farmakologi and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Kvinnokliniken i Linköping
BJOG: An International Journal of Obstetrics & Gynaecology, ISSN 1470-0328, 03/2019, Volume 126, Issue 4, pp. 486 - 492
Objective To investigate whether Roux‐en‐Y gastric bypass (RYGB) affects oral desogestrel (etonogestrel) pharmacokinetics. Design Single centre, open label,... 
hormonal contraception | oral contraceptives | Contraceptives | etonogestrel | gastric bypass surgery | desogestrel | Roux‐en‐Y gastric bypass | pharmacokinetic | obesity | Roux-en-Y gastric bypass | CONTRACEPTIVE USE | VENOUS THROMBOSIS | RISK | SOCIETY | OBSTETRICS & GYNECOLOGY | BARIATRIC SURGERY | Obesity - surgery | Gastric Bypass | Contraceptives, Oral, Synthetic - pharmacokinetics | Desogestrel - blood | Humans | Middle Aged | Postoperative Period | Obesity - blood | Young Adult | Time Factors | Desogestrel - pharmacokinetics | Adult | Female | Preoperative Period | Women | Liquid chromatography | Oral contraceptives | Mass spectrometry | Gastric bypass | Obesity | Womens health | Heart surgery | Surgery | Mass spectroscopy | Gastrointestinal surgery | Pharmacokinetics | Index Medicus | Abridged Index Medicus | Clinical Medicine | Obstetrics, Gynecology and Reproductive Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reproduktionsmedicin och gynekologi | Klinisk medicin | Contraceptives; desogestrel; etonogestrel; gastric bypass surgery; hormonal contraception; obesity; oral contraceptives; pharmacokinetic; Roux-en-Y gastric bypass
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3. Full Text Progestin-only pills for contraception
by Grimes, David A and Grimes, David A and Lopez, Laureen M and Lopez, Laureen M and O'Brien, Paul A and O'Brien, Paul A and Raymond, Elizabeth G and Raymond, Elizabeth G
The Cochrane database of systematic reviews, ISSN 1469-493X, 2013, Volume 11, Issue 11, p. CD007541
Background The introduction of a new progestin-only oral contraceptive in Europe has renewed interest in this class of oral contraceptives. Unlike the more... 
Contraceptives, Oral, Combined [administration & dosage] Contraceptives, Oral, Hormonal [administration & dosage; adverse effects] | Ethynodiol Diacetate [administration & dosage] | LEVONORGESTREL | MULTICENTER | CLINICAL-TRIAL | Desogestrel [administration & dosage; adverse effects] | Progestins [administration & dosage; adverse effects] | Humans | Uterine Hemorrhage [chemically induced] | RANDOMIZED TRIALS | Levonorgestrel [administration & dosage] | Randomized Controlled Trials as Topic | LACTATING WOMEN | MEDICINE, GENERAL & INTERNAL | INHIBITION | DESOGESTREL | DOUBLE-BLIND | Female | Contraceptives, Oral, Hormonal - adverse effects | Desogestrel - adverse effects | Contraceptives, Oral, Hormonal - administration & dosage | Progestins - adverse effects | Desogestrel - administration & dosage | Levonorgestrel - administration & dosage | Progestins - administration & dosage | Ethynodiol Diacetate - administration & dosage | Contraceptives, Oral, Combined - administration & dosage | Uterine Hemorrhage - chemically induced
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4. Full Text Desogestrel‐only contraceptive pill versus sequential contraceptive vaginal ring in the treatment of rectovaginal endometriosis infiltrating the rectum: a prospective open‐label comparative study
by Leone Roberti Maggiore, Umberto and Remorgida, Valentino and Scala, Carolina and Tafi, Emanuela and Venturini, Pier L and Ferrero, Simone
Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, 03/2014, Volume 93, Issue 3, pp. 239 - 247
Objective To compare the efficacy of two hormonal therapies in treating symptoms caused by bowel endometriosis. Design Patient preference study. Setting... 
hormonal therapy | endometriosis | desogestrel | vaginal ring | Bowel endometriosis | WOMEN | PAIN | NORETHISTERONE ACETATE | PELVIC ENDOMETRIOSIS | MEDICAL-TREATMENT | PROGESTOGEN | QUALITY-OF-LIFE | LAPAROSCOPIC RECTOSIGMOID RESECTION | IRRITABLE-BOWEL-SYNDROME | COLORECTAL ENDOMETRIOSIS | OBSTETRICS & GYNECOLOGY | Contraceptives, Oral, Synthetic - adverse effects | Rectal Diseases - etiology | Prospective Studies | Follow-Up Studies | Desogestrel - adverse effects | Humans | Contraceptive Devices, Female | Endometriosis - pathology | Rectal Diseases - drug therapy | Endometriosis - drug therapy | Endometriosis - complications | Patient Satisfaction | Contraceptives, Oral, Synthetic - administration & dosage | Ethinyl Estradiol - adverse effects | Desogestrel - administration & dosage | Desogestrel - analogs & derivatives | Adult | Female | Ethinyl Estradiol - administration & dosage | Drug Combinations | Comparative analysis | Endometriosis | Care and treatment
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5. Full Text Safety and efficacy of a single-rod etonogestrel implant (Implanon): results from 11 international clinical trials
by Darney, Philip, M.D and Patel, Ashlesha, M.D and Rosen, Kimberly, M.D and Shapiro, Lena S., Ph.D and Kaunitz, Andrew M., M.D
Fertility and Sterility, ISSN 0015-0282, 2009, Volume 91, Issue 5, pp. 1646 - 1653
Objective To present efficacy, safety, and bleeding profile results from the clinical trials that supported the U.S. Food and Drug Administration filing for... 
Internal Medicine | Obstetrics and Gynecology | Contraceptive implant | desogestrel | etonogestrel | menstruation | levonorgestrel | MULTICENTER | REPRODUCTIVE BIOLOGY | BLEEDING PATTERNS | OBSTETRICS & GYNECOLOGY | Pregnancy | Desogestrel - administration & dosage | Time Factors | Desogestrel - adverse effects | Humans | Adolescent | Contraceptive Agents, Female - administration & dosage | Adult | Female | Clinical Trials as Topic | Uterine Hemorrhage - etiology | Contraceptive drug implants | Clinical trials | Product development | Index Medicus
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6. Full Text Pharmacokinetic evaluation of desogestrel as a female contraceptive
by Grandi, Giovanni and Cagnacci, Angelo and Volpe, Annibale
Expert Opinion on Drug Metabolism & Toxicology, ISSN 1742-5255, 01/2014, Volume 10, Issue 1, pp. 1 - 10
Introduction: Desogestrel (DSG) is a third-generation 19-nortestosterone derivative progestogen. It is contained in many oral contraceptive preparations, both... 
hormonal contraception | subdermal contraception | COCs | etonogestrel | ethinylestradiol | progesterone-only pill | pharmacokinetics | contraceptive implant | metabolism | desogestrel | vaginal ring | Ethinylestradiol | Vaginal ring | Desogestrel | Etonogestrel | Contraceptive implant | Hormonal contraception | Metabolism | Pharmacokinetics | Progesterone-only pill | Subdermal contraception | BIOCHEMISTRY & MOLECULAR BIOLOGY | 75 MU-G | INSULIN SENSITIVITY | IN-VITRO | SYNTHETIC PROGESTAGEN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | 3-KETO-DESOGESTREL | ORAL-CONTRACEPTIVES | Desogestrel - administration & dosage | Animals | Administration, Oral | Contraceptive Agents, Female - chemistry | Desogestrel - chemistry | Desogestrel - pharmacokinetics | Humans | Contraceptive Agents, Female - administration & dosage | Contraceptive Agents, Female - pharmacokinetics | Female | Drug Evaluation, Preclinical | Randomized Controlled Trials as Topic | Index Medicus
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7. Full Text A 3-year multicentre randomized controlled trial of etonogestrel- and levonorgestrel-releasing contraceptive implants, with non-randomized matched copper-intrauterine device controls
by Bahamondes, Luis and Brache, Vivian and Meirik, Olav and Ali, Moazzam and Habib, Ndema and Landoulsi, Sihem and WHO Study Grp Contraceptive Implan and WHO Study Group on Contraceptive Implants for Women
Human Reproduction, ISSN 0268-1161, 11/2015, Volume 30, Issue 11, pp. 2527 - 2538
STUDY QUESTION Is there any difference in the clinical performance of the 3-year one-rod etonogestrel (ENG)- and the 5-year two-rod levonorgestrel... 
etonogestrel | randomized clinical trial | TCu380A IUD | contraception | implanon | implants | Jadelle | levonorgestrel | EFFICACY | OBSTETRICS & GYNECOLOGY | WOMEN | REPRODUCTIVE BIOLOGY | BLEEDING PATTERN | Contraceptive Agents, Female - adverse effects | Contraceptive Agents, Female - pharmacology | Levonorgestrel - pharmacology | Intrauterine Devices, Copper - adverse effects | Outcome Assessment (Health Care) | Desogestrel - adverse effects | Humans | Contraceptive Agents, Female - administration & dosage | Drug Implants - pharmacology | Drug Implants - adverse effects | Desogestrel - pharmacology | Pregnancy | Young Adult | Desogestrel - administration & dosage | Time Factors | Levonorgestrel - administration & dosage | Levonorgestrel - adverse effects | Pregnancy, Unplanned | Adult | Female
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8. Full Text Efavirenz decreases etonogestrel exposure: a pharmacokinetic evaluation of implantable contraception with antiretroviral therapy
by Chappell, Catherine A and Lamorde, Mohammed and Nakalema, Shadia and Chen, Beatrice A and Mackline, Hope and Riddler, Sharon A and Cohn, Susan E and Darin, Kristin M and Achilles, Sharon L and Scarsi, Kimberly K
AIDS, ISSN 0269-9370, 09/2017, Volume 31, Issue 14, pp. 1965 - 1972
OBJECTIVES:The primary objective of this study was to characterize the pharmacokinetics of etonogestrel (ENG) released from a contraceptive implant in Ugandan... 
family planning | nevirapine | antiretroviral therapy | etonogestrel | contraceptive implant | drug-drug interaction | efavirenz | INFECTIOUS DISEASES | COUNTRIES | DRUG-INTERACTIONS | IMPLANON(R) FAILURE | IMMUNOLOGY | TRENDS | WOMEN | RATES | VIROLOGY | HIV | 3-KETO-DESOGESTREL | PLASMA PHARMACOKINETICS | Benzoxazines - administration & dosage | Humans | Middle Aged | Contraceptive Agents, Female - administration & dosage | Young Adult | Desogestrel - administration & dosage | Drug Antagonism | Anti-Retroviral Agents - administration & dosage | Desogestrel - pharmacokinetics | Adolescent | Contraceptive Agents, Female - pharmacokinetics | Adult | Female | HIV Infections - drug therapy | Uganda | Nevirapine - administration & dosage | Contraception - methods
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9. Full Text Drospirenone as estrogen-free pill and hemostasis: coagulatory study results comparing a novel 4 mg formulation in a 24 + 4 cycle with desogestrel 75 μg per day
by Regidor, Pedro Antonio and Colli, Enrico and Schindler, Adolf E
Gynecological Endocrinology, ISSN 0951-3590, 09/2016, Volume 32, Issue 9, pp. 749 - 751
Introduction: A novel estrogen free contraceptive pill, with drospirenone 4 mg in a dosing regimen of 24 + 4, has been developed with a pearl-index of 0.51... 
ovary | uterus | Hormonal contraception | Hemostasis - drug effects | Androstenes - adverse effects | Outcome Assessment (Health Care) | Desogestrel - adverse effects | Humans | Contraceptives, Oral - pharmacology | Androstenes - pharmacology | Blood Coagulation Factors - drug effects | Androstenes - administration & dosage | Desogestrel - pharmacology | Desogestrel - administration & dosage | Desogestrel - pharmacokinetics | Contraceptives, Oral - administration & dosage | Adult | Contraceptives, Oral - adverse effects
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10. Full Text Pharmacokinetics of the etonogestrel contraceptive implant in obese women
by Mornar, Sara, DO and Chan, Lingtak-Neander, PharmD and Mistretta, Stephanie, MA and Neustadt, Amy, MPH and Martins, Summer, MPH and Gilliam, Melissa, MD, MPH
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 2012, Volume 207, Issue 2, pp. 110.e1 - 110.e6
Objective We sought to examine the pharmacokinetics and acceptability of the etonogestrel contraceptive implant in obese women. Study Design We developed and... 
Obstetrics and Gynecology | implantable devices | pharmacokinetics | contraception | obesity | EFFICACY | RISK | 3-KETO-DESOGESTREL | PREGNANCY | OBSTETRICS & GYNECOLOGY | Area Under Curve | Desogestrel - blood | Humans | European Continental Ancestry Group | Obesity - blood | Patient Satisfaction | Young Adult | Contraceptive Agents, Female - blood | Desogestrel - pharmacokinetics | Adolescent | Contraceptive Agents, Female - pharmacokinetics | Adult | Female | African Continental Ancestry Group | Obesity | Contraceptives | Implants, Artificial | Prosthesis
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11. Full Text Esters of levonorgestrel and etonogestrel intended as single, subcutaneous-injection, long-lasting contraceptives
by Meece, Frederick A and Ahmed, Gulzar and Nair, Hareesh and Santhamma, Bindu and Tekmal, Rajeshwar R and Zhao, Chumang and Pollok, Nicole E and Lara, Julia and Shaked, Ze'ev and Nickisch, Klaus
Steroids, ISSN 0039-128X, 09/2018, Volume 137, pp. 47 - 56
An effort with the goal of discovering single-dose, long-lasting (>6 months) injectable contraceptives began using levonorgestrel (LNG)-17-β esters linked to a... 
Etonogestrel | Prodrug | Injectable contraception | Levonorgestrel | MPA | WOMEN | DESIGN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | HEALTH | NORETHISTERONE | PROGRAM | Contraceptive Agents, Female - pharmacology | Levonorgestrel - pharmacology | Contraceptive Agents, Female - chemistry | Desogestrel - chemistry | Contraceptive Agents, Female - administration & dosage | Rats | Levonorgestrel - chemistry | Rats, Sprague-Dawley | Desogestrel - pharmacology | Desogestrel - administration & dosage | Animals | Esters - chemistry | Levonorgestrel - administration & dosage | Injections, Subcutaneous | Female | Ovulation - drug effects | Contraceptives | Progestational hormones, Synthetic | Contraceptive drugs | Sulfonamides | Analysis | Esters | Liquefied natural gas
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12. Full Text The role of CYP2C and CYP3A in the disposition of 3-keto-desogestrel after administration of desogestrel
by Korhonen, Tuomas and Tolonen, Ari and Uusitalo, Jouko and Lundgren, Stefan and Jalonen, Jorma and Laine, Kari
British Journal of Clinical Pharmacology, ISSN 0306-5251, 07/2005, Volume 60, Issue 1, pp. 69 - 75
Aims Our objective was to study in vivo the role of CYP2C and CYP3A4 in the disposition of 3-keto-desogestrel after administration of desogestrel, by using the... 
metabolism | desogestrel | 3-keto-desogestrel | cytochrome P450 (CYP) enzyme | drug interaction | 3‐keto‐desogestrel | Desogestrel | Drug interaction | Metabolism | Cytochrome P450 (CYP) enzyme | CONTRACEPTIVE STEROID DESOGESTREL | WARFARIN-FLUCONAZOLE | POLYMORPHISM | S-MEPHENYTOIN | IN-VITRO | SYNTHETIC PROGESTAGEN | ANTIFUNGAL AGENTS | CLINICAL RELEVANCE | PHARMACOLOGY & PHARMACY | HUMAN-LIVER-MICROSOMES | Administration, Oral | Area Under Curve | Cytochrome P-450 CYP3A | Humans | Genotype | Oxidoreductases, N-Demethylating - physiology | Contraceptives, Oral, Synthetic - pharmacology | Desogestrel - metabolism | Contraceptives, Oral, Synthetic - administration & dosage | Cross-Over Studies | Desogestrel - pharmacology | Desogestrel - administration & dosage | Aryl Hydrocarbon Hydroxylases - physiology | Adult | Female | Cytochrome P-450 Enzyme System - physiology | Drug Disposition
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13. Full Text High Variability of Hormonal Levels and No Clinically Relevant Interaction Between Ethinyl Estradiol, Desogestrel and Lopinavir/Ritonavir in a Small Sample of HIV-positive Adolescents
by Kancheva Landolt, Nadia and Bunupuradah, Torsak and Kosalaraksa, Pope and Ubolyam, Sasiwimol and Thammajaruk, Narukjaporn and Cremers, Serge and Zott, Roseann and Kerr, Stephen and Ananworanich, Jintanat and HIV-NAT 176 Study and HIV-NAT 176 study
Journal of acquired immune deficiency syndromes (1999), ISSN 1525-4135, 2016, Volume 72, Issue 5, pp. 507 - 512
We report the pharmacokinetic interactions of combined oral contraceptive (COC) containing ethinyl estradiol (EE2)/desogestrel (DSG) with lopinavir/ritonavir... 
lopinavir/ritonavir | pharmacokinetic interactions | desogestrel/ethinyl estradiol | HIV-positive adolescents | INFECTIOUS DISEASES | ethinyl estradiol | ETONOGESTREL | desogestrel | IMMUNOLOGY | NEVIRAPINE | UDP-GLUCURONOSYLTRANSFERASE | WOMEN | PLASMA | lopinavir | PHARMACOKINETICS | ritonavir | EFAVIRENZ | COMBINED ORAL-CONTRACEPTIVES | ETHINYLESTRADIOL | SERUM PROGESTERONE | Prospective Studies | Ethinyl Estradiol - pharmacokinetics | Humans | Treatment Outcome | Lopinavir - pharmacokinetics | Pilot Projects | Drug Interactions | Ritonavir - pharmacokinetics | Anti-HIV Agents - pharmacokinetics | Desogestrel - pharmacokinetics | Adolescent | Contraceptive Agents, Female - pharmacokinetics | HIV Infections - drug therapy | Drug Combinations
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14. Full Text Extended use up to 5 years of the etonogestrel-releasing subdermal contraceptive implant: comparison to levonorgestrel-releasing subdermal implant
by Ali, Moazzam and Akin, Ayse and Bahamondes, Luis and Brache, Vivian and Habib, Ndema and Landoulsi, Sihem and Hubacher, David and WHO Study Grp Subdermal Contracept and WHO study group on subdermal contraceptive implants for women
Human Reproduction, ISSN 0268-1161, 11/2016, Volume 31, Issue 11, pp. 2491 - 2498
STUDY QUESTION Is it possible to extend the use of the 3-year one-rod etonogestrel (ENG)-releasing subdermal contraceptive implant to 5 years? SUMMARY ANSWER... 
subdermal contraceptive implants | extended use | intrauterine device | etonogestrel | levonorgestrel | TRIAL | INTRAUTERINE-DEVICE | REPRODUCTIVE BIOLOGY | OBSTETRICS & GYNECOLOGY | Contraceptive Agents, Female - therapeutic use | Humans | Contraceptive Agents, Female - administration & dosage | Desogestrel - therapeutic use | Drug Implants | Treatment Outcome | Young Adult | Desogestrel - administration & dosage | Family Planning Services | Levonorgestrel - administration & dosage | Adolescent | Levonorgestrel - therapeutic use | Adult | Female | Original
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15. Full Text Safety and efficacy of the NuvaRing® Applicator in healthy females: A multicenter, open-label, randomized, 2-period crossover study
by Feldman, Robert and Frenkl, Tara L and Yacik, Carol and Wang, Yinna and Fox, Michelle C
Contraception, ISSN 0010-7824, 2016, Volume 94, Issue 4, pp. 362 - 365
Abstract Introduction We assessed performance and safety of the NuvaRing® Applicator. Methods We randomized women (18-45 years) to insert a placebo ring using... 
Obstetrics and Gynecology | Ethinyl estradiol | Etonogestrel | Applicator | Contraceptive vaginal ring | Intravaginal | Desogestrel - adverse effects | Humans | Middle Aged | Contraceptive Devices, Female | Vagina | Cross-Over Studies | Young Adult | Ethinyl Estradiol - adverse effects | Desogestrel - administration & dosage | Desogestrel - analogs & derivatives | Fingers | Adolescent | Adult | Female | Surveys and Questionnaires | Ethinyl Estradiol - administration & dosage | Drug Combinations | Women | Clinical trials | Health aspects
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16. Full Text Male Hormonal Contraception: A Double-Blind, Placebo-Controlled Study
by Mommers, Ellen and Kersemaekers, Wendy M and Elliesen, Jörg and Kepers, Marc and Apter, Dan and Behre, Hermann M and Beynon, Jennifer and Bouloux, Pierre M and Costantino, Antonietta and Gerbershagen, Hans-Peter and Grønlund, Lars and Heger-Mahn, Doris and Huhtaniemi, Ilpo and Koldewijn, Evert L and Lange, Corinna and Lindenberg, Svend and Meriggiola, M. Cristina and Meuleman, Eric and Mulders, Peter F. A and Nieschlag, Eberhard and Perheentupa, Antti and Solomon, Andrew and Väisälä, Leena and Wu, Frederick C and Zitzmann, Michael
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 07/2008, Volume 93, Issue 7, pp. 2572 - 2580
Background: This study was performed to assess spermatogenesis suppression and safety of a new combination of an etonogestrel (ENG) implant combined with... 
ETONOGESTREL IMPLANTS | SPERMATOGENESIS | TESTOSTERONE UNDECANOATE | MULTICENTER | DESOGESTREL |