Urology, ISSN 0090-4295, 2004, Volume 63, Issue 1, pp. 120 - 125
Objectives. To evaluate prospectively the combination of a luteinizing hormone-releasing hormone analog with a somatostatin analog and dexamethasone in...
ETOPOSIDE | THERAPY | ORAL ESTRAMUSTINE | CLINICAL-TRIALS | DISEASE | UROLOGY & NEPHROLOGY | CASTRATION | CARCINOMA | CELL-DEATH | Somatostatin - adverse effects | Estramustine - administration & dosage | Humans | Middle Aged | Somatostatin - administration & dosage | Bone Neoplasms - secondary | Dexamethasone - adverse effects | Male | Triptorelin Pamoate - administration & dosage | Life Tables | Peptides, Cyclic - administration & dosage | Antineoplastic Agents, Hormonal - adverse effects | Aged, 80 and over | Bone Neoplasms - drug therapy | Gonadotropin-Releasing Hormone - agonists | Prostatic Neoplasms - drug therapy | Hematologic Diseases - chemically induced | Somatostatin - analogs & derivatives | Dexamethasone - administration & dosage | Etoposide - adverse effects | Prostatic Neoplasms - surgery | Antineoplastic Agents, Hormonal - administration & dosage | Etoposide - administration & dosage | Treatment Outcome | Triptorelin Pamoate - adverse effects | Combined Modality Therapy | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Prostatic Neoplasms - mortality | Orchiectomy | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Diabetes Mellitus - chemically induced | Aged | Estramustine - adverse effects | Peptides, Cyclic - adverse effects | Gastrointestinal Diseases - chemically induced | Adenocarcinoma - mortality | Adenocarcinoma - surgery
ETOPOSIDE | THERAPY | ORAL ESTRAMUSTINE | CLINICAL-TRIALS | DISEASE | UROLOGY & NEPHROLOGY | CASTRATION | CARCINOMA | CELL-DEATH | Somatostatin - adverse effects | Estramustine - administration & dosage | Humans | Middle Aged | Somatostatin - administration & dosage | Bone Neoplasms - secondary | Dexamethasone - adverse effects | Male | Triptorelin Pamoate - administration & dosage | Life Tables | Peptides, Cyclic - administration & dosage | Antineoplastic Agents, Hormonal - adverse effects | Aged, 80 and over | Bone Neoplasms - drug therapy | Gonadotropin-Releasing Hormone - agonists | Prostatic Neoplasms - drug therapy | Hematologic Diseases - chemically induced | Somatostatin - analogs & derivatives | Dexamethasone - administration & dosage | Etoposide - adverse effects | Prostatic Neoplasms - surgery | Antineoplastic Agents, Hormonal - administration & dosage | Etoposide - administration & dosage | Treatment Outcome | Triptorelin Pamoate - adverse effects | Combined Modality Therapy | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Prostatic Neoplasms - mortality | Orchiectomy | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Diabetes Mellitus - chemically induced | Aged | Estramustine - adverse effects | Peptides, Cyclic - adverse effects | Gastrointestinal Diseases - chemically induced | Adenocarcinoma - mortality | Adenocarcinoma - surgery
Journal Article
Cancer Research, ISSN 0008-5472, 01/2008, Volume 68, Issue 1, pp. 190 - 197
Many agents are active in multiple myeloma, but the majority of patients relapse. This clinical pattern suggests most cancer cells are eliminated, but cells...
BREAST-CANCER | CIRCULATING B-CELLS | ONCOLOGY | BONE-MARROW | LEUKEMIC B | IN-VIVO | PERIPHERAL-BLOOD | TUMOR-CELLS | MICE | IDENTIFICATION | PLASMA-CELLS | Cyclophosphamide - analogs & derivatives | Clone Cells - drug effects | Neoplastic Stem Cells - drug effects | Humans | Drug Resistance, Neoplasm | Thalidomide - pharmacology | Plasma Cells - pathology | Plasma Cells - drug effects | Thalidomide - analogs & derivatives | Dexamethasone - pharmacology | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Antigens, CD20 - analysis | B-Lymphocytes - pathology | Tumor Stem Cell Assay | Bortezomib | Mice, Inbred Strains | Syndecan-1 - analysis | Multiple Myeloma - pathology | Animals | Clone Cells - pathology | Cyclophosphamide - pharmacology | Mice | Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis | Pyrazines - pharmacology | Boronic Acids - pharmacology | Index Medicus
BREAST-CANCER | CIRCULATING B-CELLS | ONCOLOGY | BONE-MARROW | LEUKEMIC B | IN-VIVO | PERIPHERAL-BLOOD | TUMOR-CELLS | MICE | IDENTIFICATION | PLASMA-CELLS | Cyclophosphamide - analogs & derivatives | Clone Cells - drug effects | Neoplastic Stem Cells - drug effects | Humans | Drug Resistance, Neoplasm | Thalidomide - pharmacology | Plasma Cells - pathology | Plasma Cells - drug effects | Thalidomide - analogs & derivatives | Dexamethasone - pharmacology | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Antigens, CD20 - analysis | B-Lymphocytes - pathology | Tumor Stem Cell Assay | Bortezomib | Mice, Inbred Strains | Syndecan-1 - analysis | Multiple Myeloma - pathology | Animals | Clone Cells - pathology | Cyclophosphamide - pharmacology | Mice | Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis | Pyrazines - pharmacology | Boronic Acids - pharmacology | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2011, Volume 17, Issue 16, pp. 5311 - 5321
Purpose: The success of bortezomib therapy for treatment of multiple myeloma (MM) led to the development of structurally and pharmacologically distinct novel...
THERAPY | CANCER CELLS | ONCOLOGY | INDUCED APOPTOSIS | GROWTH | DRUG-RESISTANCE | BORTEZOMIB | COMBINATION | NF-KAPPA-B | GENETIC ABNORMALITIES | P53 | Glycine - analogs & derivatives | Caspase 9 - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Caspase 8 - metabolism | Biological Availability | NF-kappa B - metabolism | Thalidomide - pharmacology | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Dexamethasone - pharmacology | Antineoplastic Agents - pharmacology | Glycine - pharmacokinetics | Boron Compounds - pharmacology | Cell Survival - drug effects | Bortezomib | Administration, Oral | Boron Compounds - pharmacokinetics | Enzyme Activation - drug effects | Mice, SCID | Multiple Myeloma - metabolism | Blotting, Western | Drug Synergism | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | Glycine - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Pyrazines - pharmacology | Boronic Acids - pharmacology | Novel therapeutics | Myeloma | Proteasome inhibitor | Apoptosis | Proteasome
THERAPY | CANCER CELLS | ONCOLOGY | INDUCED APOPTOSIS | GROWTH | DRUG-RESISTANCE | BORTEZOMIB | COMBINATION | NF-KAPPA-B | GENETIC ABNORMALITIES | P53 | Glycine - analogs & derivatives | Caspase 9 - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Caspase 8 - metabolism | Biological Availability | NF-kappa B - metabolism | Thalidomide - pharmacology | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Dexamethasone - pharmacology | Antineoplastic Agents - pharmacology | Glycine - pharmacokinetics | Boron Compounds - pharmacology | Cell Survival - drug effects | Bortezomib | Administration, Oral | Boron Compounds - pharmacokinetics | Enzyme Activation - drug effects | Mice, SCID | Multiple Myeloma - metabolism | Blotting, Western | Drug Synergism | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | Glycine - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Pyrazines - pharmacology | Boronic Acids - pharmacology | Novel therapeutics | Myeloma | Proteasome inhibitor | Apoptosis | Proteasome
Journal Article
Blood, ISSN 0006-4971, 11/2006, Volume 108, Issue 10, pp. 3458 - 3464
This multicenter, open-label, randomized phase 2 study evaluated 2 dose regimens of lenalidomide for relapsed, refractory myeloma. Seventy patients were...
CC-5013 | THALIDOMIDE PLUS DEXAMETHASONE | ANALOGS | COMBINATION THERAPY | NEWLY-DIAGNOSED MYELOMA | OPEN-LABEL | HIGH-DOSE CHEMOTHERAPY | DRUG-RESISTANCE | BORTEZOMIB | HEMATOLOGY | CELL | Recurrence | Salvage Therapy - adverse effects | Peripheral Nervous System Diseases - chemically induced | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Dexamethasone - administration & dosage | Venous Thrombosis - chemically induced | Multiple Myeloma - complications | Multiple Myeloma - mortality | Humans | Middle Aged | Male | Survival Rate | Thalidomide - administration & dosage | Thalidomide - toxicity | Thalidomide - pharmacokinetics | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Adult | Female | Remission Induction - methods | Aged | Salvage Therapy - methods | Neoplasia
CC-5013 | THALIDOMIDE PLUS DEXAMETHASONE | ANALOGS | COMBINATION THERAPY | NEWLY-DIAGNOSED MYELOMA | OPEN-LABEL | HIGH-DOSE CHEMOTHERAPY | DRUG-RESISTANCE | BORTEZOMIB | HEMATOLOGY | CELL | Recurrence | Salvage Therapy - adverse effects | Peripheral Nervous System Diseases - chemically induced | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Dexamethasone - administration & dosage | Venous Thrombosis - chemically induced | Multiple Myeloma - complications | Multiple Myeloma - mortality | Humans | Middle Aged | Male | Survival Rate | Thalidomide - administration & dosage | Thalidomide - toxicity | Thalidomide - pharmacokinetics | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Adult | Female | Remission Induction - methods | Aged | Salvage Therapy - methods | Neoplasia
Journal Article
Annals of Oncology, ISSN 0923-7534, 12/2006, Volume 17, Issue 12, pp. 1766 - 1771
Background: Lenalidomide is active and well tolerated in relapsed and refractory multiple myeloma. We conducted a phase I/II trial of the combination of...
Refractory | Doxil | Lenalidomide | Reduced dose dexamethasone | Multiple Myeloma | refractory | multiple myeloma | DEXAMETHASONE | ONCOLOGY-GROUP | ANALOGS | PHASE-2 | THALIDOMIDE | TNF-ALPHA PRODUCTION | THROMBOTIC COMPLICATIONS | ONCOLOGY | VINCRISTINE | UNDETERMINED SIGNIFICANCE | MONOCLONAL GAMMOPATHY | lenalidomide | reduced dose dexamethasone | Doxorubicin - therapeutic use | Recurrence | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Thalidomide - administration & dosage | Polyethylene Glycols - therapeutic use | Polyethylene Glycols - administration & dosage | Thalidomide - analogs & derivatives | Maximum Tolerated Dose | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Doxorubicin - analogs & derivatives | Female | Aged | Thalidomide - therapeutic use | Doxorubicin - administration & dosage
Refractory | Doxil | Lenalidomide | Reduced dose dexamethasone | Multiple Myeloma | refractory | multiple myeloma | DEXAMETHASONE | ONCOLOGY-GROUP | ANALOGS | PHASE-2 | THALIDOMIDE | TNF-ALPHA PRODUCTION | THROMBOTIC COMPLICATIONS | ONCOLOGY | VINCRISTINE | UNDETERMINED SIGNIFICANCE | MONOCLONAL GAMMOPATHY | lenalidomide | reduced dose dexamethasone | Doxorubicin - therapeutic use | Recurrence | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Thalidomide - administration & dosage | Polyethylene Glycols - therapeutic use | Polyethylene Glycols - administration & dosage | Thalidomide - analogs & derivatives | Maximum Tolerated Dose | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Doxorubicin - analogs & derivatives | Female | Aged | Thalidomide - therapeutic use | Doxorubicin - administration & dosage
Journal Article
British Journal of Haematology, ISSN 0007-1048, 04/2008, Volume 141, Issue 1, pp. 41 - 51
Summary We previously reported that daily dose pomalidomide (CC-4047), a thalidomide analogue, has excellent anti-myeloma activity but is associated with...
immunomodulation | myeloma | CC-4047 | pomalidomide | thalidomide analogue | CC‐4047 | Pomalidomide | Thalidomide analogue | Myeloma | Immunomodulation | CELLS | REFRACTORY MULTIPLE-MYELOMA | ANGIOGENESIS | VENOUS THROMBOSIS | PHASE-II | DRUG-RESISTANCE | POTENT INHIBITORS | THERAPY | THALIDOMIDE ANALOGS | TNF-ALPHA | HEMATOLOGY | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Antineoplastic Agents - adverse effects | Adult | Female | Drug Therapy, Combination | Neutropenia - chemically induced | Thalidomide - adverse effects | Drug Administration Schedule | Lymphocyte Subsets - drug effects | Immunologic Factors - administration & dosage | Treatment Outcome | Thalidomide - administration & dosage | Blood Cell Count | Dexamethasone - therapeutic use | Maximum Tolerated Dose | Survival Analysis | Aged | Immunologic Factors - adverse effects | Thalidomide - therapeutic use | Immunologic Factors - therapeutic use | Index Medicus
immunomodulation | myeloma | CC-4047 | pomalidomide | thalidomide analogue | CC‐4047 | Pomalidomide | Thalidomide analogue | Myeloma | Immunomodulation | CELLS | REFRACTORY MULTIPLE-MYELOMA | ANGIOGENESIS | VENOUS THROMBOSIS | PHASE-II | DRUG-RESISTANCE | POTENT INHIBITORS | THERAPY | THALIDOMIDE ANALOGS | TNF-ALPHA | HEMATOLOGY | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Antineoplastic Agents - adverse effects | Adult | Female | Drug Therapy, Combination | Neutropenia - chemically induced | Thalidomide - adverse effects | Drug Administration Schedule | Lymphocyte Subsets - drug effects | Immunologic Factors - administration & dosage | Treatment Outcome | Thalidomide - administration & dosage | Blood Cell Count | Dexamethasone - therapeutic use | Maximum Tolerated Dose | Survival Analysis | Aged | Immunologic Factors - adverse effects | Thalidomide - therapeutic use | Immunologic Factors - therapeutic use | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2015, Volume 372, Issue 2, pp. 142 - 152
In this study, the addition of carfilzomib to lenalidomide and dexamethasone improved response rates and overall survival among patients with relapsed multiple...
SINGLE-AGENT CARFILZOMIB | SURVIVAL | MEDICINE, GENERAL & INTERNAL | PLUS DEXAMETHASONE | RANDOMIZED PHASE-III | BORTEZOMIB | STEM-CELL TRANSPLANTATION | COMBINATION | LOW-DOSE DEXAMETHASONE | PX-171-006 | ESCALATION | Thalidomide - adverse effects | Recurrence | Dexamethasone - administration & dosage | Multiple Myeloma - mortality | Humans | Middle Aged | Kaplan-Meier Estimate | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Dexamethasone - adverse effects | Male | Thalidomide - administration & dosage | Oligopeptides - adverse effects | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Intention to Treat Analysis | Aged, 80 and over | Adult | Female | Aged | Oligopeptides - administration & dosage | Treatment outcome | Dexamethasone | Analysis | Multiple myeloma | Carfilzomib | Dosage and administration | Drug therapy | Risk factors | Quality of life | Chemotherapy | Clinical trials | Survival | Patients | Proteasome inhibitors
SINGLE-AGENT CARFILZOMIB | SURVIVAL | MEDICINE, GENERAL & INTERNAL | PLUS DEXAMETHASONE | RANDOMIZED PHASE-III | BORTEZOMIB | STEM-CELL TRANSPLANTATION | COMBINATION | LOW-DOSE DEXAMETHASONE | PX-171-006 | ESCALATION | Thalidomide - adverse effects | Recurrence | Dexamethasone - administration & dosage | Multiple Myeloma - mortality | Humans | Middle Aged | Kaplan-Meier Estimate | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Dexamethasone - adverse effects | Male | Thalidomide - administration & dosage | Oligopeptides - adverse effects | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Intention to Treat Analysis | Aged, 80 and over | Adult | Female | Aged | Oligopeptides - administration & dosage | Treatment outcome | Dexamethasone | Analysis | Multiple myeloma | Carfilzomib | Dosage and administration | Drug therapy | Risk factors | Quality of life | Chemotherapy | Clinical trials | Survival | Patients | Proteasome inhibitors
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 12/2009, Volume 27, Issue 34, pp. 5713 - 5719
Purpose Lenalidomide and bortezomib are active in relapsed and relapsed/refractory multiple myeloma (MM). In preclinical studies, lenalidomide sensitized MM...
CELLS | DEXAMETHASONE | PREDNISONE | THERAPY | ONCOLOGY | ANALOGS | REFRACTORY MYELOMA | OVERCOMES DRUG-RESISTANCE | THALIDOMIDE | COMBINATION | MELPHALAN | Recurrence | Glucocorticoids - administration & dosage | Humans | Middle Aged | Pyrazines - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Boronic Acids - adverse effects | Dexamethasone - adverse effects | Drug Resistance, Neoplasm | Male | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Adult | Female | Boronic Acids - administration & dosage | Glucocorticoids - adverse effects | Thalidomide - adverse effects | Bortezomib | Dexamethasone - administration & dosage | Thalidomide - administration & dosage | Maximum Tolerated Dose | Multiple Myeloma - pathology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pyrazines - adverse effects | Aged | Index Medicus | Original Reports | Hema21
CELLS | DEXAMETHASONE | PREDNISONE | THERAPY | ONCOLOGY | ANALOGS | REFRACTORY MYELOMA | OVERCOMES DRUG-RESISTANCE | THALIDOMIDE | COMBINATION | MELPHALAN | Recurrence | Glucocorticoids - administration & dosage | Humans | Middle Aged | Pyrazines - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Boronic Acids - adverse effects | Dexamethasone - adverse effects | Drug Resistance, Neoplasm | Male | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Adult | Female | Boronic Acids - administration & dosage | Glucocorticoids - adverse effects | Thalidomide - adverse effects | Bortezomib | Dexamethasone - administration & dosage | Thalidomide - administration & dosage | Maximum Tolerated Dose | Multiple Myeloma - pathology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pyrazines - adverse effects | Aged | Index Medicus | Original Reports | Hema21
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2016, Volume 375, Issue 14, pp. 1319 - 1331
The addition of daratumumab to lenalidomide and dexamethasone resulted in superior response rate and progression-free survival, as compared with lenalidomide...
SURVIVAL | CRITERIA | MEDICINE, GENERAL & INTERNAL | MONOTHERAPY | ELOTUZUMAB | ANTIBODY DARATUMUMAB | CD38 | OPEN-LABEL | INTERFERENCE | Recurrence | Dexamethasone - administration & dosage | Multiple Myeloma - mortality | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Kaplan-Meier Estimate | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Drug Resistance, Neoplasm | Thalidomide - administration & dosage | Disease-Free Survival | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Care and treatment | Usage | Dexamethasone | Diagnosis | Multiple myeloma | Thrombocytopenia | Minimal residual disease | Leukocytes | Health risk assessment | Drug therapy | Patients | Neutropenia | Pharmaceuticals
SURVIVAL | CRITERIA | MEDICINE, GENERAL & INTERNAL | MONOTHERAPY | ELOTUZUMAB | ANTIBODY DARATUMUMAB | CD38 | OPEN-LABEL | INTERFERENCE | Recurrence | Dexamethasone - administration & dosage | Multiple Myeloma - mortality | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Kaplan-Meier Estimate | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Drug Resistance, Neoplasm | Thalidomide - administration & dosage | Disease-Free Survival | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Care and treatment | Usage | Dexamethasone | Diagnosis | Multiple myeloma | Thrombocytopenia | Minimal residual disease | Leukocytes | Health risk assessment | Drug therapy | Patients | Neutropenia | Pharmaceuticals
Journal Article
Leukemia, ISSN 0887-6924, 2014, Volume 28, Issue 8, pp. 1573 - 1585
In this report, a panel of European myeloma experts discuss the role of pomalidomide in the treatment of relapsed and refractory multiple myeloma (RRMM). Based...
TUMOR-NECROSIS-FACTOR | NATURAL-KILLER-CELLS | VENOUS THROMBOEMBOLISM | ONCOLOGY | GROWTH-FACTORS | LENALIDOMIDE PLUS DEXAMETHASONE | PERIPHERAL NEUROPATHY | THALIDOMIDE ANALOGS | BORTEZOMIB | HEMATOLOGY | HIGH-DOSE DEXAMETHASONE | AMERICAN SOCIETY | Thalidomide - adverse effects | Peripheral Nervous System Diseases - chemically induced | Dexamethasone - administration & dosage | Age Factors | Drug Administration Schedule | Multiple Myeloma - psychology | Humans | Clinical Trials as Topic | Thalidomide - administration & dosage | Thalidomide - pharmacology | Infection - chemically induced | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Venous Thromboembolism - chemically induced | Quality of Life | Thalidomide - therapeutic use | Neutropenia - chemically induced | Multiple Myeloma - genetics | Immunologic Factors - therapeutic use | Dose-response relationship (Biochemistry) | Pharmacology, Experimental | Oncology, Experimental | Multiple myeloma | Research | Drug therapy | Cancer | Index Medicus | Review | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
TUMOR-NECROSIS-FACTOR | NATURAL-KILLER-CELLS | VENOUS THROMBOEMBOLISM | ONCOLOGY | GROWTH-FACTORS | LENALIDOMIDE PLUS DEXAMETHASONE | PERIPHERAL NEUROPATHY | THALIDOMIDE ANALOGS | BORTEZOMIB | HEMATOLOGY | HIGH-DOSE DEXAMETHASONE | AMERICAN SOCIETY | Thalidomide - adverse effects | Peripheral Nervous System Diseases - chemically induced | Dexamethasone - administration & dosage | Age Factors | Drug Administration Schedule | Multiple Myeloma - psychology | Humans | Clinical Trials as Topic | Thalidomide - administration & dosage | Thalidomide - pharmacology | Infection - chemically induced | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Venous Thromboembolism - chemically induced | Quality of Life | Thalidomide - therapeutic use | Neutropenia - chemically induced | Multiple Myeloma - genetics | Immunologic Factors - therapeutic use | Dose-response relationship (Biochemistry) | Pharmacology, Experimental | Oncology, Experimental | Multiple myeloma | Research | Drug therapy | Cancer | Index Medicus | Review | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Hematological Oncology, ISSN 0278-0232, 12/2013, Volume 31, Issue 4, pp. 213 - 217
Angioimmunoblastic T‐cell lymphoma (AITL) is characterized by an aggressive clinical course and unfavourable prognosis. Refractory AITL patients have very few...
chemorefractory | lenalidomide | AITL | salvage treatment | Chemorefractory | Salvage treatment | Lenalidomide | PHASE-II TRIAL | ACTIVATION | ONCOLOGY | THALIDOMIDE ANALOGS | HEMATOLOGY | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Clinical Trials as Topic - statistics & numerical data | Follow-Up Studies | Humans | Middle Aged | Salvage Therapy | Drugs, Investigational - therapeutic use | Drug Resistance, Neoplasm | Male | Vinblastine - administration & dosage | Thalidomide - analogs & derivatives | Organoplatinum Compounds - administration & dosage | Vinblastine - analogs & derivatives | Doxorubicin - analogs & derivatives | Angiogenesis Inhibitors - therapeutic use | Doxorubicin - administration & dosage | Lymphoma, T-Cell, Peripheral - drug therapy | Prednisone - administration & dosage | Dexamethasone - administration & dosage | Deoxycytidine - administration & dosage | Combined Modality Therapy | Lymphoma, T-Cell, Peripheral - radiotherapy | Remission Induction | Cytarabine - administration & dosage | Polyethylene Glycols - administration & dosage | Ifosfamide - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Thalidomide - therapeutic use | Deoxycytidine - analogs & derivatives | Immunologic Factors - therapeutic use | T cells | Radiotherapy | Lymphomas
chemorefractory | lenalidomide | AITL | salvage treatment | Chemorefractory | Salvage treatment | Lenalidomide | PHASE-II TRIAL | ACTIVATION | ONCOLOGY | THALIDOMIDE ANALOGS | HEMATOLOGY | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Clinical Trials as Topic - statistics & numerical data | Follow-Up Studies | Humans | Middle Aged | Salvage Therapy | Drugs, Investigational - therapeutic use | Drug Resistance, Neoplasm | Male | Vinblastine - administration & dosage | Thalidomide - analogs & derivatives | Organoplatinum Compounds - administration & dosage | Vinblastine - analogs & derivatives | Doxorubicin - analogs & derivatives | Angiogenesis Inhibitors - therapeutic use | Doxorubicin - administration & dosage | Lymphoma, T-Cell, Peripheral - drug therapy | Prednisone - administration & dosage | Dexamethasone - administration & dosage | Deoxycytidine - administration & dosage | Combined Modality Therapy | Lymphoma, T-Cell, Peripheral - radiotherapy | Remission Induction | Cytarabine - administration & dosage | Polyethylene Glycols - administration & dosage | Ifosfamide - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Thalidomide - therapeutic use | Deoxycytidine - analogs & derivatives | Immunologic Factors - therapeutic use | T cells | Radiotherapy | Lymphomas
Journal Article
Cell Metabolism, ISSN 1550-4131, 10/2017, Volume 26, Issue 4, pp. 620 - 632.e6
Chronic inflammation has been proposed to contribute to the pathogenesis of diet-induced obesity. However, scarce therapeutic options are available to treat...
dexamethasone | hypothalamic inflammation | conjugate | GLP-1 | type 2 diabetes | co-agonist | anti-inflammatory | drug delivery | obesity | LEPTIN | ACTIVATION | LIRAGLUTIDE | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | HYPOTHALAMIC INFLAMMATION | MICE | MECHANISMS | STRESS | BETA/NF-KAPPA-B | GLUCAGON | CELL BIOLOGY | Glucocorticoids - therapeutic use | Obesity - drug therapy | Humans | Body Weight - drug effects | Male | Dexamethasone - analogs & derivatives | Inflammation - complications | Inflammation - metabolism | Inflammation - drug therapy | HEK293 Cells | Hypothalamus - drug effects | Incretins - chemistry | Glucagon-Like Peptide 1 - analogs & derivatives | Obesity - complications | Mice, Inbred C57BL | Obesity - metabolism | Dexamethasone - therapeutic use | Animals | Hypothalamus - metabolism | Glucocorticoids - chemistry | Glucose - metabolism | Mice, Obese | Mice | Incretins - therapeutic use | Energy Metabolism - drug effects | Glucagon-Like Peptide 1 - therapeutic use | Obesity | Dexamethasone | Glucagon | Health aspects | Body weight | Steroids | Corticosteroids
dexamethasone | hypothalamic inflammation | conjugate | GLP-1 | type 2 diabetes | co-agonist | anti-inflammatory | drug delivery | obesity | LEPTIN | ACTIVATION | LIRAGLUTIDE | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | HYPOTHALAMIC INFLAMMATION | MICE | MECHANISMS | STRESS | BETA/NF-KAPPA-B | GLUCAGON | CELL BIOLOGY | Glucocorticoids - therapeutic use | Obesity - drug therapy | Humans | Body Weight - drug effects | Male | Dexamethasone - analogs & derivatives | Inflammation - complications | Inflammation - metabolism | Inflammation - drug therapy | HEK293 Cells | Hypothalamus - drug effects | Incretins - chemistry | Glucagon-Like Peptide 1 - analogs & derivatives | Obesity - complications | Mice, Inbred C57BL | Obesity - metabolism | Dexamethasone - therapeutic use | Animals | Hypothalamus - metabolism | Glucocorticoids - chemistry | Glucose - metabolism | Mice, Obese | Mice | Incretins - therapeutic use | Energy Metabolism - drug effects | Glucagon-Like Peptide 1 - therapeutic use | Obesity | Dexamethasone | Glucagon | Health aspects | Body weight | Steroids | Corticosteroids
Journal Article