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Clinical Pharmacokinetics, ISSN 0312-5963, 1/2011, Volume 50, Issue 1, pp. 25 - 39
Etravirine (formerly TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with activity against wild-type and NNRTI-resistant strains of HIV-1.... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Drug-interactions | Ribavirin, drug interactions | Antiepileptic-drugs, drug interactions | Simvastatin, drug interactions | Voriconazole, drug interactions | Dexamethasone, drug interactions | Fibric-acid-derivatives, drug interactions | Rifampicin, drug interactions | Opioid-analgesics, drug interactions | Antidepressants, drug interactions | Atorvastatin, drug interactions | Antiretrovirals, drug interactions | Anti-infectives, drug interactions | Histamine-H2-receptor-antagonists, drug interactions | Diazepam, drug interactions | Ketoconazole, drug interactions | Fluconazole, drug interactions | Hypericum, drug interactions | HMG-CoA-reductase-inhibitors, drug interactions | Oral-contraceptives, drug interactions | Sildenafil, drug interactions | Omeprazole, drug interactions | Buprenorphine, drug interactions | Rosuvastatin, drug interactions | Non-nucleoside-reverse-transcriptase-inhibitors, drug interactions | Type-5-cyclic-nucleotide- phosphodiesterase-inhibitors, drug interactions | Corticosteroids, drug interactions | Paroxetine, drug interactions | Fluoxetine, drug interactions | Rifapentine, drug interactions | Ethinylestradiolnorethisterone, drug interactions | Ranitidine, drug interactions | Etravirine, drug interactions | Antifungals, drug interactions | Digoxin, drug interactions | Warfarin, drug interactions | Methadone, drug interactions | Fluvastatin, drug interactions | Rifabutin, drug interactions | Sertraline, drug interactions | Azithromycin, drug interactions | Pharmacokinetics | Calcineurin-inhibitors, drug interactions | Itraconazole, drug interactions | Proton-pump-inhibitors, drug interactions | Clarithromycin, drug interactions | METABOLISM | EFFICACY | METHADONE | EXPERIENCED HIV-1-INFECTED PATIENTS | TMC125 ETRAVIRINE | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | HUMAN LIVER | PHARMACODYNAMICS | 2 DIFFERENT FORMULATIONS | CLINICAL PHARMACOKINETICS | Reverse Transcriptase Inhibitors - adverse effects | Reverse Transcriptase Inhibitors - pharmacokinetics | Drug Interactions | Drug-Related Side Effects and Adverse Reactions | Humans | Pyridazines - pharmacokinetics | Drug Therapy, Combination | Pyridazines - adverse effects | Etravirine | Drug interactions | Physiological aspects | Dosage and administration | Research | Properties | Drug therapy | HIV infection
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 09/2016, Volume 6, Issue 5, pp. 413 - 425
Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously believed. The discovery of multiple important... 
Cyclophosphamide | CYP2B6 | CAR | PXR | Drug-drug interaction | Efavirenz | Polymorphism | HUMAN CYTOCHROME P4502B6 | CYP2B6 983T-GREATER-THAN-C POLYMORPHISM | N-DEMETHYLATION | PREGNANE-X-RECEPTOR | DISRUPTOR PESTICIDE-METHOXYCHLOR | BUPROPION HYDROXYLATION | ANTI-HIV THERAPY | CONSTITUTIVE ANDROSTANE RECEPTOR | PHARMACOLOGY & PHARMACY | IN-VITRO BIOTRANSFORMATION | RESPONSIVE ENHANCER MODULE | IFA, Ifosfamide | DEX, dexamethasone | HNF, hepatocyte nuclear factor | Review | CITCO, (6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime) | NVP, nevirapine | 2, nuclear receptor binding site 1 | GRE, glucocorticoid responsive element | MAOI, monoamine oxidase inhibitor | PXR, pregnane X receptor | CYP, cytochrome P450 | enhancer-binding protein | UGT, UDP-glucuronosyl transferase | PCN, pregnenolone 16 alpha-carbonitrile | PBREM, phenobarbital-responsive enhancer module | Drug–drug interaction | EBP, CCAAT | CAR, constitutive androstane receptor | COUP-TF, chicken ovalbumin upstream promoter-transcription factor | ERE, estrogen responsive element | HAART, highly active antiretroviral therapy | NR1 | PB, phenobarbital | NNRTI, non-nucleotide reverse-transcriptase inhibitor | CPA, cyclophosphamide | SNP, single nucleotide polymorphism | TCPOBOP, 1,4-bis[3,5-dichloropyridyloxy]benzene | CHOP, cyclophosphamide–doxorubicin–vincristine–prednisone | 4-OH-CPA, 4-hydroxycyclophosphamide | DDI, drug–drug interaction | EFV, efavirenz | GR, glucocorticoid receptor | E2, estradiol | RIF, rifampin
Journal Article
Oncogene, ISSN 0950-9232, 04/2014, Volume 33, Issue 17, pp. 2169 - 2178
Drug resistance in acute lymphoblastic leukemia (ALL) remains a major problem warranting new treatment strategies. Wnt/catenin signaling is critical for the... 
CBP | p300 | ICG-001 | small-molecule inhibitor | drug resistance | acute lymphoblastic leukemia | RUBINSTEIN-TAYBI-SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTIONAL COACTIVATOR CBP | SELF-RENEWAL | BETA-CATENIN | HISTONE ACETYLATION | CELL BIOLOGY | CREB-BINDING PROTEIN | ONCOLOGY | PRE-B | HEMATOPOIETIC STEM-CELLS | GENETICS & HEREDITY | WNT/BETA-CATENIN PATHWAY | DIFFERENTIAL ROLES | Sialoglycoproteins - genetics | Vincristine - pharmacology | Inhibitor of Apoptosis Proteins - genetics | Humans | Sialoglycoproteins - metabolism | Drug Resistance, Neoplasm | Asparaginase - pharmacology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Dexamethasone - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Peptide Fragments - genetics | Wnt Signaling Pathway | Cell Survival - drug effects | Peptide Fragments - metabolism | Sialoglycoproteins - antagonists & inhibitors | Down-Regulation - drug effects | Mice, SCID | beta Catenin - metabolism | Drug Synergism | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Mutation | Care and treatment | Oncology, Experimental | Genetic aspects | Acute lymphocytic leukemia | Research | Drug resistance | Cancer | Cloning | Leukemia | Index Medicus | Acute lymphoblastic leukemia | small molecule inhibitor
Journal Article
Nature Neuroscience, ISSN 1097-6256, 01/2013, Volume 16, Issue 1, pp. 33 - 41
Although the fact that genetic predisposition and environmental exposures interact to shape development and function of the human brain and, ultimately, the... 
POSTTRAUMATIC-STRESS-DISORDER | METHYLATION | GLUCOCORTICOID-RECEPTOR | POLYMORPHISMS | ABUSE | INCREASES | RISK | MODERATION | EXPRESSION | NEUROSCIENCES | ADULT DEPRESSION | Neuroimaging | Organophosphates - metabolism | Stress Disorders, Post-Traumatic - etiology | Humans | Middle Aged | Male | Gene-Environment Interaction | Young Adult | Dexamethasone - pharmacology | Transfection | HEK293 Cells | Adult | Female | Neurons - metabolism | Peptide Elongation Factor 1 - genetics | Hydrocortisone - blood | Neurons - drug effects | Child | Cell Line | Genetic Predisposition to Disease | Introns - genetics | Gene Frequency | Gene Expression Regulation | Models, Molecular | Genotype | Logistic Models | DNA Methylation - genetics | Signal Transduction - genetics | Hippocampus - cytology | Tacrolimus Binding Proteins - genetics | Stress Disorders, Post-Traumatic - blood | Signal Transduction - drug effects | Child Abuse - psychology | Glucocorticoids - chemistry | Glucocorticoids - pharmacology | Polymorphism, Single Nucleotide - genetics | Stress Disorders, Post-Traumatic - genetics | DNA Methylation - drug effects | Peptide Elongation Factor 1 - metabolism | Cohort Studies | Care and treatment | Corticosteroids | DNA | Physiological aspects | Research | Methylation | Binding proteins | Health aspects | Risk factors | Post-traumatic stress disorder in children | PTSD | Emotional Abuse | Child Sexual Abuse | Predisposition | Epigenetics | Genetics | Genetic Markers | Child Abuse | Neurophysiology
Journal Article
Journal of Chemotherapy, ISSN 1120-009X, 07/2018, Volume 30, Issue 5, pp. 296 - 303
Voriconazole is used to treat fungal infections in patients receiving glucocorticoid therapy in clinic. The objective of this study was to characterize the... 
Physiologically based pharmacokinetics | Glucocorticoids | Drug-drug interaction | Voriconazole | Drug‐drug interaction | CLEARANCE | INFECTIOUS DISEASES | DEXAMETHASONE | METHYLPREDNISOLONE | SIMULATION | P-GLYCOPROTEIN | PREDICTION | INHIBITION | PHARMACOKINETICS | METABOLISM | ONCOLOGY | TISSUE DISTRIBUTION | PHARMACOLOGY & PHARMACY
Journal Article
Macromolecular Materials and Engineering, ISSN 1438-7492, 06/2015, Volume 300, Issue 6, pp. 596 - 610
Journal Article
Journal Article
Xenobiotica, ISSN 0049-8254, 06/2018, Volume 48, Issue 6, pp. 637 - 646
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 05/2019, Volume 85, Issue 5, pp. 986 - 992
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 02/2018, Volume 58, Issue 2, pp. 180 - 192
Journal Article
ACS Nano, ISSN 1936-0851, 10/2018, Volume 12, Issue 10, pp. 9866 - 9880
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