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Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 24, pp. 9982 - 9987
Arginine contains the guanidinium group and thus has structural similarity to ligands of imidazoline and α-2 adrenoceptors (α-2 AR). Therefore, we investigated... 
Cell culture techniques | Signal transduction | Receptors | Imidazolines | Fluorescence | Agonists | Ligands | Toxins | Endothelial cells | Whooping cough | Calcium | Agmatine | Rauwolscine | rauwolscine | calcium | DEPENDENT VASODILATION | VASCULAR RELAXATION | MULTIDISCIPLINARY SCIENCES | agmatine | RELAXING FACTOR | PORCINE CORONARY-ARTERIES | RELEASE | SYNTHASE | SMOOTH-MUSCLE | CHOLESTEROL-FED RABBITS | S-NITROSOTHIOLS | Endothelium, Vascular - cytology | Aniline Compounds | Humans | Receptors, Adrenergic, alpha-2 - metabolism | Culture Media, Serum-Free | Adrenergic alpha-Antagonists - pharmacology | Calcium - analysis | Agmatine - pharmacology | Virulence Factors, Bordetella - pharmacology | Type C Phospholipases - antagonists & inhibitors | Yohimbine - pharmacology | Dose-Response Relationship, Drug | Idazoxan - pharmacology | Arginine - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Agmatine - chemistry | Dexmedetomidine - pharmacology | Molecular Structure | Cell Culture Techniques | Nitric Oxide Synthase Type III - metabolism | Umbilical Veins - cytology | Nitrates - analysis | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Nifedipine - pharmacology | Idazoxan - chemistry | Endothelial Cells - metabolism | Nitric Oxide - antagonists & inhibitors | Cells, Cultured | Imidazolines - pharmacology | Calcium Channel Blockers - pharmacology | Enzyme Activation - drug effects | Arginine - chemistry | Xanthenes | Endothelial Cells - cytology | Arginine - pharmacology | Lipopolysaccharides - pharmacology | Second Messenger Systems - physiology | Nitrites - analysis | Endothelial Cells - enzymology | Fluorescent Dyes | Biological Sciences
Journal Article
Life Sciences, ISSN 0024-3205, 2006, Volume 79, Issue 4, pp. 331 - 341
CYP1A2, a principal catalyst for metabolism of various therapeutic drugs and carcinogens, among others, is in part regulated by the stress response. This study... 
Benzo( α)pyrene | Catecholamines | Adrenoceptors | Rat | CYP1A2 | Benzo(α)pyrene | benzo(alpha)pyrene | MEDICINE, RESEARCH & EXPERIMENTAL | catecholamines | rat | BIOACTIVATION | METABOLIC-ACTIVATION | CYTOCHROMES P-450 | ENZYMES | LIVER | PHARMACOLOGY & PHARMACY | HYDROCARBON RECEPTOR | adrenoceptors | RAT-BRAIN | STRESS | NORADRENALINE | Gene Expression Regulation, Enzymologic - drug effects | Up-Regulation | Catecholamines - metabolism | Rats, Wistar | Male | Adrenergic alpha-Antagonists - pharmacology | RNA, Messenger - metabolism | Prazosin - pharmacology | Cytochrome P-450 CYP1A2 - genetics | Sympatholytics - pharmacology | Reserpine - pharmacology | Dexmedetomidine - pharmacology | Benzo(a)pyrene - pharmacology | Oxidoreductases - biosynthesis | Levodopa - pharmacology | Signal Transduction | Oxidoreductases - genetics | Receptors, Adrenergic - metabolism | Rats | Animals | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Adrenergic Uptake Inhibitors - pharmacology | Adrenergic alpha-Agonists - pharmacology | Cytochromes | Guanethidine - pharmacology | Epinephrine - pharmacology | Comparative Study | Reserpine/pharmacology | Cytochrome P-450 Enzyme System/biosynthesis/genetics | Receptors; Adrenergic/metabolism | Dexmedetomidine/pharmacology | Oxidoreductases/biosynthesis/genetics | Research Support; Non-U.S. Gov't | Epinephrine/pharmacology | Guanethidine/pharmacology | Gene Expression Regulation; Enzymologic/drug effects | Cytochrome P-450 CYP1A2/genetics | Rats; Wistar | RNA; Messenger/metabolism | Adrenergic alpha-Agonists/pharmacology | Prazosin/pharmacology | Benzo(a)pyrene/pharmacology | Sympatholytics/pharmacology | Adrenergic Uptake Inhibitors/pharmacology | Catecholamines/metabolism | Adrenergic alpha-Antagonists/pharmacology | Levodopa/pharmacology
Journal Article
Anesthesia & Analgesia, ISSN 0003-2999, 05/2016, Volume 122, Issue 5, pp. 1556 - 1566
BACKGROUND:Dexmedetomidine is a highly selective α2-agonist with hypnotic, analgesic, and anxiolytic properties. Despite off-label administration,... 
DRUG | ANESTHESIA | PHARMACOKINETICS | PEDIATRIC-PATIENTS | GLUCURONIDATION | CARDIAC-CATHETERIZATION | ANESTHESIOLOGY | EXPRESSION | INTENSIVE-CARE | DEVELOPMENTAL ASPECTS | CHILDREN | Age Factors | Analgesics, Non-Narcotic - pharmacokinetics | Hypnotics and Sedatives - adverse effects | Heart Defects, Congenital - surgery | Adrenergic alpha-2 Receptor Agonists - pharmacokinetics | Humans | Hypnotics and Sedatives - administration & dosage | Child, Preschool | Infant | Metabolic Clearance Rate | Chromatography, High Pressure Liquid | Drug Monitoring - methods | Tandem Mass Spectrometry | Adrenergic alpha-2 Receptor Agonists - administration & dosage | Cardiac Surgical Procedures | Drug Dosage Calculations | Adrenergic alpha-2 Receptor Agonists - adverse effects | Analgesics, Non-Narcotic - adverse effects | Computer Simulation | Infant, Newborn | Term Birth | Dexmedetomidine - administration & dosage | Analgesics, Non-Narcotic - blood | Drug Administration Schedule | Hypnotics and Sedatives - pharmacokinetics | Dexmedetomidine - pharmacokinetics | Treatment Outcome | Analgesics, Non-Narcotic - administration & dosage | Respiration, Artificial | Dexmedetomidine - adverse effects | Adrenergic alpha-2 Receptor Agonists - blood | Models, Biological | Dexmedetomidine - blood | Heart Defects, Congenital - diagnosis | Hypnotics and Sedatives - blood | Infusions, Intravenous | Nonlinear Dynamics | Monte Carlo Method | Index Medicus | Abridged Index Medicus
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 11/2014, Volume 307, Issue 9, pp. H1288 - H1297
Journal Article
Journal Article
Medical Hypotheses, ISSN 0306-9877, 03/2019, Volume 124, pp. 42 - 52
The neural correlates of consciousness and the mechanisms by which general anesthesia (GA) modulate such correlates to induce loss of consciousness (LOC) has... 
Coma | Consciousness | Minimally conscious state | Long-term potentiation (LTP) | Memory | Reactive oxygen species (ROS) | Vegetative state | Isoflurane | Stress | Sevoflurane | Learning | Ketamine | AMP-activated protein kinase (AMPK) | Dexmedetomidine | Anesthesia | Propofol | Midazolam | Metformin | Calcium (Ca2+) | Caffeine | MEDICINE, RESEARCH & EXPERIMENTAL | DEPENDENT AUTOPHAGY | COMMON MECHANISM | LATENT HIV-1 | LONG-TERM POTENTIATION | GLUCOSE-UPTAKE | ACTIVATED PROTEIN-KINASE | CORTICAL SPREADING DEPRESSION | FOCAL CEREBRAL-ISCHEMIA | GENERAL-ANESTHESIA | ISCHEMIA-REPERFUSION INJURY | AMP-Activated Protein Kinases - metabolism | Anesthesia - methods | Cell Proliferation | Reactive Oxygen Species - metabolism | Isoflurane - pharmacology | Calcium - metabolism | Humans | Ketamine - chemistry | Propofol - pharmacology | Anesthetics - pharmacology | Nicotine - pharmacology | Sevoflurane - pharmacology | Dexmedetomidine - pharmacology | Consciousness Disorders - metabolism | Unconsciousness | Metformin - pharmacology | Consciousness Disorders - chemically induced | Cell Lineage | Animals | Long-Term Potentiation | Anesthesia Recovery Period | Brain Mapping | Models, Neurological | Ketamine - pharmacology | Midazolam - pharmacology | Neurons | Glutamate | Proteins | Persistent vegetative state | Histamine | Neural circuitry | Analysis | Stem cells | GABA | Hypoglycemic agents | Acetylcholine | Protein kinases
Journal Article