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Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1292 - 1300
Polymorphisms in the cytochrome P450 2D6 (CYP2D6) gene are a major cause of pharmacokinetic variability in human. Although the poor metabolizer phenotype is... 
IN-VITRO | 2D6 | DRUGS | CATALYTIC ACTIVITY | PHARMACOLOGY & PHARMACY | HUMAN CYTOCHROME-P450 ENZYMES | HUMAN LIVER-MICROSOMES | LOW-AFFINITY | CLINICAL-PRACTICE | DEBRISOQUINE | EXPRESSION | Microsomes - metabolism | Quinidine - chemistry | Tramadol - chemistry | Humans | Dextromethorphan - metabolism | Imipramine - chemistry | Propylamines - pharmacokinetics | Codeine - chemistry | Debrisoquin - metabolism | Enzyme Inhibitors - chemistry | Fluoxetine - analogs & derivatives | Quinidine - pharmacokinetics | Propylamines - chemistry | Cocaine - chemistry | Cytochrome P-450 CYP2D6 - genetics | Recombinant Proteins - antagonists & inhibitors | Debrisoquin - chemistry | Enzyme Inhibitors - metabolism | Hydroxylation | Cocaine - pharmacokinetics | Ethanolamines - chemistry | Tramadol - pharmacokinetics | Nortriptyline - metabolism | Fluoxetine - metabolism | Cytochrome P-450 CYP2D6 - metabolism | Kinetics | Thioridazine - metabolism | Cytochrome P-450 CYP2D6 Inhibitors | Nortriptyline - chemistry | Cocaine - metabolism | Fluoxetine - pharmacokinetics | Debrisoquin - pharmacokinetics | Ethanolamines - pharmacokinetics | Codeine - metabolism | Enzyme Inhibitors - pharmacokinetics | Thioridazine - pharmacokinetics | Atomoxetine Hydrochloride | Codeine - pharmacokinetics | Thioridazine - chemistry | Dextromethorphan - pharmacokinetics | Molecular Structure | Quinidine - metabolism | Recombinant Proteins - metabolism | Imipramine - pharmacokinetics | Nortriptyline - pharmacokinetics | Dextromethorphan - chemistry | Fluoxetine - chemistry | Tramadol - metabolism | Ethanolamines - metabolism | Imipramine - metabolism | Polymorphism, Single Nucleotide | Propylamines - metabolism
Journal Article
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 11/2007, Volume 35, Issue 11, pp. 2119 - 2126
Predicting drug-drug interactions requires an assessment of the drug concentration available to the enzyme active site, both in vivo, and within an in vitro... 
Tolbutamide - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 CYP3A | Microsomes, Liver - metabolism | Cytochrome P-450 Enzyme System - metabolism | Dextromethorphan - metabolism | Male | Fluconazole - metabolism | Quinine - pharmacology | Microsomes, Liver - enzymology | Tolbutamide - metabolism | Fluoxetine - pharmacology | Dextromethorphan - pharmacology | Enzyme Inhibitors - metabolism | Enzyme Inhibitors - pharmacology | Fluvoxamine - pharmacokinetics | Ketoconazole - pharmacokinetics | Rats | Rats, Sprague-Dawley | Catalysis - drug effects | Miconazole - pharmacokinetics | Miconazole - pharmacology | Fluoxetine - metabolism | Cytochrome P-450 CYP2D6 - metabolism | Kinetics | Midazolam - pharmacology | Hepatocytes - enzymology | Cytochrome P-450 CYP2D6 Inhibitors | Quinine - pharmacokinetics | Fluconazole - pharmacology | Tolbutamide - pharmacokinetics | Fluoxetine - pharmacokinetics | Ketoconazole - metabolism | Hepatocytes - metabolism | Ketoconazole - pharmacology | Hepatocytes - cytology | Enzyme Inhibitors - pharmacokinetics | Phenytoin - pharmacology | Dextromethorphan - pharmacokinetics | Phenytoin - metabolism | Quinine - metabolism | Fluvoxamine - metabolism | Cells, Cultured | Midazolam - pharmacokinetics | Fluvoxamine - pharmacology | Miconazole - metabolism | Fluconazole - pharmacokinetics | Animals | Midazolam - metabolism | Phenytoin - pharmacokinetics
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 10/2016, Volume 163, pp. 183 - 192
16-dehydropregnenolone (DHP) is a promising novel antihyperlipidemic agent developed and patented by Central Drug Research Institute (CDRI), India. The purpose... 
16-dehydropregnenolone | Cocktail | Pharmacokinetics | CYP450 | Real time RT-PCR | Microsomes | COCKTAIL PROBE DRUGS | IN-VITRO COCKTAIL | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | TANDEM MASS-SPECTROMETRY | INHIBITION | METABOLISM | ENDOCRINOLOGY & METABOLISM | SCHISANDRA-CHINENSIS | DRUG-DRUG INTERACTIONS | Tolbutamide - pharmacology | Liver - enzymology | Chlorzoxazone - metabolism | Pregnenolone - pharmacokinetics | Aryl Hydrocarbon Hydroxylases - genetics | Dextromethorphan - metabolism | Male | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Steroid 16-alpha-Hydroxylase - metabolism | Cytochrome P-450 CYP3A - genetics | Liver - drug effects | Microsomes, Liver - drug effects | Cytochrome P-450 CYP1A2 - genetics | Caffeine - pharmacology | Cytochrome P450 Family 2 - genetics | Microsomes, Liver - enzymology | Tolbutamide - metabolism | Caffeine - metabolism | Dextromethorphan - pharmacology | Administration, Oral | Gene Expression Regulation | Rats | Cytochrome P-450 CYP1A2 - metabolism | Rats, Sprague-Dawley | Aryl Hydrocarbon Hydroxylases - metabolism | Dapsone - metabolism | Animals | Pregnenolone - analogs & derivatives | Cytochrome P450 Family 2 - metabolism | Cytochrome P-450 CYP3A - metabolism | Chlorzoxazone - pharmacology | Hypolipidemic Agents - administration & dosage | Steroid 16-alpha-Hydroxylase - genetics | Dapsone - pharmacology | Hypolipidemic Agents - pharmacokinetics | Pregnenolone - administration & dosage | Physiological aspects | Enzymes | Liquid chromatography | Gastrointestinal agents | RNA | Mass spectrometry | Cytochrome P-450
Journal Article
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 08/2018, Volume 40, Issue 8, pp. 1322 - 1337
Red ginseng is one of the world's most popular herbal medicines; it exhibits a wide range of pharmacologic activities and is often co-ingested with other... 
pharmacokinetics | cytochrome P450 | red ginseng | drug interaction | OATP1B1 | CYTOCHROME-P450 | PANAX-GINSENG | TRANSPORTERS | DISPOSITION | COCKTAIL APPROACH | DISEASES | ENZYMES | PHARMACOLOGY & PHARMACY | GINSENOSIDES | EXTRACT | Caffeine - metabolism | Panax | Omeprazole - metabolism | Humans | Cytochrome P-450 Enzyme System - metabolism | Dextromethorphan - metabolism | Male | Omeprazole - pharmacokinetics | Losartan - metabolism | Random Allocation | Midazolam - pharmacokinetics | Cytochrome P-450 CYP1A2 - metabolism | Caffeine - pharmacokinetics | Liver-Specific Organic Anion Transporter 1 - metabolism | Young Adult | Drug Interactions | Cytochrome P-450 CYP3A - metabolism | Plant Preparations - pharmacology | Cytochrome P-450 CYP2D6 - metabolism | Midazolam - metabolism | Adult | Cytochrome P-450 CYP2C19 - metabolism | Dextromethorphan - pharmacokinetics | Losartan - pharmacokinetics | Medical research | Medicine, Botanic | Analysis | Drug interactions | Cytochrome P-450 | Medicine, Experimental | Medicine, Herbal | Cytochrome | Laboratories | Liver | Dextromethorphan | Hepatitis | Metabolites | Cryopreservation | Trademarks | Drug interaction | Drug dosages | CYP2D6 protein | Caffeine | Enzymes | Cytochrome P450 | Pharmacology | CYP1A2 protein | Substrates | Catheters | Microsomes | Omeprazole | Herbal medicine | Organic anion transporting polypeptide | Hepatocytes | Cytochromes | In vivo methods and tests | Midazolam | Ginseng | Transporter
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 2011, Volume 43, Issue 3, pp. 89 - 98
Journal Article
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2008, Volume 36, Issue 12, pp. 2547 - 2555
The atypical antipsychotic drug clozapine (CLZ) is effective in a substantial number of patients who exhibit treatment-resistance to conventional agents.... 
SEROTONIN REUPTAKE INHIBITORS | IN-VITRO | SERUM CONCENTRATIONS | METABOLISM | N-DESMETHYLCLOZAPINE | ALLELIC VARIANTS | FLUVOXAMINE | ERYTHROMYCIN | PHARMACOLOGY & PHARMACY | FUNCTIONAL-CHARACTERIZATION | CYP3A4 | Cytochrome P-450 CYP2C9 | Clozapine - metabolism | Oxidoreductases, N-Demethylating - genetics | Cytochrome P-450 Enzyme Inhibitors | Humans | Microsomes, Liver - metabolism | Aryl Hydrocarbon Hydroxylases - genetics | Biotransformation - genetics | Cytochrome P-450 Enzyme System - metabolism | Dextromethorphan - metabolism | Ketoconazole - pharmacology | Oxygenases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 Inhibitors | Testosterone - metabolism | Cytochrome P-450 CYP3A - genetics | Isoenzymes - metabolism | Microsomes, Liver - drug effects | Oxygenases - metabolism | Cytochrome P-450 CYP1A2 - genetics | Catalysis | Oxidoreductases, N-Demethylating - metabolism | Tolbutamide - metabolism | Recombinant Proteins - metabolism | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Oxidation-Reduction | Isoenzymes - genetics | Enzyme Inhibitors - pharmacology | Clozapine - analogs & derivatives | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Fluvoxamine - pharmacology | Aryl Hydrocarbon Hydroxylases - metabolism | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - metabolism | Biotransformation - drug effects | Alleles | Cytochrome P-450 Enzyme System - genetics | Kinetics | Oxygenases - genetics | Cytochrome P-450 CYP2B6 | Isoenzymes - antagonists & inhibitors
Journal Article