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PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 2, pp. e16556 - e16556
Berberine (BBR) is a compound originally identified in a Chinese herbal medicine Huanglian (Coptis chinensis French). It improves glucose metabolism in type 2... 
ACTIVATED PROTEIN-KINASE | MECHANISM DISTINCT | INSULIN-RESISTANCE | MUSCLE ATROPHY | LIVER | BIOLOGY | CARBOHYDRATE | ELEMENT-BINDING PROTEIN | FOXO TRANSCRIPTION FACTORS | LIPID HOMEOSTASIS | EXPRESSION | Diabetes Mellitus, Experimental - drug therapy | Streptozocin | Gluconeogenesis - drug effects | Male | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Diabetes Mellitus, Experimental - blood | Liver - drug effects | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Drug Evaluation, Preclinical | Hypoglycemic Agents - therapeutic use | Blood Glucose - analysis | Liver - metabolism | Rats | Down-Regulation - drug effects | Rats, Sprague-Dawley | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Berberine - pharmacology | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Animals | Glucose - metabolism | Berberine - therapeutic use | Diabetes Mellitus, Type 2 - chemically induced | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Phosphatases | Blood sugar | Genes | DNA binding proteins | Muscle proteins | Fatty acids | Insulin | Glucose metabolism | Synthesis | Adenylic acid | Protein kinases | Adenosine triphosphate | Protein binding | Transcription factors | Peptides | Liver | Glucose | Blood | Proteins | Signal transduction | Mitochondria | Hyperglycemia | Forkhead protein | Inhibition | Drug dosages | Gluconeogenesis | Binding | Carbohydrates | Berberine | AMP | Metabolism | Fatty-acid synthase | Hepatocytes | Protein synthesis | Glucose-6-phosphatase | Endocrinology | Biomedical research | Kinases | High fat diet | Fatty liver | FOXO1 protein | Rodents | Statins | Fasting | Adenosine monophosphate | Diabetes mellitus | Oxygen consumption | Steatosis | Herbal medicine | Musculoskeletal system | Signaling | Protein kinase | Adenosine kinase | Coronary vessels | Insulin resistance | Diabetes | Respiration | Laboratory animals | ATP | Index Medicus
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 11/2016, Volume 192, pp. 382 - 389
Liuwei Dihaung decoction (LWDHT) is a well-known classic traditional Chinese medicine formula, consists of six herbs including Rehmannia glutinosa... 
PI3K/Akt signaling pathway | Liuwei Dihuang decoction | Type 2 diabetes mellitus | CHEMISTRY, MEDICINAL | INTEGRATIVE & COMPLEMENTARY MEDICINE | GENES | PHARMACOLOGY & PHARMACY | PLANT SCIENCES | Diabetes Mellitus, Experimental - drug therapy | Liver - pathology | Phosphorylation | Liver - enzymology | Diabetes Mellitus, Experimental - enzymology | Streptozocin | Drugs, Chinese Herbal - pharmacology | Male | Insulin Receptor Substrate Proteins - metabolism | Insulin - blood | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-akt - genetics | Diabetes Mellitus, Experimental - blood | Liver - drug effects | Time Factors | Diabetes Mellitus, Experimental - chemically induced | Insulin Receptor Substrate Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Pancreas - enzymology | RNA, Messenger - genetics | Diabetes Mellitus, Type 2 - enzymology | Insulin Resistance | Pancreas - drug effects | Pancreas - pathology | Biomarkers - blood | Rats, Sprague-Dawley | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Gene Expression Regulation, Enzymologic | Diabetes Mellitus, Type 2 - blood | Animals | Phosphatidylinositol 3-Kinase - genetics | Signal Transduction - drug effects | Diabetes Mellitus, Type 2 - chemically induced | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Insulin resistance | Medicine, Chinese | Liver | Physiological aspects | Blood sugar | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 8, pp. 2503 - 2508
Journal Article
Nature Nanotechnology, ISSN 1748-3387, 06/2016, Volume 11, Issue 6, pp. 566 - 572
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 27, pp. 8260 - 8265
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 01/2013, Volume 304, Issue 2, pp. F156 - F157
Journal Article
Gut, ISSN 0017-5749, 04/2012, Volume 61, Issue 4, pp. 543 - 553
ObjectiveThe gut microbiota, which is considered a causal factor in metabolic diseases as shown best in animals, is under the dual influence of the host genome... 
PERMEABILITY | INSULIN-RESISTANCE | GLUCO-OLIGOSACCHARIDES | INFLAMMATION | MACROPHAGES | RECEPTOR | ECOLOGY | MICE | GASTROENTEROLOGY & HEPATOLOGY | INDUCED OBESITY | LYMPHOCYTES | Glucose Tolerance Test | Liver - metabolism | Mice, Inbred C57BL | Adaptation, Physiological - physiology | Male | Muscle, Skeletal - metabolism | Cecum - microbiology | Permeability | Metagenome - physiology | Diabetes Mellitus, Experimental - blood | Lipopolysaccharides - blood | Phenotype | Animals | Intestines - microbiology | Diet, High-Fat | Fatty Acids, Nonesterified - blood | Mice | Cytokines - blood | Diabetes Mellitus, Experimental - physiopathology | Intestinal Absorption - physiology | Metabolic diseases | Development and progression | Models | Research | Microbiota (Symbiotic organisms) | Ketogenic diet | Obesity | Nutrition research | Genotype & phenotype | Hyperglycemia | Diet | Insulin resistance | Triglycerides | Inflammation | Diabetes | Fatty acids | Insulin | Metabolic disorders | Index Medicus | Abridged Index Medicus | Adaptation, Physiological | Intestines | Cytokines | Liver | Cecum | Intestinal Absorption | Lipopolysaccharides | Life Sciences | Diabetes Mellitus, Experimental | Fatty Acids, Nonesterified | Genetics | Muscle, Skeletal | Metagenome | intestinal barrier function | ANAL | high-fat diet responsiveness | diabetes mellitus | Gut microbes pyrosequencing | metabolic heterogeneity | bone marrow transplantation | gastrointestinal physiology | intestinal bacteria | type 2 diabetes | Gut Microbiota | bacterial translocation | 1507 | 1506
Journal Article
Cancer Research, ISSN 0008-5472, 01/2010, Volume 70, Issue 2, pp. 741 - 751
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e61477 - e61477
Obesity is important for the development of type-2 diabetes as a result of obesity-induced insulin resistance accompanied by impaired compensation of insulin... 
BODY-WEIGHT | MEDICAL THERAPY | DIET | FOOD-INTAKE | GLUCOSE | MULTIDISCIPLINARY SCIENCES | VASOPRESSIN | BARIATRIC SURGERY | SCHIZOPHRENIA | MICE | BLOOD-BRAIN-BARRIER | Diabetes Mellitus, Experimental - drug therapy | Obesity - drug therapy | Humans | Middle Aged | Male | Prediabetic State - drug therapy | Obesity - blood | Glucose Intolerance - blood | Diabetes Mellitus, Experimental - blood | Young Adult | Glucose Intolerance - drug therapy | Hypoglycemic Agents - administration & dosage | Adult | Female | Insulin Secretion | Prediabetic State - blood | Mice, Inbred C57BL | Diabetes Mellitus, Type 2 - prevention & control | Insulin Resistance | Blood Glucose | Oxytocin - analogs & derivatives | Administration, Intranasal | Oxytocin - administration & dosage | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Pilot Projects | Animals | Lipid Metabolism - drug effects | Mice | Type 2 diabetes | Obesity | Medical colleges | Pancreatic beta cells | Insulin resistance | Glucose | Drug therapy | Health aspects | Insulin | Prediabetic state | Dextrose | Diabetes therapy | Animal models | Breastfeeding & lactation | Mental disorders | Peptides | Streptozocin | Schizophrenia | Homeostasis | Cardiovascular disease | Neuropeptides | Analogs | Reduction | Blood-brain barrier | Rodents | Pancreas | Oxytocin | Secretion | Diabetes mellitus | Metabolism | Patients | Beta cells | Medicine | Studies | Glucose tolerance | Intolerance | Weight control | Brain research | Hospitals | Regulation | Diabetes | Gastrointestinal surgery | Index Medicus
Journal Article
Kidney International, ISSN 0085-2538, 01/2018, Volume 93, Issue 1, pp. 95 - 109
Inflammation plays a central role in the etiology of diabetic nephropathy, a global health issue. We observed a significant reduction in the renal expression... 
cytokines | fibrosis | inflammation | mesangial cells | diabetic nephropathy | PATHWAYS | ACTIVATION | JNK | KINASE | FIBROBLAST-GROWTH-FACTOR | PATHOGENESIS | OBESITY | INSULIN-RESISTANCE | UROLOGY & NEPHROLOGY | NF-KAPPA-B | EXPRESSION | Diabetes Mellitus, Experimental - drug therapy | Kidney - pathology | Rats, Wistar | Diabetic Nephropathies - etiology | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | Diabetes Mellitus, Type 1 - complications | Diabetic Nephropathies - blood | Diabetes Mellitus, Experimental - blood | Kidney - metabolism | Inflammation Mediators - metabolism | Diabetes Mellitus, Experimental - complications | Diabetic Nephropathies - prevention & control | Diabetes Mellitus, Type 2 - complications | Cell Line | Diabetic Nephropathies - pathology | Kidney - drug effects | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Recombinant Proteins - pharmacology | Diabetes Mellitus, Type 1 - drug therapy | Blood Glucose - drug effects | Fibroblast Growth Factor 1 - blood | Diabetes Mellitus, Type 2 - blood | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Diabetes Mellitus, Type 1 - blood | Fibroblast Growth Factor 1 - pharmacology | Macrophages - drug effects | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Index Medicus
Journal Article