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1. Full Text Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis
by Xia, Xuan and Yan, Jinhua and Shen, Yunfeng and Tang, Kuanxiao and Yin, Jun and Zhang, Yanhua and Yang, Dongjie and Liang, Hua and Ye, Jianping and Weng, Jianping
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 2, pp. e16556 - e16556
Berberine (BBR) is a compound originally identified in a Chinese herbal medicine Huanglian (Coptis chinensis French). It improves glucose metabolism in type 2... 
ACTIVATED PROTEIN-KINASE | MECHANISM DISTINCT | INSULIN-RESISTANCE | MUSCLE ATROPHY | LIVER | BIOLOGY | CARBOHYDRATE | ELEMENT-BINDING PROTEIN | FOXO TRANSCRIPTION FACTORS | LIPID HOMEOSTASIS | EXPRESSION | Diabetes Mellitus, Experimental - drug therapy | Streptozocin | Gluconeogenesis - drug effects | Male | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Diabetes Mellitus, Experimental - blood | Liver - drug effects | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Drug Evaluation, Preclinical | Hypoglycemic Agents - therapeutic use | Blood Glucose - analysis | Liver - metabolism | Rats | Down-Regulation - drug effects | Rats, Sprague-Dawley | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Berberine - pharmacology | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Animals | Glucose - metabolism | Berberine - therapeutic use | Diabetes Mellitus, Type 2 - chemically induced | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Phosphatases | Blood sugar | Genes | DNA binding proteins | Muscle proteins | Fatty acids | Insulin | Glucose metabolism | Synthesis | Adenylic acid | Protein kinases | Adenosine triphosphate | Protein binding | Transcription factors | Peptides | Liver | Glucose | Blood | Proteins | Signal transduction | Mitochondria | Hyperglycemia | Forkhead protein | Inhibition | Drug dosages | Gluconeogenesis | Binding | Carbohydrates | Berberine | AMP | Metabolism | Fatty-acid synthase | Hepatocytes | Protein synthesis | Glucose-6-phosphatase | Endocrinology | Biomedical research | Kinases | High fat diet | Fatty liver | FOXO1 protein | Rodents | Statins | Fasting | Adenosine monophosphate | Diabetes mellitus | Oxygen consumption | Steatosis | Herbal medicine | Musculoskeletal system | Signaling | Protein kinase | Adenosine kinase | Coronary vessels | Insulin resistance | Diabetes | Respiration | Laboratory animals | ATP | Index Medicus
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2. Full Text The effect of Liuwei Dihuang decoction on PI3K/Akt signaling pathway in liver of type 2 diabetes mellitus (T2DM) rats with insulin resistance
by Dai, Bing and Wu, Qinxuan and Zeng, Chengxi and Zhang, Jiani and Cao, Luting and Xiao, Zizeng and Yang, Menglin
Journal of Ethnopharmacology, ISSN 0378-8741, 11/2016, Volume 192, pp. 382 - 389
Liuwei Dihaung decoction (LWDHT) is a well-known classic traditional Chinese medicine formula, consists of six herbs including Rehmannia glutinosa... 
PI3K/Akt signaling pathway | Liuwei Dihuang decoction | Type 2 diabetes mellitus | CHEMISTRY, MEDICINAL | INTEGRATIVE & COMPLEMENTARY MEDICINE | GENES | PHARMACOLOGY & PHARMACY | PLANT SCIENCES | Diabetes Mellitus, Experimental - drug therapy | Liver - pathology | Phosphorylation | Liver - enzymology | Diabetes Mellitus, Experimental - enzymology | Streptozocin | Drugs, Chinese Herbal - pharmacology | Male | Insulin Receptor Substrate Proteins - metabolism | Insulin - blood | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-akt - genetics | Diabetes Mellitus, Experimental - blood | Liver - drug effects | Time Factors | Diabetes Mellitus, Experimental - chemically induced | Insulin Receptor Substrate Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Pancreas - enzymology | RNA, Messenger - genetics | Diabetes Mellitus, Type 2 - enzymology | Insulin Resistance | Pancreas - drug effects | Pancreas - pathology | Biomarkers - blood | Rats, Sprague-Dawley | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Gene Expression Regulation, Enzymologic | Diabetes Mellitus, Type 2 - blood | Animals | Phosphatidylinositol 3-Kinase - genetics | Signal Transduction - drug effects | Diabetes Mellitus, Type 2 - chemically induced | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Insulin resistance | Medicine, Chinese | Liver | Physiological aspects | Blood sugar | Index Medicus
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3. Full Text Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway
by May-Yun Wang and Hai Yan and Zhiqing Shi and Matthew R. Evans and Xinxin Yu and Young Lee and Shiuhwei Chen and Annie Williams and Jacques Philippe and Michael G. Roth and Roger H. Unger
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 8, pp. 2503 - 2508
Insulin monotherapy can neither maintain normoglycemia in type 1 diabetes (T1D) nor prevent the long-term damage indicated by elevated glycation products in... 
Glucagon receptor | Antibody | Type 1 diabetes | Insulin | HYPERGLUCAGONEMIA | type 1 diabetes | GLYCEMIC CONTROL | antibody | insulin | glucagon receptor | MULTIDISCIPLINARY SCIENCES | RELEASE | DEFICIENCY | ENDOGENOUS GLUCAGON | HYPERGLYCEMIA | GLUCOSE | MICE | SECRETION | IMMUNONEUTRALIZATION | Diabetes Mellitus, Experimental - drug therapy | Antibodies, Monoclonal - pharmacology | Humans | Diabetes Mellitus, Type 1 - pathology | Rats | Antibodies, Monoclonal - therapeutic use | Diabetes Mellitus, Type 1 - drug therapy | Receptors, Glucagon - immunology | Diabetes Mellitus, Experimental - blood | Rats, Zucker | Animals | Diabetes Mellitus, Type 1 - blood | Paracrine Communication - drug effects | Diabetes Mellitus, Experimental - pathology | Female | Mice, Inbred NOD | Mice | Glucagon - secretion | Blood Glucose - metabolism | Insulin - therapeutic use | Hyperglycemia | Cell receptors | Glucagon | Development and progression | Genetic aspects | Health aspects | Hemoglobin | T cell receptors | Diabetes | Rodents | Index Medicus | Biological Sciences
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4. Full Text A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
by Lee, Hyunjae and Choi, Tae Kyu and Lee, Young Bum and Cho, Hye Rim and Ghaffari, Roozbeh and Wang, Liu and Choi, Hyung Jin and Chung, Taek Dong and Lu, Nanshu and Hyeon, Taeghwan and Choi, Seung Hong and Kim, Dae-Hyeong
Nature Nanotechnology, ISSN 1748-3387, 06/2016, Volume 11, Issue 6, pp. 566 - 572
Owing to its high carrier mobility, conductivity, flexibility and optical transparency, graphene is a versatile material in micro- and macroelectronics.... 
CIRCUITS | PRESSURE | CONDUCTORS | METFORMIN | TRANSISTORS | MATERIALS SCIENCE, MULTIDISCIPLINARY | SENSOR | NANOSCIENCE & NANOTECHNOLOGY | ELECTRONIC SKIN | TRANSPARENT | COMPOSITE | DELIVERY | Gold - chemistry | Diabetes Mellitus, Experimental - drug therapy | Drug Delivery Systems - instrumentation | Graphite - therapeutic use | Metformin - therapeutic use | Blood Glucose - analysis | Humans | Electrochemical Techniques - instrumentation | Equipment Design | Diabetes Mellitus, Experimental - blood | Sweat - chemistry | Theranostic Nanomedicine - instrumentation | Animals | Gold - therapeutic use | Female | Monitoring, Physiologic - instrumentation | Needles | Mice | Graphite - chemistry | Metformin - administration & dosage | Gold | pH sensors | Therapy | Drug delivery systems | Diabetes mellitus | Serpentine | Glucose | Chemical vapor deposition | Organic chemistry | Electrical resistivity | Graphene | Electrochemistry | Diabetes | Metformin | Chemical synthesis | Biosensors | Carrier mobility | Sweat | Monitoring | Bilayers | Index Medicus | Devices
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5. Full Text Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery
by Jicheng Yu and Yuqi Zhang and Yanqi Ye and Rocco DiSanto and Wujin Sun and Davis Ranson and Frances S. Ligler and John B. Buse and Zhen Gu
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 27, pp. 8260 - 8265
A glucose-responsive “closed-loop” insulin delivery system mimicking the function of pancreatic cells has tremendous potential to improve quality of life and... 
Drug delivery | Diabetes | Glucose-responsive | Hypoxia-sensitive | Microneedle | glucose-responsive | CATIONIC COPOLYMER HYDROGELS | PROTEIN DRUGS | MULTIDISCIPLINARY SCIENCES | drug delivery | RELEASE | microneedle | THERAPY | OXIDASE | IN-VIVO | hypoxia-sensitive | SKIN | diabetes | TRANSDERMAL DRUG-DELIVERY | Diabetes Mellitus, Experimental - drug therapy | Drug Delivery Systems - instrumentation | Humans | Male | Hypoxia - metabolism | Diabetes Mellitus, Experimental - blood | Hypoglycemic Agents - administration & dosage | Molecular Structure | Microscopy, Electron, Transmission | Glucose Oxidase - metabolism | Reproducibility of Results | Blood Glucose - analysis | Oxidation-Reduction | Mice, Inbred C57BL | Hyaluronic Acid - chemistry | Insulin - administration & dosage | Hypoglycemic Agents - chemistry | Diabetes Mellitus, Type 1 - drug therapy | Insulin - metabolism | Animals | Insulin - chemistry | Diabetes Mellitus, Type 1 - blood | Hyaluronic Acid - metabolism | Glucose - metabolism | Drug Delivery Systems - methods | Drugs | Drug delivery systems | Usage | Dosage and administration | Insulin | Methods | Diabetes therapy | Vehicles | Hypoxia | Glucose | Hydrophobic surfaces | Transdermal medication | Index Medicus | Biological Sciences
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6. Full Text Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus
by Vallon, Volker and Rose, Michael and Gerasimova, Maria and Satriano, Joseph and Platt, Kenneth A and Koepsell, Hermann and Cunard, Robyn and Sharma, Kumar and Thomson, Scott C and Rieg, Timo
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 01/2013, Volume 304, Issue 2, pp. F156 - F157
Vallon V, Rose M, Gerasimova M, Satriano J, Platt KA, Koepsell H, Cunard R, Sharma K, Thomson SC, Rieg T. Knockout of Na-glucose transporter SGLT2 attenuates... 
Proximal tubule | Renal growth | Fibrosis | Glomerular hyperfiltration | Diabetic nephropathy | Inflammation | Diabetes | CELLS | PHYSIOLOGY | RATS | ORNITHINE-DECARBOXYLASE | RENAL HYPERTROPHY | CELLULAR AUTOPHAGY | inflammation | renal growth | INDUCED OXIDATIVE STRESS | UROLOGY & NEPHROLOGY | COTRANSPORTER SGLT1 | fibrosis | FILTRATION-RATE | STREPTOZOTOCIN | proximal tubule | diabetes | glomerular hyperfiltration | diabetic nephropathy | Glomerular Filtration Rate | Kidney - pathology | Sodium-Glucose Transporter 2 - metabolism | Diabetic Nephropathies - metabolism | Mice, Inbred C57BL | Kidney - growth & development | Organ Size | Blood Glucose | Diabetic Nephropathies - genetics | Male | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Diabetes Mellitus, Experimental - blood | Hyperglycemia - metabolism | Animals | Hyperglycemia - blood | Mice | Diabetes Mellitus, Experimental - metabolism | Real-Time Polymerase Chain Reaction | Sodium-Glucose Transporter 2 - genetics | Prevention | Hyperglycemia | Kidneys | Physiological aspects | Development and progression | Glucose | Health aspects | Dextrose | Genotype & phenotype | Rodents | Gene expression | Autophagy | Index Medicus
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7. Full Text Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota
by Serino, Matteo and Luche, Elodie and Gres, Sandra and Baylac, Audrey and Bergé, Mathieu and Cenac, Claire and Waget, Aurelie and Klopp, Pascale and Iacovoni, Jason and Klopp, Christophe and Mariette, Jerome and Bouchez, Olivier and Lluch, Jerome and Ouarné, Francoise and Monsan, Pierre and Valet, Philippe and Roques, Christine and Amar, Jacques and Bouloumié, Anne and Théodorou, Vassilia and Burcelin, Remy
Gut, ISSN 0017-5749, 04/2012, Volume 61, Issue 4, pp. 543 - 553
ObjectiveThe gut microbiota, which is considered a causal factor in metabolic diseases as shown best in animals, is under the dual influence of the host genome... 
PERMEABILITY | INSULIN-RESISTANCE | GLUCO-OLIGOSACCHARIDES | INFLAMMATION | MACROPHAGES | RECEPTOR | ECOLOGY | MICE | GASTROENTEROLOGY & HEPATOLOGY | INDUCED OBESITY | LYMPHOCYTES | Glucose Tolerance Test | Liver - metabolism | Mice, Inbred C57BL | Adaptation, Physiological - physiology | Male | Muscle, Skeletal - metabolism | Cecum - microbiology | Permeability | Metagenome - physiology | Diabetes Mellitus, Experimental - blood | Lipopolysaccharides - blood | Phenotype | Animals | Intestines - microbiology | Diet, High-Fat | Fatty Acids, Nonesterified - blood | Mice | Cytokines - blood | Diabetes Mellitus, Experimental - physiopathology | Intestinal Absorption - physiology | Metabolic diseases | Development and progression | Models | Research | Microbiota (Symbiotic organisms) | Ketogenic diet | Obesity | Nutrition research | Genotype & phenotype | Hyperglycemia | Diet | Insulin resistance | Triglycerides | Inflammation | Diabetes | Fatty acids | Insulin | Metabolic disorders | Index Medicus | Abridged Index Medicus | Adaptation, Physiological | Intestines | Cytokines | Liver | Cecum | Intestinal Absorption | Lipopolysaccharides | Life Sciences | Diabetes Mellitus, Experimental | Fatty Acids, Nonesterified | Genetics | Muscle, Skeletal | Metagenome | intestinal barrier function | ANAL | high-fat diet responsiveness | diabetes mellitus | Gut microbes pyrosequencing | metabolic heterogeneity | bone marrow transplantation | gastrointestinal physiology | intestinal bacteria | type 2 diabetes | Gut Microbiota | bacterial translocation | 1507 | 1506
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8. Full Text Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes
by Novosyadlyy, Ruslan and Lann, Danielle E and Vijayakumar, Archana and Rowzee, Anne and Lazzarino, Deborah A and Fierz, Yvonne and Carboni, Joan M and Gottardis, Marco M and Pennisi, Patricia A and Molinolo, Alfredo A and Kurshan, Naamit and Mejia, Wilson and Santopietro, Stefania and Yakar, Shoshana and Wood, Teresa L and LeRoith, Derek
Cancer Research, ISSN 0008-5472, 01/2010, Volume 70, Issue 2, pp. 741 - 751
Epidemiologic studies suggest that type 2 diabetes (T2D) increases breast cancer risk and mortality, but there is limited experimental evidence supporting this... 
SIGNALING PATHWAYS | METABOLIC SYNDROME | IGF-I | METAANALYSIS | ONCOLOGY | TRANSGENIC MOUSE | 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED MAMMARY-CARCINOMA | RECEPTOR | MICE | CELL-LINES | GROWTH-FACTOR-I | Receptor, IGF Type 1 - metabolism | Phosphorylation | Receptor, IGF Type 1 - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Mammary Neoplasms, Experimental - metabolism | Diabetes Mellitus, Experimental - blood | Mammary Glands, Animal - growth & development | Mammary Neoplasms, Experimental - pathology | Female | Diabetes Mellitus, Experimental - metabolism | Oncogene Protein v-akt - metabolism | Hyperinsulinism - blood | Diabetes Mellitus, Type 2 - complications | Disease Models, Animal | Hyperinsulinism - metabolism | Mice, Transgenic | Receptor, Insulin - antagonists & inhibitors | Mammary Neoplasms, Experimental - blood | Hyperinsulinism - pathology | Diabetes Mellitus, Type 2 - blood | Animals | Mammary Glands, Animal - metabolism | Benzimidazoles - pharmacology | Receptor, Insulin - metabolism | Mice | Diabetes Mellitus, Type 2 - pathology | Mammary Neoplasms, Experimental - etiology | Pyridones - pharmacology | Index Medicus
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9. Full Text Treatment of Obesity and Diabetes Using Oxytocin or Analogs in Patients and Mouse Models
by Zhang, Hai and Wu, Chenguang and Chen, Qiaofen and Chen, Xiaoluo and Xu, Zhigang and Wu, Jing and Cai, Dongsheng
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e61477 - e61477
Obesity is important for the development of type-2 diabetes as a result of obesity-induced insulin resistance accompanied by impaired compensation of insulin... 
BODY-WEIGHT | MEDICAL THERAPY | DIET | FOOD-INTAKE | GLUCOSE | MULTIDISCIPLINARY SCIENCES | VASOPRESSIN | BARIATRIC SURGERY | SCHIZOPHRENIA | MICE | BLOOD-BRAIN-BARRIER | Diabetes Mellitus, Experimental - drug therapy | Obesity - drug therapy | Humans | Middle Aged | Male | Prediabetic State - drug therapy | Obesity - blood | Glucose Intolerance - blood | Diabetes Mellitus, Experimental - blood | Young Adult | Glucose Intolerance - drug therapy | Hypoglycemic Agents - administration & dosage | Adult | Female | Insulin Secretion | Prediabetic State - blood | Mice, Inbred C57BL | Diabetes Mellitus, Type 2 - prevention & control | Insulin Resistance | Blood Glucose | Oxytocin - analogs & derivatives | Administration, Intranasal | Oxytocin - administration & dosage | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Pilot Projects | Animals | Lipid Metabolism - drug effects | Mice | Type 2 diabetes | Obesity | Medical colleges | Pancreatic beta cells | Insulin resistance | Glucose | Drug therapy | Health aspects | Insulin | Prediabetic state | Dextrose | Diabetes therapy | Animal models | Breastfeeding & lactation | Mental disorders | Peptides | Streptozocin | Schizophrenia | Homeostasis | Cardiovascular disease | Neuropeptides | Analogs | Reduction | Blood-brain barrier | Rodents | Pancreas | Oxytocin | Secretion | Diabetes mellitus | Metabolism | Patients | Beta cells | Medicine | Studies | Glucose tolerance | Intolerance | Weight control | Brain research | Hospitals | Regulation | Diabetes | Gastrointestinal surgery | Index Medicus
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10. Full Text Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism
by Liang, Guang and Song, Lintao and Chen, Zilu and Qian, Yuanyuan and Xie, Junjun and Zhao, Longwei and Lin, Qian and Zhu, Guanghui and Tan, Yi and Li, Xiaokun and Mohammadi, Moosa and Huang, Zhifeng
Kidney International, ISSN 0085-2538, 01/2018, Volume 93, Issue 1, pp. 95 - 109
Inflammation plays a central role in the etiology of diabetic nephropathy, a global health issue. We observed a significant reduction in the renal expression... 
cytokines | fibrosis | inflammation | mesangial cells | diabetic nephropathy | PATHWAYS | ACTIVATION | JNK | KINASE | FIBROBLAST-GROWTH-FACTOR | PATHOGENESIS | OBESITY | INSULIN-RESISTANCE | UROLOGY & NEPHROLOGY | NF-KAPPA-B | EXPRESSION | Diabetes Mellitus, Experimental - drug therapy | Kidney - pathology | Rats, Wistar | Diabetic Nephropathies - etiology | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | Diabetes Mellitus, Type 1 - complications | Diabetic Nephropathies - blood | Diabetes Mellitus, Experimental - blood | Kidney - metabolism | Inflammation Mediators - metabolism | Diabetes Mellitus, Experimental - complications | Diabetic Nephropathies - prevention & control | Diabetes Mellitus, Type 2 - complications | Cell Line | Diabetic Nephropathies - pathology | Kidney - drug effects | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Recombinant Proteins - pharmacology | Diabetes Mellitus, Type 1 - drug therapy | Blood Glucose - drug effects | Fibroblast Growth Factor 1 - blood | Diabetes Mellitus, Type 2 - blood | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Diabetes Mellitus, Type 1 - blood | Fibroblast Growth Factor 1 - pharmacology | Macrophages - drug effects | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Index Medicus
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11. Full Text A prevascularized subcutaneous device-less site for islet and cellular transplantation
by Pepper, Andrew R and Gala-Lopez, Boris and Pawlick, Rena and Merani, Shaheed and Kin, Tatsuya and Shapiro, A M James
Nature Biotechnology, ISSN 1087-0156, 05/2015, Volume 33, Issue 5, pp. 518 - 523
Transplantation of donor-derived islets into the liver is a successful cellular replacement therapy for individuals with diabetes. However, the hepatic... 
REVASCULARIZATION | PANCREATIC-ISLETS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TISSUE | GROWTH | MICE | IMPLANTS | NEOVASCULARIZATION | REVERSAL | Humans | Liver | Translational Medical Research | Blood Glucose | Graft Survival | Cell- and Tissue-Based Therapy | Diabetes Mellitus, Experimental - therapy | Neovascularization, Pathologic - blood | Neovascularization, Pathologic - pathology | Diabetes Mellitus, Experimental - blood | Animals | Diabetes Mellitus, Experimental - pathology | Islets of Langerhans Transplantation | Mice | Neovascularization, Pathologic - therapy | Medical equipment | Care and treatment | Usage | Innovations | Transplantation | Diabetes | Physiological apparatus | Cells | Cellular biology | Transplants & implants | Rodents | Index Medicus
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