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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 32, pp. 13505 - 13510
Diabetes is associated with poor outcomes following acute vascular occlusive events. This results in part from a failure to form adequate compensatory... 
Diabetic angiopathies | Wound healing | Diabetes complications | Diabetes mellitus | Fibroblasts | Hypoxia | Mice | Diabetes | Type 2 diabetes mellitus | Transactivation | HIF-1 | Hyperglycemia | Ischemia | Deferoxamine | MOBILIZATION | STABILIZATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | VESSEL FORMATION | MELLITUS | ischemia | HYDROXYLASES | hyperglycemia | deferoxamine | METABOLISM | COMPLICATIONS | INDUCIBLE FACTOR-1 | ENDOTHELIAL GROWTH-FACTOR | Diabetes Mellitus - pathology | Reactive Oxygen Species - metabolism | Humans | Transcriptional Activation - drug effects | Hyperglycemia - complications | Vascular Endothelial Growth Factor A - metabolism | Neovascularization, Pathologic - complications | Neovascularization, Pathologic - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Protein Binding - drug effects | Hyperglycemia - pathology | Diabetes Mellitus, Experimental - complications | Diabetes Complications - pathology | Diabetes Mellitus, Experimental - metabolism | Wound Healing - drug effects | Disease Models, Animal | Deferoxamine - pharmacology | Pyruvaldehyde - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Diabetes Complications - metabolism | Cells, Cultured | Diabetes Mellitus - metabolism | Glucose - pharmacology | Hypoxia - complications | Up-Regulation - drug effects | p300-CBP Transcription Factors - metabolism | Animals | Diabetes Mellitus, Experimental - pathology | Research | Neovascularization | Vascular endothelial growth factor | Glucose | Rodents | Index Medicus | Biological Sciences
Journal Article
Circulation, ISSN 0009-7322, 05/2013, Volume 127, Issue 18, pp. 1888 - +
Journal Article
Journal Article
MOLECULES, ISSN 1420-3049, 03/2019, Volume 24, Issue 5, p. 846
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2018, Volume 13, Issue 11, pp. e0206509 - e0206509
Proteome analysis of serum from type 2 diabetics with complications may lead to the discovery of diagnostic or prognostic biomarkers. To circumvent the... 
C-REACTIVE PROTEIN | METABOLIC DISEASE | APOLIPOPROTEIN-H | PLASMA-PROTEINS | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | HUMANS | D-BINDING PROTEIN | MICE | MELLITUS | FETUIN-B | Rats | Male | Diabetes Mellitus, Type 2 - metabolism | Blood Proteins - metabolism | Rats, Sprague-Dawley | Systems Biology | Diabetes Mellitus, Experimental - blood | Diabetes Mellitus, Type 2 - blood | Animals | Proteomics | Diabetes Mellitus, Experimental - complications | Protein Processing, Post-Translational | Diabetes Mellitus, Experimental - metabolism | Diabetes Mellitus, Type 2 - complications | Type 2 diabetes | Post-translational modification | Complications and side effects | Development and progression | Research | Biological markers | Transcription factors | Pathogenesis | Liver | Glucose | Serum proteins | Proteins | Hyperglycemia | Post-translation | Electrophoresis | Life sciences | Bioindicators | Metal ions | Enzymes | Translation | Hyperlipidemia | Secretome | Metabolism | Apolipoproteins | Concanavalin A | Immune response (humoral) | Nutrition research | Diet | Biomarkers | Metabolic pathways | Hypertrophy | Enrichment | Transcription | Toxicity | Inflammatory response | High fat diet | Fatty liver | Pathways | Affinity chromatography | Hepatocyte nuclear factor 4 | Diabetes mellitus (non-insulin dependent) | Antigen presentation | Kidneys | Immune response | Gel electrophoresis | Complications | Diabetes mellitus | Inflammation | Immune systems | Medicine | Epigenetics | Insulin resistance | Diagnostic systems | Diabetes | Laboratory animals | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 04/2016, Volume 65, Issue 4, pp. 1061 - 1071
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 03/2018, Volume 314, Issue 3, pp. E191 - E200
Long noncoding RNAs (lncRNAs) have gained widespread interest due to their prevailing presence in various diseases. lncRNA ANRIL (a. k. a. CDKN2B-AS1) is... 
ANRIL | P300 | Diabetic complications | Collagen1α4 | Vascular endothelial growth factor | Fibronectin | Enhancer of zeste 2 | diabetic complications | KIDNEY-DISEASE | PHYSIOLOGY | enhancer of zeste 2 | LONG NONCODING RNAS | CARDIOMYOPATHY | TRANSCRIPTIONAL COACTIVATOR | p300 | RENAL FIBROSIS | collagen1 alpha 4 | fibronectin | vascular endothelial growth factor | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | GENE-EXPRESSION | VASCULAR ENDOTHELIAL-CELLS | CORONARY-ARTERY-DISEASE | MOLECULAR-MECHANISMS | Kidney - pathology | Diabetes Mellitus, Type 2 - genetics | Diabetes Mellitus, Experimental - genetics | Male | Vascular Endothelial Growth Factor A - metabolism | Diabetes Mellitus, Type 2 - metabolism | RNA, Long Noncoding - physiology | Vascular Endothelial Growth Factor A - genetics | Kidney - metabolism | Vasodilator Agents - metabolism | Female | Diabetes Complications - genetics | Diabetes Mellitus, Experimental - complications | Diabetes Complications - pathology | Diabetes Mellitus, Experimental - metabolism | Diabetes Mellitus, Type 2 - complications | Extracellular Matrix Proteins - metabolism | Disease Models, Animal | Diabetes Complications - metabolism | RNA, Long Noncoding - genetics | Mice, Knockout | Animals | Vasoconstrictor Agents - metabolism | Diabetes Mellitus, Experimental - pathology | Mice | Complications and side effects | Physiological aspects | Extracellular matrix | Physiological research | Genetic aspects | Research | Diabetes | Biological control systems | Heart | Renal function | Cardiomyopathy | Streptozocin | INK4a protein | Event-related potentials | mRNA | Tissues | Proteins | Alterations | Matrix | Vasoactive agents | Rodents | Collagen (type IV) | Cyclin-dependent kinase inhibitors | Stains | Diabetes mellitus (non-insulin dependent) | Heart diseases | Euthanasia | Urine | Creatinine | Kidneys | Complications | Diabetes mellitus | Coronary artery | Albumin | INK4 protein | Ribonucleic acid--RNA | Cells | Diseases | Polycomb group proteins | Nephropathy | Chromosome 9 | Structure-function relationships | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 03/2016, Volume 65, Issue 3, pp. 755 - 767
Overcoming refractory massive proteinuria remains a clinical and research issue in diabetic nephropathy. This study was designed to investigate the... 
MAINTENANCE | LYSOSOMES | NUMBER | MICROALBUMINURIA | INCREASE | ENDOCRINOLOGY & METABOLISM | TUBULE | MICE | DIFFERENTIATION | MTOR | REMISSION | Kidney - pathology | Microtubule-Associated Proteins - genetics | Diabetic Nephropathies - etiology | Humans | Middle Aged | Rats, Long-Evans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Diabetes Mellitus, Type 2 - metabolism | Proteinuria - pathology | Autophagy | Young Adult | Kidney - metabolism | Lysosomes - metabolism | Diet, High-Fat | Adult | Female | Lysosomes - pathology | Diabetes Mellitus, Experimental - complications | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | RNA-Binding Proteins - blood | Diabetes Mellitus, Experimental - metabolism | Diabetes Mellitus, Type 2 - complications | Intravital Microscopy | Proteinuria - etiology | Severity of Illness Index | Cell Line | Microscopy, Electron, Transmission | Diabetic Nephropathies - pathology | Microscopy, Electron, Scanning | Podocytes - metabolism | Diabetic Nephropathies - metabolism | Mice, Inbred C57BL | Proteinuria - metabolism | Rats | Mice, Transgenic | Blotting, Western | Mice, Knockout | Autophagy-Related Protein 7 | Animals | Autophagy-Related Protein 5 | Diabetes Mellitus, Experimental - pathology | Aged | Mice | Diabetes Mellitus, Type 2 - pathology | Apoptosis | Care and treatment | Diabetic nephropathies | Homeostasis | Influence | Dosage and administration | Research | Insulin | Proteinuria | Proteins | Diabetic neuropathy | Diabetes | Pathogenesis | Index Medicus | Abridged Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2014, Volume 443, Issue 3, pp. 828 - 833
Dipeptidyl peptidase-4 (DPP-4) inhibitors are incretin-based drugs in patients with type 2 diabetes. In our previous study, we showed that glucagon-like... 
Dipeptidyl peptidase-4 inhibitor | Diabetic nephropathy | Inflammation | Macrophage | GLP-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | DEFICIENT MICE | NEPHROPATHY | PATHOGENESIS | RESISTANT | BIOPHYSICS | GLUCAGON-LIKE PEPTIDE-1 | IV INHIBITOR | GLOMERULI | Diabetes Mellitus, Experimental - drug therapy | Nitriles - pharmacology | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Diabetes Mellitus, Type 1 - metabolism | Diabetic Nephropathies - drug therapy | Glucagon-Like Peptide 1 - blood | Male | Diabetes Mellitus, Type 1 - complications | Diabetic Nephropathies - blood | Protective Agents - therapeutic use | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Protective Agents - pharmacology | Adamantane - therapeutic use | Anti-Inflammatory Agents - therapeutic use | Diabetes Mellitus, Experimental - complications | Kidney Diseases - complications | Diabetes Mellitus, Experimental - metabolism | Cyclic AMP - urine | Adamantane - analogs & derivatives | Disease Models, Animal | Kidney Diseases - metabolism | Adamantane - pharmacology | Diabetic Nephropathies - pathology | Anti-Inflammatory Agents - pharmacology | Kidney Diseases - pathology | Kidney Glomerulus - drug effects | Diabetes Mellitus, Type 1 - pathology | Kidney Diseases - drug therapy | Rats | Kidney Glomerulus - pathology | Rats, Sprague-Dawley | Diabetes Mellitus, Type 1 - drug therapy | Diabetic Nephropathies - complications | Animals | Diabetes Mellitus, Experimental - pathology | Nitriles - therapeutic use | Glucose metabolism | Anti-inflammatory drugs | Type 1 diabetes | Diabetic nephropathies | Index Medicus | AMP | MACROPHAGES | ANTIMICROBIAL AGENTS | RATS | 60 APPLIED LIFE SCIENCES | GROWTH FACTORS | GLUCOSE | INFLAMMATION | RADIOPROTECTIVE SUBSTANCES | RECEPTORS | BLOOD | GLUCAGON
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2017, Volume 7, Issue 1, pp. 41337 - 41337
Enhancing mitochondrial biogenesis and reducing mitochondrial oxidative stress have emerged as crucial therapeutic strategies to ameliorate diabetic myocardial... 
ISCHEMIA-REPERFUSION INJURY | ACTIVATED PROTEIN-KINASE | BIOGENESIS | METABOLISM | PROTECTION | ANTIOXIDANT | MULTIDISCIPLINARY SCIENCES | CADMIUM-INDUCED HEPATOTOXICITY | DYSFUNCTION | STRESS | SIRT3 | AMP-Activated Protein Kinases - metabolism | Diabetes Mellitus, Experimental - drug therapy | Sirtuin 3 - metabolism | Apoptosis - drug effects | Myocardial Reperfusion Injury - complications | Streptozocin | Male | Diabetes Mellitus, Type 1 - complications | Cardiotonic Agents - therapeutic use | Myocardial Reperfusion Injury - pathology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Glucose - toxicity | Diabetes Mellitus, Experimental - complications | Myocardial Reperfusion Injury - drug therapy | Superoxide Dismutase - metabolism | Glucose Tolerance Test | Signal Transduction | Cytochromes c - metabolism | Diabetes Mellitus, Type 1 - pathology | Myocardium - pathology | Mitochondria - metabolism | Cardiotonic Agents - pharmacology | Mitochondria - drug effects | Rats, Sprague-Dawley | Diabetes Mellitus, Type 1 - drug therapy | Transcription Factors - metabolism | Animals | Melatonin - therapeutic use | Diabetes Mellitus, Experimental - pathology | Cytosol - metabolism | Mice | Oxidative Stress - drug effects | Melatonin - pharmacology | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 11, pp. 1263 - 1269
Type 2 diabetes (T2D) has reached an epidemic level globally. Most current treatments ameliorate the hyperglycemic symptom of the disease but are not effective... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE-PHOSPHORYLATION | METFORMIN | ACTIVATED PROTEIN-KINASE | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | INDUCED INSULIN-RESISTANCE | CELL BIOLOGY | SKELETAL-MUSCLE | HYPERGLYCEMIA | OBESE GENE | IN-VIVO | NIH 3T3 Cells | Diabetes Mellitus, Experimental - drug therapy | Liver - pathology | Uncoupling Agents - pharmacology | Fatty Liver - pathology | Humans | Fatty Liver - complications | Hyperglycemia - complications | Male | Hyperglycemia - drug therapy | Mitochondria - ultrastructure | Uncoupling Agents - therapeutic use | Diabetes Mellitus, Experimental - blood | Liver - drug effects | Niclosamide - administration & dosage | Fasting - blood | Niclosamide - chemistry | Niclosamide - pharmacology | Diet, High-Fat | Cell Respiration - drug effects | Hyperglycemia - pathology | Diabetes Mellitus, Experimental - complications | Disease Models, Animal | Mammals - metabolism | Liver - ultrastructure | Administration, Oral | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Mitochondria - metabolism | Mitochondria - drug effects | Uncoupling Agents - administration & dosage | Uncoupling Agents - chemistry | Fatty Liver - drug therapy | Hep G2 Cells | Animals | Hyperglycemia - blood | Diabetes Mellitus, Experimental - pathology | Mice | Glucose Clamp Technique | Blood Glucose - metabolism | Energy Metabolism - drug effects | Niclosamide - therapeutic use | Type 2 diabetes | Mitochondria | Research | Analysis | Hyperglycemia | Transgenic animals | Rodents | Lipids | Diabetes | Metabolism | Index Medicus
Journal Article