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Diabetes, obesity & metabolism, ISSN 1462-8902, 1999
Journal
Kidney International, ISSN 0085-2538, 08/2011, Volume 80, Issue 4, pp. 358 - 368
...Diabetes mellitus is associated with several debilitating complications including kidney disease or diabetic nephropathy (DN), a main cause for patients... 
TGF-β | fibrosis | diabetic nephropathy | gene expression | cell signaling | Up-Regulation | Diabetes Mellitus, Type 2 - genetics | Homeodomain Proteins - metabolism | Transforming Growth Factor beta1 - metabolism | Diabetes Mellitus, Experimental - genetics | Diabetes Mellitus, Type 1 - metabolism | Homeostasis | MicroRNAs - metabolism | Diabetes Mellitus, Type 2 - metabolism | Transfection | Time Factors | Kruppel-Like Transcription Factors - metabolism | Upstream Stimulatory Factors - metabolism | Diabetes Mellitus, Type 1 - chemically induced | Diabetes Mellitus, Experimental - chemically induced | 3' Untranslated Regions | Diabetes Mellitus, Experimental - metabolism | Binding Sites | Collagen Type IV - metabolism | Promoter Regions, Genetic | Diabetic Nephropathies - pathology | Collagen Type I - metabolism | Diabetic Nephropathies - metabolism | Cells, Cultured | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - genetics | Diabetic Nephropathies - genetics | Transforming Growth Factor beta1 - genetics | Mesangial Cells - metabolism | Oligonucleotides - metabolism | Animals | Fibrosis | Diabetes Mellitus, Experimental - pathology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Diabetes Mellitus, Type 2 - pathology | Mutation | Zinc Finger E-box-Binding Homeobox 1
Journal Article
Diabetes, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2872 - 2882
OBJECTIVE-To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic a-cells and how this sudden massive depletion affects... 
INSULIN | HYPERGLUCAGONEMIA | ENDOCRINE PANCREAS | GLUCOSE-HOMEOSTASIS | ENDOCRINOLOGY & METABOLISM | RECEPTOR GENE | SECRETION | DIFFERENTIATION | HYPERPLASIA | ISLET CELLS | EXPRESSION | Insulin-Secreting Cells - secretion | Apoptosis - drug effects | Cell Count | Glucagon - genetics | Male | Diphtheria Toxin - toxicity | Insulin - blood | Glucagon - blood | Diabetes Mellitus, Experimental - blood | Hypoglycemia - prevention & control | Intercellular Signaling Peptides and Proteins - metabolism | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Hyperglycemia - chemically induced | Glucagon-Secreting Cells - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Glucagon-Secreting Cells - secretion | Hyperglycemia - prevention & control | Promoter Regions, Genetic | Signal Transduction | Glucagon-Secreting Cells - pathology | Intercellular Signaling Peptides and Proteins - genetics | Pancreas - drug effects | Pancreas - pathology | Receptors, Glucagon - metabolism | Mice, Transgenic | Pancreas - metabolism | Heparin-binding EGF-like Growth Factor | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Tamoxifen - pharmacology | Diabetes Mellitus, Experimental - pathology | Glucagon - metabolism | Mice | Streptozocin - toxicity | Insulin-Secreting Cells - pathology | Selective Estrogen Receptor Modulators - pharmacology | Islet Studies
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2016, Volume 37, Issue 2, pp. 205 - 217
Diabetes mellitus increasingly afflicts our aging and dysmetabolic population. Type 2 diabetes mellitus and the antecedent metabolic syndrome represent the vast majority of the disease burden... 
amputation | dementia | arteriosclerosis | diabetes mellitus | vascular calcification | FATTY LIVER-DISEASE | ANKLE-BRACHIAL INDEX | GENE REGULATORY PROGRAM | GILFORD PROGERIA SYNDROME | RECEPTOR-DEFICIENT MICE | BONE MORPHOGENETIC PROTEIN-7 | ACCELERATES VASCULAR CALCIFICATION | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | CHRONIC KIDNEY-DISEASE | HEMATOLOGY | GLYCATION END-PRODUCTS | Hyperlipidemias - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Experimental - genetics | Diabetes Mellitus, Type 1 - metabolism | Diabetic Angiopathies - etiology | Male | Diabetes Mellitus, Type 1 - complications | Diabetes Mellitus, Type 2 - metabolism | Arteries - metabolism | Atherosclerosis - etiology | Vascular Calcification - metabolism | Diabetic Angiopathies - pathology | Vascular Calcification - etiology | Diet, High-Fat | Female | Diabetes Mellitus, Experimental - complications | Diabetes Mellitus, Experimental - metabolism | Diabetes Mellitus, Type 2 - complications | Hyperlipidemias - complications | Disease Models, Animal | Diabetic Angiopathies - metabolism | Atherosclerosis - pathology | Genetic Predisposition to Disease | Signal Transduction | Animals, Genetically Modified | Translational Medical Research | Diabetes Mellitus, Type 1 - genetics | Rats | Arteries - pathology | Plaque, Atherosclerotic | Vascular Calcification - pathology | Atherosclerosis - metabolism | Phenotype | Animals
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 2, p. e16556
... (Coptis chinensis French). It improves glucose metabolism in type 2 diabetic patients. The mechanisms involve in activation of adenosine monophosphate activated protein kinase (AMPK... 
ACTIVATED PROTEIN-KINASE | MECHANISM DISTINCT | INSULIN-RESISTANCE | MUSCLE ATROPHY | LIVER | BIOLOGY | CARBOHYDRATE | ELEMENT-BINDING PROTEIN | FOXO TRANSCRIPTION FACTORS | LIPID HOMEOSTASIS | EXPRESSION | Diabetes Mellitus, Experimental - drug therapy | Streptozocin | Gluconeogenesis - drug effects | Male | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Diabetes Mellitus, Experimental - blood | Liver - drug effects | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Drug Evaluation, Preclinical | Hypoglycemic Agents - therapeutic use | Blood Glucose - analysis | Liver - metabolism | Rats | Down-Regulation - drug effects | Rats, Sprague-Dawley | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Berberine - pharmacology | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Animals | Glucose - metabolism | Berberine - therapeutic use | Diabetes Mellitus, Type 2 - chemically induced | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Phosphatases | Blood sugar | Genes | DNA binding proteins | Muscle proteins | Fatty acids | Insulin | Glucose metabolism | Synthesis | Adenylic acid | Protein kinases | Adenosine triphosphate | Protein binding | Transcription factors | Peptides | Liver | Glucose | Blood | Proteins | Signal transduction | Mitochondria | Hyperglycemia | Forkhead protein | Inhibition | Drug dosages | Gluconeogenesis | Binding | Carbohydrates | Berberine | AMP | Metabolism | Fatty-acid synthase | Hepatocytes | Protein synthesis | Glucose-6-phosphatase | Endocrinology | Biomedical research | Kinases | High fat diet | Fatty liver | FOXO1 protein | Rodents | Statins | Fasting | Adenosine monophosphate | Diabetes mellitus | Oxygen consumption | Steatosis | Herbal medicine | Musculoskeletal system | Signaling | Protein kinase | Adenosine kinase | Coronary vessels | Insulin resistance | Diabetes | Respiration | Laboratory animals | ATP
Journal Article
Journal
Metabolism, ISSN 0026-0495, 2013, Volume 62, Issue 11, pp. 1623 - 1632
Abstract Objective CCR2 inhibition has produced promising experimental and clinical anti-hyperglycemic effects... 
Endocrinology & Metabolism | Hyperglycemia | Adipose | MCP-1 | Insulin | Macrophage | METABOLIC SYNDROME | LIPID-METABOLISM | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | AMELIORATES INSULIN-RESISTANCE | DIET-INDUCED OBESITY | SKELETAL-MUSCLE | RECEPTOR 2 CCR2 | ENDOCRINOLOGY & METABOLISM | CHEMOKINE RECEPTOR | HEPATIC STEATOSIS | ADIPOSE-TISSUE | Diabetes Mellitus, Experimental - drug therapy | Male | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Macrophages | Obesity - blood | Receptors, CCR2 - antagonists & inhibitors | Diabetes Mellitus, Experimental - blood | Dose-Response Relationship, Drug | Inflammation - metabolism | Glycogen - metabolism | Diet, High-Fat | Diabetes Mellitus, Type 2 - etiology | Obesity - etiology | Diabetes Mellitus, Experimental - metabolism | Hypoglycemic Agents - therapeutic use | Obesity - complications | Liver - metabolism | Mice, Inbred C57BL | Adipose Tissue - pathology | Insulin Resistance | Insulin - administration & dosage | Biomarkers - blood | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Obesity - metabolism | Triglycerides - metabolism | Adiponectin - blood | Diabetes Mellitus, Type 2 - blood | Receptors, CCR2 - metabolism | Animals | Diabetes Mellitus, Experimental - etiology | Diabetes Mellitus, Experimental - pathology | Glycosuria - diagnosis | Mice | Diabetes Mellitus, Type 2 - pathology | Insulin-Secreting Cells - pathology | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Insulin resistance | Usage | Drug therapy | Analysis | Diabetes therapy
Journal Article
Translational Research, ISSN 1931-5244, 2011, Volume 157, Issue 4, pp. 253 - 264
Diabetes mellitus is a complex disease resulting in altered glucose homeostasis. In both type 1 and type 2 diabetes mellitus, pancreatic β... 
Internal Medicine | interferon-γ | Goto-Kakizaki | mRNA | nonobese diabetic mice | precursor microRNA | interleukin-1β | IFN-γ | UTR | messenger RNA | myocyte enhancer factor 2C | miRNA | insulin-like growth factor | RNase | sterol regulatory element binding protein | MEF2C | NOD | SREBP | IGF | untranslated region | adenoassociated virus | IL-1β | ribonucleases | TNF-α | AAV | tumor necrosis factor-α | adenosine triphosphate | microRNA | pre-miRNA | ATP | MEDICINE, RESEARCH & EXPERIMENTAL | POSTTRANSCRIPTIONAL REGULATION | DIFFERENTIAL EXPRESSION | SMALL RNAS | HUMAN SKELETAL-MUSCLE | MEDICINE, GENERAL & INTERNAL | ENDURANCE EXERCISE | MUSCLE-SPECIFIC MICRORNAS | IN-VIVO | GENE-EXPRESSION | ANIMAL-MODELS | PANCREATIC BETA-CELLS | MEDICAL LABORATORY TECHNOLOGY | Diabetes Mellitus - genetics | Humans | Liver - metabolism | Adipose Tissue - physiopathology | Gene Expression Regulation | Diabetes Mellitus - metabolism | MicroRNAs - metabolism | Muscle, Skeletal - metabolism | Muscle, Skeletal - physiology | Liver - physiopathology | Adipose Tissue - metabolism | Insulin-Secreting Cells - metabolism | Animals | Muscle, Skeletal - physiopathology | MicroRNAs - genetics | Type 2 diabetes | Pancreatic beta cells | Blood sugar | Antisense RNA | Development and progression | Ribonuclease | Research | Muscle proteins | Biological response modifiers | Messenger RNA | Analysis | Diabetes | Adenosine triphosphate | Protein binding | Interferon gamma
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 12, p. e52013
...: An experimental diabetic rat model was induced by low dose of streptozoticin(STZ) combined with high energy intake on rats... 
FIBROSIS | CELLS | OXIDATIVE STRESS | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | GENE-EXPRESSION | CARDIAC DYSFUNCTION | PPAR-GAMMA | RECEPTOR | GLYCATION END-PRODUCTS | DIASTOLIC DYSFUNCTION | Inflammation - pathology | Diabetes Mellitus, Experimental - drug therapy | Fibrosis - drug therapy | Diabetic Cardiomyopathies - metabolism | Diabetic Cardiomyopathies - drug therapy | Rats, Wistar | Apoptosis - drug effects | Diabetes Mellitus, Experimental - genetics | Apoptosis - genetics | Glycogen Synthase Kinase 3 beta | Male | Fibrosis - metabolism | Proto-Oncogene Proteins c-akt - genetics | Inflammation - metabolism | Cell Death - genetics | Ventricular Dysfunction, Left - genetics | Inflammation - drug therapy | Myocardium - metabolism | Ventricular Dysfunction, Left - pathology | Cell Death - drug effects | Phosphorylation - drug effects | Diabetes Mellitus, Experimental - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor for Advanced Glycation End Products | Fibrosis - genetics | Curcumin - pharmacology | Oxidative Stress - genetics | Rats | Myocardium - pathology | Glycogen Synthase Kinase 3 - metabolism | Diabetic Cardiomyopathies - genetics | Ventricular Dysfunction, Left - metabolism | Animals | Ventricular Dysfunction, Left - drug therapy | Glycogen Synthase Kinase 3 - genetics | Diabetes Mellitus, Experimental - pathology | Heart - drug effects | Inflammation - genetics | Diabetic Cardiomyopathies - pathology | Fibrosis - pathology | Oxidative Stress - drug effects | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Oxidases | Heart | Biological products | Cardiomyopathy | Heart diseases | Enzyme-linked immunosorbent assay | Apoptosis | Oxidative stress | Phosphorylation | Bax protein | Bcl-2 protein | Science | AKT protein | Cardiovascular disease | Caspase-3 | NAD(P)H oxidase | Accumulation | Proteins | Signal transduction | Hyperglycemia | Ultrastructure | Biochemical tests | Curcumin | Age | Energy intake | Enzymes | Advanced glycosylation end products | Echocardiography | Abnormalities | Diabetes mellitus | Caspase | Rac1 protein | Pharmacology | Inflammation | Glycosylation | IL-1β | Gene expression | Metabolism | Studies | Signaling | Cell death | Fibrosis | Diabetes | Aberration | Laboratory animals | Metabolic disorders | Hypertrophy
Journal Article