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Journal of Ethnopharmacology, ISSN 0378-8741, 11/2016, Volume 192, pp. 382 - 389
Liuwei Dihaung decoction (LWDHT) is a well-known classic traditional Chinese medicine formula, consists of six herbs including Rehmannia glutinosa... 
PI3K/Akt signaling pathway | Liuwei Dihuang decoction | Type 2 diabetes mellitus | CHEMISTRY, MEDICINAL | INTEGRATIVE & COMPLEMENTARY MEDICINE | GENES | PHARMACOLOGY & PHARMACY | PLANT SCIENCES | Diabetes Mellitus, Experimental - drug therapy | Liver - pathology | Phosphorylation | Liver - enzymology | Diabetes Mellitus, Experimental - enzymology | Streptozocin | Drugs, Chinese Herbal - pharmacology | Male | Insulin Receptor Substrate Proteins - metabolism | Insulin - blood | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-akt - genetics | Diabetes Mellitus, Experimental - blood | Liver - drug effects | Time Factors | Diabetes Mellitus, Experimental - chemically induced | Insulin Receptor Substrate Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Pancreas - enzymology | RNA, Messenger - genetics | Diabetes Mellitus, Type 2 - enzymology | Insulin Resistance | Pancreas - drug effects | Pancreas - pathology | Biomarkers - blood | Rats, Sprague-Dawley | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Gene Expression Regulation, Enzymologic | Diabetes Mellitus, Type 2 - blood | Animals | Phosphatidylinositol 3-Kinase - genetics | Signal Transduction - drug effects | Diabetes Mellitus, Type 2 - chemically induced | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Insulin resistance | Medicine, Chinese | Liver | Physiological aspects | Blood sugar
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 10/2012, Volume 14, Issue 10, pp. 869 - 881
Journal Article
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2013, Volume 98, Issue 6, pp. 2553 - 2561
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 01/2009, Volume 66, Issue 1, pp. 27 - 42
The glucokinase (GCK) gene was one of the first candidate genes to be identified as a human “diabetes gene". Subsequently, important advances were made in... 
Biochemistry, general | hepatocyte | insulin | Biomedicine general | Cell Biology | Life Sciences | islet of Langerhans | MODY | Life Sciences, general | Glucokinase | diabetes | glucose metabolism | hexokinase | Glucose metabolism | Hepatocyte | Islet of Langerhans | Diabetes | Insulin | Hexokinase | INSULIN-DEPENDENT INDUCTION | HEPATIC GLYCOGEN-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | YOUNG TYPE-2 MODY-2 | BETA-CELL GLUCOKINASE | CELL BIOLOGY | PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA | GENE-EXPRESSION | REGULATORY PROTEIN | LIVER-X-RECEPTOR | GROWTH-FACTOR-I | Hexokinase - physiology | Liver - enzymology | Insulin - physiology | Islets of Langerhans - enzymology | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Type 2 - enzymology | Gene Expression Regulation | Brain - enzymology | Congenital Hyperinsulinism - enzymology | Congenital Hyperinsulinism - genetics | Homeostasis - physiology | Glucose - metabolism | Mitochondrial Membranes - enzymology | Adaptor Proteins, Signal Transducing - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Hexokinase - genetics | Hexokinase - chemistry | Homeostasis - genetics | Anopheles | Isoenzymes | Analysis | Physiological aspects | Glucose | Gene expression | Dextrose | Proteins | Enzymes | Biochemistry | Molecular biology | Review
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 510, Issue 7506, pp. 542 - 546
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 258 - 262
In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased selectively in adipocytes(1). Adipose-specific knockout or overexpression of... 
METABOLISM | MULTIDISCIPLINARY SCIENCES | MOUSE | LIVER | RESISTANCE | MICE | CDNA CLONING | EXPRESSION | SIRT1 | CANCER | ADIPOSE-TISSUE | Sirtuin 1 - metabolism | Acetyltransferases - metabolism | Adipocytes - secretion | Ornithine Decarboxylase - metabolism | Liver - enzymology | Glucose Transporter Type 4 - metabolism | Adipose Tissue, White - metabolism | Male | Diabetes Mellitus, Type 2 - metabolism | Nicotinamide N-Methyltransferase - metabolism | Glucose Intolerance | Glucose Transporter Type 4 - deficiency | Obesity - genetics | Thinness - metabolism | Gene Knockdown Techniques | Adipose Tissue - metabolism | Nicotinamide N-Methyltransferase - deficiency | Obesity - etiology | NAD - metabolism | Spermine - analogs & derivatives | Nicotinamide N-Methyltransferase - genetics | Thinness - enzymology | Glucose Transporter Type 4 - genetics | Niacinamide - metabolism | Mice, Inbred C57BL | Diabetes Mellitus, Type 2 - enzymology | Insulin Resistance | Oxidoreductases Acting on CH-NH Group Donors - metabolism | Fatty Liver | Animals | Diet | Energy Metabolism | Adipocytes - metabolism | Obesity - prevention & control | Spermine - metabolism | Adipose Tissue, White - enzymology | Adipose Tissue - enzymology | Mice | Obesity - enzymology | S-Adenosylmethionine - metabolism | Adipose tissues | Type 2 diabetes | Obesity | Care and treatment | Analysis | Transferases | Physiological aspects | Genetic aspects | Research | Gene expression | Enzymes | Body fat | Adipocytes | Polyamines | Variance analysis | Proteins | Weight control | Metabolites | Rodents | Insulin resistance | Diabetes | Mass spectrometry | Food
Journal Article
Nature Reviews Cardiology, ISSN 1759-5002, 02/2013, Volume 10, Issue 2, pp. 73 - 84
Dipeptidyl peptidase 4 (DPP-4) inhibitors (commonly referred to as gliptins) are a novel class of oral antihyperglycaemic agents with demonstrated efficacy in... 
DRUG-NAIVE PATIENTS | ENDOTHELIAL PROGENITOR CELLS | DIPEPTIDYL PEPTIDASE-4 INHIBITORS | CARDIAC & CARDIOVASCULAR SYSTEMS | GLUCAGON-LIKE PEPTIDE-1 | ACUTE MYOCARDIAL-INFARCTION | INCRETIN-BASED THERAPIES | RANDOMIZED CLINICAL-TRIALS | TYPE-2 DIABETES-MELLITUS | ANGIOTENSIN-CONVERTING ENZYME | CORONARY-ARTERY-DISEASE | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Heart Failure - enzymology | Humans | Heart Failure - physiopathology | Endothelium, Vascular - drug effects | Lipids - blood | Myocardial Ischemia - physiopathology | Blood Pressure - drug effects | Myocardial Ischemia - mortality | Heart Failure - mortality | Risk Factors | Diabetes Mellitus, Type 2 - enzymology | Endothelium, Vascular - physiopathology | Inflammation Mediators - blood | Myocardial Ischemia - blood | Treatment Outcome | Myocardial Ischemia - enzymology | Biomarkers - blood | Myocardial Ischemia - drug therapy | Heart Failure - drug therapy | Blood Glucose - drug effects | Cardiovascular Agents - therapeutic use | Diabetes Mellitus, Type 2 - blood | Animals | Diabetes Mellitus, Type 2 - physiopathology | Diabetes Mellitus, Type 2 - mortality | Oxidative Stress - drug effects | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Complications and side effects | Hypoglycemic agents | Dosage and administration | Research | Drug therapy | Cardiovascular diseases | Risk factors
Journal Article