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Atherosclerosis, ISSN 0021-9150, 2015, Volume 243, Issue 2, pp. 438 - 448
Abstract Objective The circulating irisin increases energy expenditure and improves insulin resistance in mice and humans. The improvement of insulin... 
Cardiovascular | Irisin | AMPK | Diabetes mellitus | Atherosclerosis | Endothelium | APOPTOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | CHOLESTEROL | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | CIRCULATING IRISIN | KINASE-C | CORONARY-ARTERY | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | CELL | ASSOCIATION | Diabetes Mellitus, Experimental - drug therapy | Apolipoproteins E - deficiency | Human Umbilical Vein Endothelial Cells - metabolism | Apoptosis - drug effects | Atherosclerosis - genetics | Diabetes Mellitus, Experimental - genetics | Endothelium, Vascular - drug effects | Male | Diabetic Angiopathies - physiopathology | RNA Interference | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Diabetic Angiopathies - prevention & control | Proto-Oncogene Proteins c-akt - metabolism | Cytokines - genetics | Cytoprotection | Diabetes Mellitus, Experimental - physiopathology | Atherosclerosis - pathology | Fibronectins - pharmacology | Genetic Predisposition to Disease | Human Umbilical Vein Endothelial Cells - drug effects | Atherosclerosis - physiopathology | Endothelial Cells - metabolism | Plaque, Atherosclerotic | Nitric Oxide Synthase Type III - genetics | Atherosclerosis - metabolism | Mice, Knockout | Nitric Oxide Synthase Type III - antagonists & inhibitors | Macrophages - metabolism | Phenotype | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Endothelium, Vascular - pathology | Human Umbilical Vein Endothelial Cells - pathology | Oxidative Stress - drug effects | Vasodilation - drug effects | Endothelial Cells - pathology | AMP-Activated Protein Kinases - genetics | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Diabetic Angiopathies - pathology | Transfection | Nitric Oxide Synthase Type III - metabolism | Diabetes Mellitus, Experimental - metabolism | Diabetic Angiopathies - genetics | Diabetic Angiopathies - metabolism | Cytokines - metabolism | AMP-Activated Protein Kinases - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Endothelium, Vascular - physiopathology | Animals | Apolipoproteins E - genetics | Diabetes Mellitus, Experimental - pathology | Macrophages - drug effects | Protein Kinase Inhibitors - pharmacology | Atherosclerosis - prevention & control | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Endothelial Cells - drug effects | Insulin resistance | Diabetes | Apolipoproteins | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 05/2013, Volume 62, Issue 5, pp. 1697 - 1708
Impaired cardiac microvascular function contributes to cardiovascular complications in diabetes. Glucagon-like peptide-1 (GLP-1) exhibits potential... 
OXIDATIVE STRESS | IN-VITRO | GLP-1 | RECEPTOR AGONISTS | GLUCOSE | ENDOTHELIAL-CELLS | DISEASE | KINASE | ENDOCRINOLOGY & METABOLISM | ANGIOTENSIN-II | DYSFUNCTION | Endothelium, Vascular - cytology | Microvessels - physiopathology | AMP-Activated Protein Kinases - metabolism | Diabetic Cardiomyopathies - metabolism | Microvessels - metabolism | Microvessels - pathology | Endothelium, Vascular - drug effects | Male | Diabetic Cardiomyopathies - physiopathology | Cardiotonic Agents - therapeutic use | Diabetic Angiopathies - physiopathology | Diabetic Angiopathies - pathology | Diabetic Cardiomyopathies - prevention & control | Diabetic Angiopathies - prevention & control | Hyperglycemia - physiopathology | Cyclic AMP - metabolism | Heart Ventricles - pathology | Disease Models, Animal | Hypoglycemic Agents - therapeutic use | Diabetic Angiopathies - metabolism | Second Messenger Systems - drug effects | Glucagon-Like Peptide 1 - metabolism | Glucagon-Like Peptide 1 - analogs & derivatives | Cells, Cultured | Microvessels - drug effects | Rats | Random Allocation | Rats, Sprague-Dawley | Animals | Heart Ventricles - physiopathology | Hyperglycemia - blood | Endothelium, Vascular - metabolism | rho GTP-Binding Proteins - metabolism | Venoms - therapeutic use | Diabetic Cardiomyopathies - pathology | Endothelium, Vascular - pathology | Heart Ventricles - metabolism | Oxidative Stress - drug effects | Peptides - therapeutic use | Glucagon-Like Peptide 1 - therapeutic use | Heart Ventricles - drug effects | Prevention | Type 2 diabetes | Complications and side effects | Glucagon | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Cardiovascular diseases | Risk factors | Index Medicus | Abridged Index Medicus | Original Research
Journal Article
Journal Article
Journal Article
Atherosclerosis, ISSN 0021-9150, 2012, Volume 221, Issue 2, pp. 387 - 396
Highlights ► STZ–CML–HFD for 4 months could induce atherosclerotic calcification of diabetes. ► We constructed a new calcification model in a high-lipid,... 
Cardiovascular | Advanced glycation end-products | Phenotype transformation | OSTEOGENIC DIFFERENTIATION | RECEPTOR | MECHANISMS | RAGE | CORONARY-ARTERY CALCIFICATION | Atherosclerosis | DISEASE | Vascular calcification | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | INTRAVASCULAR ULTRASOUND | APOPTOTIC BODIES | Diabetes | Vascular smooth muscle cells | Apoptosis | Immunohistochemistry | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Alkaline Phosphatase - metabolism | Diabetic Angiopathies - etiology | Male | Vascular Calcification - metabolism | Time Factors | Vascular Calcification - etiology | Diet, High-Fat | Cell Differentiation | Diabetes Mellitus, Experimental - complications | Lipoproteins, LDL - metabolism | Lysine - metabolism | Receptor for Advanced Glycation End Products | Lysine - analogs & derivatives | Atherosclerosis - pathology | Core Binding Factor Alpha 2 Subunit - metabolism | Macrophages - pathology | Lysine - administration & dosage | Rats | Vascular Calcification - pathology | Atherosclerosis - metabolism | Blotting, Western | Disease Progression | Mice, Knockout | Macrophages - metabolism | Staining and Labeling | Glucose - metabolism | Mice | Injections, Intravenous | Muscle, Smooth, Vascular - metabolism | Vascular Calcification - genetics | Myocytes, Smooth Muscle - pathology | Atherosclerosis - etiology | Diabetic Angiopathies - pathology | Bone Morphogenetic Protein 2 - metabolism | Diabetes Mellitus, Experimental - metabolism | Diabetic Angiopathies - genetics | Myocytes, Smooth Muscle - metabolism | Cell Line | Diabetic Angiopathies - metabolism | Mice, Inbred C57BL | Muscle, Smooth, Vascular - pathology | Animals | Apolipoproteins E - genetics | Osteogenesis | Receptors, Immunologic - metabolism | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 02/2013, Volume 112, Issue 3, pp. 510 - 522
RATIONALE:The impact of diabetes mellitus on bone marrow (BM) structure is incompletely understood. OBJECTIVE:Investigate the effect of type-2 diabetes... 
microangiopathy | stem cells | macroangiopathy | diabetes mellitus type 2 | bone marrow | CARDIAC & CARDIOVASCULAR SYSTEMS | TRANSCRIPTION | MICRORNAS | TRANSPLANTATION | HEART | ENDOTHELIAL PROGENITOR CELLS | DISEASE | PERIPHERAL VASCULAR DISEASE | COMPLICATIONS | NEOVASCULARIZATION | DIFFERENTIATION | HEMATOLOGY | EXPRESSION | Immunohistochemistry | Humans | Middle Aged | Microvessels - metabolism | Hematopoietic Stem Cells - pathology | Microvessels - pathology | Male | MicroRNAs - metabolism | Ischemia - genetics | Adipose Tissue - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Forkhead Transcription Factors - metabolism | Bone Marrow Cells - immunology | Aged, 80 and over | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Ischemia - pathology | Biomarkers - metabolism | Peripheral Arterial Disease - metabolism | Stem Cell Niche | Signal Transduction | Endothelial Cells - metabolism | Adipose Tissue - pathology | Bone Marrow Cells - pathology | Bone Marrow Examination | Cell Lineage | MicroRNAs - genetics | Diabetes Mellitus, Type 2 - pathology | Endothelial Cells - pathology | Forkhead Box Protein O3 | Antigens, CD34 - metabolism | Peripheral Arterial Disease - pathology | Diabetes Mellitus, Type 2 - genetics | Diabetes Mellitus, Type 2 - metabolism | Microvessels - immunology | Case-Control Studies | Hematopoietic Stem Cells - immunology | Diabetic Angiopathies - pathology | Flow Cytometry | Transfection | Peripheral Arterial Disease - genetics | Adult | Female | Diabetic Angiopathies - genetics | Diabetic Angiopathies - metabolism | Cells, Cultured | Gene Expression Regulation | Ischemia - metabolism | Hematopoietic Stem Cells - metabolism | Forkhead Transcription Factors - genetics | Aged | Bone Marrow Cells - metabolism | Apoptosis | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 01/2015, Volume 64, Issue 1, pp. 266 - 278
Journal Article
Diabetes, ISSN 0012-1797, 12/2015, Volume 64, Issue 12, pp. 4046 - 4060
Diabetes exacerbates cardiovascular disease, at least in part through suppression of macrophage cholesterol efflux and levels of the cholesterol transporters... 
SIGNALING PATHWAYS | ATHEROSCLEROTIC PLAQUES | GENERAL CONTRASTS | STATIN THERAPY | FOAM-CELL-FORMATION | IN-VIVO | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | PPAR-GAMMA | DEFICIENT MICE | GLYCATION END-PRODUCTS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Lipoproteins - genetics | Humans | Male | Aorta - metabolism | PPAR gamma - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Lipoproteins - antagonists & inhibitors | Diabetic Angiopathies - pathology | ATP-Binding Cassette Transporters - genetics | Biological Transport | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Plaque, Atherosclerotic - blood | Receptor for Advanced Glycation End Products - genetics | Plaque, Atherosclerotic - pathology | Macrophages - immunology | PPAR gamma - genetics | Receptor for Advanced Glycation End Products - blood | Recombinant Proteins - metabolism | Cell Line | Diabetic Angiopathies - metabolism | Promoter Regions, Genetic | Macrophages - pathology | Plaque, Atherosclerotic - metabolism | Receptor for Advanced Glycation End Products - metabolism | Cells, Cultured | Recombinant Proteins - chemistry | Aorta - immunology | Diabetic Angiopathies - blood | Macrophages - cytology | Plaque, Atherosclerotic - immunology | Receptor for Advanced Glycation End Products - agonists | Cholesterol - metabolism | Mice, Knockout | Aorta - pathology | Macrophages - metabolism | Animals | Diabetic Angiopathies - immunology | Glycation End Products, Advanced - metabolism | Glycation End Products, Advanced - blood | Ligands | ATP Binding Cassette Transporter 1 - genetics | ATP-Binding Cassette Transporters - antagonists & inhibitors | Diabetic acidosis | Care and treatment | Ketoacidosis | Research | Cardiovascular diseases | Macrophages | Risk factors | Cardiovascular disease | Diabetes | Rodents | Cholesterol | Adenosine triphosphatase | Index Medicus | Abridged Index Medicus | Metabolism
Journal Article
Journal Article
CARDIOVASCULAR RESEARCH, ISSN 0008-6363, 01/2017, Volume 113, Issue 1, pp. 90 - 101
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2007, Volume 282, Issue 42, pp. 31038 - 31045
Methylglyoxal is a highly reactive dicarbonyl degradation product formed from triose phosphates during glycolysis. Methylglyoxal forms stable adducts primarily... 
DIABETIC-RETINOPATHY | ACTIVATION | ADVANCED GLYCATION | SP1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | O-GLYCOSYLATION | MICE | 3 MAJOR PATHWAYS | EXPRESSION | HYPERGLYCEMIC DAMAGE | GLYOXALASE-I | Tumor Necrosis Factor-alpha - metabolism | Transcription, Genetic - drug effects | Kidney - pathology | Sweetening Agents - metabolism | Angiopoietin-2 - genetics | Protein Processing, Post-Translational - genetics | Diabetes Mellitus, Experimental - genetics | N-Acetylglucosaminyltransferases - genetics | Glycolysis - drug effects | Acetylglucosamine - metabolism | Glycolysis - genetics | Pyruvaldehyde - metabolism | Kidney - metabolism | Diabetic Angiopathies - pathology | Protein Processing, Post-Translational - drug effects | Arginine - genetics | Intercellular Adhesion Molecule-1 - biosynthesis | Vascular Cell Adhesion Molecule-1 - genetics | Response Elements - genetics | Diabetes Mellitus, Experimental - metabolism | Diabetic Angiopathies - genetics | Repressor Proteins - metabolism | Sp3 Transcription Factor - metabolism | Diabetic Angiopathies - metabolism | Sweetening Agents - pharmacology | Endothelial Cells - metabolism | Gene Expression Regulation - genetics | Sp3 Transcription Factor - genetics | Angiopoietin-2 - biosynthesis | Repressor Proteins - genetics | Glucose - pharmacology | Acetylglucosamine - genetics | N-Acetylglucosaminyltransferases - metabolism | Gene Expression Regulation - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Animals | Intercellular Adhesion Molecule-1 - genetics | Diabetes Mellitus, Experimental - pathology | Glucose - metabolism | Vascular Cell Adhesion Molecule-1 - biosynthesis | Mice | Endothelial Cells - pathology | Arginine - metabolism | Cell Line, Transformed | Index Medicus
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2013, Volume 58, Issue 3, pp. 766 - 775.e12
Objective The present study is designed to understand the contribution of peripheral vascular disease and peripheral neuropathy to the wound-healing impairment... 
Surgery | CONNECTION | SURGERY | CELLS | REPAIR | INHIBITION | NEUROPATHY | INFLAMMATION | EAR | ANIMAL-MODELS | PERIPHERAL VASCULAR DISEASE | SUBSTANCE-P | RECEPTORS | Up-Regulation | Diabetic Neuropathies - etiology | Skin - metabolism | Diabetes Mellitus, Experimental - genetics | Diabetic Angiopathies - etiology | Ischemia - genetics | Skin Ulcer - etiology | Skin Ulcer - immunology | Wound Healing | Skin Ulcer - metabolism | Diabetic Neuropathies - genetics | Diabetic Angiopathies - pathology | Ischemia - immunology | Time Factors | Inflammation Mediators - metabolism | Diabetic Neuropathies - immunology | Diabetes Mellitus, Experimental - complications | Neuropeptides - genetics | Diabetes Mellitus, Experimental - metabolism | Diabetic Angiopathies - genetics | Cytokines - genetics | Ischemia - pathology | Macrophages - immunology | Skin - pathology | Skin - immunology | Diabetic Angiopathies - metabolism | Rabbits | Cytokines - metabolism | Down-Regulation | Skin Ulcer - genetics | Ischemia - metabolism | Neuropeptides - metabolism | Diabetes Mellitus, Experimental - immunology | Skin Ulcer - pathology | Animals | Diabetic Angiopathies - immunology | Diabetic Neuropathies - pathology | Diabetic Neuropathies - metabolism | Ischemia - etiology | Neuropeptide Y | Blood circulation disorders | Wound healing | Diabetes | Cytokines | Analysis | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 01/2010, Volume 121, Issue 1, pp. 110 - 122
Background-High-density lipoprotein (HDL)-raising therapies are currently under intense evaluation, but the effects of HDL may be highly heterogeneous. We... 
Lipids | Free radicals | Diabetes mellitus | Nitric oxide | Endothelium | endothelium | free radicals | lipids | nitric oxide | METABOLIC SYNDROME | CARDIAC & CARDIOVASCULAR SYSTEMS | VASCULAR OXIDATIVE STRESS | NITRIC-OXIDE SYNTHASE | PROGENITOR-CELL MOBILIZATION | TORCETRAPIB | diabetes mellitus | SCAVENGER RECEPTOR-BI | REVERSE CHOLESTEROL TRANSPORT | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | HDL CHOLESTEROL | SIMVASTATIN | Lipoproteins, HDL - blood | Humans | Middle Aged | NADPH Oxidases - metabolism | Male | Metabolic Syndrome - metabolism | Diabetes Mellitus, Type 2 - metabolism | Metabolic Syndrome - drug therapy | Niacin - administration & dosage | Mice, Mutant Strains | Lipid Peroxidation - drug effects | Superoxides - metabolism | Free Radicals - metabolism | Female | Vasodilation - physiology | Diabetic Angiopathies - metabolism | Endothelial Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Diabetic Angiopathies - drug therapy | Animals | Mice, Nude | Hypolipidemic Agents - administration & dosage | Aged | Mice | Vasodilation - drug effects | Diabetes Mellitus, Type 2 - drug therapy | Nitric Oxide - metabolism | Delayed-Action Preparations | Endothelial Cells - drug effects | Peroxidase - metabolism | Type 2 diabetes | Usage | High density lipoproteins | Patient outcomes | Physiological aspects | Research | Drug therapy | Niacin | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article