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The New England Journal of Medicine, ISSN 0028-4793, 04/2011, Volume 364, Issue 17, pp. 1643 - 1656
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, p. e52013
Objectives: Diabetic cardiomyopathy (DCM), characterized by myocardial structural and functional changes, is an independent cardiomyopathy that develops in... 
FIBROSIS | CELLS | OXIDATIVE STRESS | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | GENE-EXPRESSION | CARDIAC DYSFUNCTION | PPAR-GAMMA | RECEPTOR | GLYCATION END-PRODUCTS | DIASTOLIC DYSFUNCTION | Inflammation - pathology | Diabetes Mellitus, Experimental - drug therapy | Fibrosis - drug therapy | Diabetic Cardiomyopathies - metabolism | Diabetic Cardiomyopathies - drug therapy | Rats, Wistar | Apoptosis - drug effects | Diabetes Mellitus, Experimental - genetics | Apoptosis - genetics | Glycogen Synthase Kinase 3 beta | Male | Fibrosis - metabolism | Proto-Oncogene Proteins c-akt - genetics | Inflammation - metabolism | Cell Death - genetics | Ventricular Dysfunction, Left - genetics | Inflammation - drug therapy | Myocardium - metabolism | Ventricular Dysfunction, Left - pathology | Cell Death - drug effects | Phosphorylation - drug effects | Diabetes Mellitus, Experimental - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor for Advanced Glycation End Products | Fibrosis - genetics | Curcumin - pharmacology | Oxidative Stress - genetics | Rats | Myocardium - pathology | Glycogen Synthase Kinase 3 - metabolism | Diabetic Cardiomyopathies - genetics | Ventricular Dysfunction, Left - metabolism | Animals | Ventricular Dysfunction, Left - drug therapy | Glycogen Synthase Kinase 3 - genetics | Diabetes Mellitus, Experimental - pathology | Heart - drug effects | Inflammation - genetics | Diabetic Cardiomyopathies - pathology | Fibrosis - pathology | Oxidative Stress - drug effects | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Oxidases | Heart | Biological products | Cardiomyopathy | Heart diseases | Enzyme-linked immunosorbent assay | Apoptosis | Oxidative stress | Phosphorylation | Bax protein | Bcl-2 protein | Science | AKT protein | Cardiovascular disease | Caspase-3 | NAD(P)H oxidase | Accumulation | Proteins | Signal transduction | Hyperglycemia | Ultrastructure | Biochemical tests | Curcumin | Age | Energy intake | Enzymes | Advanced glycosylation end products | Echocardiography | Abnormalities | Diabetes mellitus | Caspase | Rac1 protein | Pharmacology | Inflammation | Glycosylation | IL-1β | Gene expression | Metabolism | Studies | Signaling | Cell death | Fibrosis | Diabetes | Aberration | Laboratory animals | Metabolic disorders | Hypertrophy
Journal Article
Circulation, ISSN 0009-7322, 05/2012, Volume 125, Issue 19, pp. 2323 - 2333
Background-cGMP phosphodiesterase type 5 protein is upregulated in myocardial hypertrophy. However, it has never been ascertained whether phosphodiesterase... 
fibrosis | phosphodiesterase inhibitors heart failure | diabetes mellitus type 2 | cardiac magnetic resonance imaging | diabetic diastolic heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | PULMONARY-HYPERTENSION | ENDOTHELIAL DYSFUNCTION | SILDENAFIL CITRATE | AORTIC-STENOSIS | DIASTOLIC HEART-FAILURE | HYPERTROPHY | FLOW-MEDIATED DILATATION | NITRIC-OXIDE | VALVE-REPLACEMENT | PERIPHERAL VASCULAR DISEASE | TYPE-5 INHIBITION | Piperazines - administration & dosage | Diabetic Cardiomyopathies - drug therapy | Follow-Up Studies | Phosphodiesterase 5 Inhibitors - adverse effects | Humans | Middle Aged | Sulfones - adverse effects | Magnetic Resonance Imaging - methods | Male | Purines - administration & dosage | Torsion, Mechanical | Sildenafil Citrate | Hypertrophy, Left Ventricular - pathology | Purines - adverse effects | Cardiac Imaging Techniques - methods | Hypertrophy, Left Ventricular - drug therapy | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Diabetes Mellitus, Type 2 - complications | Phosphodiesterase 5 Inhibitors - administration & dosage | Treatment Outcome | Piperazines - adverse effects | Diabetic Cardiomyopathies - pathology | Aged | Ventricular Remodeling - drug effects | Sulfones - administration & dosage | Care and treatment | Magnetic resonance imaging | Cardiomyopathy | Clinical trials | Diagnosis | Phosphodiesterases | Heart diseases | Health aspects | Methods
Journal Article
Journal Article