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JAMA : the journal of the American Medical Association, ISSN 0098-7484, 09/2015, Volume 314, Issue 9, pp. 884 - 894
IMPORTANCE: Steroidal mineralocorticoid receptor antagonists, when added to a renin-angiotensin system blocker, further reduce proteinuria in patients with... 
Blood Pressure | Creatinine | Glomerular Filtration Rate | Diabetic Nephropathies | Double-Blind Method | Drug Administration Schedule | Naphthyridines | Administration, Oral | Angiotensin Receptor Antagonists | Humans | Middle Aged | Male | Albuminuria | Incidence | Dose-Response Relationship, Drug | Hyperkalemia | Analysis of Variance | Angiotensin-Converting Enzyme Inhibitors | Least-Squares Analysis | Female | Aged | Diabetes Mellitus, Type 2 | Mineralocorticoid Receptor Antagonists | Potassium | KIDNEY-DISEASE | MEDICINE, GENERAL & INTERNAL | ANTAGONIST | INHIBITION | MORBIDITY | SPIRONOLACTONE | BAY 94-8862 | PROTEINURIA | BLOCKADE | BLOOD-PRESSURE | MINERALOCORTICOID RECEPTOR | Naphthyridines - adverse effects | Diabetic Nephropathies - drug therapy | Diabetes Mellitus, Type 2 - ethnology | Glomerular Filtration Rate - drug effects | Diabetic Nephropathies - physiopathology | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Hyperkalemia - epidemiology | Blood Pressure - drug effects | Diabetes Mellitus, Type 2 - complications | Diabetic Nephropathies - urine | Diabetes Mellitus, Type 2 - urine | Diabetic Nephropathies - ethnology | Creatinine - urine | Mineralocorticoid Receptor Antagonists - therapeutic use | Albuminuria - drug therapy | Hyperkalemia - chemically induced | Potassium - blood | Angiotensin Receptor Antagonists - therapeutic use | Naphthyridines - administration & dosage | Proteins | Clinical trials | Side effects | Diabetes | Antagonist drugs | ACE inhibitors
Journal Article
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 2, p. e54442
... Pollock 1 , Amanda Mather 1 Introduction Diabetic nephropathy is the leading cause of end stage kidney disease and its escalating incidence is a challenge to health... 
MATRIX | STIMULATION | MULTIDISCIPLINARY SCIENCES | DISEASE | HIGH GLUCOSE | GENE-EXPRESSION | PPAR-GAMMA AGONISTS | TRANSFORMING GROWTH FACTOR-BETA | Diabetes Mellitus - pathology | Epithelial Cells - metabolism | Gene Expression - drug effects | Diabetes Mellitus - genetics | Transcription Factor AP-1 - genetics | Epithelial Cells - drug effects | Humans | Diabetic Nephropathies - drug therapy | NF-kappa B - metabolism | Smad3 Protein - metabolism | Transcription Factor AP-1 - metabolism | Sodium-Glucose Transporter 1 - genetics | Smad3 Protein - genetics | Sodium-Glucose Transporter 1 - metabolism | Phosphorylation - drug effects | Interleukin-6 - metabolism | Transforming Growth Factor beta1 - pharmacology | Sodium-Glucose Transporter 2 - genetics | Collagen Type IV - metabolism | Sodium-Glucose Transporter 1 - antagonists & inhibitors | Promoter Regions, Genetic | Diabetic Nephropathies - pathology | Glucosides - pharmacology | Kidney Tubules, Proximal - pathology | Interleukin-6 - genetics | Sodium-Glucose Transporter 2 - metabolism | Diabetic Nephropathies - metabolism | Diabetes Mellitus - drug therapy | Diabetes Mellitus - metabolism | Toll-Like Receptor 4 - genetics | Diabetic Nephropathies - genetics | Epithelial Cells - pathology | Glucose - pharmacology | Toll-Like Receptor 4 - metabolism | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | NF-kappa B - genetics | Kidney Tubules, Proximal - metabolism | Collagen Type IV - genetics | Protein Binding | Benzhydryl Compounds - pharmacology | Kidney Tubules, Proximal - drug effects | Physiological aspects | Care and treatment | Genetic aspects | Research | Transforming growth factors | Diabetic nephropathies | Chromatin | Immunoprecipitation | Transforming growth factor-b | Interleukin | Clinical trials | Systematic review | Smad3 protein | Glucose | Kinases | Interleukin 6 | Proteins | Hyperglycemia | Rodents | Toll-like receptors | Collagen (type IV) | Hypoglycemic agents | Inhibition | Growth factors | Deoxyribonucleic acid--DNA | Immune system | Binding | Glucose transporter | Medical research | NF-κB protein | Diabetes mellitus | Markers | Activator protein 1 | Blocking | Reabsorption | Inflammation | Gene expression | Glucose transport | Medicine | High mobility group proteins | Hospitals | Inhibitors | Nephropathy | Sodium | Fibrosis | Kidney diseases | Diabetes | Transporter | Adenosine triphosphatase | Kidney transplantation | Deoxyribonucleic acid | DNA
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2013, Volume 369, Issue 20, pp. 1892 - 1903
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2019, Volume 380, Issue 24, pp. 2295 - 2306
Journal Article
Diabetes, obesity & metabolism, ISSN 1462-8902, 2018, Volume 20, Issue 6, pp. 1369 - 1376
...), with a large variability between patients. We are assessing its effect on renal outcomes in the Study Of diabetic Nephropathy with AtRasentan (SONAR; NCT01858532... 
ANTAGONIST | INHIBITION | ALBUMINURIA | PREDICTORS | HEART-FAILURE | MULTIPLE RISK MARKERS | CHRONIC KIDNEY-DISEASE | diabetic kidney disease | endothelin receptor antagonist | randomized controlled clinical trial | atrasentan | personalized medicine | ENDOCRINOLOGY & METABOLISM | Humans | Diabetic Nephropathies - drug therapy | Male | Renal Insufficiency, Chronic - complications | Renal Insufficiency, Chronic - drug therapy | Drug Therapy, Combination - adverse effects | Diabetic Nephropathies - physiopathology | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Adult | Endothelin A Receptor Antagonists - adverse effects | Female | Diabetes Mellitus, Type 2 - complications | Drug Resistance | Endothelin A Receptor Antagonists - therapeutic use | Kidney - physiopathology | Precision Medicine | Severity of Illness Index | Kidney - drug effects | Double-Blind Method | Renal Insufficiency, Chronic - physiopathology | Disease Progression | Randomized Controlled Trials as Topic | Kidney Failure, Chronic - prevention & control | Kidney Failure, Chronic - complications | Atrasentan - therapeutic use | Angiotensin Receptor Antagonists - therapeutic use | Atrasentan - adverse effects | Research Design | Type 2 diabetes | Antimitotic agents | Medical research | Endothelin | Chronic kidney failure | Diabetic nephropathies | Angiotensin | Clinical trials | Albumin | Medicine, Experimental | Antineoplastic agents | Risk factors | Creatinine | Renin | Nephropathy | Kidneys | Diabetes mellitus | Diabetes | Kidney diseases | Diabetes mellitus (non-insulin dependent) | Patients | Clinical Trial Design
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2008, Volume 358, Issue 23, pp. 2433 - 2446
Journal Article
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 12/2010, Volume 17, Issue 34, pp. 4256 - 4269
Journal Article