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Diabetes, obesity & metabolism, ISSN 1462-8902, 06/2018, Volume 20, Issue 6, pp. 1369 - 1376
...), with a large variability between patients. We are assessing its effect on renal outcomes in the Study Of diabetic Nephropathy with AtRasentan (SONAR; NCT01858532... 
ANTAGONIST | INHIBITION | ALBUMINURIA | PREDICTORS | HEART-FAILURE | MULTIPLE RISK MARKERS | CHRONIC KIDNEY-DISEASE | diabetic kidney disease | endothelin receptor antagonist | randomized controlled clinical trial | atrasentan | personalized medicine | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Humans | Diabetic Nephropathies - drug therapy | Male | Renal Insufficiency, Chronic - complications | Renal Insufficiency, Chronic - drug therapy | Drug Therapy, Combination - adverse effects | Diabetic Nephropathies - physiopathology | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Adult | Endothelin A Receptor Antagonists - adverse effects | Female | Diabetes Mellitus, Type 2 - complications | Drug Resistance | Endothelin A Receptor Antagonists - therapeutic use | Kidney - physiopathology | Precision Medicine | Severity of Illness Index | Kidney - drug effects | Double-Blind Method | Renal Insufficiency, Chronic - physiopathology | Disease Progression | Randomized Controlled Trials as Topic | Kidney Failure, Chronic - prevention & control | Kidney Failure, Chronic - complications | Atrasentan - therapeutic use | Angiotensin Receptor Antagonists - therapeutic use | Atrasentan - adverse effects | Research Design | Type 2 diabetes | Antimitotic agents | Medical research | Endothelin | Chronic kidney failure | Diabetic nephropathies | Angiotensin | Clinical trials | Albumin | Medicine, Experimental | Antineoplastic agents | Risk factors | Creatinine | Renin | Nephropathy | Kidneys | Diabetes mellitus | Diabetes | Kidney diseases | Diabetes mellitus (non-insulin dependent) | Patients | Index Medicus | Clinical Trial Design
Journal Article
The New England journal of medicine, ISSN 1533-4406, 06/2019, Volume 380, Issue 24, pp. 2295 - 2306
This double-blind, randomized trial compared canagliflozin with placebo in patients with type 2 diabetes and evidence of kidney disease that was treated with... 
KIDNEY-DISEASE | EMPAGLIFLOZIN | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Sodium-Glucose Transporter 2 Inhibitors - therapeutic use | Glomerular Filtration Rate | Sodium-Glucose Transporter 2 Inhibitors - adverse effects | Double-Blind Method | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Diabetic Nephropathies - drug therapy | Male | Canagliflozin - adverse effects | Diabetic Nephropathies - complications | Diabetes Mellitus, Type 2 - blood | Kidney Failure, Chronic - epidemiology | Kidney Failure, Chronic - prevention & control | Canagliflozin - therapeutic use | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Creatinine - blood | Female | Aged | Diabetes Mellitus, Type 2 - drug therapy | Diabetes Mellitus, Type 2 - complications | Myocardial infarction | End-stage renal disease | Laboratories | Hemodialysis | Clinical trials | Immunosuppressive agents | Clinical outcomes | Renin | Amputation | Diabetes mellitus (non-insulin dependent) | Heart diseases | Creatinine | Cerebral infarction | Enzymes | Kidneys | Diabetes mellitus | Glomerular filtration rate | Nephropathy | Sodium | Collaboration | Angiotensin | Renal failure | Death | Diabetes | Kidney diseases | Cardiovascular diseases | Kidney transplantation | Index Medicus | Abridged Index Medicus
Journal Article
Journal of lipid research, ISSN 1539-7262, 12/2017, Volume 58, Issue 12, pp. 2264 - 2274
Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy (DN... 
Apolipoprotein B | Proteoglycans | Transforming growth factor-β | Extracellular matrix | Biglycan | Diabetes | Cholesterol | Kidney | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Apolipoproteins B - metabolism | Diabetes Mellitus, Experimental - drug therapy | Kidney - pathology | Biglycan - genetics | Streptozocin | Diabetes Mellitus, Experimental - genetics | Diabetic Nephropathies - drug therapy | Diet, High-Fat - adverse effects | Male | Kidney - metabolism | Receptors, LDL - deficiency | Transforming Growth Factor beta - antagonists & inhibitors | Albuminuria - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Albuminuria - pathology | Biglycan - deficiency | Receptors, LDL - genetics | Diabetic Nephropathies - pathology | Kidney - drug effects | Diabetic Nephropathies - metabolism | Mice, Inbred C57BL | Antibodies, Neutralizing - pharmacology | Diabetic Nephropathies - genetics | Apolipoproteins B - genetics | Mice, Knockout | Albuminuria - genetics | Animals | Transforming Growth Factor beta - genetics | Albuminuria - drug therapy | Survival Analysis | Mice | Transforming Growth Factor beta - metabolism | Kidneys | High cholesterol diet | Hyperlipidemia | Transforming growth factor | Diabetes mellitus | Prevention | Lipoproteins | Nephropathy | Rodents | Lipoprotein (low density) receptors | Hypertrophy | Index Medicus | proteoglycans | kidney | transforming growth factor-β | cholesterol | biglycan | diabetes | apolipoprotein B | extracellular matrix
Journal Article
The New England journal of medicine, ISSN 1533-4406, 08/2017, Volume 377, Issue 9, pp. 839 - 848
Journal Article
Journal Article