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中华医学杂志:英文版, ISSN 0366-6999, 2015, Volume 128, Issue 24, pp. 3276 - 3282
Journal Article
Diabetes/Metabolism Research and Reviews, ISSN 1520-7552, 05/2015, Volume 31, Issue 4, pp. 411 - 420
BackgroundThis study aimed to assess the associations between clinical characteristics and chronic complications in latent autoimmune diabetes in adults (LADA)... 
cardiovascular disease | latent autoimmune diabetes in adults | type 2 diabetes | diabetic retinopathy | diabetic nephropathy | Latent autoimmune diabetes in adults | Type 2 diabetes | Diabetic retinopathy | Cardiovascular disease | Diabetic nephropathy | AUTOANTIBODIES | METABOLIC SYNDROME | CAROTID ATHEROSCLEROSIS | RISK-FACTORS | GLUTAMIC-ACID DECARBOXYLASE | PREVALENCE | CHINESE POPULATION | LADA | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | COMMUNITY-BASED PATIENTS | Diabetes Mellitus - blood | Autoimmune Diseases - physiopathology | Microvessels - physiopathology | Prevalence | Humans | Middle Aged | Male | Diabetic Cardiomyopathies - physiopathology | Diabetic Cardiomyopathies - immunology | Diabetic Angiopathies - physiopathology | Diabetes Mellitus, Type 2 - immunology | Cardiovascular Diseases - epidemiology | Adult | Autoantibodies - analysis | Diabetic Neuropathies - immunology | Female | Registries | Retrospective Studies | Diabetes Mellitus, Type 2 - complications | Diabetic Neuropathies - physiopathology | Cardiovascular Diseases - physiopathology | Risk Factors | Autoimmune Diseases - complications | Autoimmune Diseases - immunology | China - epidemiology | Disease Progression | Autoimmune Diseases - blood | Cardiovascular Diseases - immunology | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 2 - physiopathology | Diabetes Mellitus - immunology | Diabetes Mellitus - physiopathology | Diabetic Angiopathies - immunology | Diabetic Cardiomyopathies - epidemiology | Diabetic Neuropathies - epidemiology | Diabetic Angiopathies - epidemiology | ROC Curve | Aged | Autoimmunity | Complications and side effects | Adults | Diabetic nephropathies | Rodents | Diabetes | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 08/2018, Volume 67, Issue 8, pp. 1616 - 1626
Previously, we had shown that a vasopeptidase inhibitor drug containing ACE and neprilysin inhibitors was an effective treatment for diabetic vascular and... 
NEPRILYSIN INHIBITION | NERVE | OBESITY | GENE-RELATED PEPTIDE | NEUROPATHY | ACE-INHIBITOR | NEUTRAL ENDOPEPTIDASE | ENDOCRINOLOGY & METABOLISM | VASOPEPTIDASE INHIBITOR | ILEPATRIL | ANGIOTENSIN-CONVERTING-ENZYME | Neuroprotective Agents - therapeutic use | Diabetic Retinopathy - drug therapy | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Diet, High-Fat - adverse effects | Male | Aminobutyrates - therapeutic use | Diabetic Retinopathy - physiopathology | Diabetic Angiopathies - physiopathology | Valsartan - therapeutic use | Vascular Resistance - drug effects | Neural Conduction - drug effects | Diabetic Angiopathies - prevention & control | Protease Inhibitors - therapeutic use | Diabetes Mellitus, Type 2 - complications | Diabetic Neuropathies - physiopathology | Diabetic Neuropathies - prevention & control | Diabetic Neuropathies - drug therapy | Diabetic Angiopathies - drug therapy | Neprilysin - metabolism | Rats, Sprague-Dawley | Disease Progression | Cardiovascular Agents - therapeutic use | Diabetic Retinopathy - prevention & control | Animals | Neprilysin - antagonists & inhibitors | Tetrazoles - therapeutic use | Angiotensin Receptor Antagonists - therapeutic use | Drug Combinations | Complications and side effects | Polyneuropathies | Valsartan | Dosage and administration | Diabetes | Drug therapy | Risk factors | Cornea | Diabetes mellitus | Diabetic neuropathy | T cell receptors | Vasopeptidase | Peripheral neuropathy | Nerve conduction | Regeneration | Angiotensin | Sensory neurons | Neprilysin | Skin | Angiotensin II | ACE inhibitors | Diabetes mellitus (non-insulin dependent) | Index Medicus | Abridged Index Medicus
Journal Article
Diabetologia, ISSN 0012-186X, 7/2012, Volume 55, Issue 7, pp. 1911 - 1918
In type 2 diabetic patients at low risk for cardiovascular disease (CVD), the relationship between the clinical course of nephropathy by stage of chronic... 
Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | Cardiovascular disease | Diabetic nephropathy | Chronic kidney disease | Albuminuria | Glomerular filtration rate | MORTALITY | EVENTS | RISK | MELLITUS | GLOMERULAR-FILTRATION-RATE | MICROALBUMINURIA | ENDOCRINOLOGY & METABOLISM | ASSOCIATION | Prospective Studies | Outcome Assessment (Health Care) | Diabetic Nephropathies - etiology | Albuminuria - blood | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Diabetic Angiopathies - etiology | Male | Diabetic Nephropathies - blood | Diabetic Angiopathies - physiopathology | Diabetic Nephropathies - physiopathology | Cardiovascular Diseases - blood | Cardiovascular Diseases - mortality | Renal Insufficiency, Chronic - mortality | Female | Diabetes Mellitus, Type 2 - complications | Cardiovascular Diseases - physiopathology | Glomerular Filtration Rate | Risk Factors | Diabetic Angiopathies - mortality | Diabetic Angiopathies - blood | Renal Insufficiency, Chronic - physiopathology | Disease Progression | Diabetic Nephropathies - mortality | Renal Insufficiency, Chronic - blood | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 2 - physiopathology | Diabetes Mellitus, Type 2 - mortality | Creatinine - blood | Primary Health Care | Cohort Studies | Type 2 diabetes | Medical research | Diabetics | Medical colleges | Corticosteroids | Diabetic nephropathies | Research | Chronic kidney failure | Analysis | Medicine, Experimental | Diabetes | Kidney diseases | Cardiovascular diseases | Index Medicus
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2013, Volume 58, Issue 3, pp. 766 - 775.e12
Objective The present study is designed to understand the contribution of peripheral vascular disease and peripheral neuropathy to the wound-healing impairment... 
Surgery | CONNECTION | SURGERY | CELLS | REPAIR | INHIBITION | NEUROPATHY | INFLAMMATION | EAR | ANIMAL-MODELS | PERIPHERAL VASCULAR DISEASE | SUBSTANCE-P | RECEPTORS | Up-Regulation | Diabetic Neuropathies - etiology | Skin - metabolism | Diabetes Mellitus, Experimental - genetics | Diabetic Angiopathies - etiology | Ischemia - genetics | Skin Ulcer - etiology | Skin Ulcer - immunology | Wound Healing | Skin Ulcer - metabolism | Diabetic Neuropathies - genetics | Diabetic Angiopathies - pathology | Ischemia - immunology | Time Factors | Inflammation Mediators - metabolism | Diabetic Neuropathies - immunology | Diabetes Mellitus, Experimental - complications | Neuropeptides - genetics | Diabetes Mellitus, Experimental - metabolism | Diabetic Angiopathies - genetics | Cytokines - genetics | Ischemia - pathology | Macrophages - immunology | Skin - pathology | Skin - immunology | Diabetic Angiopathies - metabolism | Rabbits | Cytokines - metabolism | Down-Regulation | Skin Ulcer - genetics | Ischemia - metabolism | Neuropeptides - metabolism | Diabetes Mellitus, Experimental - immunology | Skin Ulcer - pathology | Animals | Diabetic Angiopathies - immunology | Diabetic Neuropathies - pathology | Diabetic Neuropathies - metabolism | Ischemia - etiology | Neuropeptide Y | Blood circulation disorders | Wound healing | Diabetes | Cytokines | Analysis | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2008, Volume 105, Issue 19, pp. 6998 - 7003
Significant morbidity and mortality among patients with diabetes mellitus result largely from a greatly increased incidence of microvascular complications.... 
Diabetic angiopathies | Diabetic retinopathy | Kidneys | Diabetes complications | Diabetic nephropathies | Medical genetics | Type 2 diabetes mellitus | Diabetes | Epics | Type 1 diabetes mellitus | Association | SNP | End stage renal disease | Proliferative diabetic retinopathy | Diabetic microvascular complication | MULTIDISCIPLINARY SCIENCES | association | NEPHROPATHY | end stage renal disease | ALLELIC VARIATION | HUMAN GENOME | BLOOD-GROUPS | DISEASE | RETINOPATHY | UTAH MORMONS | SUSCEPTIBILITY LOCUS | proliferative diabetic retinopathy | EXPRESSION | diabetic microvascular complication | Haplotypes | Retina - metabolism | Luciferases - metabolism | Kidney - pathology | Humans | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Diabetic Retinopathy - complications | Kidney - metabolism | Erythropoietin - metabolism | Genes, Reporter | Cell Line | Genetic Predisposition to Disease | RNA, Messenger - genetics | Gene Expression Regulation | Diabetic Nephropathies - genetics | Diabetic Retinopathy - genetics | Diabetic Nephropathies - complications | Erythropoietin - genetics | Animals | Alleles | Polymorphism, Single Nucleotide - genetics | Mice | Retina - pathology | Cohort Studies | Eye | Medical examination | Erythropoietin | Development and progression | Genetic aspects | Properties | Identification and classification | Genetic polymorphisms | Genotype & phenotype | Kidney diseases | Gene expression | Eyes & eyesight | Polymorphism | Index Medicus | Biological Sciences
Journal Article
Diabetologia, ISSN 0012-186X, 7/2009, Volume 52, Issue 7, pp. 1279 - 1289
This study was designed to determine whether the relationship of glycated haemoglobin to diabetic microvascular complications shows any natural thresholds that... 
Retinopathy | Medicine & Public Health | Human Physiology | Diabetes mellitus | Metabolic Diseases | Internal Medicine | Chronic kidney disease | Glycated haemoglobin | Peripheral neuropathy | Receiver operating characteristic curve | Microalbuminuria | KIDNEY-DISEASE | BLOOD-GLUCOSE | RISK | MELLITUS | FASTING GLUCOSE | INTENSIVE TREATMENT | SINGAPORE MALAY EYE | JAPANESE POPULATION | ENDOCRINOLOGY & METABOLISM | PLASMA-GLUCOSE | Albuminuria - epidemiology | Predictive Value of Tests | Prevalence | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Microvessels - metabolism | Male | Diabetes Complications - diagnosis | Diabetic Nephropathies - diagnosis | Diabetic Retinopathy - diagnosis | Albuminuria - diagnosis | Sensitivity and Specificity | Aged, 80 and over | Diabetes Complications - epidemiology | Adult | Female | Albuminuria - metabolism | Severity of Illness Index | Diabetes Complications - metabolism | Diabetic Nephropathies - metabolism | Risk Factors | Diabetic Retinopathy - metabolism | Diabetic Retinopathy - epidemiology | Singapore - epidemiology | Diabetic Neuropathies - epidemiology | Diabetic Neuropathies - diagnosis | Aged | Diabetic Nephropathies - epidemiology | Diabetic Neuropathies - metabolism | Complications and side effects | Chronic kidney failure | Albumin | Glycosylated hemoglobin | Diabetes | Diagnosis | Ophthalmology | Analysis | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 05/2013, Volume 62, Issue 5, pp. 1697 - 1708
Impaired cardiac microvascular function contributes to cardiovascular complications in diabetes. Glucagon-like peptide-1 (GLP-1) exhibits potential... 
OXIDATIVE STRESS | IN-VITRO | GLP-1 | RECEPTOR AGONISTS | GLUCOSE | ENDOTHELIAL-CELLS | DISEASE | KINASE | ENDOCRINOLOGY & METABOLISM | ANGIOTENSIN-II | DYSFUNCTION | Endothelium, Vascular - cytology | Microvessels - physiopathology | AMP-Activated Protein Kinases - metabolism | Diabetic Cardiomyopathies - metabolism | Microvessels - metabolism | Microvessels - pathology | Endothelium, Vascular - drug effects | Male | Diabetic Cardiomyopathies - physiopathology | Cardiotonic Agents - therapeutic use | Diabetic Angiopathies - physiopathology | Diabetic Angiopathies - pathology | Diabetic Cardiomyopathies - prevention & control | Diabetic Angiopathies - prevention & control | Hyperglycemia - physiopathology | Cyclic AMP - metabolism | Heart Ventricles - pathology | Disease Models, Animal | Hypoglycemic Agents - therapeutic use | Diabetic Angiopathies - metabolism | Second Messenger Systems - drug effects | Glucagon-Like Peptide 1 - metabolism | Glucagon-Like Peptide 1 - analogs & derivatives | Cells, Cultured | Microvessels - drug effects | Rats | Random Allocation | Rats, Sprague-Dawley | Animals | Heart Ventricles - physiopathology | Hyperglycemia - blood | Endothelium, Vascular - metabolism | rho GTP-Binding Proteins - metabolism | Venoms - therapeutic use | Diabetic Cardiomyopathies - pathology | Endothelium, Vascular - pathology | Heart Ventricles - metabolism | Oxidative Stress - drug effects | Peptides - therapeutic use | Glucagon-Like Peptide 1 - therapeutic use | Heart Ventricles - drug effects | Prevention | Type 2 diabetes | Complications and side effects | Glucagon | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Cardiovascular diseases | Risk factors | Index Medicus | Abridged Index Medicus | Original Research
Journal Article
2016, International Review of Neurobiology, ISBN 9780128039403, Volume 127
Web Resource
Journal Article
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Journal Article