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Scientific Reports, ISSN 2045-2322, 03/2017, Volume 7, Issue 1, p. 43412
This study was conducted to investigate impacts of dietary protein levels on gut bacterial community and gut barrier. The intestinal microbiota of finishing... 
POSTWEANING DIARRHEA | HOST METABOLISM | CELLS | FINISHING PIGS | HOMEOSTASIS | PIGLETS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MODULATING INTESTINAL PERMEABILITY | BUTYRATE | PROMOTES | Dietary Proteins - administration & dosage | Peptostreptococcus - drug effects | Tight Junction Proteins - genetics | Receptors, G-Protein-Coupled - metabolism | Colon - drug effects | Ileum - metabolism | Escherichia - metabolism | Escherichia - classification | Fatty Acids, Volatile - metabolism | Intestinal Mucosa - drug effects | Occludin - metabolism | Genetic Variation | Polycomb Repressive Complex 1 - genetics | Dietary Proteins - metabolism | Ileum - drug effects | Swine | Shigella - metabolism | Tight Junction Proteins - metabolism | Firmicutes - isolation & purification | Intestinal Mucosa - microbiology | Peptostreptococcus - isolation & purification | Colon - metabolism | Gastrointestinal Microbiome - drug effects | Claudin-1 - genetics | Escherichia - drug effects | Receptors, G-Protein-Coupled - genetics | Escherichia - isolation & purification | Firmicutes - drug effects | Animal Feed | Peptostreptococcus - classification | Intestinal Mucosa - metabolism | Polycomb Repressive Complex 1 - metabolism | Shigella - classification | Gastrointestinal Microbiome - physiology | Clostridium - isolation & purification | Shigella - drug effects | Clostridium - classification | Occludin - genetics | Claudin-1 - metabolism | Biogenic Amines - metabolism | Diet, Protein-Restricted - methods | Firmicutes - metabolism | Digestion - drug effects | Firmicutes - classification | Shigella - isolation & purification | Peptostreptococcus - metabolism | Digestion - physiology | Gene Expression Regulation - drug effects | Animals | Clostridium - metabolism | Colon - microbiology | Ileum - microbiology | Clostridium - drug effects | Amines | Digestive system | Mucosa | Ileum | Studies | Proteins | Protein composition | Metabolites | Intestine | Fish | Intestinal microflora | Colon | Digestive tract | Biogenic amines | Colonization
Journal Article
American journal of physiology. Gastrointestinal and liver physiology, ISSN 0193-1857, 11/2014, Volume 307, Issue 10, pp. G979 - G991
Enteroendocrine cells secrete over a dozen different hormones responsible for coordinating digestion, absorption, metabolism, and gut motility. Loss of... 
Islet1 | incretins | enteroendocrine | glucose regulation | PHYSIOLOGY | ENDOCRINE CELL-DEVELOPMENT | GASTROINTESTINAL-TRACT | FATE SPECIFICATION | ENTEROINSULAR AXIS | CONGENITAL MALABSORPTIVE DIARRHEA | CHROMOGRANIN-A | INCRETIN HORMONES | HOMEOBOX GENE ISL-1 | GLUCAGON-LIKE PEPTIDE-1 | RECEPTOR KNOCKOUT MICE | GASTROENTEROLOGY & HEPATOLOGY | Dietary Fats - metabolism | Intestinal Mucosa - metabolism | Gastric Inhibitory Polypeptide - metabolism | Age Factors | Intestine, Small - pathology | Transcription Factors - deficiency | Male | Malabsorption Syndromes - metabolism | Intestinal Absorption | Cholecystokinin - metabolism | LIM-Homeodomain Proteins - deficiency | Glucose Metabolism Disorders - metabolism | Female | Chromogranin A - metabolism | Enteroendocrine Cells - metabolism | Weight Gain | Microfilament Proteins - genetics | Somatostatin - metabolism | Animals, Newborn | Enteroendocrine Cells - pathology | Glucose Tolerance Test | Glucagon-Like Peptide 1 - metabolism | Mice, Inbred C57BL | Genotype | Biomarkers - blood | Transcription Factors - genetics | Gastrins - metabolism | Malabsorption Syndromes - genetics | Mice, Knockout | Ghrelin - metabolism | LIM-Homeodomain Proteins - genetics | Phenotype | Animals | Diarrhea - genetics | Glucose Metabolism Disorders - genetics | Serotonin - metabolism | Glucose Metabolism Disorders - blood | Diarrhea - metabolism | Intestine, Small - metabolism | Blood Glucose - metabolism | Integrases - genetics | Intestinal Mucosa - pathology | Glucose metabolism | Pancreatic beta cells | Cell research | Gene mutations | Homeostasis | Genetic research | Genetic aspects | Research | Health aspects | Hormones and Signaling
Journal Article
Glycobiology, ISSN 0959-6658, 11/2013, Volume 23, Issue 11, pp. 1281 - 1292
Human milk oligosaccharides (HMOS) are not digested in the proximal intestine. In distal intestine, HMOS collectively modify the microbiota, but the response... 
Glycosidase | Human milk oligosaccharides | Mutualist bacteria | Commensal bacteria | Organic acids | human milk oligosaccharides | DIARRHEA | STRATEGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SIALIC-ACID CATABOLISM | BIFIDOBACTERIAL CONSUMPTION | organic acids | VIBRIO-CHOLERAE | mutualist bacteria | MOUSE INTESTINE | glycosidase | commensal bacteria | BREAST-FED INFANTS | INHIBIT | PATHOGENS | Escherichia coli K12 - growth & development | Lactobacillus delbrueckii - isolation & purification | Fucose - metabolism | Humans | Bifidobacterium - isolation & purification | Clostridium - isolation & purification | Bifidobacterium - growth & development | Streptococcus thermophilus - growth & development | Escherichia coli K12 - metabolism | Microbiota | Streptococcus thermophilus - metabolism | Culture Media | Escherichia coli K12 - isolation & purification | Bifidobacterium - metabolism | Lactobacillus delbrueckii - metabolism | Streptococcus thermophilus - isolation & purification | Milk, Human - metabolism | alpha-L-Fucosidase - metabolism | Clostridium - growth & development | Sialic Acids - metabolism | Gastrointestinal Tract - microbiology | Lactobacillus delbrueckii - growth & development | Enterococcus faecalis - growth & development | Glycosylation | Bacteroides - growth & development | Oligosaccharides - metabolism | Bacteroides - metabolism | Enterococcus faecalis - isolation & purification | Enterococcus faecalis - metabolism | Bacterial Proteins - metabolism | Clostridium - metabolism | Bacteroides - isolation & purification | Hydrogen-Ion Concentration | Original
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 4, pp. 1425 - 1434
Journal Article
Current Protein and Peptide Science, ISSN 1389-2037, 08/2017, Volume 18, Issue 8, pp. 795 - 808
There is growing recognition that composition and metabolic activity of the gut microbiota can be modulated by the dietary proteins which in turn impact... 
Dietary protein | Metabolites | Amino acid balance | Intestinal microbiota | Gut barrier | Digestibility | LIPID-METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | BARRIER FUNCTION | HYDROGEN-SULFIDE | CELL-GROWTH | WEANED PIGS | BUTYRATE-PRODUCING BACTERIA | metabolites | GROWTH-PERFORMANCE | POSTWEANING DIARRHEA | intestinal microbiota | amino acid balance | SOYBEAN-MEAL | CHAIN FATTY-ACIDS | gut barrier | digestibility | Dietary Proteins - administration & dosage | Proteobacteria - metabolism | Humans | Gastrointestinal Microbiome - physiology | Dietary Carbohydrates - metabolism | Fusobacteria - metabolism | Dietary Proteins - metabolism | Proteolysis | Actinobacteria - metabolism | Firmicutes - metabolism | Verrucomicrobia - growth & development | Dietary Carbohydrates - administration & dosage | Firmicutes - growth & development | Fatty Acids, Volatile - biosynthesis | Ammonia - metabolism | Gastrointestinal Tract - microbiology | Gastrointestinal Tract - drug effects | Fermentation | Amines - metabolism | Fusobacteria - growth & development | Verrucomicrobia - metabolism | Gastrointestinal Microbiome - drug effects | Bacteroidetes - metabolism | Actinobacteria - growth & development | Bacteroidetes - growth & development | Proteobacteria - growth & development | Sulfide | Inflammatory bowel diseases | Amines | Protein turnover | Proteins | Low carbohydrate diet | Carcinogens | Microorganisms | Microbiota | Colon cancer | Intestine | Colon | Digestive tract | Low protein diet | Immune system | Carbohydrates | Protein metabolism | Nutrient deficiency | Secretion | Digestive system | Health | Health risks | Dietary supplements | Amino acid composition | Gastrointestinal tract | Gene expression | Metabolism | Fatty acids | Gases | Cytotoxins | Ammonia | Signaling | Diet | Cancer
Journal Article
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 8/2015, Volume 467, Issue 8, pp. 1795 - 1807
A dysfunction of the Na+/H+ exchanger isoform 3 (NHE3) significantly contributes to the reduced salt absorptive capacity of the inflamed intestine. We... 
Inflammatory bowel disease | Biomedicine | Sodium absorption | Human Physiology | Intestinal inflammation | pH regulation | Electrolyte transport | ACTIVATION | PHYSIOLOGY | DIARRHEA | PERMEABILITY | TRANSPORTERS | MODEL | INFLAMMATORY-BOWEL-DISEASE | INHIBITION | ABSORPTION | EXPRESSION | CAMP | Tumor Necrosis Factor-alpha - metabolism | Dextran Sulfate | Ileum - pathology | Enterocytes - metabolism | Colitis - genetics | Humans | Ileitis - chemically induced | Tumor Necrosis Factor-alpha - genetics | Ileum - metabolism | Colitis - pathology | Intracellular Signaling Peptides and Proteins - metabolism | Mice, 129 Strain | RNA, Messenger - metabolism | Ileitis - pathology | Sodium-Hydrogen Exchangers - metabolism | DNA-Binding Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Transfection | RNA Interference | Colitis - chemically induced | Inflammation Mediators - metabolism | Interleukin-10 - metabolism | Sodium-Hydrogen Exchangers - genetics | Enterocytes - pathology | Ileitis - metabolism | Retrospective Studies | Intracellular Signaling Peptides and Proteins - genetics | Disease Models, Animal | Caco-2 Cells | Colon - pathology | Down-Regulation | DNA-Binding Proteins - genetics | Colon - metabolism | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Microvilli - metabolism | Biopsy | Interleukin-10 - genetics | Colitis - metabolism | Ileitis - genetics | Sodium-Hydrogen Exchanger 3 | Molecular and Cellular Mechanisms of Disease
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0181863
Background We evaluated the effect of Saccharomyces boulardii CNCM I-745 on intestinal neuromuscular anomalies in an IBS-type mouse model of gastrointestinal... 
INTESTINAL-MUCOSA | CONTROLLED-TRIAL | IMMUNE-SYSTEM | ABDOMINAL-PAIN | ENTERIC NERVOUS-SYSTEM | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | DOUBLE-BLIND | QUALITY-OF-LIFE | GUT MICROBIOTA | IRRITABLE-BOWEL-SYNDROME | Tumor Necrosis Factor-alpha - metabolism | Muscles - microbiology | Irritable Bowel Syndrome - therapy | Muscles - virology | Gastrointestinal Motility - drug effects | Ileum - metabolism | Male | Myenteric Plexus - metabolism | Myenteric Plexus - microbiology | Diarrhea - microbiology | Inflammation - metabolism | Interleukin-1beta - metabolism | Herpes Simplex - microbiology | Interleukin-10 - metabolism | Colon - virology | Saccharomyces boulardii - growth & development | Irritable Bowel Syndrome - virology | Muscles - metabolism | Disease Models, Animal | Inflammation - microbiology | Irritable Bowel Syndrome - metabolism | Cytokines - metabolism | Enteric Nervous System - metabolism | Interleukin-4 - metabolism | Mice, Inbred C57BL | Diarrhea - virology | Inflammation - virology | Probiotics - pharmacology | Colon - metabolism | Enteric Nervous System - microbiology | Herpes Simplex - metabolism | Irritable Bowel Syndrome - microbiology | Myenteric Plexus - virology | Herpes Simplex - virology | Ileum - virology | Animals | Enteric Nervous System - virology | Diarrhea - metabolism | Colon - microbiology | Mice | Ileum - microbiology | Herpesvirus 1, Human - pathogenicity | Care and treatment | Saccharomyces boulardii | Usage | Gastrointestinal diseases | Analysis | Irritable bowel syndrome | Research | Health aspects | Herpes simplex virus | Quality of life | Immunohistochemistry | Gastrointestinal tract diseases | Nervous system | Segments | Colony-forming cells | Saccharomyces | Expulsion | Neuronal-glial interactions | Alterations | Enteric nervous system | Microorganisms | Water content | Tension | Feces | Constipation | Medical research | Immunoglobulins | Cytokines | Dietary supplements | Gene expression | Transit | Studies | Probiotics | Nitric oxide | Interleukin 10 | Peripherin | Beads | Anomalies | Neurosciences | Yeast | Interleukin | Viruses | Stimulation | Infections | Intestinal motility | Kinases | Fibers | Lysates | Interleukin 4 | Glass beads | Moisture content | Intestine | Colon | Digestive tract | Gastric motility | Inflammation | Pharmacology | Muscle contraction | Medicine | Dextran | Carbachol | Fluorescein | Viral infections | Inoculum | Integrity
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 04/2008, Volume 294, Issue 4, pp. G1060 - G1069
Probiotics promote intestinal epithelial integrity and reduce infection and diarrhea. We evaluated the effect of Lactobacillus rhamnosus GG-produced soluble... 
Protein kinase C | Zonula occludens-1 | Intestine | Lactobacillus rhamnosus GG | Mucosal protection | Occludin | zonula occludens-1 | mucosal protection | OXIDATIVE STRESS | PHYSIOLOGY | intestine | DIARRHEA | PERMEABILITY | CYTOSKELETON | CACO-2 CELL MONOLAYER | LACTOBACILLUS GG | TIGHT JUNCTIONS | occludin | IN-VIVO | GROWTH | INTESTINAL BARRIER | GASTROENTEROLOGY & HEPATOLOGY | protein kinase C | Protein Kinase C beta | Intestinal Mucosa - metabolism | Cadherins - metabolism | Nitriles - pharmacology | Humans | Tight Junctions - enzymology | Phosphoproteins - metabolism | Intestinal Mucosa - drug effects | Dose-Response Relationship, Drug | Lactobacillus rhamnosus - chemistry | Time Factors | Protein Kinase C - metabolism | Intestinal Mucosa - enzymology | Indoles - pharmacology | Membrane Proteins - metabolism | Tight Junctions - drug effects | Caco-2 Cells | Hydrogen Peroxide - toxicity | Tight Junctions - metabolism | Butadienes - pharmacology | Protein Kinase C - antagonists & inhibitors | Electric Impedance | Permeability | Probiotics - pharmacology | beta Catenin - metabolism | Probiotics - isolation & purification | Protein Transport | HT29 Cells | Bacterial Proteins - pharmacology | Pyrroles - pharmacology | Zonula Occludens-1 Protein | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Protein Kinase C-epsilon - metabolism | Inulin - metabolism | Protein Kinase Inhibitors - pharmacology | Bacterial Proteins - isolation & purification | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2016, Volume 68, pp. 1 - 10
Abstract Purpose We performed a multi-centre phase I study to assess the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of the orally available small... 
Hematology, Oncology and Palliative Medicine | Pharmacodynamics | MEK inhibitor | Phase I | Optimal biological dose | Pharmacokinetics | BRAF-MUTATED MELANOMA | MULTICENTER | SELUMETINIB PLUS DOCETAXEL | SAFETY | TRAMETINIB | CELL LUNG-CANCER | TRIAL | DOSE-ESCALATION | ONCOLOGY | DOUBLE-BLIND | AZD6244 ARRY-142886 | Lung Neoplasms - drug therapy | Pancreatic Neoplasms - metabolism | Nausea - chemically induced | Allosteric Regulation | Humans | Lung Neoplasms - metabolism | Middle Aged | Male | Fatigue - chemically induced | Ribosomal Protein S6 Kinases, 70-kDa - drug effects | Protein Kinase Inhibitors - adverse effects | Colorectal Neoplasms - drug therapy | Chromatography, Liquid | Proto-Oncogene Proteins c-akt - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Bile Duct Neoplasms - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Administration, Oral | Carcinoma, Non-Small-Cell Lung - metabolism | Neoplasms - drug therapy | Maximum Tolerated Dose | Mesothelioma - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Anorexia - chemically induced | Glycogen Synthase Kinase 3 beta - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Neoplasms - metabolism | Phosphoproteins - drug effects | Mitogen-Activated Protein Kinase 1 - drug effects | Cholangiocarcinoma - metabolism | Chromatography, High Pressure Liquid | Diarrhea - chemically induced | Mitogen-Activated Protein Kinase 3 - drug effects | Pancreatic Neoplasms - drug therapy | Tandem Mass Spectrometry | Uterine Cervical Neoplasms - metabolism | Esophageal Neoplasms - metabolism | Adult | Female | Colorectal Neoplasms - metabolism | Bile Duct Neoplasms - drug therapy | Drug Eruptions - etiology | Abdominal Pain - chemically induced | Uterine Cervical Neoplasms - drug therapy | Glycogen Synthase Kinase 3 beta - metabolism | Mesothelioma - drug therapy | Cholangiocarcinoma - drug therapy | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Aged | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Esophageal Neoplasms - drug therapy | Proto-Oncogene Proteins c-akt - drug effects | Care and treatment | Protein kinases | Mitogens | Cells | Tumors
Journal Article