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Journal of Neuroinflammation, ISSN 1742-2094, 11/2011, Volume 8, Issue 1, pp. 149 - 149
Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of nontraumatic... 
Experimental autoimmune encephalomyelitis | Neuroprotection | Katp channel | Multiple sclerosis | Diazoxide | Microglia | Antihypertensive Agents - pharmacology | Diazoxide - pharmacology | Humans | Antihypertensive Agents - administration & dosage | Nitrites - metabolism | Multiple Sclerosis - physiopathology | Microglia - immunology | Diazoxide - therapeutic use | Tumor Necrosis Factor-alpha - immunology | Anti-Inflammatory Agents - therapeutic use | Anti-Inflammatory Agents - administration & dosage | Female | Disease Models, Animal | Microglia - cytology | Cell Line | Encephalomyelitis, Autoimmune, Experimental - physiopathology | Microglia - drug effects | Administration, Oral | Anti-Inflammatory Agents - pharmacology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Disease Progression | KATP Channels - metabolism | Animals | Interleukin-6 - immunology | Lipopolysaccharides - pharmacology | Mice | Diazoxide - administration & dosage | Interferon-gamma - pharmacology | Multiple Sclerosis - drug therapy | Proteins | Neurodegeneration | Rodents | Nitric oxide | Alzheimers disease | Autoimmune diseases | Potassium | Manuscripts | Binding sites | Assaigs clínics de medicaments | Esclerosi múltiple | Drug testing | experimental autoimmune encephalomyelitis | KATP channel | microglia | multiple sclerosis | neuroprotection
Journal Article
Journal Article
JOURNAL OF NEUROINFLAMMATION, ISSN 1742-2094, 11/2011, Volume 8
Background: Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of... 
K-ATP channel | POTASSIUM CHANNELS | multiple sclerosis | NITRIC-OXIDE SYNTHASE | Diazoxide | ROS PRODUCTION | NEUROSCIENCES | TUMOR-NECROSIS-FACTOR | experimental autoimmune encephalomyelitis | neuroprotection | AMYLOID-BETA | NEURONS | CENTRAL-NERVOUS-SYSTEM | RAT HIPPOCAMPUS | microglia | UP-REGULATION
Journal Article
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 11/2018, Volume 103, Issue 11, pp. 4014 - 4022
Journal Article
Journal Article
Fundamental & Clinical Pharmacology, ISSN 0767-3981, 08/2011, Volume 25, Issue 4, pp. 479 - 484
Combination of opioid and potassium channel openers holds immense potential for the treatment for most acute and chronic pain. Therefore, the study was... 
tail‐flick test | antinociception | potassium channel openers | formalin test | morphine | Antinociception | Morphine | Potassium channel openers | Tail-flick test | Formalin test | ENKEPHALINS | ENDOGENOUS OPIOID-PEPTIDES | MECHANISM | INVOLVEMENT | tail-flick test | DIAZOXIDE | INHIBITION | PHARMACOLOGY & PHARMACY | RECEPTORS | ANALGESIA | GLIBENCLAMIDE | Male | Pain - chemically induced | Minoxidil - therapeutic use | Diazoxide - therapeutic use | Glyburide - pharmacology | Minoxidil - administration & dosage | Female | Glyburide - administration & dosage | Morphine - antagonists & inhibitors | Cromakalim - therapeutic use | Pain - prevention & control | Injections, Intraperitoneal | Mice, Inbred Strains | Potassium Channels - drug effects | Cromakalim - administration & dosage | Calcium Channel Agonists - administration & dosage | Drug Therapy, Combination - methods | Pain Measurement - methods | Animals | Naloxone - pharmacology | Drug Interactions - physiology | Calcium Channel Agonists - therapeutic use | Mice | Naloxone - administration & dosage | Diazoxide - administration & dosage | Morphine - administration & dosage | Morphine - therapeutic use | Care and treatment | Pain | Models | Potassium channels | Glibenclamide | Minoxidil | Formaldehyde | Chronic pain | Drugs | Animal models | Pain perception | Naloxone | Analgesics | Opioids | Sex | glibenclamide
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 05/2005, Volume 80, Issue 3, pp. 442 - 449
Our previous studies revealed that iptakalim, a novel ATP‐sensitive potassium channel opener, has a significant neuroprotective function against ischemia in... 
mitochondrial ATP‐sensitive potassium channels | iptakalim | Parkinson's disease | diazoxide | inducible nitric oxide synthase | Mitochondrial ATP-sensitive potassium channels | Diazoxide | Inducible nitric oxide synthase | Iptakalim | ACTIVATION | TYROSINE-HYDROXYLASE | MITOCHONDRIAL | PEROXYNITRITE | NITRIC-OXIDE SYNTHASE | FOCAL CEREBRAL-ISCHEMIA | mitochondrial ATP-sensitive potassium channels | NEURONAL CELL-DEATH | DOPAMINERGIC-NEURONS | NEUROSCIENCES | PC12 CELLS | PARKINSONS-DISEASE | Brain Chemistry - drug effects | Uncoupling Agents - antagonists & inhibitors | Catalepsy - drug therapy | Diazoxide - pharmacology | Uncoupling Agents - pharmacology | Catalepsy - prevention & control | Basal Ganglia - metabolism | Nitric Oxide Synthase - drug effects | Male | Nitric Oxide Synthase - genetics | RNA, Messenger - metabolism | ATP-Binding Cassette Transporters - agonists | Brain - metabolism | Parkinsonian Disorders - metabolism | Neuroprotective Agents - pharmacology | Nitric Oxide Synthase Type I | Parkinsonian Disorders - drug therapy | Adenosine Triphosphate - metabolism | Rotenone - antagonists & inhibitors | Rotenone - pharmacology | ATP-Binding Cassette Transporters - metabolism | Catalepsy - chemically induced | Dopamine - metabolism | Potassium Channel Blockers - pharmacology | Disease Models, Animal | RNA, Messenger - drug effects | Drug Administration Schedule | Basal Ganglia - physiopathology | Brain - physiopathology | Rats | Potassium Channels, Inwardly Rectifying - agonists | Parkinsonian Disorders - chemically induced | Down-Regulation - drug effects | Nerve Tissue Proteins - drug effects | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Brain Chemistry - physiology | Brain - drug effects | Down-Regulation - physiology | Nerve Tissue Proteins - metabolism | Animals | Nitric Oxide Synthase - metabolism | Propylamines - pharmacology | Potassium Channels, Inwardly Rectifying - metabolism | Basal Ganglia - drug effects
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2006, Volume 531, Issue 1, pp. 87 - 95
The possible participation of the nitric oxide (NO)-cyclic GMP-protein kinase G (PKG) pathway on gabapentin-induced spinal antiallodynic activity was assessed... 
Pinacidil | Gabapentin | Nitric oxide | Protein kinase G | Diazoxide | Guanylyl cyclase | K + channel opener | Neuropathic pain | channel opener | SENSITIVE POTASSIUM CHANNELS | nitric oxide | TACTILE ALLODYNIA | K+ channel opener | RANDOMIZED CONTROLLED-TRIAL | NERVE INJURY | VASCULAR SMOOTH-MUSCLE | guanylyl cyclase | neuropathic pain | gabapentin | diazoxide | pinacidil | RABBIT VENTRICULAR MYOCYTES | PHARMACOLOGY & PHARMACY | protein kinase G | UP-REGULATION | CALCIUM-CHANNEL | PERIPHERAL ANTINOCICEPTIVE ACTION | Analgesics - pharmacology | Okadaic Acid - pharmacology | Potassium Channels - physiology | Pinacidil - administration & dosage | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Glyburide - pharmacology | Time Factors | Charybdotoxin - pharmacology | Oxadiazoles - pharmacology | Potassium Channel Blockers - pharmacology | Spinal Nerves - injuries | Spinal Nerves - physiopathology | Enzyme Inhibitors - pharmacology | Cyclohexanecarboxylic Acids - administration & dosage | Rats | gamma-Aminobutyric Acid - pharmacology | Indazoles - pharmacology | NG-Nitroarginine Methyl Ester - chemistry | Cyclic GMP - metabolism | Signal Transduction - drug effects | Pain - physiopathology | Nitric Oxide Synthase - metabolism | Carbazoles - pharmacology | Amines - pharmacology | Diazoxide - administration & dosage | Cyclic GMP - antagonists & inhibitors | Diazoxide - pharmacology | Rats, Wistar | Stereoisomerism | Nitric Oxide Synthase - antagonists & inhibitors | gamma-Aminobutyric Acid - administration & dosage | Apamin - pharmacology | Cyclic GMP-Dependent Protein Kinases - metabolism | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Amines - administration & dosage | Female | Indoles - pharmacology | Injections, Spinal | NG-Nitroarginine Methyl Ester - pharmacology | Pinacidil - pharmacology | Vasodilator Agents - pharmacology | Pain - prevention & control | Nitric Oxide - antagonists & inhibitors | Analgesics - administration & dosage | Animals | Cyclohexanecarboxylic Acids - pharmacology | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Nitric Oxide - metabolism | Vasodilator Agents - administration & dosage
Journal Article
Journal Article