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1. Full Text Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose
by Obach, R. Scott and Kalgutkar, Amit S and Soglia, John R and Zhao, Sabrina X
Chemical research in toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
Physical Sciences | Toxicology | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
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2. Full Text Uptake and Biological Effects of Environmentally Relevant Concentrations of the Nonsteroidal Anti-inflammatory Pharmaceutical Diclofenac in Rainbow Trout (Oncorhynchus mykiss)
by Mehinto, Alvine C and Hill, Elizabeth M and Tyler, Charles R
Environmental science & technology, ISSN 0013-936X, 03/2010, Volume 44, Issue 6, pp. 2176 - 2182
Ecotoxicology and Human Environmental Health | Engineering | Engineering, Environmental | Life Sciences & Biomedicine | Technology | Environmental Sciences & Ecology | Science & Technology | Environmental Sciences | Biomarkers - metabolism | Oncorhynchus mykiss - metabolism | Cytochrome P-450 CYP1A1 - genetics | Cyclooxygenase 1 - genetics | Intestines - pathology | Gene Expression - drug effects | Kidney - pathology | Liver - metabolism | Tumor Suppressor Protein p53 - metabolism | Intestines - metabolism | Cytochrome P-450 CYP1A1 - metabolism | RNA, Messenger - metabolism | Tumor Suppressor Protein p53 - genetics | Dose-Response Relationship, Drug | Water Pollutants, Chemical - metabolism | Kidney - metabolism | Animals | Cyclooxygenase 2 - genetics | Cyclooxygenase 2 - metabolism | Female | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Cyclooxygenase 1 - metabolism | Diclofenac - metabolism | Environmental science | Gene expression | Trout | Genes | Pharmaceuticals | Aquatic ecosystems | Index Medicus
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3. Full Text Uptake and metabolism of diclofenac in Typha latifolia – How plants cope with human pharmaceutical pollution
by Bartha, Bernadett and Huber, Christian and Schröder, Peter
Plant science (Limerick), ISSN 0168-9452, 10/2014, Volume 227, pp. 12 - 20
Oxidative stress | Metabolism | Uptake | LC–MS | Diclofenac | Typha ssp | LC-MS | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Biodegradation, Environmental | Diclofenac - pharmacology | Plant Roots - metabolism | Water Pollutants, Chemical - pharmacology | Glutathione - metabolism | Antioxidants - metabolism | Glutathione Transferase - metabolism | Typhaceae - metabolism | Wetlands | Water Pollutants, Chemical - metabolism | Glycosyltransferases - metabolism | Glycosides - metabolism | Plant Shoots - metabolism | Typhaceae - drug effects | Oxidative Stress - drug effects | Diclofenac - metabolism | Physiological aspects | Enzymes | Pollution | Plants | Pharmaceutical industry | Index Medicus
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4. Full Text Metabolism of diclofenac in plants – Hydroxylation is followed by glucose conjugation
by Huber, Christian and Bartha, Bernadett and Schröder, Peter
Journal of hazardous materials, ISSN 0304-3894, 12/2012, Volume 243, pp. 250 - 256
Barley | Hairy root culture | Metabolism | LC–MS | Diclofenac | LC-MS | Engineering | Engineering, Environmental | Life Sciences & Biomedicine | Technology | Environmental Sciences & Ecology | Science & Technology | Environmental Sciences | Wastewaters | Applied sciences | Pollution | General purification processes | Exact sciences and technology | Water treatment and pollution | Armoracia - metabolism | Biodegradation, Environmental | Microsomes - metabolism | Diclofenac - isolation & purification | Plant Roots - metabolism | Hydroxylation | Glucosidases - metabolism | Hordeum - metabolism | Cytochrome P-450 Enzyme System - metabolism | Chromatography, High Pressure Liquid | Glycosyltransferases - metabolism | Plants - metabolism | Mass Spectrometry | Plant Roots - enzymology | Glucose - metabolism | Plant Leaves - enzymology | Diclofenac - metabolism | Physiological aspects | Glucose | Nonsteroidal anti-inflammatory drugs | Metabolites | Dextrose | Index Medicus
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5. Full Text The impact of the hepatocyte-to-plasma pH gradient on the prediction of hepatic clearance and drug-drug interactions for CYP2C9 and CYP3A4 substrates
by Rougée, Luc R. A and Mohutsky, Michael A and Bedwell, David W and Ruterbories, Kenneth J and Hall, Stephen D
Drug metabolism and disposition, ISSN 0090-9556, 09/2017, Volume 45, Issue 9, pp. 1008 - 1018
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Humans | Warfarin - metabolism | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Dextromethorphan - metabolism | Male | Hepatocytes - metabolism | Testosterone - pharmacokinetics | Warfarin - pharmacology | Testosterone - metabolism | Plasma - metabolism | Drug Interactions | Computer Simulation | Female | Dextromethorphan - pharmacokinetics | Cytochrome P-450 CYP2C9 - metabolism | Diclofenac - analogs & derivatives | Midazolam - pharmacokinetics | Diclofenac - pharmacokinetics | Warfarin - pharmacokinetics | Warfarin - analogs & derivatives | Cytochrome P-450 CYP3A Inhibitors - metabolism | Cytochrome P-450 CYP3A - metabolism | Plasma - enzymology | Midazolam - metabolism | Kinetics | Diclofenac - metabolism | Hepatocytes - enzymology | Hydrogen-Ion Concentration | Protein kinase A | Liver | Amiodarone | Dextromethorphan | Inactivation | pH effects | Diclofenac | Drug metabolism | Nonsteroidal anti-inflammatory drugs | Buffers | Itraconazole | Warfarin | Deactivation | Parameters | Fluconazole | Incubation | Substrate inhibition | Pharmacology | Clozapine | Metabolism | Substrates | Testosterone | Predictions | In vivo methods and tests | Midazolam | Intracellular | Enzyme kinetics | Fluvoxamine | Index Medicus
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6. Full Text Uptake and accumulation of four PPCP/EDCs in two leafy vegetables
by Dodgen, L.K and Li, J and Parker, D and Gan, J.J
Environmental pollution (1987), ISSN 0269-7491, 11/2013, Volume 182, pp. 150 - 156
Non-extractable residue | Reclaimed water | Plant uptake | Pharmaceuticals | Endocrine disrupting chemicals | Environmental Sciences & Ecology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Wastewaters | Fundamental and applied biological sciences. Psychology | Food industries | Pollution | Exact sciences and technology | Water treatment and pollution | Applied sciences | Biological and medical sciences | Food toxicology | Endocrine Disruptors - metabolism | Brassica - metabolism | Endocrine Disruptors - analysis | Waste Disposal, Fluid | Phenols - metabolism | Soil Pollutants - analysis | Water Pollutants, Chemical - analysis | Soil Pollutants - metabolism | Water Pollutants, Chemical - metabolism | Pharmaceutical Preparations - metabolism | Phenols - analysis | Diclofenac - analysis | Vegetables - metabolism | Benzhydryl Compounds - analysis | Pharmaceutical Preparations - analysis | Benzhydryl Compounds - metabolism | Diclofenac - metabolism | Lettuce - metabolism | Endocrine disruptors | Vegetables | Bisphenol-A | Naproxen | Diclofenac | Index Medicus | Human | Bisphenol A | Uptakes | Leaves | Sodium | Risk | Plants (organisms) | Stems | plant uptake | pharmaceuticals | endocrine disrupting chemicals | non-extractable residue
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7. Full Text Removal of trace organic chemical contaminants by a membrane bioreactor
by Trinh, T and Van Den Akker, B and Stuetz, R.M and Coleman, H.M and Le-Clech, P and Khan, S.J
Water science and technology, ISSN 0273-1223, 2012, Volume 66, Issue 9, pp. 1856 - 1863
Pharmaceuticals and personal care products | Membrane bioreactor | Decentralised treatment system | Pesticides | Steroidal hormones | Engineering | Physical Sciences | Engineering, Environmental | Life Sciences & Biomedicine | Technology | Water Resources | Environmental Sciences & Ecology | Science & Technology | Environmental Sciences | Pharmaceutical Preparations - isolation & purification | Omeprazole - metabolism | Diclofenac - isolation & purification | Diazepam - isolation & purification | Diazepam - metabolism | Organic Chemicals - metabolism | Trimethoprim - metabolism | Water Pollutants, Chemical - isolation & purification | Carbamazepine - metabolism | Sulfamethoxazole - metabolism | Organic Chemicals - isolation & purification | Amitriptyline - metabolism | Trimethoprim - isolation & purification | Gemfibrozil - isolation & purification | Sulfamethoxazole - isolation & purification | Water Pollutants, Chemical - metabolism | Amitriptyline - isolation & purification | Pharmaceutical Preparations - metabolism | Waste Disposal, Fluid - methods | Bioreactors | Fluoxetine - metabolism | Omeprazole - isolation & purification | Carbamazepine - isolation & purification | Gemfibrozil - metabolism | Diclofenac - metabolism | Fluoxetine - isolation & purification | Drugs | Removal | Organic contaminants | Trimethoprim | Hormones | Diclofenac | Waste water | Agrochemicals | Xenoestrogens | Recycling | Diazepam | Caffeine | Amitriptyline | Consumer products | Fluoxetine | Chemical wastewater | Chemical contaminants | Wastewater treatment | Carbamazepine | Omeprazole | Contaminants | Water reuse | Gemfibrozil | Water quality | Organic chemicals | Index Medicus
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8. Full Text Evaluation of Human Hepatocytes Cultured by Three-dimensional Spheroid Systems for Drug Metabolism
by Ohkura, Takako and Ohta, Kunihiro and Nagao, Takuya and Kusumoto, Kumiko and Koeda, Akiko and Ueda, Tadayoshi and Jomura, Tomoko and Ikeya, Takeshi and Ozeki, Emiko and Wada, Kazuki and Naitoh, Kazushi and Inoue, Yukiko and Takahashi, Naoki and Iwai, Hisakazu and Arakawa, Hiroshi and Ogihara, Takuo
Drug metabolism and pharmacokinetics, ISSN 1347-4367, 2014, Volume 29, Issue 5, pp. 373 - 378
metabolic enzymes | sequential metabolism | biotransformation | human hepatocyte | spheroid | Spheroid | Human hepatocyte | Sequential metabolism | Metabolic enzymes | Biotransformation | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Triazines - metabolism | Acetaminophen - metabolism | Humans | Albuterol - metabolism | Cytochrome P-450 Enzyme System - metabolism | Hepatocytes - metabolism | Tandem Mass Spectrometry | Hepatocytes - cytology | Pharmaceutical Preparations - metabolism | Glucuronosyltransferase - metabolism | Propranolol - metabolism | Chromatography, Liquid | Midazolam - metabolism | Spheroids, Cellular | Diclofenac - metabolism | Hepatocytes - enzymology | Index Medicus
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9. Full Text Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout
by Lahti, Marja and Brozinski, Jenny‐Maria and Jylhä, Antti and Kronberg, Leif and Oikari, Aimo
Environmental toxicology and chemistry, ISSN 0730-7268, 06/2011, Volume 30, Issue 6, pp. 1403 - 1411
Metabolism | Bioconcentration | Rainbow trout | Pharmaceuticals | Bile | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Oncorhynchus mykiss - metabolism | Bisoprolol - analysis | Carbamazepine - analysis | Ibuprofen - analysis | Bile - metabolism | Fresh Water - chemistry | Water Pollutants, Chemical - analysis | Bisoprolol - metabolism | Naproxen - metabolism | Ibuprofen - metabolism | Water Pollutants, Chemical - metabolism | Pharmaceutical Preparations - metabolism | Animals | Diclofenac - analysis | Biotransformation | Carbamazepine - metabolism | Naproxen - analysis | Pharmaceutical Preparations - analysis | Diclofenac - metabolism | Trout | Uptakes | Metabolites | Naproxen | Ibuprofen | Diclofenac | Index Medicus
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10. Full Text Effects of environmentally relevant concentrations of the anti-inflammatory drug diclofenac in freshwater fish Rhamdia quelen
by Guiloski, Izonete Cristina and Stein Piancini, Laercio Dante and Dagostim, Ana Carolina and de Morais Calado, Sabrina Loise and Fávaro, Luis Fernando and Boschen, Suelen Lúcio and Cestari, Marta Margarete and da Cunha, Cláudio and Silva de Assis, Helena Cristina
Ecotoxicology and environmental safety, ISSN 0147-6513, 05/2017, Volume 139, pp. 291 - 300
Oxidative stress | Neurotransmitters | NSAIDs | Genotoxicity | Steroids | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Estradiol - blood | Testis - metabolism | Liver - enzymology | Glutathione - metabolism | Male | Diclofenac - toxicity | Testis - drug effects | Brain - metabolism | Liver - drug effects | Lipid Peroxidation - drug effects | Fresh Water | Testosterone - blood | Dopamine - metabolism | Superoxide Dismutase - metabolism | Glutathione Peroxidase - metabolism | 3,4-Dihydroxyphenylacetic Acid - metabolism | Glutathione Transferase - metabolism | Catfishes - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Anti-Inflammatory Agents, Non-Steroidal - toxicity | Brain - drug effects | Catalase - metabolism | Animals | Water Pollutants, Chemical - toxicity | DNA Damage | Oxidative Stress - drug effects | Testosterone | Metabolites | Glutathione transferase | Analysis | Liver | Fish as food | Peroxidase | Superoxide | Nonsteroidal anti-inflammatory drugs | Estradiol | Cells | Antioxidants | Estrogen | Index Medicus
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