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Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 07/2018, Volume 104, Issue 1, pp. 188 - 200
The accuracy of physiologically based pharmacokinetic (PBPK) model prediction in children, especially those younger than 2 years old, has not been... 
CLEARANCE | TISSUE DISTRIBUTION | IN-VIVO | VOLUME | ONTOGENY | PROTON PUMP INHIBITORS | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS | SIMULATION | DESLORATADINE | EXPOSURE | Humans | Anti-Asthmatic Agents - metabolism | Child, Preschool | Cytochrome P-450 Enzyme System - metabolism | Sufentanil - metabolism | Bronchodilator Agents - metabolism | Quinolines - pharmacokinetics | Theophylline - pharmacokinetics | Esomeprazole - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Ondansetron - metabolism | Child | Cytochrome P-450 CYP2C9 - metabolism | Histamine H1 Antagonists, Non-Sedating - pharmacokinetics | Infant, Newborn | Itraconazole - metabolism | Serotonin Antagonists - pharmacokinetics | Tramadol - pharmacokinetics | Theophylline - metabolism | Cytochrome P-450 CYP3A - metabolism | Models, Biological | Proton Pump Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Cytochrome P-450 CYP2D6 - metabolism | Serotonin Antagonists - metabolism | Analgesics, Opioid - metabolism | Diclofenac - metabolism | Lansoprazole - pharmacokinetics | Loratadine - pharmacokinetics | Sufentanil - pharmacokinetics | Infant | Anti-Asthmatic Agents - pharmacokinetics | Itraconazole - pharmacokinetics | Antifungal Agents - pharmacokinetics | Antifungal Agents - metabolism | Loratadine - metabolism | Cytochrome P-450 CYP2C8 - metabolism | Lansoprazole - metabolism | Acetates - metabolism | Esomeprazole - pharmacokinetics | Cytochrome P-450 CYP1A2 - metabolism | Ondansetron - pharmacokinetics | Tramadol - metabolism | Diclofenac - pharmacokinetics | Quinolines - metabolism | Pharmaceutical Preparations - metabolism | Proton Pump Inhibitors - pharmacokinetics | Bronchodilator Agents - pharmacokinetics | Analgesics, Opioid - pharmacokinetics | Cytochrome P-450 CYP2C19 - metabolism | Loratadine - analogs & derivatives | Histamine H1 Antagonists, Non-Sedating - metabolism | Pharmacokinetics | Acetates - pharmacokinetics
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a... 
ACYL GLUCURONIDES | CHEMISTRY, MEDICINAL | PROTEIN | RAT | REACTIVE METABOLITES | TIENILIC ACID | HEPATIC-NECROSIS | BIOACTIVATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | TOXICOLOGY | HUMAN URINE | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e66987
Non-steroidal anti-inflammatory drugs such as diclofenac exhibit potent anticancer effects. Up to now these effects were mainly attributed to its classical... 
MONOCARBOXYLATE TRANSPORTERS | COLON-CANCER CELLS | SALICYLIC-ACID | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GROWTH | C-MYC | MALIGNANT-MELANOMA | INDUCE APOPTOSIS | Melanoma - metabolism | Neoplasms - metabolism | Diclofenac - pharmacology | Humans | Lactic Acid - metabolism | Leukemia - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Gene Expression Regulation - drug effects | Animals | Neoplasms - genetics | Melanoma - genetics | Intracellular Space - metabolism | Cell Line, Tumor | Glucose - metabolism | Carcinoma - genetics | Biological Transport - drug effects | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-myc - genetics | Carcinoma - metabolism | Metabolic Networks and Pathways - drug effects | Leukemia - genetics | Glucose metabolism | Aspirin | Anti-inflammatory drugs | Leukemia | Genes | Melanoma | Glucose | Gene expression | Dextrose | Cell proliferation | Drugs | c-Myc protein | Myc protein | Kinases | Cancer therapies | Accumulation | Diclofenac | Anticancer properties | Cell growth | Psychiatrists | Nonsteroidal anti-inflammatory drugs | Glucose transporter | Efflux | Antiinflammatory agents | Secretion | Tumor cells | Lactate dehydrogenase | Inflammation | Metabolism | L-Lactate dehydrogenase | Inhibitors | Glycolysis | Lactic acid | Cyclooxygenase-2 | Intracellular | Transporter
Journal Article
Water Science and Technology, ISSN 0273-1223, 2012, Volume 66, Issue 9, pp. 1856 - 1863
Emerging wastewater treatment processes such as membrane bioreactors (MBRs) have attracted a significant amount of interest internationally due to their... 
Pharmaceuticals and personal care products | Membrane bioreactor | Decentralised treatment system | Pesticides | Steroidal hormones | ESTROGENS | WASTE-WATER TREATMENT | MUNICIPAL SEWAGE | AUSTRALIA | steroidal hormones | PHARMACEUTICALS | pharmaceuticals and personal care products | WATER RESOURCES | decentralised treatment system | ENVIRONMENTAL SCIENCES | membrane bioreactor | ENGINEERING, ENVIRONMENTAL | pesticides | TREATMENT PLANTS | ENDOCRINE DISRUPTING COMPOUNDS | SYSTEMS | Pharmaceutical Preparations - isolation & purification | Omeprazole - metabolism | Diclofenac - isolation & purification | Diazepam - isolation & purification | Diazepam - metabolism | Organic Chemicals - metabolism | Trimethoprim - metabolism | Water Pollutants, Chemical - isolation & purification | Carbamazepine - metabolism | Sulfamethoxazole - metabolism | Organic Chemicals - isolation & purification | Amitriptyline - metabolism | Trimethoprim - isolation & purification | Gemfibrozil - isolation & purification | Sulfamethoxazole - isolation & purification | Water Pollutants, Chemical - metabolism | Amitriptyline - isolation & purification | Pharmaceutical Preparations - metabolism | Waste Disposal, Fluid - methods | Bioreactors | Fluoxetine - metabolism | Omeprazole - isolation & purification | Carbamazepine - isolation & purification | Gemfibrozil - metabolism | Diclofenac - metabolism | Fluoxetine - isolation & purification | Drugs | Removal | Organic contaminants | Trimethoprim | Hormones | Diclofenac | Waste water | Agrochemicals | Xenoestrogens | Recycling | Diazepam | Caffeine | Amitriptyline | Consumer products | Fluoxetine | Chemical wastewater | Chemical contaminants | Wastewater treatment | Carbamazepine | Omeprazole | Contaminants | Water reuse | Gemfibrozil | Water quality | Organic chemicals
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 2007, Volume 168, Issue 1, pp. 30 - 50
The pharmaceutical industry is committed to marketing safer drugs with fewer side effects, predictable pharmacokinetic properties and quantifiable drug–drug... 
Drug metabolism | Human hepatocytes | Cytochrome P450 | Drug–drug interaction | In vitro/ in vivo extrapolation | Drug-drug interaction | In vitro/in vivo extrapolation | human hepatocytes | NONSTEROIDAL ANTIINFLAMMATORY DRUG | RAT HEPATOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CULTURED HUMAN HEPATOCYTES | cytochrome P450 | HUMAN LIVER-MICROSOMES | QUANTITATIVE RT-PCR | INTRINSIC CLEARANCE | MASS-SPECTROMETRY | STRUCTURE ELUCIDATION | CYTOCHROME-P450 ENZYMES | drug metabolism | in vitro/in vivo extrapolation | SPECIES-DIFFERENCES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | drug-drug interaction | Humans | Cytochrome P-450 Enzyme System - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Drug-Related Side Effects and Adverse Reactions - metabolism | Hepatocytes - metabolism | Diclofenac - chemistry | Genetic Variation | Drug Interactions | Biotransformation | Metabolic Networks and Pathways - physiology | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Hepatocytes - drug effects | Diclofenac - analogs & derivatives | Inactivation, Metabolic - physiology | Cells, Cultured | Metabolic Networks and Pathways - genetics | Pharmaceutical Preparations - metabolism | Models, Biological | Cytochrome P-450 Enzyme System - genetics | Inactivation, Metabolic - genetics | In Vitro Techniques | Pharmacokinetics | Diclofenac - metabolism | Hepatocytes - enzymology
Journal Article
Journal Article