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1. Full Text Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children
by Zhou, Wangda and Johnson, Trevor N and Bui, Khanh H and Cheung, S.Y. Amy and Li, Jianguo and Xu, Hongmei and Al‐Huniti, Nidal and Zhou, Diansong
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 07/2018, Volume 104, Issue 1, pp. 188 - 200
The accuracy of physiologically based pharmacokinetic (PBPK) model prediction in children, especially those younger than 2 years old, has not been... 
CLEARANCE | TISSUE DISTRIBUTION | IN-VIVO | VOLUME | ONTOGENY | PROTON PUMP INHIBITORS | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS | SIMULATION | DESLORATADINE | EXPOSURE | Humans | Anti-Asthmatic Agents - metabolism | Child, Preschool | Cytochrome P-450 Enzyme System - metabolism | Sufentanil - metabolism | Bronchodilator Agents - metabolism | Quinolines - pharmacokinetics | Theophylline - pharmacokinetics | Esomeprazole - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Ondansetron - metabolism | Child | Cytochrome P-450 CYP2C9 - metabolism | Histamine H1 Antagonists, Non-Sedating - pharmacokinetics | Infant, Newborn | Itraconazole - metabolism | Serotonin Antagonists - pharmacokinetics | Tramadol - pharmacokinetics | Theophylline - metabolism | Cytochrome P-450 CYP3A - metabolism | Models, Biological | Proton Pump Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Cytochrome P-450 CYP2D6 - metabolism | Serotonin Antagonists - metabolism | Analgesics, Opioid - metabolism | Diclofenac - metabolism | Lansoprazole - pharmacokinetics | Loratadine - pharmacokinetics | Sufentanil - pharmacokinetics | Infant | Anti-Asthmatic Agents - pharmacokinetics | Itraconazole - pharmacokinetics | Antifungal Agents - pharmacokinetics | Antifungal Agents - metabolism | Loratadine - metabolism | Cytochrome P-450 CYP2C8 - metabolism | Lansoprazole - metabolism | Acetates - metabolism | Esomeprazole - pharmacokinetics | Cytochrome P-450 CYP1A2 - metabolism | Ondansetron - pharmacokinetics | Tramadol - metabolism | Diclofenac - pharmacokinetics | Quinolines - metabolism | Pharmaceutical Preparations - metabolism | Proton Pump Inhibitors - pharmacokinetics | Bronchodilator Agents - pharmacokinetics | Analgesics, Opioid - pharmacokinetics | Cytochrome P-450 CYP2C19 - metabolism | Loratadine - analogs & derivatives | Histamine H1 Antagonists, Non-Sedating - metabolism | Pharmacokinetics | Acetates - pharmacokinetics
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2. Full Text Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose
by Obach, R. Scott and Kalgutkar, Amit S and Soglia, John R and Zhao, Sabrina X
Chemical Research in Toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a... 
ACYL GLUCURONIDES | CHEMISTRY, MEDICINAL | PROTEIN | RAT | REACTIVE METABOLITES | TIENILIC ACID | HEPATIC-NECROSIS | BIOACTIVATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | TOXICOLOGY | HUMAN URINE | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
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3. Full Text Uptake and biological effects of environmentally relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in rainbow trout (oncorhynchus mykiss)
by Mehinto, Alvine C and Hill, Elizabeth M and Tyler, Charles R
Environmental Science and Technology, ISSN 0013-936X, 03/2010, Volume 44, Issue 6, pp. 2176 - 2182
Diclofenac, a nonsteroidal anti-inflammatory drug, is widely detected in surface waters and can potentially cause deleterious effects in fish. Here, we... 
SEWAGE EFFLUENTS | BIOACCUMULATION | ENVIRONMENTAL SCIENCES | HEPATOCYTES | METABOLITES | SOLVENTS | ENGINEERING, ENVIRONMENTAL | FISH | TRUTTA-F-FARIO | TOXICITY | RESIDUES | EXPOSURE | Biomarkers - metabolism | Oncorhynchus mykiss - metabolism | Cytochrome P-450 CYP1A1 - genetics | Cyclooxygenase 1 - genetics | Intestines - pathology | Gene Expression - drug effects | Kidney - pathology | Liver - metabolism | Tumor Suppressor Protein p53 - metabolism | Intestines - metabolism | Cytochrome P-450 CYP1A1 - metabolism | RNA, Messenger - metabolism | Tumor Suppressor Protein p53 - genetics | Dose-Response Relationship, Drug | Water Pollutants, Chemical - metabolism | Kidney - metabolism | Animals | Cyclooxygenase 2 - genetics | Cyclooxygenase 2 - metabolism | Female | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Cyclooxygenase 1 - metabolism | Diclofenac - metabolism
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4. Full Text Metabolism of diclofenac in plants – Hydroxylation is followed by glucose conjugation
by Huber, Christian and Bartha, Bernadett and Schröder, Peter
Journal of Hazardous Materials, ISSN 0304-3894, 12/2012, Volume 243, pp. 250 - 256
► First report on the metabolism of diclofenac in plants. ► Metabolism of diclofenac in plants follows mammalian metabolism. ► Main primary metabolite is the... 
Barley | Hairy root culture | Metabolism | LC–MS | Diclofenac | LC-MS | PHARMACEUTICALS | AQUATIC ENVIRONMENT | HUMAN LIVER-MICROSOMES | IDENTIFICATION | ENVIRONMENTAL SCIENCES | XENOBIOTICS | ENGINEERING, CIVIL | PHARMACOKINETICS | ENGINEERING, ENVIRONMENTAL | GROWTH | DEGRADATION | RESIDUES | WATER | Armoracia - metabolism | Biodegradation, Environmental | Microsomes - metabolism | Diclofenac - isolation & purification | Plant Roots - metabolism | Hydroxylation | Glucosidases - metabolism | Hordeum - metabolism | Cytochrome P-450 Enzyme System - metabolism | Chromatography, High Pressure Liquid | Glycosyltransferases - metabolism | Plants - metabolism | Mass Spectrometry | Plant Roots - enzymology | Glucose - metabolism | Plant Leaves - enzymology | Diclofenac - metabolism | Physiological aspects | Glucose | Nonsteroidal anti-inflammatory drugs | Metabolites | Dextrose
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5. Full Text Uptake and metabolism of diclofenac in Typha latifolia – How plants cope with human pharmaceutical pollution
by Bartha, Bernadett and Huber, Christian and Schröder, Peter
Plant Science, ISSN 0168-9452, 10/2014, Volume 227, pp. 12 - 20
The fate of pharmaceuticals in our environment is a very important issue for environmental and health research. Although these substances have been detected in... 
Oxidative stress | Metabolism | Uptake | LC–MS | Diclofenac | Typha ssp | LC-MS | WASTE-WATER TREATMENT | DETOXIFICATION | RAINBOW-TROUT | GLUTATHIONE-S-TRANSFERASES | SEEDLINGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | PLANT SCIENCES | RESPONSES | XENOBIOTICS | PEROXIDASE | LIVER | Biodegradation, Environmental | Diclofenac - pharmacology | Plant Roots - metabolism | Water Pollutants, Chemical - pharmacology | Glutathione - metabolism | Antioxidants - metabolism | Glutathione Transferase - metabolism | Typhaceae - metabolism | Wetlands | Water Pollutants, Chemical - metabolism | Glycosyltransferases - metabolism | Glycosides - metabolism | Plant Shoots - metabolism | Typhaceae - drug effects | Oxidative Stress - drug effects | Diclofenac - metabolism | Physiological aspects | Enzymes | Pollution | Plants | Pharmaceutical industry
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6. Full Text Uptake and accumulation of four PPCP/EDCs in two leafy vegetables
by Dodgen, L.K and Li, J and Parker, D and Gan, J.J
Environmental Pollution, ISSN 0269-7491, 11/2013, Volume 182, pp. 150 - 156
Many pharmaceutical and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) are present in reclaimed water, leading to concerns of human... 
Non-extractable residue | Reclaimed water | Plant uptake | Pharmaceuticals | Endocrine disrupting chemicals | HUMAN PHARMACEUTICALS | TRANSLOCATION | PERSONAL CARE PRODUCTS | WASTE-WATER CONTAMINANTS | ENVIRONMENT | NONYLPHENOL | ENVIRONMENTAL SCIENCES | IN-VITRO | BISPHENOL-A | NATIONAL RECONNAISSANCE | Endocrine Disruptors - metabolism | Brassica - metabolism | Endocrine Disruptors - analysis | Waste Disposal, Fluid | Phenols - metabolism | Soil Pollutants - analysis | Water Pollutants, Chemical - analysis | Soil Pollutants - metabolism | Water Pollutants, Chemical - metabolism | Pharmaceutical Preparations - metabolism | Phenols - analysis | Diclofenac - analysis | Vegetables - metabolism | Benzhydryl Compounds - analysis | Pharmaceutical Preparations - analysis | Benzhydryl Compounds - metabolism | Diclofenac - metabolism | Lettuce - metabolism | Endocrine disruptors | Vegetables | Bisphenol-A | Naproxen | Diclofenac | Human | Bisphenol A | Uptakes | Leaves | Sodium | Risk | Plants (organisms) | Stems | plant uptake | pharmaceuticals | endocrine disrupting chemicals | non-extractable residue
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7. Full Text New Aspects of an Old Drug - Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells
by Gottfried, Eva and Lang, Sven A and Renner, Kathrin and Bosserhoff, Anja and Gronwald, Wolfram and Rehli, Michael and Einhell, Sabine and Gedig, Isabel and Singer, Katrin and Seilbeck, Anton and Mackensen, Andreas and Grauer, Oliver and Hau, Peter and Dettmer, Katja and Andreesen, Reinhard and Oefner, Peter J and Kreutz, Marina
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e66987
Non-steroidal anti-inflammatory drugs such as diclofenac exhibit potent anticancer effects. Up to now these effects were mainly attributed to its classical... 
MONOCARBOXYLATE TRANSPORTERS | COLON-CANCER CELLS | SALICYLIC-ACID | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GROWTH | C-MYC | MALIGNANT-MELANOMA | INDUCE APOPTOSIS | Melanoma - metabolism | Neoplasms - metabolism | Diclofenac - pharmacology | Humans | Lactic Acid - metabolism | Leukemia - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Gene Expression Regulation - drug effects | Animals | Neoplasms - genetics | Melanoma - genetics | Intracellular Space - metabolism | Cell Line, Tumor | Glucose - metabolism | Carcinoma - genetics | Biological Transport - drug effects | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-myc - genetics | Carcinoma - metabolism | Metabolic Networks and Pathways - drug effects | Leukemia - genetics | Glucose metabolism | Aspirin | Anti-inflammatory drugs | Leukemia | Genes | Melanoma | Glucose | Gene expression | Dextrose | Cell proliferation | Drugs | c-Myc protein | Myc protein | Kinases | Cancer therapies | Accumulation | Diclofenac | Anticancer properties | Cell growth | Psychiatrists | Nonsteroidal anti-inflammatory drugs | Glucose transporter | Efflux | Antiinflammatory agents | Secretion | Tumor cells | Lactate dehydrogenase | Inflammation | Metabolism | L-Lactate dehydrogenase | Inhibitors | Glycolysis | Lactic acid | Cyclooxygenase-2 | Intracellular | Transporter
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8. Full Text Removal of trace organic chemical contaminants by a membrane bioreactor
by Trinh, T and Van Den Akker, B and Stuetz, R.M and Coleman, H.M and Le-Clech, P and Khan, S.J
Water Science and Technology, ISSN 0273-1223, 2012, Volume 66, Issue 9, pp. 1856 - 1863
Emerging wastewater treatment processes such as membrane bioreactors (MBRs) have attracted a significant amount of interest internationally due to their... 
Pharmaceuticals and personal care products | Membrane bioreactor | Decentralised treatment system | Pesticides | Steroidal hormones | ESTROGENS | WASTE-WATER TREATMENT | MUNICIPAL SEWAGE | AUSTRALIA | steroidal hormones | PHARMACEUTICALS | pharmaceuticals and personal care products | WATER RESOURCES | decentralised treatment system | ENVIRONMENTAL SCIENCES | membrane bioreactor | ENGINEERING, ENVIRONMENTAL | pesticides | TREATMENT PLANTS | ENDOCRINE DISRUPTING COMPOUNDS | SYSTEMS | Pharmaceutical Preparations - isolation & purification | Omeprazole - metabolism | Diclofenac - isolation & purification | Diazepam - isolation & purification | Diazepam - metabolism | Organic Chemicals - metabolism | Trimethoprim - metabolism | Water Pollutants, Chemical - isolation & purification | Carbamazepine - metabolism | Sulfamethoxazole - metabolism | Organic Chemicals - isolation & purification | Amitriptyline - metabolism | Trimethoprim - isolation & purification | Gemfibrozil - isolation & purification | Sulfamethoxazole - isolation & purification | Water Pollutants, Chemical - metabolism | Amitriptyline - isolation & purification | Pharmaceutical Preparations - metabolism | Waste Disposal, Fluid - methods | Bioreactors | Fluoxetine - metabolism | Omeprazole - isolation & purification | Carbamazepine - isolation & purification | Gemfibrozil - metabolism | Diclofenac - metabolism | Fluoxetine - isolation & purification | Drugs | Removal | Organic contaminants | Trimethoprim | Hormones | Diclofenac | Waste water | Agrochemicals | Xenoestrogens | Recycling | Diazepam | Caffeine | Amitriptyline | Consumer products | Fluoxetine | Chemical wastewater | Chemical contaminants | Wastewater treatment | Carbamazepine | Omeprazole | Contaminants | Water reuse | Gemfibrozil | Water quality | Organic chemicals
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9. Full Text Hepatocytes—the choice to investigate drug metabolism and toxicity in man: In vitro variability as a reflection of in vivo
by Gómez-Lechón, María José and Castell, José Vicente and Donato, María Teresa
Chemico-Biological Interactions, ISSN 0009-2797, 2007, Volume 168, Issue 1, pp. 30 - 50
The pharmaceutical industry is committed to marketing safer drugs with fewer side effects, predictable pharmacokinetic properties and quantifiable drug–drug... 
Drug metabolism | Human hepatocytes | Cytochrome P450 | Drug–drug interaction | In vitro/ in vivo extrapolation | Drug-drug interaction | In vitro/in vivo extrapolation | human hepatocytes | NONSTEROIDAL ANTIINFLAMMATORY DRUG | RAT HEPATOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CULTURED HUMAN HEPATOCYTES | cytochrome P450 | HUMAN LIVER-MICROSOMES | QUANTITATIVE RT-PCR | INTRINSIC CLEARANCE | MASS-SPECTROMETRY | STRUCTURE ELUCIDATION | CYTOCHROME-P450 ENZYMES | drug metabolism | in vitro/in vivo extrapolation | SPECIES-DIFFERENCES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | drug-drug interaction | Humans | Cytochrome P-450 Enzyme System - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Drug-Related Side Effects and Adverse Reactions - metabolism | Hepatocytes - metabolism | Diclofenac - chemistry | Genetic Variation | Drug Interactions | Biotransformation | Metabolic Networks and Pathways - physiology | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Hepatocytes - drug effects | Diclofenac - analogs & derivatives | Inactivation, Metabolic - physiology | Cells, Cultured | Metabolic Networks and Pathways - genetics | Pharmaceutical Preparations - metabolism | Models, Biological | Cytochrome P-450 Enzyme System - genetics | Inactivation, Metabolic - genetics | In Vitro Techniques | Pharmacokinetics | Diclofenac - metabolism | Hepatocytes - enzymology
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10. Full Text Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat
by Kobayashi, Kaoru and Urashima, Kikuko and Shimada, Noriaki and Chiba, Kan
Biochemical Pharmacology, ISSN 0006-2952, 2002, Volume 63, Issue 5, pp. 889 - 896
In this study, we performed a screening of the specificities of rat cytochrome P450 (CYP) isoforms for metabolic reactions known as the specific probes of... 
Drug metabolism | CYP | Rat | Probe | Substrate specificity | cDNA-expression system | rat | HEPATIC CYTOCHROME-P-450 | HYDROXYLATION | HUMAN LIVER-MICROSOMES | POLYMORPHISM | DEBRISOQUINE 4-HYDROXYLASE | probe | PHENACETIN O-DEETHYLASE | IN-VITRO | substrate specificity | drug metabolism | STEREOSELECTIVE METABOLISM | CATALYTIC ACTIVITY | PHARMACOLOGY & PHARMACY | DRUG OXIDATION | Coumarins - metabolism | Chlorzoxazone - metabolism | Cytochrome P-450 CYP3A | Humans | Mephenytoin - metabolism | Nitrophenols - metabolism | DNA, Complementary - genetics | Cytochrome P-450 Enzyme System - metabolism | Substrate Specificity | Baculoviridae - genetics | Dextromethorphan - metabolism | Testosterone - metabolism | Isoenzymes - metabolism | Phenacetin - metabolism | Tumor Cells, Cultured | Gene Expression | Isoenzymes - genetics | Cells, Cultured | Rats | Pharmaceutical Preparations - metabolism | Animals | Ethanolamines - metabolism | Insecta - cytology | Cytochrome P-450 Enzyme System - genetics | Midazolam - metabolism | Aryl Hydrocarbon Hydroxylases | Diclofenac - metabolism
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11. Full Text In vitro interaction of emerging contaminants with the cytochrome P450 system of mediterranean deep-sea fish
by Ribalta, Carla and Solé, Montserrat
Environmental Science and Technology, ISSN 0013-936X, 10/2014, Volume 48, Issue 20, pp. 12327 - 12335
The interactions of emerging contaminants with the xenobiotic and endogenous metabolizing system of deep-sea fish were compared. The drugs diclofenac,... 
BIOACCUMULATION | GEMFIBROZIL | ENVIRONMENTAL SCIENCES | RAINBOW-TROUT | MARINE WATERS | PERSONAL CARE PRODUCTS | ANTIFUNGAL IMIDAZOLE | PHARMACEUTICALS | ENGINEERING, ENVIRONMENTAL | LIVER | XENOBIOTIC-METABOLIZING ENZYMES | BIOMARKER RESPONSES | Fishes - metabolism | Triclosan - metabolism | Cytochrome P-450 Enzyme System - metabolism | Fish Proteins - metabolism | Benzopyrans - metabolism | Male | Phenols - metabolism | Water Pollutants, Chemical - metabolism | Animals | Fluoxetine - metabolism | Female | Xenobiotics - metabolism | Mediterranean Sea | Gemfibrozil - metabolism | Diclofenac - metabolism | Index Medicus
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12. Full Text Predicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes
by Wang, Shuting and Tang, Xiange and Yang, Tingting and Xu, Jiong and Zhang, Jiaxin and Liu, Xiaodong and Liu, Li
Xenobiotica, ISSN 0049-8254, 02/2019, Volume 49, Issue 2, pp. 161 - 168
Contributions of cytochrome P450 (CYP450) isoforms to drug metabolism are often predicted using relative activity factor (RAF) method, assuming RAF values were... 
cytochrome P450 | probe-dependence | intrinsic clearance | relative activity factor | CYP450 contribution | RAT | MOUSE | IN-VITRO METABOLISM | CYP3A4 | IDENTIFICATION | IMPACT | PHARMACOKINETICS | ENZYMES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | SELECTION | MIDAZOLAM | Atorvastatin - metabolism | Humans | Microsomes, Liver - metabolism | Warfarin - metabolism | Cytochrome P-450 Enzyme System - metabolism | Protein Isoforms - physiology | Testosterone - metabolism | Protein Isoforms - metabolism | Midazolam - metabolism | Kinetics | Cytochrome P-450 Enzyme System - physiology | Verapamil - metabolism | Diclofenac - metabolism | Tolbutamide - metabolism
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13. Full Text Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout
by Lahti, Marja and Brozinski, Jenny‐Maria and Jylhä, Antti and Kronberg, Leif and Oikari, Aimo
Environmental Toxicology and Chemistry, ISSN 0730-7268, 06/2011, Volume 30, Issue 6, pp. 1403 - 1411
An urgent need exists to assess the exposure of fish to pharmaceuticals. The aim of the present study was to assess the uptake and metabolism of waterborne... 
Metabolism | Bioconcentration | Rainbow trout | Pharmaceuticals | Bile | METABOLITES | ONCORHYNCHUS-MYKISS | DICLOFENAC | IONIZABLE ORGANIC-CHEMICALS | TOXICITY | TANDEM MASS-SPECTROMETRY | BIOACCUMULATION | ENVIRONMENTAL SCIENCES | FISH BILE | TOXICOLOGY | RESIN ACIDS | Oncorhynchus mykiss - metabolism | Bisoprolol - analysis | Carbamazepine - analysis | Ibuprofen - analysis | Bile - metabolism | Fresh Water - chemistry | Water Pollutants, Chemical - analysis | Bisoprolol - metabolism | Naproxen - metabolism | Ibuprofen - metabolism | Water Pollutants, Chemical - metabolism | Pharmaceutical Preparations - metabolism | Animals | Diclofenac - analysis | Biotransformation | Carbamazepine - metabolism | Naproxen - analysis | Pharmaceutical Preparations - analysis | Diclofenac - metabolism | Uptakes | Metabolites | Trout | Naproxen | Ibuprofen | Diclofenac | Index Medicus
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