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Drug Metabolism and Disposition, ISSN 0090-9556, 11/2007, Volume 35, Issue 11, pp. 2076 - 2085
P-glycoprotein (P-gp)-mediated efflux at the blood-brain barrier has been implicated in limiting the brain distribution of many anti-HIV1 drugs, primarily... 
RABBIT BRAIN | HIV-1 PROTEASE INHIBITORS | CF-1 MICE DEFICIENT | IN-VITRO | REVERSE-TRANSCRIPTASE INHIBITORS | PHARMACOLOGY & PHARMACY | INFECTED PATIENTS | ZIDOVUDINE TRANSPORT | MULTIDRUG-RESISTANCE | CEREBROSPINAL-FLUID | ANTIRETROVIRAL TREATMENT | Vinblastine - metabolism | Zidovudine - metabolism | Dibenzocycloheptenes - chemistry | Area Under Curve | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Zidovudine - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Reverse Transcriptase Inhibitors - chemistry | Vinblastine - pharmacokinetics | Brain - metabolism | Quinolines - pharmacokinetics | Biological Transport, Active | Reverse Transcriptase Inhibitors - pharmacokinetics | ATP-Binding Cassette Transporters - genetics | Tetrahydroisoquinolines - chemistry | Dibenzocycloheptenes - metabolism | ATP-Binding Cassette Transporters - metabolism | Acridines - pharmacokinetics | Cell Membrane - metabolism | Molecular Structure | Anti-HIV Agents - metabolism | Acridines - chemistry | Dideoxynucleosides - metabolism | Cell Line | Vinblastine - chemistry | Acridines - metabolism | Dibenzocycloheptenes - pharmacokinetics | Quinolines - chemistry | Adenosine Triphosphatases - metabolism | Mice, Inbred Strains | Dideoxynucleosides - chemistry | Zidovudine - chemistry | Mice, Knockout | Dideoxynucleosides - pharmacokinetics | Quinolines - metabolism | Anti-HIV Agents - chemistry | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Tetrahydroisoquinolines - metabolism | Anti-HIV Agents - pharmacokinetics | Tetrahydroisoquinolines - pharmacokinetics | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Mice | Reverse Transcriptase Inhibitors - metabolism | ATP Binding Cassette Transporter, Sub-Family B - genetics
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 11/2018, Volume 46, Issue 11, pp. 1817 - 1826
Journal Article
The EMBO Journal, ISSN 0261-4189, 03/2007, Volume 26, Issue 5, pp. 1327 - 1339
DNA replication of eukaryotic chromosomes initiates at a number of discrete loci, called replication origins. Distribution and regulation of origins are... 
DNA microarray | subtelomere | centromere | fission yeast | replication origin | Replication origin | Centromere | Fission yeast | Subtelomere | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | EUKARYOTIC DNA-REPLICATION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | CHROMOSOME | HETEROCHROMATIN | SEQUENCE | PROTEINS | BINDING | SCHIZOSACCHAROMYCES-POMBE | Cell Cycle - genetics | Chromosomes, Fungal | Hydroxyurea - pharmacology | Schizosaccharomyces - drug effects | Oligonucleotide Array Sequence Analysis | DNA Replication - drug effects | Electrophoresis, Gel, Two-Dimensional | Minichromosome Maintenance Complex Component 6 | Centromere - metabolism | Origin Recognition Complex - metabolism | Schizosaccharomyces - genetics | Genome, Fungal | Heterochromatin - metabolism | Schizosaccharomyces pombe Proteins - metabolism | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Origin Recognition Complex - genetics | Dideoxynucleosides - metabolism | Schizosaccharomyces pombe Proteins - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | DNA, Intergenic - genetics | Schizosaccharomyces - metabolism | Replication Origin - genetics | Checkpoint Kinase 2 | DNA Replication - genetics | Yeast | Deoxyribonucleic acid | DNA | Genomics | Cell cycle | Molecular biology | Chromosomes
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2005, Volume 25, Issue 19, pp. 4755 - 4765
Immature neurons express GABA and glutamate receptors before synapse formation, and both transmitters are released at an early developmental stage. We have now... 
GABA | Neurotransmitter | Neuron | Glutamate | Migration | Hippocampus | hippocampus | NMDA RECEPTORS | neuron | TISSUE-CULTURE | DEVELOPING CEREBRAL-CORTEX | NEUROSCIENCES | SYNAPTIC VESICLE FUSION | CALCIUM TRANSIENTS | HIPPOCAMPAL REGION | CORTICAL-NEURONS | HORMONE NEURONS | CELL-MIGRATION | migration | CULTURED ASTROCYTES | neurotransmitter | glutamate | Rats, Wistar | Embryo, Mammalian | Microtubule-Associated Proteins - metabolism | gamma-Aminobutyric Acid - metabolism | 2-Amino-5-phosphonovalerate - pharmacology | Receptors, N-Methyl-D-Aspartate - metabolism | Green Fluorescent Proteins - genetics | Cell Movement - physiology | Patch-Clamp Techniques - methods | N-Methylaspartate - pharmacology | Drug Interactions | Mice, Mutant Strains | Gene Expression - physiology | Neurons - physiology | Bromodeoxyuridine - metabolism | Electric Stimulation - methods | Animals, Newborn | Dideoxynucleosides - metabolism | Green Fluorescent Proteins - metabolism | Munc18 Proteins - genetics | Rats | Mice, Transgenic | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Bicuculline - pharmacology | Hippocampus - cytology | GABA Antagonists - pharmacology | Immunohistochemistry - methods | Animals | Picrotoxin - pharmacology | Glutamic Acid - metabolism | Mice | Receptors, GABA-A - metabolism | Dizocilpine Maleate - pharmacology | In Vitro Techniques | Immunohistochemistry | Green Fluorescent Proteins | Excitatory Amino Acid Agonists | Electric Stimulation | Dizocilpine Maleate | Neurons and Cognition | Bromodeoxyuridine | Receptors, GABA-A | Dideoxynucleosides | Munc18 Proteins | Life Sciences | Picrotoxin | gamma-Aminobutyric Acid | Gene Expression | Neurons | Microtubule-Associated Proteins | Receptors, N-Methyl-D-Aspartate | Glutamic Acid | Patch-Clamp Techniques | N-Methylaspartate | 2-Amino-5-phosphonovalerate | Excitatory Amino Acid Antagonists | GABA Antagonists | Bicuculline | Cell Movement | Plasticity | Development | Repair
Journal Article
Immunity, ISSN 1074-7613, 2008, Volume 28, Issue 6, pp. 822 - 832
Journal Article
Journal Article
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7619, pp. S60 - S62
Drug-Related Side Effects and Adverse Reactions - prevention & control | Humans | Warfarin - metabolism | Warfarin - adverse effects | Male | Antidepressive Agents - metabolism | Warfarin - administration & dosage | Warfarin - therapeutic use | Evidence-Based Medicine - trends | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Pharmacogenetics - trends | Purine-Pyrimidine Metabolism, Inborn Errors - complications | Mercaptopurine - therapeutic use | Drug Hypersensitivity - enzymology | Drug-Related Side Effects and Adverse Reactions - genetics | Drug Hypersensitivity - genetics | Mercaptopurine - metabolism | Succinylcholine - adverse effects | Dideoxynucleosides - adverse effects | Drug Hypersensitivity - complications | Child | HLA-B Antigens - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications | Pharmacogenetics - methods | HIV Infections - genetics | Mercaptopurine - administration & dosage | Mercaptopurine - adverse effects | Purine-Pyrimidine Metabolism, Inborn Errors - enzymology | Antidepressive Agents - therapeutic use | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Genetic Testing - utilization | Purine-Pyrimidine Metabolism, Inborn Errors - genetics | Precision Medicine - trends | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Antidepressive Agents - administration & dosage | HIV Infections - drug therapy | Antidepressive Agents - adverse effects | Primaquine - adverse effects | Precision Medicine - methods
Journal Article
PLoS One, ISSN 1932-6203, 2015, Volume 10, Issue 5, p. e0126220
Today HIV-1 infection is recognized as a chronic disease with obligatory lifelong treatment to keep viral titers below detectable levels. The continuous intake... 
MUTANTS | REVERSE-TRANSCRIPTASE INHIBITORS | DISEASES | ZIDOVUDINE | ANTIVIRAL NUCLEOSIDE ANALOGS | ANTIRETROVIRAL-THERAPY | DNA | MULTIDISCIPLINARY SCIENCES | ENERGY-METABOLISM | NEMATODE | HIV-INFECTED PATIENTS | Drug Evaluation - methods | Zalcitabine - toxicity | DNA, Mitochondrial - antagonists & inhibitors | Reverse Transcriptase Inhibitors - toxicity | Anti-HIV Agents - toxicity | Humans | Ubiquinone - metabolism | Mitochondrial Proteins - genetics | Mitochondria - ultrastructure | DNA-Directed DNA Polymerase - genetics | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Caenorhabditis elegans - metabolism | Dideoxynucleosides - toxicity | DNA, Mitochondrial - metabolism | Caenorhabditis elegans - genetics | Mitochondrial Proteins - antagonists & inhibitors | Mitochondria - metabolism | Mitochondria - drug effects | Ubiquinone - antagonists & inhibitors | Stavudine - toxicity | Animals | Caenorhabditis elegans - drug effects | Models, Biological | Oxygen Consumption - drug effects | Zidovudine - toxicity | Didanosine - toxicity | DNA-Directed DNA Polymerase - metabolism | Drugs | Caenorhabditis elegans | Abnormalities | Physiological aspects | Genetic aspects | Mitochondrial DNA | Research | Health aspects | Risk factors | DNA polymerase | Toxicity | Chronic infection | Genomes | Mitochondria | Antiretroviral agents | Human immunodeficiency virus--HIV | Life sciences | Deoxyribonucleic acid--DNA | Worms | Quantitative analysis | Antiretroviral drugs | Medical treatment | Metabolism | Polymerase | Side effects | Hypotheses | Morphology | Nematodes | Food safety | Mutation | Molecular biology | Nucleoside analogs | DNA-directed DNA polymerase | Deoxyribonucleic acid | HIV | Human immunodeficiency virus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2011, Volume 17, Issue 24, pp. 7614 - 7624
Journal Article