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DNA Repair, ISSN 1568-7864, 01/2017, Volume 49, pp. 51 - 59
Human PrimPol is a recently discovered bifunctional enzyme that displays DNA template-directed primase and polymerase activities. PrimPol has been implicated... 
Polymerase fidelity | DNA polymerase sugar selectivity | Enzyme regulation | Human PrimPol | Pre-steady-state kinetics | POLYMERIZATION | SULFOLOBUS-SOLFATARICUS P2 | GEMCITABINE | NUCLEOTIDE ANALOGS | REPLICATION | STRUCTURAL BASIS | GENETICS & HEREDITY | TOXICOLOGY | KINETIC BASIS | 1ST-LINE THERAPY | MITOCHONDRIAL-DNA POLYMERASE | MANGANESE MUTAGENESIS | Humans | Cytidine Triphosphate - metabolism | DNA Primase - metabolism | Antineoplastic Agents - therapeutic use | Lamivudine - analogs & derivatives | Antiviral Agents - metabolism | Multifunctional Enzymes - metabolism | Arabinofuranosylcytosine Triphosphate - therapeutic use | Antineoplastic Agents - metabolism | Coenzymes - metabolism | Cations, Divalent - metabolism | Dideoxynucleotides - metabolism | Lamivudine - therapeutic use | Emtricitabine - metabolism | Arabinofuranosylcytosine Triphosphate - metabolism | Emtricitabine - therapeutic use | Antiviral Agents - therapeutic use | Lamivudine - metabolism | DNA Replication | Magnesium - metabolism | Dideoxynucleotides - therapeutic use | DNA - metabolism | Emtricitabine - analogs & derivatives | Manganese - metabolism | Deoxyribonucleotides - metabolism | Cytidine Triphosphate - analogs & derivatives | DNA-Directed DNA Polymerase - metabolism | Kinetics | Cytidine Triphosphate - therapeutic use | Antiviral agents | Enzymes | DNA replication | Anisotropy | Analysis | DNA polymerases | Mitochondrial DNA
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2001, Volume 276, Issue 26, pp. 23616 - 23623
Mitochondrial toxicity can result hom antiviral nucleotide analog therapy used to control human immunodeficiency virus type 1 infection. We evaluated the... 
INTRACELLULAR PHOSPHORYLATION | EXONUCLEASE ACTIVITY | SUBSTRATE-SPECIFICITY | NUCLEOSIDE ANALOGS | (-)-2'-DEOXY-3'-THIACYTIDINE 3TC | BIOCHEMISTRY & MOLECULAR BIOLOGY | REVERSE-TRANSCRIPTASE | ANTI-HIV DEOXYNUCLEOTIDES | INSERTION FIDELITY | HUMAN-IMMUNODEFICIENCY-VIRUS | MITOCHONDRIAL-DNA | Anti-HIV Agents - pharmacology | DNA Polymerase gamma | Zidovudine - metabolism | Deoxyribonucleotides - pharmacology | DNA Replication - drug effects | Humans | Cytidine Triphosphate - metabolism | Reverse Transcriptase Inhibitors - pharmacology | Substrate Specificity | Zalcitabine - pharmacology | Exodeoxyribonucleases - antagonists & inhibitors | Lamivudine - analogs & derivatives | Nucleic Acid Synthesis Inhibitors | Stavudine - pharmacology | Thymine Nucleotides - metabolism | DNA - biosynthesis | Deoxyguanine Nucleotides - metabolism | Anti-HIV Agents - metabolism | Thymine Nucleotides - pharmacology | Cytidine Triphosphate - pharmacology | Deoxyguanine Nucleotides - pharmacology | Lamivudine - metabolism | Zidovudine - pharmacology | Zalcitabine - metabolism | Stavudine - metabolism | Deoxyribonucleotides - metabolism | Zidovudine - analogs & derivatives | Exodeoxyribonucleases - metabolism | Cytidine Triphosphate - analogs & derivatives | Lamivudine - pharmacology | Reverse Transcriptase Inhibitors - metabolism | DNA-Directed DNA Polymerase - metabolism | Dideoxynucleotides | Kinetics
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 2014, Volume 196, Issue 15, pp. 2842 - 2850
Journal Article
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 10/2010, Volume 17, Issue 10, pp. 1202 - 1209
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 2014, Volume 58, Issue 8, pp. 4915 - 4919
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 2007, Volume 121, Issue 1, pp. 19 - 27
Therapies including nucleoside analogs are associated with severe toxic side effects and acquirement of drug resistance. We have previously reported the drug... 
Nucleoside analogs 5′-triphosphates | Delivery vehicle | Nanogel polymer network | Influenza A virus | Mitochondrial toxicity | EFFICIENT GENE-TRANSFER | CELLS | ASSAY | nucleoside analogs 5'-triphosphates | BLOCK | MECHANISMS | delivery vehicle | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | STRATEGIES | nanogel polymer network | DNA | influenza a virus | PHARMACOLOGY & PHARMACY | mitochondrial toxicity | VIRUSES | Zidovudine - metabolism | Humans | Fluorescent Dyes - metabolism | Polyethylene Glycols - chemistry | Luminescent Measurements | Rhodamines - metabolism | Drug Carriers - chemistry | Polyethyleneimine - toxicity | Dose-Response Relationship, Drug | Tetrazolium Salts - metabolism | Polyethyleneimine - chemistry | Sensitivity and Specificity | Thymine Nucleotides - metabolism | Inhibitory Concentration 50 | L-Lactate Dehydrogenase - analysis | Female | Thymine Nucleotides - toxicity | Polyethyleneimine - chemical synthesis | Membrane Potentials - drug effects | Polyethylene Glycols - metabolism | Cell Line | Cell Survival - drug effects | Antiviral Agents - pharmacology | Polyethyleneimine - metabolism | Kidney - drug effects | Adenosine Triphosphate - analysis | Kidney - cytology | Polyethylene Glycols - toxicity | Thymine Nucleotides - chemistry | Zidovudine - chemistry | Animals | Breast Neoplasms - pathology | Zidovudine - analogs & derivatives | Dogs | Zidovudine - toxicity | Cell Line, Tumor | Polyethylene Glycols - chemical synthesis | Dideoxynucleotides | Influenza A virus - drug effects | Mitochondria - physiology | Formazans - metabolism | Nanotechnology | Ribavirin - pharmacology | Drugs | Antiviral agents | Drug delivery systems | Influenza | Drug resistance | Polymers | Nucleoside analogs | Vehicles | nucleoside analogs 5′-triphosphates | influenza A virus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2013, Volume 56, Issue 18, pp. 7431 - 7441
Journal Article
Biochimie, ISSN 0300-9084, 12/2012, Volume 94, Issue 12, pp. 2498 - 2507
Treatment of HIV-1 with nucleoside reverse transcription inhibitors leads to the emergence of resistance mutations in the reverse transcriptase (RT) gene.... 
Resistance | Reverse transcription | Retrovirus | Excision | Pyrophosphorolysis | 3'-AZIDO-3'-DEOXYTHYMIDINE AZT | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG-RESISTANCE | HUMAN-IMMUNODEFICIENCY-VIRUS | PRIMER-UNBLOCKING | ATP-MEDIATED EXCISION | TYPE-1 REVERSE-TRANSCRIPTASE | THYMIDINE NUCLEOTIDE ANALOGS | INORGANIC PYROPHOSPHATASE | NUCLEOSIDE INHIBITORS | MOLECULAR-MECHANISMS | Anti-HIV Agents - pharmacology | Zidovudine - metabolism | Diphosphates - metabolism | HIV Reverse Transcriptase - antagonists & inhibitors | Pyrophosphatases - genetics | Substrate Specificity | Virion - genetics | HIV Reverse Transcriptase - genetics | Adenosine Triphosphate - metabolism | Dideoxynucleotides - metabolism | Stavudine - pharmacology | Thymine Nucleotides - metabolism | Virion - enzymology | Anti-HIV Agents - metabolism | HIV-1 - drug effects | DNA, Viral - metabolism | Zidovudine - pharmacology | HIV-1 - genetics | Stavudine - metabolism | Virion - drug effects | Pyrophosphatases - metabolism | HIV Reverse Transcriptase - metabolism | Drug Resistance, Viral - genetics | Zidovudine - analogs & derivatives | Drug Resistance, Viral - drug effects | HIV-1 - enzymology | Kinetics | Mutation | DNA, Viral - genetics | Phosphates | Genes | DNA | DNA polymerases | DNA synthesis | Reverse transcriptase inhibitors | Genetic transcription | HIV (Viruses)
Journal Article