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Food & function, ISSN 2042-6496, 12/2014, Volume 6, Issue 1, pp. 21 - 217
In the digestive tract of humans, bioactive peptides, i.e. protein fragments impacting the physiological activity of the body, may be released during the digestion of food proteins, including those of fish... 
Food Science & Technology | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Oligopeptides - analysis | Antihypertensive Agents - pharmacology | Protein Hydrolysates - metabolism | Angiotensin-Converting Enzyme Inhibitors - analysis | Antioxidants - chemistry | Antihypertensive Agents - analysis | Antioxidants - metabolism | Humans | Gastric Juice - enzymology | Antihypertensive Agents - metabolism | Gastric Juice - chemistry | Intestinal Secretions - chemistry | Dietary Proteins - metabolism | Dietary Proteins - pharmacology | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Oligopeptides - chemistry | Protein Hydrolysates - chemistry | Fish Proteins - chemistry | Gastric Juice - metabolism | Fish Proteins - metabolism | Digestion | Oligopeptides - metabolism | Protein Hydrolysates - pharmacology | Intestinal Secretions - enzymology | Angiotensin-Converting Enzyme Inhibitors - chemistry | Dietary Proteins - chemistry | Peptide Fragments - analysis | Antihypertensive Agents - chemistry | Dietary Proteins - analysis | Peptide Fragments - chemistry | Models, Biological | Intestinal Secretions - metabolism | Kinetics | Fish Proteins - analysis | Oligopeptides - pharmacology | Seafood - analysis | Aquaculture | Angiotensin-Converting Enzyme Inhibitors - metabolism | Peptide Fragments - pharmacology | Functional Food - analysis | Fish Proteins - pharmacology | Muscle, Skeletal - chemistry | Muscle Proteins - metabolism | Poland | Antioxidants - analysis | Peptide Fragments - metabolism | Duodenum | Carps | Antioxidants - pharmacology | Muscle Proteins - pharmacology | Animals | Muscle Proteins - analysis | Muscle Proteins - chemistry | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, pp. e46781 - e46781
.... Here, we studied the effect of NWT-03, an egg protein hydrolysate with DPP4- and ACE-inhibitory activity, on renovascular damage in Zucker diabetic fatty (ZDF) rats... 
METABOLIC SYNDROME | CYCLOOXYGENASE-2 | GENE-EXPRESSION | INJURY | ANGIOTENSIN-II | INHIBITORS | KIDNEY | UP-REGULATION | NEPHROPATHY | UMCG Approved | DIPEPTIDYL PEPTIDASE-IV | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Immunohistochemistry | Dipeptidyl Peptidase 4 - metabolism | Nitriles - pharmacology | Diabetes Mellitus, Type 2 - genetics | Dipeptidyl Peptidase 4 - blood | Endothelium, Vascular - drug effects | Aorta - metabolism | Diabetes Mellitus, Type 2 - metabolism | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Endothelium, Vascular - physiology | Pyrrolidines - pharmacology | Kidney - metabolism | Peptidyl-Dipeptidase A - blood | E-Selectin - genetics | Peptidyl-Dipeptidase A - metabolism | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Blood Pressure - drug effects | Adamantane - analogs & derivatives | Rats, Inbred SHR | Adamantane - pharmacology | Egg Proteins - pharmacology | Kidney - drug effects | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Aorta - drug effects | Diabetes Mellitus, Type 2 - prevention & control | Rats | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion Molecules - metabolism | Protein Hydrolysates - pharmacology | Blotting, Western | Rats, Zucker | Animals | Prostaglandin-Endoperoxide Synthases - metabolism | Vasodilation - drug effects | In Vitro Techniques | Aorta - physiology | Type 2 diabetes | Glucagon | RNA | Protein hydrolysates | Angiotensin | Indomethacin | Diabetes therapy | Drinking water | Peptides | Syngeneic grafts | Interleukin | Western blotting | Proteins | Prostaglandins | Metabolites | Peptidyl-dipeptidase A | Rodents | Aorta | Supplementation | Damage | Food | Formulations | Hypertension | Enzymes | Departments | Peptidase | Kidneys | Diabetes mellitus | Dietary supplements | Contractility | Pharmacology | Interleukin 13 | Inflammation | Tumor necrosis factor-α | Metabolism | Gene expression | Insulin | Hydrolysates | Endothelium | Studies | Polymerase chain reaction | p22phox Protein | Cyclooxygenase-1 | Coronary vessels | Fibrosis | Diabetes | Laboratory animals | Endocrinology | Index Medicus | metabolic syndrome | up-regulation | angiotensin-ii | kidney | inhibitors | dipeptidyl peptidase-iv | cyclooxygenase-2 | nephropathy | gene-expression | injury
Journal Article
by Zhang, Y and Li, R and Meng, Y and Li, S and Donelan, W and Zhao, Y and Qi, L and Zhang, M and Wang, X and Cui, T and Yang, L.-J and Tang, D
Diabetes (New York, N.Y.), ISSN 1939-327X, 10/2013, Volume 63, Issue 2, pp. 514 - 525
.... This effect was possibly mediated by irisin-induced phosphorylation of the p38 mitogen-activated protein kinase (p38 MAPK... 
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Adipose Tissue, White - metabolism | Caenorhabditis elegans Proteins - metabolism | Adipocytes - cytology | Male | Adipocytes - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Recombinant Proteins | Extracellular Signal-Regulated MAP Kinases - genetics | Pichia - metabolism | Membrane Transport Proteins - genetics | Dietary Fats | Membrane Transport Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Butadienes - pharmacology | Fibronectins - pharmacology | Fibronectins - administration & dosage | Mice, Inbred C57BL | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | 3T3-L1 Cells | Rats, Sprague-Dawley | Animals | Adipocytes - metabolism | Pichia - genetics | Protein Binding | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Fibronectins - genetics | Mice | Pyridines - pharmacology | Mutation | Mitochondrial Uncoupling Proteins | Caenorhabditis elegans Proteins - genetics | Adipose Tissue, White - drug effects | Physiological research | Cellular signal transduction | Research | Identification and classification | Membrane proteins | Proteins | Homeostasis | Diabetes | Kinases | Genes | Cells | Index Medicus | Abridged Index Medicus
Journal Article
American journal of physiology. Heart and circulatory physiology, ISSN 0363-6135, 2017, Volume 312, Issue 2, pp. H289 - H304
High consumption of simple sugars causes adverse cardiometabolic effects. We investigated the mechanisms underlying the metabolic and vascular effects of... 
Insulin resistance | Glucose | Liver | Fructose | Adiponectin | Cardiac & Cardiovascular Systems | Physiology | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | PPAR alpha - drug effects | Phosphorylation | Aorta - metabolism | Nitroprusside - pharmacology | Carrier Proteins - drug effects | Phenylephrine - pharmacology | Liver - drug effects | Fructose - pharmacology | Carnitine O-Palmitoyltransferase - metabolism | Adiponectin - metabolism | Carnitine O-Palmitoyltransferase - drug effects | Female | Aorta - physiopathology | Nitric Oxide Donors - pharmacology | Nitric Oxide Synthase Type III - metabolism | Real-Time Polymerase Chain Reaction | Bradykinin - pharmacology | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Dietary Sucrose - pharmacology | Signal Transduction | Acetylcholine - pharmacology | Aorta - drug effects | Liver - metabolism | Rats | Glucose - pharmacology | Energy Intake | Rats, Sprague-Dawley | Blotting, Western | Triglycerides - metabolism | Insulin - metabolism | Animals | Carrier Proteins - metabolism | Lipogenesis - drug effects | Lipid Metabolism - drug effects | PPAR alpha - metabolism | Nitric Oxide Synthase Type III - drug effects | Physiological aspects | Aorta | Health aspects | Sugar | Cardiovascular system | Protein expression | Bioenergetics | Metabolism | Index Medicus | Proteïnes de la sang | Resistència a la insulina | Fetge | Fructosa | Disorders of metabolism | Glucosa | Trastorns del metabolisme | Blood proteins | adiponectin | fructose | glucose | liver | insulin resistance
Journal Article
American journal of physiology: endocrinology and metabolism, ISSN 1522-1555, 02/2008, Volume 294, Issue 2, pp. E392 - E400
Journal Article
American journal of physiology. Heart and circulatory physiology, ISSN 1522-1539, 04/2011, Volume 300, Issue 4, pp. H1336 - H1344
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 01/2010, Volume 298, Issue 1, pp. 59 - 67
The recently discovered peptide apelin is known to be involved in the maintenance of insulin sensitivity. However, questions persist regarding its precise role... 
Obesity | Insulin resistance | Diabetes | Hormones | Endocrinology & Metabolism | Physiology | Life Sciences & Biomedicine | Science & Technology | Phosphorylation - physiology | AMP-Activated Protein Kinases - metabolism | Deoxyglucose - metabolism | Receptors, Leptin - genetics | Muscle, Skeletal - metabolism | Tritium | Diabetes Mellitus, Type 2 - metabolism | Myoblasts - metabolism | Insulin Resistance - physiology | Myoblasts - cytology | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Apelin | Hyperinsulinism - physiopathology | Hyperinsulinism - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Dietary Sucrose - pharmacology | Intercellular Signaling Peptides and Proteins | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Obesity - physiopathology | Adipokines | Mice, Knockout | Obesity - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Diabetes Mellitus, Type 2 - physiopathology | Signal Transduction - drug effects | Signal Transduction - physiology | Mice | Receptors, Leptin - metabolism | AMP-Activated Protein Kinases - genetics | Prevention | Glucose metabolism | Physiological aspects | Research | Peptide hormones | Risk factors | Musculoskeletal system | Glucose | Peptides | Drug resistance | Insulin | Rodents | Index Medicus | hormones | insulin resistance | diabetes | obesity | Medicin och hälsovetenskap
Journal Article