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Journal Article
Asian Journal of Pharmaceutical and Clinical Research, ISSN 0974-2441, 12/2018, Volume 11, Issue 12, pp. 255 - 257
Journal Article
Science, ISSN 0036-8075, 7/2007, Volume 317, Issue 5834, pp. 121 - 124
Journal Article
Journal Article
by Zhang, WK and Gu, HW and Li, XJ and Li, YS and Tang, HB and Tian, GH and Shang, HC
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, ISSN 1549-9634, 02/2017, Volume 13, Issue 2, pp. 701 - 711
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 2567 - 8
Journal Article
06/2013
We previously observed that postnatal exposure of mice to the procarcinogen 4-aminobiphenyl (ABP) produced liver tumors only in wild-type males, while... 
0433 | Aromatic amines | Diethylnitrosamine | 0383 | 4-aminobiphenyl | Hepatocellular carcinoma | 0419 | Inflammation | 0307 | Carcinogenesis | Hepatotoxicity
Dissertation
Cytokine, ISSN 1043-4666, 2018
Chronic liver diseases and the development of hepatocellular carcinoma are closely linked and pose a major medical challenge as treatment options are limited.... 
Chemical carcinogen | Growth hormone | Diethylnitrosamine | Hepatocellular carcinoma formation
Journal Article
Journal Article
Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, ISSN 1383-5718, 2009, Volume 680, Issue 1, pp. 95 - 105
The circadian timing system rhythmically controls behavior, physiology, cellular proliferation and xenobiotic metabolism over the 24-h period. The... 
Mouse liver | Circadian disruption | Chronic jet-lag | Carcinogenesis | Diethylnitrosamine | TRANSCRIPTION FACTORS | TUMOR PROGRESSION | METASTATIC COLORECTAL-CANCER | SHIFT-WORK | BREAST-CANCER | NIGHT-WORK | SUPRACHIASMATIC NUCLEUS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | TOXICOLOGY | QUALITY-OF-LIFE | INDUCED HEPATOCARCINOGENESIS | SEQUENTIAL-ANALYSIS | Diethylnitrosamine - toxicity | Bile Duct Neoplasms - chemically induced | Carcinoma, Hepatocellular - chemically induced | Liver - pathology | Cholangiocarcinoma - chemically induced | Body Weight - drug effects | Liver Neoplasms - chemically induced | Male | Alanine Transaminase - blood | Bile Ducts, Intrahepatic - drug effects | Carcinogens - administration & dosage | Carcinogens - toxicity | Dose-Response Relationship, Drug | Liver Neoplasms - blood | Liver - drug effects | Sarcoma - chemically induced | Time Factors | Diethylnitrosamine - administration & dosage | Liver Neoplasms - pathology | Bile Ducts, Intrahepatic - pathology | Injections, Intraperitoneal | Neoplasms, Multiple Primary - pathology | Sarcoma - pathology | Neoplasms, Multiple Primary - chemically induced | Cholangiocarcinoma - pathology | Animals | Aspartate Aminotransferases - blood | Carcinoma, Hepatocellular - pathology | Mice | Bile Duct Neoplasms - pathology | Circadian Rhythm - drug effects | Phorbol esters | Analysis | Liver | Physiological aspects | Tumor proteins | Xenobiotics | Tumors | Index Medicus
Journal Article
Toxicology and Industrial Health, ISSN 0748-2337, 8/2016, Volume 32, Issue 8, pp. 1405 - 1413
Several chemicals such as N-diethylnitrosamine (DEN) promote hepatocellular cancer in rodents and induce hepatocyte injury. DEN affects the initiation stage of... 
taurine | diethylnitrosamine | carnosine | Hepatic injury | betaine | oxidative stress | ACID | HEPATOCELLULAR-CARCINOMA | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | DISEASES | CHEMICAL HEPATOCARCINOGENESIS | ETHANOL | MICE | TOXICOLOGY | INDUCED HEPATOTOXICITY | Carcinogens, Environmental - chemistry | Diethylnitrosamine - toxicity | Liver - pathology | Rats, Wistar | Glutathione - metabolism | Male | Carnosine - therapeutic use | Liver - physiopathology | Protein Carbonylation - drug effects | Carcinogens, Environmental - toxicity | Tyrosine - analogs & derivatives | Glutathione - agonists | Carcinogens, Environmental - administration & dosage | Liver - drug effects | Diethylnitrosamine - administration & dosage | Lipid Peroxidation - drug effects | Chemical and Drug Induced Liver Injury - pathology | Taurine - therapeutic use | Betaine - therapeutic use | Biomarkers - metabolism | Chemical and Drug Induced Liver Injury - prevention & control | Liver - metabolism | Injections, Intraperitoneal | Glutathione - antagonists & inhibitors | Biomarkers - blood | Random Allocation | Chemical and Drug Induced Liver Injury - physiopathology | Antioxidants - therapeutic use | Tyrosine - metabolism | Animals | Chemical and Drug Induced Liver Injury - metabolism | Diethylnitrosamine - antagonists & inhibitors | Oxidative Stress - drug effects | Dietary Supplements | Tyrosine - antagonists & inhibitors | Cell proliferation | Drinking water | Oxidative stress | Reactive oxygen species | Liver | Superoxide dismutase | Carnosine | Carcinogenesis | Necrosis | Antioxidants | Carcinogens | Glutathione transferase | Betaine | Rodents | Diethylnitrosamine | Gangrene | Peroxidase | Glutathione | Carbonyls | Glutathione peroxidase | Stresses | Alanine | Rats | Lactate dehydrogenase | Superoxide | Malondialdehyde | L-Lactate dehydrogenase | Injury prevention | Alanine transaminase | Aspartate aminotransferase | Nitrotyrosine | Lactic acid | Cancer | Index Medicus | Pretreatment | Injuries | Betaines
Journal Article
Drug and Chemical Toxicology, ISSN 0148-0545, 04/2018, pp. 1 - 9
The effect of chlormethiazole (CMZ) at single and multiple doses on the toxicokinetics of diethylnitrosamine (DEN) was investigated in normal rats and those... 
toxicokinetics | diethylnitrosamine | liver fibrosis | CYP2E1 | chlomethiazole
Journal Article
Drug and Chemical Toxicology, ISSN 0148-0545, 04/2018, pp. 1 - 8
Diethylnitrosamine (DEN) and 1,2-dimethylhydrazine (DMH) are classical carcinogens used in experimental rodent carcinogenesis. However, the interaction effects... 
hepatocarcinogenicity | xenobiotic-metabolizing enzymes | Diethylnitrosamine | hepatotoxicity | 1,2-dimethylhydrazine
Journal Article
Biomarkers, ISSN 1354-750X, 07/2019, Volume 24, Issue 5, pp. 436 - 447
Context: Chronic liver damage has serious medical consequences. Objective: To investigate the hepatoprotective effect of dry Zingiber officinale (ginger) and... 
hepatoprotective effect in vivo | essential oil | Diethylnitrosamine toxicity | ginger
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 08/2017, Volume 18, Issue 8, p. 1801
The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2'-deoxyguanosine (8-OHdG) residue in DNA, was... 
8-hydroxy-2′-deoxyguanosine | Multiorgan carcinogenesis bioassay | DNA repair | Oxoguanine glycosylase 1 (Ogg1) | LUNG | oxoguanine glycosylase 1 (Ogg1) | OXIDATIVE DNA-DAMAGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | CELL-PROLIFERATION | KNOCKOUT MICE | CHEMISTRY, MULTIDISCIPLINARY | multiorgan carcinogenesis bioassay | GENE | CLONING | LIVER | 8-HYDROXYGUANINE | 8-hydroxy-2 '-deoxyguanosine | HUMAN HOMOLOG | Diethylnitrosamine - toxicity | Carcinoma, Hepatocellular - chemically induced | Lung Neoplasms - chemically induced | Butylhydroxybutylnitrosamine - toxicity | Adenocarcinoma - chemically induced | Carcinogenesis - chemically induced | Liver Neoplasms - chemically induced | Methylnitrosourea - administration & dosage | Male | Carcinogens - administration & dosage | Carcinogens - toxicity | Carcinoma, Hepatocellular - genetics | Diethylnitrosamine - administration & dosage | Nitrosamines - administration & dosage | Female | Adenocarcinoma - genetics | Lung Neoplasms - genetics | Liver Neoplasms - genetics | 1,2-Dimethylhydrazine - administration & dosage | Mice, Inbred C57BL | Carcinogenesis - genetics | DNA Glycosylases - genetics | 1,2-Dimethylhydrazine - toxicity | Nitrosamines - toxicity | Mice, Knockout | Animals | Butylhydroxybutylnitrosamine - administration & dosage | Methylnitrosourea - toxicity | Mutation | Syngeneic grafts | Hyperplasia | Liver | Bladder | Homology | Males | Renal tubules | Carcinogenesis | Small intestine | Incidence | Carcinogens | Urinary bladder | Diethylnitrosamine | Rodents | Colon | Deoxyribonucleic acid--DNA | Enzymes | Bioassay | Kidneys | Nitrosamine | Bioassays | N-Methyl-N-nitrosourea | Organs | 1,2-Dimethylhydrazine | Biological assays | Deoxyguanosine | OGG1 protein | Mice | Females | Tumors | Cancer | Index Medicus
Journal Article
18.