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1. Full Text Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma
by Schmitz, Roland and Wright, George W and Huang, Da Wei and Johnson, Calvin A and Phelan, James D and Wang, James Q and Roulland, Sandrine and Kasbekar, Monica and Young, Ryan M and Shaffer, Arthur L and Hodson, Daniel J and Xiao, Wenming and Yu, Xin and Yang, Yandan and Zhao, Hong and Zhao, Yongmei and Xu, Weihong and Liu, Xuelu and Zhou, Bin and Du, Wei and Chan, Wing C and Jaffe, Elaine S and Gascoyne, Randy D and Connors, Joseph M and Campo, Elias and Lopez-Guillermo, Armando and Rosenwald, Andreas and Ott, German and Delabie, Jan and Rimsza, Lisa M and Tay Kuang Wei, Kevin and Zelenetz, Andrew D and Leonard, John P and Bartlett, Nancy L and Tran, Bao and Shetty, Jyoti and Soppet, Dan R and Pittaluga, Stefania and Wilson, Wyndham H and Staudt, Louis M
The New England Journal of Medicine, ISSN 0028-4793, 04/2018, Volume 378, Issue 15, pp. 1396 - 1407
Gene-expression profiling of 574 cases of diffuse large B-cell lymphoma revealed four new subtypes based on the co-occurrence of mutation patterns. The... 
PRIMARY CNS LYMPHOMA | SURVIVAL | MEDICINE, GENERAL & INTERNAL | ACTIVATION | BRUTON TYROSINE KINASE | RECEPTOR LEVELS | SIGNATURES | IBRUTINIB | MARGINAL ZONE LYMPHOMA | EXPRESSION | GENOME | Lymphoma, Large B-Cell, Diffuse - drug therapy | Prognosis | Epigenesis, Genetic | Humans | Kaplan-Meier Estimate | Transcriptome | Genotype | Gene Expression Profiling | Sequence Analysis, DNA | Genetic Heterogeneity | Exome | Lymphoma, Large B-Cell, Diffuse - mortality | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Biopsy | Lymphoma, Large B-Cell, Diffuse - classification | Mutation | Lymphoma, Large B-Cell, Diffuse - genetics | Genetic aspects | Research | Lymphocytic leukemia | Cancer | Translocation | Medical research | Biomedical research | Laboratories | Pathogenesis | Event-related potentials | B-cell receptor | Gene expression | Cancer therapies | Lymphoma | Medicine | Pathology | Chemotherapy | Lymphocytes B | Genetic analysis | Classification | Lymphomas | Deoxyribonucleic acid--DNA | DNA sequencing | Bcl-6 protein | B-cell lymphoma | Index Medicus | Abridged Index Medicus | Genetics | Genètica | Cèl·lules B | Limfomes | B cells
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2. Full Text Genetic heterogeneity of diffuse large B-cell lymphoma
by Jenny Zhang and Vladimir Grubor and Cassandra L. Love and Anjishnu Banerjee and Kristy L. Richards and Piotr A. Mieczkowski and Cherie Dunphy and William Choi and Wing Yan Au and Gopesh Srivastava and Patricia L Lugar and David A. Rizzieri and Anand S. Lagoo and Leon Bernal-Mizrachi and Karen P. Mann and Christopher Flowers and Kikkeri Naresh and Andrew Evens and Leo I. Gordon and Magdalena Czader and Javed I. Gill and Eric D. Hsi and Qingquan Liu and Alice Fan and Katherine Walsh and Dereje Jima and Lisa L. Smith and Amy J. Johnson and John C. Byrd and Micah A. Luftig and Ting Ni and Jun Zhu and Amy Chadburn and Shawn Levy and David Dunson and Sandeep S. Dave
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1398 - 1403
Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma in adults. The disease exhibits a striking heterogeneity in gene expression profiles... 
Exome | Genes | Cell lines | Medical genetics | Genomes | Genetic mutation | Sequencing | Lymphoma | Genetic heterogeneity | Oncogenes | cancer genetics | next-generation sequencing | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | FREQUENCY | MUTATIONS | cancer heterogeneity | GENOME | Humans | Molecular Sequence Data | Molecular Targeted Therapy | Genetic Variation | DNA Mutational Analysis | Base Sequence | Adult | Proto-Oncogene Proteins c-kit - genetics | Gene Expression | Lymphoma, Large B-Cell, Diffuse - drug therapy | Phosphatidylinositol 3-Kinases - chemistry | Models, Molecular | Signal Transduction - genetics | Sequence Homology, Nucleic Acid | Genetic Heterogeneity | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | Receptor, Platelet-Derived Growth Factor alpha - genetics | Cell Line, Tumor | Protein Conformation | DNA, Neoplasm - genetics | Mutation | Lymphoma, Large B-Cell, Diffuse - genetics | Epigenetic inheritance | Physiological aspects | Development and progression | Lymphomas | Genetic aspects | B cells | Research | Health aspects | Cancer | Proteins | Chromatin | Genetic diversity | Gene expression | Index Medicus | Biological Sciences
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3. Full Text Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
by Neelapu, Sattva S and Locke, Frederick L and Bartlett, Nancy L and Lekakis, Lazaros J and Miklos, David B and Jacobson, Caron A and Braunschweig, Ira and Oluwole, Olalekan O and Siddiqi, Tanya and Lin, Yi and Timmerman, John M and Stiff, Patrick J and Friedberg, Jonathan W and Flinn, Ian W and Goy, Andre and Hill, Brian T and Smith, Mitchell R and Deol, Abhinav and Farooq, Umar and McSweeney, Peter and Munoz, Javier and Avivi, Irit and Castro, Januario E and Westin, Jason R and Chavez, Julio C and Ghobadi, Armin and Komanduri, Krishna V and Levy, Ronald and Jacobsen, Eric D and Witzig, Thomas E and Reagan, Patrick and Bot, Adrian and Rossi, John and Navale, Lynn and Jiang, Yizhou and Aycock, Jeff and Elias, Meg and Chang, David and Wiezorek, Jeff and Go, William Y
The New England Journal of Medicine, ISSN 0028-4793, 12/2017, Volume 377, Issue 26, pp. 2531 - 2544
In 101 patients with refractory large B-cell lymphoma, anti-CD19 chimeric antigen receptor (CAR) T-cell therapy (axicabtagene ciloleucel) resulted in an... 
TRANSPLANT-ELIGIBLE PATIENTS | MEDICINE, GENERAL & INTERNAL | CYTOKINE RELEASE SYNDROME | REMISSIONS | CHIMERIC-ANTIGEN-RECEPTOR | NON-HODGKINS-LYMPHOMA | SALVAGE-CHEMOTHERAPY | OUTCOMES | LEUKEMIA | Immunotherapy, Adoptive | Interleukins - blood | Humans | Middle Aged | Receptors, Antigen, T-Cell - therapeutic use | Male | Survival Rate | Biomarkers - blood | T-Lymphocytes - transplantation | Lymphoma, Large B-Cell, Diffuse - mortality | Young Adult | Disease-Free Survival | Lymphoma, Large B-Cell, Diffuse - therapy | Receptors, Antigen, T-Cell - blood | Adult | Antigens, CD19 | Female | Nervous System Diseases - chemically induced | T-Lymphocytes - immunology | Aged | Neutropenia - chemically induced | Treatment outcome | Care and treatment | Lymphocytic leukemia | Analysis | Thrombocytopenia | CD19 antigen | Cytokines | Body weight | Clinical trials | Lymphocytes T | Patients | Lymphoma | Cancer therapies | Studies | Cyclophosphamide | Chemotherapy | Fludarabine | Lymphocytes B | Lymphocytes | Medical prognosis | Myelosuppression | Lymphomas | Drug dosages | Neutropenia | B-cell lymphoma | Index Medicus | Abridged Index Medicus
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4. Full Text Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma
by Wilson, Wyndham H and Young, Ryan M and Schmitz, Roland and Yang, Yandan and Pittaluga, Stefania and Wright, George and Lih, Chih-Jian and Williams, P Mickey and Shaffer, Arthur L and Gerecitano, John and De Vos, Sven and Goy, Andre and Kenkre, Vaishalee P and Barr, Paul M and Blum, Kristie A and Shustov, Andrei and Advani, Ranjana and Fowler, Nathan H and Vose, Julie M and Elstrom, Rebecca L and Habermann, Thomas M and Barrientos, Jacqueline C and McGreivy, Jesse and Fardis, Maria and Chang, Betty Y and Clow, Fong and Munneke, Brian and Moussa, Davina and Beaupre, Darrin M and Staudt, Louis M
Nature Medicine, ISSN 1078-8956, 08/2015, Volume 21, Issue 8, pp. 922 - 926
The two major subtypes of diffuse large B cell lymphoma (DLBCL)-activated B cell-like (ABC) and germinal center B cell-like (GCB)-arise by distinct mechanisms,... 
PATHOGENESIS | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | BTK | CHRONIC LYMPHOCYTIC-LEUKEMIA | MUTATIONS | NF-KAPPA-B | CELL BIOLOGY | Lymphoma, Large B-Cell, Diffuse - drug therapy | Humans | Middle Aged | Myeloid Differentiation Factor 88 - genetics | Molecular Sequence Data | Male | Pyrimidines - pharmacology | Lymphoma, Large B-Cell, Diffuse - mortality | Signal Transduction - drug effects | Base Sequence | Adult | Female | Receptors, Antigen, B-Cell - physiology | Aged | Protein Kinase Inhibitors - pharmacology | CD79 Antigens - genetics | Mutation | Lymphoma, Large B-Cell, Diffuse - genetics | Pyrazoles - pharmacology | Signal transduction | Chemotherapy | Lymphomas | Pharmacology | Lymphocytes | Index Medicus
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5. Full Text Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma
by Georg Lenz and R. Eric Davis and Vu N. Ngo and Lloyd Lam and Thaddeus C. George and George W. Wright and Sandeep S. Dave and Hong Zhao and Weihong Xu and Andreas Rosenwald and German Ott and Hans Konrad Muller-Hermelink and Randy D. Gascoyne and Joseph M. Connors and Lisa M. Rimsza and Elias Campo and Elaine S. Jaffe and Jan Delabie and Erlend B. Smeland and Richard I. Fisher and Wing C. Chan and Louis M. Staudt
Science, ISSN 0036-8075, 3/2008, Volume 319, Issue 5870, pp. 1676 - 1679
Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. In the least curable (ABC) subtype of DLBCL, survival of the malignant... 
T lymphocytes | Medical research | Biomedical research | B lymphocytes | B cell lymphoma | Cell lines | Cell aggregates | Research facilities | Biopsies | Reports | Genetic mutation | SURVIVAL | ACTIVATION | PHOSPHORYLATION | CARMA1 | MULTIDISCIPLINARY SCIENCES | HODGKIN LYMPHOMA | PROLIFERATION | CHEMOTHERAPY | REQUIREMENT | Protein Structure, Tertiary | Amino Acid Sequence | Jurkat Cells | Apoptosis Regulatory Proteins - chemistry | Humans | Molecular Sequence Data | Cytoplasm - metabolism | Guanylate Cyclase - metabolism | Mutation, Missense | Sequence Analysis, DNA | Apoptosis Regulatory Proteins - metabolism | CARD Signaling Adaptor Proteins - genetics | CARD Signaling Adaptor Proteins - metabolism | NF-kappa B | I-kappa B Kinase - metabolism | Apoptosis Regulatory Proteins - genetics | CARD Signaling Adaptor Proteins - chemistry | Cell Line, Tumor | Guanylate Cyclase - genetics | Receptors, Antigen, B-Cell - physiology | Guanylate Cyclase - chemistry | Lymphoma, Large B-Cell, Diffuse - genetics | Oncogenes | Lymphomas | Genetic aspects | Research | Gene mutations | Health aspects | Proteins | Cellular biology | Genetics | Mutation | Tumors | Index Medicus
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6. Full Text Analysis of the coding genome of diffuse large B-cell lymphoma
by Pasqualucci, Laura and Trifonov, Vladimir and Fabbri, Giulia and Ma, Jing and Rossi, Davide and Chiarenza, Annalisa and Wells, Victoria A and Grunn, Adina and Messina, Monica and Elliot, Oliver and Chan, Joseph and Bhagat, Govind and Chadburn, Amy and Gaidano, Gianluca and Mullighan, Charles G and Rabadan, Raul and Dalla-Favera, Riccardo
Nature Genetics, ISSN 1061-4036, 09/2011, Volume 43, Issue 9, pp. 830 - 837
Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma. Although a number of structural alterations have been associated with the... 
MULTIPLE-MYELOMA | ANALYSIS REVEALS | GENETICS & HEREDITY | CHRONIC LYMPHOCYTIC-LEUKEMIA | HODGKIN LYMPHOMA | ACUTE MYELOID-LEUKEMIA | PHD FINGER | MUTATIONS | NF-KAPPA-B | CANCER | GENETIC ALTERATIONS | Chromatin - metabolism | Lymphoma, Large B-Cell, Diffuse - pathology | Germinal Center - immunology | Humans | Gene Dosage | Gene Expression Regulation, Leukemic | Neoplasm Recurrence, Local - immunology | Neoplasm Recurrence, Local - pathology | Point Mutation | Diploidy | DNA Mutational Analysis | Lymphoma, Large B-Cell, Diffuse - immunology | Neoplasm Recurrence, Local - genetics | T-Lymphocytes - immunology | Polymorphism, Single Nucleotide | Genome, Human | Methylation | Lymphoma, Large B-Cell, Diffuse - genetics | Polymerase chain reaction | Usage | Physiological aspects | Genomes | Lymphomas | Genetic aspects | Research | Genetics | Mutation | Genes | Cancer | Index Medicus
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7. Full Text Double-hit diffuse large B-cell lymphoma
by Friedberg, Jonathan W
Journal of Clinical Oncology, ISSN 0732-183X, 10/2012, Volume 30, Issue 28, pp. 3439 - 3443
A 72-year-old previously healthy woman presented with acute abdominal pain and a 10-lb weight loss. Positron emission tomography demonstrated... 
TRIAL | BURKITT-LYMPHOMA | ONCOLOGY | PROGNOSIS | MYC | PLUS RITUXIMAB | NON-HODGKINS-LYMPHOMA | PHASE-II | CHOP | REGIMEN | CHEMOTHERAPY | Immunohistochemistry | Doxorubicin - therapeutic use | Translocation, Genetic | Lymphoma, Large B-Cell, Diffuse - drug therapy | Prognosis | Humans | Rituximab | In Situ Hybridization, Fluorescence | Genes, bcl-2 | Cyclophosphamide - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Genes, myc - genetics | Vincristine - therapeutic use | Female | Aged | Lymphoma, Large B-Cell, Diffuse - genetics | Prednisone - therapeutic use | Antibodies, Monoclonal, Murine-Derived - therapeutic use | Index Medicus
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8. Full Text Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma
by Reddy, Nishitha and Reddy, Anupama and Zhang, Jenny and Davis, Nicholas S and Moffitt, Andrea B and Love, Cassandra L and Waldrop, Alexander and Leppa, Sirpa and Pasanen, Annika and Meriranta, Leo and Karjalainen-Lindsberg, Marja-Liisa and Nørgaard, Peter and Pedersen, Mette and Gang, Anne O and Høgdall, Estrid and Heavican, Tayla B and Lone, Waseem and Iqbal, Javeed and Qin, Qiu and Li, Guojie and Li, Shaoying and Kim, So Young and Healy, Jane and Richards, Kristy L and Fedoriw, Yuri and Bernal-Mizrachi, Leon and Koff, Jean L and Staton, Ashley D and Flowers, Christopher R and Paltiel, Ora and Goldschmidt, Neta and Calaminici, Maria and Clear, Andrew and Gribben, John and Nguyen, Evelyn and Czader, Magdalena B and Ondrejka, Sarah L and Collie, Angela and Hsi, Eric D and Tse, Eric and Au-Yeung, Rex K.H and Kwong, Yok-Lam and Srivastava, Gopesh and Choi, William W.L and Evens, Andrew M and Pilichowska, Monika and Sengar, Manju and Chadburn, Amy and Gordon, Leo I and Jaffe, Elaine S and Levy, Shawn and Rempel, Rachel and Tzeng, Tiffany and Happ, Lanie E and Dave, Tushar and Dave, Sandeep S and Rajagopalan, Deepthi and Datta, Jyotishka and Dunson, David B
Cell, ISSN 0092-8674, 10/2017, Volume 171, Issue 2, pp. 481 - 494.e15
Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is characterized by a striking degree of genetic and clinical heterogeneity.... 
exome sequencing | genetic mutations | DLBCL | diffuse large B cell lymphoma | TCGA | The Cancer Genome Atlas | HETEROGENEITY | RITUXIMAB PLUS CYCLOPHOSPHAMIDE | RNA-SEQ | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLASSIFICATION | PRIORITIZATION | EXPRESSION | CANCER | SOMATIC MUTATIONS | GENOME | DISCOVERY | CELL BIOLOGY | Exome | Rituximab - administration & dosage | Lymphoma, Large B-Cell, Diffuse - drug therapy | Humans | CRISPR-Cas Systems | Cells, Cultured | Cell Line, Tumor | Female | Male | Gene Expression Profiling | Antineoplastic Agents - administration & dosage | Lymphoma, Large B-Cell, Diffuse - genetics | Automobile drivers | Analysis | Lymphomas | Index Medicus
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9. Full Text Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma
by Schuster, Stephen J and Bishop, Michael R and Tam, Constantine S and Waller, Edmund K and Borchmann, Peter and McGuirk, Joseph P and Jäger, Ulrich and Jaglowski, Samantha and Andreadis, Charalambos and Westin, Jason R and Fleury, Isabelle and Bachanova, Veronika and Foley, S. Ronan and Ho, P. Joy and Mielke, Stephan and Magenau, John M and Holte, Harald and Pantano, Serafino and Pacaud, Lida B and Awasthi, Rakesh and Chu, Jufen and Anak, Özlem and Salles, Gilles and Maziarz, Richard T and JULIET Investigators
The New England Journal of Medicine, ISSN 0028-4793, 01/2019, Volume 380, Issue 1, pp. 45 - 56
The capacity to use CAR T-cell therapy has been limited by the need to produce cells in a specialized laboratory. In this study, 40% of patients with relapsed... 
MEDICINE, GENERAL & INTERNAL | OUTCOMES | SALVAGE REGIMENS | CHEMOTHERAPY | TRANSPLANTATION | Recurrence | Immunotherapy, Adoptive | Lymphoma, Large B-Cell, Diffuse - pathology | Humans | Middle Aged | Receptors, Antigen, T-Cell - therapeutic use | Male | Lymphoma, Large B-Cell, Diffuse - mortality | Young Adult | Receptors, Chimeric Antigen - therapeutic use | Lymphoma, Large B-Cell, Diffuse - therapy | Neoplasm Grading | Progression-Free Survival | Survival Analysis | Adult | Female | Aged | Edema | Autografts | CD19 antigen | Transplants & implants | Cytokines | Stem cell transplantation | Clinical trials | Lymphocytes T | FDA approval | Patients | Lymphoma | Hemopoiesis | Chemotherapy | Immune checkpoint | Lymphocytes B | Biopsy | Medical prognosis | Biomarkers | Lymphomas | Editorials | Adults | Neutropenia | B-cell lymphoma | Index Medicus | Abridged Index Medicus | Life Sciences | Cancer
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10. Full Text Salvage Regimens With Autologous Transplantation for Relapsed Large B-Cell Lymphoma in the Rituximab Era
by Christian Gisselbrecht and Bertram Glass and Nicolas Mounier and Devinder Singh Gill and David C. Linch and Marek Trneny and Andre Bosly and Nicolas Ketterer and Ofer Shpilberg and Hans Hagberg and David Ma and Josette Brière and Craig H. Moskowitz and Norbert Schmitz and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för onkologi, radiologi och klinisk immunologi and Uppsala universitet and Enheten för onkologi
Journal of Clinical Oncology, ISSN 0732-183X, 09/2010, Volume 28, Issue 27, pp. 4184 - 4190
Purpose Salvage chemotherapy followed by high-dose therapy and autologous stem-cell transplantation (ASCT) is the standard treatment for relapsed diffuse large... 
SURVIVAL | PARMA TRIAL | THERAPY | BONE-MARROW TRANSPLANTATION | ONCOLOGY | NON-HODGKINS-LYMPHOMA | CHOP | AGGRESSIVE LYMPHOMA | RANDOMIZED CONTROLLED-TRIAL | CHEMOTHERAPY PLUS RITUXIMAB | ELDERLY-PATIENTS | Recurrence | Humans | Middle Aged | Salvage Therapy | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Transplantation, Autologous | New York City | Stem Cell Transplantation | Young Adult | Time Factors | Lymphoma, Large B-Cell, Diffuse - immunology | Adult | Female | Antigens, CD20 - analysis | Chemotherapy, Adjuvant | Antibodies, Monoclonal, Murine-Derived | Dexamethasone - administration & dosage | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - surgery | Lymphoma, Large B-Cell, Diffuse - pathology | Risk Assessment | Europe | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Carboplatin - administration & dosage | Rituximab | Etoposide - administration & dosage | Treatment Outcome | Cytarabine - administration & dosage | Lymphoma, Large B-Cell, Diffuse - mortality | Disease-Free Survival | Ifosfamide - administration & dosage | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Israel | Australia | Neoplasm Staging | Index Medicus | Bone2 | Original Reports | Hema13 | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | Surgery | Onkologi | Oncology | Cancer and Oncology | Klinisk medicin | MEDICINE | Kirurgi | Cancer och onkologi
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