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CNS Neuroscience & Therapeutics, ISSN 1755-5930, 07/2017, Volume 23, Issue 7, pp. 605 - 619
Summary Background The absence of transthyretin (TTR) in AD mice decreases brain Aβ clearance and reduces the low‐density lipoprotein receptor‐related protein... 
blood–brain barrier | liver | Alzheimer's disease | transthyretin | stability | blood-brain barrier | RETINOL-BINDING-PROTEIN | SERUM | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | THYROXINE-BINDING | PEPTIDE | PLASMA | MOUSE MODEL | PHARMACOLOGY & PHARMACY | MICE | RECEPTOR-RELATED PROTEIN-1 | CELL-LINE | Escherichia coli | Humans | Protein Multimerization | Lysosomes - metabolism | Liver - drug effects | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Protein Denaturation | Urea - metabolism | Prealbumin - chemistry | Protein Stability | Recombinant Proteins - metabolism | Cell Line | Diflunisal - analogs & derivatives | Tumor Suppressor Proteins - metabolism | Diflunisal - pharmacology | Liver - metabolism | Presenilin-1 - genetics | Receptors, LDL - metabolism | Recombinant Proteins - chemistry | Mice, Transgenic | Blood-Brain Barrier - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Amyloid beta-Protein Precursor - genetics | Animals | Prealbumin - metabolism | Presenilin-1 - metabolism | Alzheimer Disease - metabolism | Proteins | Denaturation | Low density lipoproteins | Neuroprotection | Flow cytometry | Neurodegenerative diseases | Liver | Transthyretin | Lysosomes | Hepatoma | Studies | Urea | Blood-brain barrier | Internalization | Rodents | β-Amyloid | Receptor density | Microvasculature | Alzheimers disease | Enzyme-linked immunosorbent assay
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2014, Volume 89, Issue 4, pp. 464 - 476
We previously identified salicylate as a novel catalytic inhibitor of human DNA topoisomerase II (topo II; EC 5.99.1.3) that preferentially targets the alpha... 
Salicylate | Sulfasalazine | Catalytic inhibitor | Diflunisal | Topoisomerase II | DOSE ASPIRIN | ACID | MECHANISM | POISONS | CLEAVAGE | CANCER | GREEN TEA | HORMONE | DISEASE | PHARMACOLOGY & PHARMACY | DNA TOPOISOMERASES | Hydrolysis - drug effects | DNA, Neoplasm - metabolism | Doxorubicin - antagonists & inhibitors | Humans | Neoplasm Proteins - antagonists & inhibitors | Sulfasalazine - pharmacology | Neoplasm Proteins - metabolism | Sodium Salicylate - analogs & derivatives | Antigens, Neoplasm - chemistry | Sodium Salicylate - pharmacology | DNA, Neoplasm - chemistry | Salicylates - chemistry | DNA-Binding Proteins - metabolism | Salicylates - pharmacology | Sulfasalazine - chemistry | Sodium Salicylate - chemistry | MCF-7 Cells | Biocatalysis - drug effects | Adenosine Triphosphate - metabolism | Enzyme Inhibitors - chemistry | DNA Topoisomerases, Type II - chemistry | DNA, Superhelical - chemistry | Antigens, Neoplasm - metabolism | Antineoplastic Agents - pharmacology | DNA Fragmentation - drug effects | DNA, Catenated - chemistry | Molecular Conformation - drug effects | DNA Topoisomerases, Type II - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Antineoplastic Agents - antagonists & inhibitors | Diflunisal - pharmacology | Enzyme Inhibitors - pharmacology | Models, Molecular | Neoplasm Proteins - chemistry | Antineoplastic Agents - chemistry | DNA, Catenated - metabolism | DNA-Binding Proteins - chemistry | Plasmids - metabolism | Diflunisal - chemistry | DNA, Kinetoplast - chemistry | Plasmids - chemistry | DNA, Kinetoplast - metabolism | Adenosine Triphosphate - chemistry | DNA, Superhelical - metabolism | Doxorubicin - pharmacology | Index Medicus
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2014, Volume 39, Issue 2, pp. 357 - 370
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, p. e0153529
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2004, Volume 381, Issue 2, pp. 351 - 356
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, p. e0153112
Journal Article
eLife, ISSN 2050-084X, 05/2016, Volume 5, Issue 2016
Salicylate and acetylsalicylic acid are potent and widely used anti-inflammatory drugs. They are thought to exert their therapeutic effects through multiple... 
INDUCIBLE CYCLOOXYGENASE | ACTIVATED PROTEIN-KINASE | TRANSCRIPTIONAL COACTIVATOR P300 | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | SODIUM-SALICYLATE | G1/S TRANSITION | BIOLOGY | RANDOMIZED-TRIAL | HISTONE ACETYLTRANSFERASE | NF-KAPPA-B | TERMINAL KINASE | Leukocytes - pathology | Oncogene Proteins, Fusion - metabolism | p300-CBP Transcription Factors - antagonists & inhibitors | Humans | Structure-Activity Relationship | Leukocytes - enzymology | Salicylic Acid - chemistry | Leukemia, Myeloid, Acute - enzymology | Salicylic Acid - pharmacology | p300-CBP Transcription Factors - genetics | Enzyme Inhibitors - chemistry | HEK293 Cells | Leukemia, Myeloid, Acute - drug therapy | RUNX1 Translocation Partner 1 Protein - genetics | Antineoplastic Agents - pharmacology | RUNX1 Translocation Partner 1 Protein - metabolism | Binding, Competitive | Catalytic Domain | Core Binding Factor Alpha 2 Subunit - metabolism | Signal Transduction | Diflunisal - pharmacology | Leukemia, Myeloid, Acute - pathology | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Leukemic | Antineoplastic Agents - chemistry | Mice, SCID | Acetyl Coenzyme A - metabolism | Xenograft Model Antitumor Assays | p300-CBP Transcription Factors - metabolism | Acetylation - drug effects | Diflunisal - chemistry | Animals | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Protein Binding | Leukocytes - drug effects | Acetyl Coenzyme A - antagonists & inhibitors | Mice | Core Binding Factor Alpha 2 Subunit - genetics | Leukemia, Myeloid, Acute - genetics | Metabolites | Salicylic acid | Health aspects | Event-related potentials | Acetylsalicylic acid | Cell fusion | Kinases | Confidence intervals | Proteins | Coenzyme A | Acetyltransferase | Acetylation | Fusion protein | Drug dosages | NF-κB protein | Medical research | Immunoglobulins | Antiinflammatory agents | Oral administration | Inflammation | Tumor cell lines | Medicine | AML1 protein | Acids | Sodium | Lysine | Cell lines | Insulin resistance | Antitumor activity | Software | Cancer | Apoptosis
Journal Article
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 06/2014, Volume 135, pp. 28 - 39
Journal Article