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chemistry, organic (30) 30
difluoromethylenation (27) 27
fluorine (14) 14
gem-difluoromethylenation (11) 11
carbonyl-compounds (10) 10
aldehydes (8) 8
trifluoromethylation (8) 8
chemistry, multidisciplinary (7) 7
fluorination (7) 7
aryl boronic acids (6) 6
arylboronic acids (6) 6
chemistry, inorganic & nuclear (6) 6
derivatives (6) 6
reagents (6) 6
catalysis (5) 5
cross-coupling reactions (5) 5
difluorocarbene (5) 5
fluoroalkylation reactions (5) 5
room-temperature (5) 5
analogs (4) 4
copper (4) 4
difluoromethylation (4) 4
ethyl bromodifluoroacetate (4) 4
fluorides (4) 4
fluoroalkylation (4) 4
nucleophilic difluoromethylation (4) 4
radicals (4) 4
acid (3) 3
acids (3) 3
alkenes (3) 3
arenes (3) 3
aryl (3) 3
carboxylic-acids (3) 3
copper-mediated difluoromethylation (3) 3
cyclization (3) 3
efficient (3) 3
efficient access (3) 3
efficient synthesis (3) 3
facile synthesis (3) 3
gem-difluoroolefination (3) 3
heteroarenes (3) 3
index medicus (3) 3
ketones (3) 3
oxidation (3) 3
palladium (3) 3
phenyl sulfone (3) 3
phosphonates (3) 3
route (3) 3
trifluoromethylthiolation (3) 3
[ chim.orga ] chemical sciences/organic chemistry (2) 2
alkyl-halides (2) 2
alkynes (2) 2
alpha,alpha-difluoroarylacetic acids (2) 2
alpha-silyldifluoromethylphosphonates (2) 2
article (2) 2
aryl bromides (2) 2
aryl iodides (2) 2
bisaminosulfur trifluoride (2) 2
bond (2) 2
bond formation (2) 2
building-blocks (2) 2
c-h functionalization (2) 2
carbene addition (2) 2
carbon center (2) 2
catalyst (2) 2
catalyzed alpha-arylation (2) 2
chemical sciences (2) 2
chemistry (2) 2
conversion (2) 2
cross-coupling reaction (2) 2
diazo-compounds (2) 2
difluoroalkene (2) 2
difluoroalkenes (2) 2
difluoromethylenations (2) 2
difluromethylations (2) 2
direct cupration (2) 2
electron-deficient alkenes (2) 2
elimination (2) 2
enhanced thermal-stability (2) 2
equivalent (2) 2
f bond activation (2) 2
fluorescence (2) 2
fluorinated compounds (2) 2
fullerene (2) 2
inhibitors (2) 2
isomers (2) 2
lactones (2) 2
light photoredox catalysis (2) 2
me3sicf2sph (2) 2
medicinal chemistry (2) 2
metal assisted (2) 2
metal free (2) 2
molecular structure (2) 2
monfluoromethylations (2) 2
monofluoromethylenations (2) 2
nitrogen heterocycles (2) 2
nucleophilic addition (2) 2
nucleophilic cyclopropanation (2) 2
nucleophilic fluoroalkylations (2) 2
nucleophilic trifluoromethylation (2) 2
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European Journal of Organic Chemistry, ISSN 1434-193X, 10/2013, Volume 2013, Issue 30, pp. 6844 - 6858
PhSCF2TMS was utilized as a useful gem‐difluoromethylene building block for the synthesis of gem‐difluoromethylenated spiro‐γ‐butyrolactones. The radical... 
Cyclization | Difluoromethylenation | Fluorine | Lactones
Journal Article
Organic Letters, ISSN 1523-7060, 01/2018, Volume 20, Issue 2, pp. 481 - 484
A copper-mediated difluoromethylenation of o-bromophenols with trifluoromethanethiolate is described. This one-pot protocol proceeds through an intermolecular... 
DIRECT DEHYDROXYTRIFLUOROMETHYLTHIOLATION | ALCOHOLS | REAGENTS | TRIFLUOROMETHYLTHIOLATION | DIFLUOROCARBENE | EFFICIENT SYNTHESIS | REACTIVITY | CHEMISTRY, ORGANIC | DIFLUOROMETHYLENATION
Journal Article
Organic Letters, ISSN 1523-7060, 10/2016, Volume 18, Issue 19, pp. 5158 - 5161
A highly regio- and stereoselective copper-mediated cyanodifluoro­alkylation of alkynes with ethyl difluoroiodoacetate and trimethylsilyl cyanide (TMSCN) is... 
ALKENES | ETHYL BROMODIFLUOROACETATE | HETEROARENES | ARYL BORONIC ACIDS | CHEMISTRY, ORGANIC | CATALYZED ALPHA-ARYLATION | FLUORINE | TRANSFER RADICAL-ADDITION | C-H FUNCTIONALIZATION | ALKYNES | GEM-DIFLUOROMETHYLENATION
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 07/2014, Volume 2014, Issue 21, pp. 4477 - 4481
The transition‐metal‐free 2,2,2‐trifluoroethylation and gem‐difluorovinylation of arylboronic acids were developed. By employing different reaction conditions,... 
gem‐Difluorovinylation | Diazo compounds | Boron | Fluorine | Trifluoroethylation | gem-Difluorovinylation | 1,1-DIFLUORO OLEFINS | EFFICIENT APPROACH | CHEMISTRY, ORGANIC | DIAZO-COMPOUNDS | CONVENIENT ROUTE | CROSS-COUPLING REACTIONS | INHIBITORS | DERIVATIVES | TRIFLUOROMETHYLATION | DIFLUOROMETHYLENATION | Fluorides
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2018, Volume 16, Issue 24, pp. 4558 - 4562
An efficient catalytic method for the synthesis of 2,2-difluoro-1,3-benzoxathioles(selenoles) from the reaction of o-bromophenols with... 
ENHANCED THERMAL-STABILITY | REAGENTS | TRIFLUOROMETHYLTHIOLATION | DIFLUOROCARBENE | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | SPECTRUM DEOXOFLUORINATING AGENT | ARYL | BIS(2-METHOXYETHYL)AMINOSULFUR TRIFLUORIDE | TRIFLUOROMETHANETHIOLATE | DIFLUOROMETHYLENATION
Journal Article
Synthesis, ISSN 0039-7881, 08/2017, Volume 49, Issue 15, pp. 3394 - 3406
Journal Article
Tetrahedron, ISSN 0040-4020, 08/2019, Volume 75, Issue 32, pp. 4325 - 4336
Gem-difluoroalkenes are an easily accessed fluorinated functional group, and a useful intermediate for elaborating into more complex fluorinated compounds.... 
Hydrophenolation | Base catalysis | Fluorination | Difluoroalkene | Organocatalysis | ACIDS | CHEMISTRY, ORGANIC | ME3SICF2SPH | F BOND ACTIVATION | FUNCTIONALIZATION | MONOFLUOROALKENYLATION | ETHERS | HEXAFLUOROPROPENE | ALPHA-FLUOROALKENYLATION | DIFLUOROMETHYLENATION | Fluorides | Catalysis
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2017, Volume 15, Issue 25, pp. 5308 - 5317
A silver-catalyzed oxidative decarboxylative gem-difluoromethylenation of difluoroacetates with activated alkenes under mild reaction conditions has been... 
ROOM-TEMPERATURE | PALLADIUM | EFFICIENT ACCESS | CARBON CENTER | LIGHT PHOTOREDOX CATALYSIS | CHEMISTRY, ORGANIC | ELECTRON-DEFICIENT ALKENES | ALPHA,ALPHA-DIFLUOROARYLACETIC ACIDS | ARYLBORONIC ACIDS | CARBOXYLIC-ACIDS | GEM-DIFLUOROMETHYLENATION
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 06/2017, Volume 15, Issue 25, pp. 5308 - 5317
A silver-catalyzed oxidative decarboxylative gem-difluoromethylenation of difluoroacetates with activated alkenes under mild reaction conditions has been... 
Journal Article
Organic Letters, ISSN 1523-7060, 04/2017, Volume 19, Issue 7, pp. 1570 - 1573
A nucleophilic addition reaction of aryl thiols to readily available beta,beta-difluorostyrenes provides alpha,alpha-difluoroalkylthioethers: The reaction... 
VISIBLE-LIGHT | PERFLUOROISOBUTENE | 1,1-DIFLUORO-1-OLEFINS | GEM-DIFLUOROOLEFINATION | CHEMISTRY, ORGANIC | FLUOROALKENE CHEMISTRY | FLUORINATION | RADICAL-ADDITION | CONJUGATE ADDITION | ALKYL-HALIDES | DIFLUOROMETHYLENATION
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 10/2016, Volume 2016, Issue 28, pp. 4916 - 4921
The first AgI‐mediated C–H ethoxycarbonyl difluoromethylation with TMSCF2COOEt (TMS = trimethylsilyl) has been developed. The radical difluoromethylation... 
Silver | Arenes | Regioselectivity | Fluorine | Radicals | ROOM-TEMPERATURE | REAGENTS | FLUOROALKYLATION | CHEMISTRY, ORGANIC | TRIFLUOROMETHYLATION REACTIONS | COPPER | ARYLBORONIC ACIDS | HETEROARENES | ARYL BORONIC ACIDS | CATALYZED DIFLUOROMETHYLATION | GEM-DIFLUOROMETHYLENATION
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 01/2018, Volume 16, Issue 24, pp. 4558 - 4562
An efficient catalytic method for the synthesis of 2,2-difluoro-1,3-benzoxathioles(selenoles) from the reaction of o-bromophenols with... 
Chemical synthesis | Catalysis | Selenium
Journal Article
Asian Journal of Organic Chemistry, ISSN 2193-5807, 10/2019, Volume 8, Issue 10, pp. 1924 - 1932
Thermally‐induced CF2 addition to Cs‐C70(CF3)8 upon reaction with sodium chlorodifluoroacetate is found to proceed via the nucleophilic cyclopropanation... 
carbene addition | nucleophilic cyclopropanation | fluorescence | oxidation | trifluoromethyl | difluoromethylenation | fullerene
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 02/2014, Volume 2014, Issue 5, pp. 928 - 932
The decarboxylation of potassium 2‐pyridinyl sulfonyldifluoroacetate and its subsequent reaction with aldehydes was found to be an efficient approach for the... 
Sulfur | Aldehydes | Fluorine | Olefination | Decarboxylation | CONVERSION | PHENYL SULFONE | CHEMISTRY, ORGANIC | ENZYMES | ISOLABLE 2,2-DIFLUOROVINYLSILANES | INHIBITORS | FUNCTIONALIZED 1,1-DIFLUORO-1-ALKENES | DERIVATIVES | DIFLUOROMETHYLENATION | Sulfur compounds | Fluorides
Journal Article
Chemical Communications: Chem Comm, ISSN 1359-7345, 02/2016, Volume 52, Issue 18, pp. 3657 - 3660
A new method for the generation of the "PhSO sub(2)CF sub(2)Cu" species from readily available difluoromethyl phenyl sulfone (PhSO sub(2)CF sub(2)H) has been... 
Phenyls | Sulfones | Reagents
Journal Article
Topics in Organometallic Chemistry, ISSN 1436-6002, 2014, Volume 52, pp. 113 - 142
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 11/2015, Volume 179, pp. 116 - 120
A one-pot synthesis of gem-difluorostyrenes from benzyl bromide via sequential reactions is described. The sequential reactions, including quarternization of... 
One-pot | Benzyl bromide | Olefination | Phosphonium ylide | gem-Difluorostyrenes | Difluorocarbene | DIFLUOROOLEFINATION | DIFLUOROVINYL | CONVERSION | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | ALDEHYDES | CHEMISTRY, INORGANIC & NUCLEAR | DIFLUOROALKENES | CHEMISTRY | CONCISE SYNTHESIS | DIFLUOROMETHYLENATION | TRIFLUOROMETHYLATION
Journal Article
Chinese Journal of Chemistry, ISSN 1001-604X, 07/2013, Volume 31, Issue 7, pp. 885 - 891
A mild and versatile approach for the direct introduction of ethoxycarbonyldifluoromethyl‐group to heteroarenes via visible‐light photocatalysis has been... 
heteroarenes | visible‐light photocatalysis | difluoromethylenation | visible-light photocatalysis | ROOM-TEMPERATURE | AROMATIC-COMPOUNDS | CHEMISTRY, MULTIDISCIPLINARY | PHOTOREDOX CATALYSIS | ARYL BROMIDES | MEDICINAL CHEMISTRY | IODIDES | CROSS-COUPLING REACTIONS | SYNTHETIC APPLICATIONS | FLUORINE | TRIFLUOROMETHYLATION
Journal Article
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