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Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 7519 - 12
In silico network-based methods have shown promising results in the field of drug development. Yet, most of networks used in the previous research have not... 
SYSTEM | DATABASE | RENIN | GENE | PATHWAY | MULTIDISCIPLINARY SCIENCES | TISSUE | KEGG | NEBIVOLOL | HYPERTENSION | BLOOD-PRESSURE | Hematologic Diseases - pathology | Liver - pathology | Metabolic Diseases - pathology | Respiratory Tract Diseases - metabolism | Kidney - pathology | Skin - metabolism | Hematologic Diseases - metabolism | Humans | Muscle, Skeletal - metabolism | Respiratory Tract Diseases - drug therapy | Respiratory Tract Diseases - genetics | Brain - metabolism | Musculoskeletal Diseases - pathology | Kidney - metabolism | Liver - drug effects | Muscle, Skeletal - drug effects | Myocardium - metabolism | Nervous System Diseases - metabolism | Nutrition Disorders - pathology | Computational Biology - methods | Kidney - drug effects | Liver - metabolism | Nervous System Diseases - drug therapy | Connective Tissue Diseases - metabolism | Neoplasms - drug therapy | Brain - drug effects | Connective Tissue Diseases - drug therapy | Connective Tissue Diseases - pathology | Lung - drug effects | Brain - pathology | Hematologic Diseases - genetics | Prescription Drugs - pharmacokinetics | Digestive System Diseases - pathology | Neoplasms - metabolism | Cardiovascular Diseases - drug therapy | Drugs, Investigational - pharmacokinetics | Respiratory Tract Diseases - pathology | Hematologic Diseases - drug therapy | Metabolic Diseases - drug therapy | Cardiovascular Diseases - pathology | Nervous System Diseases - genetics | Cardiovascular Diseases - genetics | Musculoskeletal Diseases - genetics | Neoplasms - genetics | Lung - metabolism | Skin - pathology | Nervous System Diseases - pathology | Lung - pathology | Musculoskeletal Diseases - drug therapy | Cardiovascular Diseases - metabolism | Musculoskeletal Diseases - metabolism | Nutrition Disorders - drug therapy | Nutrition Disorders - genetics | Myocardium - pathology | Organ Specificity | Digestive System Diseases - genetics | Algorithms | Digestive System Diseases - drug therapy | Nutrition Disorders - metabolism | Metabolic Diseases - metabolism | Digestive System Diseases - metabolism | Metabolic Diseases - genetics | Connective Tissue Diseases - genetics | Muscle, Skeletal - pathology | Neoplasms - pathology | Skin - drug effects | Drug development | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0141847 - e0141847
The clinical manifestations of chronic Chagas disease include the cardiac form of the disease and the digestive form. Not all the factors that act in the... 
CHEMOKINE RECEPTOR EXPRESSION | HIV-1 | CRUZI-ELICITED MYOCARDITIS | TRYPANOSOMA-CRUZI | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | CARDIOMYOPATHY | MONONUCLEAR-CELLS | INFECTION | HARDY-WEINBERG EQUILIBRIUM | T-CELLS | Gene Frequency - genetics | Genetic Predisposition to Disease | Chagas Cardiomyopathy - genetics | Humans | Middle Aged | Receptors, CCR5 - genetics | Male | Systole | Case-Control Studies | Digestive System Diseases - genetics | Chagas Cardiomyopathy - physiopathology | Chagas Disease - physiopathology | Genes, Dominant | Heart Ventricles - physiopathology | Aged, 80 and over | Inheritance Patterns - genetics | Polymorphism, Single Nucleotide - genetics | Adult | Female | Aged | Models, Genetic | Chagas Disease - genetics | Chronic Disease | Complications and side effects | Genetic susceptibility | Genetic research | Genetic aspects | Research | Chagas' disease | Cardiovascular diseases | Health aspects | Genetic polymorphisms | Risk factors | Heart | Cardiomyopathy | Antibodies | Infections | Arthritis | Heart diseases | Enzyme-linked immunosorbent assay | Genotypes | Vector-borne diseases | Protozoa | CCR5 protein | Parasitology | Cytokines | Blood & organ donations | Inflammation | Statistical tests | Disease control | Patients | Equilibrium | Coronary artery disease | Polymerase chain reaction | Studies | Restriction fragment length polymorphism | Ventricle | Chemokines | Polymorphism | Index Medicus
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 07/2018, Volume 12, Issue 7, pp. e0006589 - e0006589
Chronic chagasic cardiomyopathy (CCC) is observed in 30% to 50% of the individuals infected by Trypanosoma cruzi and heart failure is the important cause of... 
C-REACTIVE PROTEIN | CLINICAL FORMS | VENTRICULAR-ARRHYTHMIAS | HEART-DISEASE | NUCLEAR-FACTOR | IFN-GAMMA | TRYPANOSOMA-CRUZI INFECTION | T-CELLS | PARASITOLOGY | TROPICAL MEDICINE | NALP3 INFLAMMASOME | CUTTING EDGE | Chagas Cardiomyopathy - immunology | Chagas Cardiomyopathy - parasitology | Chagas Cardiomyopathy - genetics | Interleukin-12 - genetics | Humans | Middle Aged | NLR Proteins - genetics | Interleukin-1beta - immunology | Male | Caspase 1 - immunology | Interleukin-1beta - genetics | NLR Proteins - immunology | Digestive System Diseases - genetics | Trypanosoma cruzi - physiology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Caspase 1 - genetics | Interleukin-12 - immunology | Digestive System Diseases - immunology | Adult | Female | Aged | Digestive System Diseases - parasitology | Immune response | Cardiomyopathy | Cardiac patients | Patient outcomes | Genetic aspects | Research | Gene expression | Health aspects | Heart diseases | Risk factors | Protein binding | Heart | Pathogenesis | Funding | Leukocytes (mononuclear) | Interleukin 23 | Nucleotides | Immunity | Caspase-1 | Proteins | Signal transduction | Receptors | Pathogens | Antigens | Parasitology | Cytokines | Adapters | Interleukin 12 | Tumor necrosis factor-α | Patients | Interleukin 18 | TLR2 protein | Rectum | MyD88 protein | Chagas' disease | Ejection | Correlation | β-Interferon | Innate immunity | Lymphocytes T | Infections | Parasites | Interleukin 6 | Molecules | Lymphocytes | Toll-like receptors | Peripheral blood mononuclear cells | Supervision | Vector-borne diseases | Protozoa | Caspase | Population decline | Immune systems | TLR1 protein | Lymphocytes B | Levels | Ventricle | Index Medicus
Journal Article
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 9/2018, Volume 82, Issue 3, pp. 421 - 428
Digestive tract cancer patients treated with oxaliplatin are often associated with the development of peripheral neuropathy. The aim of the present study is to... 
Single-nucleotide polymorphisms | Oxaliplatin | Medicine & Public Health | Digestive tract cancer | Oncology | Cancer Research | Pharmacology/Toxicology | Peripheral neuropathy | Cyclin H | MULTICENTER | CUMULATIVE NEUROPATHY | PHASE-II | NEUROTOXICITY | CHEMOTHERAPY | GEMCITABINE | COLON-CANCER | CAPECITABINE | ONCOLOGY | COLORECTAL-CANCER | PHARMACOLOGY & PHARMACY | ILEVAL | Cell Cycle - genetics | Digestive System Neoplasms - metabolism | Peripheral Nervous System Diseases - chemically induced | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Prospective Studies | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Oxaliplatin - adverse effects | Oxaliplatin - pharmacokinetics | Young Adult | Digestive System Neoplasms - drug therapy | Adult | Female | Oxaliplatin - administration & dosage | Peripheral Nervous System Diseases - genetics | Digestive System Neoplasms - genetics | Genetic Predisposition to Disease | Aged | Polymorphism, Single Nucleotide | Cell Cycle - drug effects | Cohort Studies | Cyclin H - genetics | Antimitotic agents | Chemotherapy | Care and treatment | Analysis | Genes | Physiological aspects | Genetic research | Development and progression | Genetic aspects | Single nucleotide polymorphisms | Antineoplastic agents | Cancer | Excretion | Chloroform | Detoxification | Single-nucleotide polymorphism | Metabolism | Patients | Incidence | Genetic variance | Genotyping | Glutathione transferase | Cell cycle | Peripheral blood | Phenols | H gene | Digestive tract | Deoxyribonucleic acid--DNA
Journal Article
Traffic, ISSN 1398-9219, 11/2018, Volume 19, Issue 11, pp. 879 - 892
Journal Article