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2011, ISBN 1459700570, 240
Book
European Journal of Heart Failure, ISSN 1388-9842, 08/2005, Volume 7, Issue 5, pp. 710 - 721
Surveys of prescribing patterns in both hospitals and primary care have usually shown delays in translating the evidence from clinical trials of... 
Heart failure | Isosorbide dinitrate | Beta‐blockers | Digoxin | Angiotensin receptor blockers | Pharmacology | Aldosterone antagonists | Treatment | Eplerenone | Spironolactone | Hydralazine | ACE inhibitors | Clinical recommendations | Beta-blockers | VENTRICULAR SYSTOLIC DYSFUNCTION | heart failure | treatment | CARDIAC & CARDIOVASCULAR SYSTEMS | angiotensin receptor blockers | QUALITY-OF-CARE | hydralazine | eplerenone | isosorbide dinitrate | RANDOMIZED INTERVENTION TRIAL | beta-blockers | MEDICAL-TREATMENT | GENERAL-PRACTICE | digoxin | spironolactone | CONVERTING-ENZYME-INHIBITORS | clinical recommendations | CARDIAC-INSUFFICIENCY | pharmacology | NATIONAL-SURVEY | aldosterone antagonists | ELDERLY-PATIENTS | Benzopyrans - therapeutic use | Valsartan | Angiotensin Receptor Antagonists | Bisoprolol - therapeutic use | Humans | Carbazoles - administration & dosage | Heart Failure - physiopathology | Valine - administration & dosage | Enalapril - therapeutic use | Ethanolamines - administration & dosage | Indoles - administration & dosage | Ramipril - administration & dosage | Captopril - therapeutic use | Propanolamines - therapeutic use | Lisinopril - therapeutic use | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Benzimidazoles - administration & dosage | Tetrazoles - administration & dosage | Ramipril - therapeutic use | Drug Therapy, Combination | Enalapril - administration & dosage | Spironolactone - therapeutic use | Adrenergic beta-Antagonists - administration & dosage | Adrenergic beta-Antagonists - therapeutic use | Benzimidazoles - therapeutic use | Lisinopril - administration & dosage | Nebivolol | Valine - analogs & derivatives | Metoprolol - therapeutic use | Metoprolol - administration & dosage | Evidence-Based Medicine | Angiotensin-Converting Enzyme Inhibitors - administration & dosage | Bisoprolol - administration & dosage | Heart Failure - drug therapy | Mineralocorticoid Receptor Antagonists - therapeutic use | Stroke Volume | Benzopyrans - administration & dosage | Captopril - administration & dosage | Guideline Adherence | Ethanolamines - therapeutic use | Indoles - therapeutic use | Metoprolol - analogs & derivatives | Tetrazoles - therapeutic use | Valine - therapeutic use | Carbazoles - therapeutic use | Propanolamines - administration & dosage | Practice Guidelines as Topic | Prescription writing | Corticosteroids | Isosorbide mononitrate | Family medicine | Nitrates | Peptide hormones | Aldosterone | Preventive health services | Cardiac patients | Angiotensin | Antiandrogens | Medicine, Preventive | Steroids | Kardiologi | converting-enzyme-inhibitors | Cardiac and Cardiovascular Systems | randomized intervention trial | quality-of-care | elderly-patients | cardiac-insufficiency | national-survey | medical-treatment | ventricular systolic dysfunction | general-practice
Journal Article
BMC Nephrology, ISSN 1471-2369, 10/2015, Volume 16, Issue 1, p. 158
Background: Dose adjustment for certain drugs is required in patients with reduced renal function to avoid toxicity as many drugs are eliminated by the... 
Prospective | Dose adjustment | Renal impairment | DOSING ADJUSTMENTS | ERRORS | DIET | UROLOGY & NEPHROLOGY | CHRONIC KIDNEY-DISEASE | Prospective Studies | Spironolactone - administration & dosage | Humans | Middle Aged | Fluconazole - administration & dosage | Antihypertensive Agents - administration & dosage | Male | Young Adult | Drug Dosage Calculations | Aged, 80 and over | Adult | Female | Cimetidine - administration & dosage | Enalapril - administration & dosage | Pharmaceutical Preparations - administration & dosage | Medication Errors | Severity of Illness Index | Diuretics - administration & dosage | Vancomycin - administration & dosage | Cross-Sectional Studies | Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage | Hospitalization | Acute Kidney Injury - physiopathology | Anti-Arrhythmia Agents - administration & dosage | Creatinine - urine | Renal Insufficiency, Chronic - physiopathology | Anti-Ulcer Agents - administration & dosage | Gout Suppressants - administration & dosage | Drug Prescriptions - statistics & numerical data | Allopurinol - administration & dosage | Digoxin - administration & dosage | Adolescent | Ceftazidime - administration & dosage | Creatinine - blood | Aged | Anti-Bacterial Agents - administration & dosage | Antifungal Agents - administration & dosage | Ethiopia | Drugs | Prescribing | Medical research | Hospital patients | Prescription writing | Analysis | Medicine, Experimental | Medical care | Quality management
Journal Article
Journal of Nephrology, ISSN 1121-8428, 12/2014, Volume 27, Issue 6, pp. 659 - 666
The novel iron-based phosphate binder sucroferric oxyhydroxide is being investigated for the treatment of hyperphosphatemia. Patients with chronic kidney... 
Nephrology | Phase I | Medicine & Public Health | Urology/Andrology | Hyperphosphatemia | Chronic kidney disease | Pharmacokinetics | Sucroferric oxyhydroxide | MORTALITY | PHOSPHORUS | PHOSPHATE BINDER | BIOAVAILABILITY | INDIVIDUALS | DIALYSIS PATIENTS | PA21 | CALCIUM | UROLOGY & NEPHROLOGY | HEMODIALYSIS | CHRONIC KIDNEY-DISEASE | Digoxin - adverse effects | Diuretics - pharmacokinetics | Chelating Agents - administration & dosage | Humans | Middle Aged | Half-Life | Male | Metabolic Clearance Rate | Angiotensin II Type 1 Receptor Blockers - pharmacokinetics | Warfarin - administration & dosage | Young Adult | Drug Interactions | Proton Pump Inhibitors - administration & dosage | Cardiotonic Agents - adverse effects | Diuretics - blood | Angiotensin II Type 1 Receptor Blockers - administration & dosage | Diuretics - administration & dosage | Risk Assessment | Furosemide - pharmacokinetics | Cardiotonic Agents - pharmacokinetics | Omeprazole - administration & dosage | Sucrose - adverse effects | Anticoagulants - adverse effects | Anticoagulants - blood | Cardiotonic Agents - administration & dosage | Models, Biological | Ferric Compounds - adverse effects | Losartan - administration & dosage | Diuretics - adverse effects | Furosemide - administration & dosage | Angiotensin II Type 1 Receptor Blockers - adverse effects | Anticoagulants - administration & dosage | Area Under Curve | Losartan - blood | Omeprazole - blood | Warfarin - adverse effects | Ferric Compounds - administration & dosage | Healthy Volunteers | Furosemide - adverse effects | Adult | Female | Proton Pump Inhibitors - blood | Digoxin - blood | Losartan - pharmacokinetics | Chelating Agents - adverse effects | Furosemide - blood | Sucrose - administration & dosage | Proton Pump Inhibitors - adverse effects | Drug Administration Schedule | Omeprazole - adverse effects | Omeprazole - pharmacokinetics | Models, Statistical | Digoxin - pharmacokinetics | Warfarin - pharmacokinetics | Proton Pump Inhibitors - pharmacokinetics | Digoxin - administration & dosage | Cardiotonic Agents - blood | Warfarin - blood | Losartan - adverse effects | Anticoagulants - pharmacokinetics | Angiotensin II Type 1 Receptor Blockers - blood | Drug Combinations | Original
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 04/2011, Volume 51, Issue 4, pp. 575 - 585
Drug interactions are a significant clinical concern, particularly in patients with conditions such as heart disease and hypertension, in whom coadministration... 
Nebivolol | pharmacokinetics | β‐blockers | drug‐drug interactions | CYP2D6 | vasodilating | β-blockers | Drug-drug interactions | Vasodilating | Pharmacokinetics | MANAGEMENT | beta-blockers | PREVALENCE | DISPOSITION | drug-drug interactions | PROFILE | METABOLISM | PHARMACOLOGY & PHARMACY | HYPERTENSION | Furosemide - administration & dosage | Hydrochlorothiazide - pharmacokinetics | Fluoxetine - pharmacokinetics | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Male | Ethanolamines - administration & dosage | Warfarin - administration & dosage | Ramipril - administration & dosage | Young Adult | Ethanolamines - pharmacokinetics | Drug Interactions | Adult | Female | Losartan - pharmacokinetics | Cytochrome P-450 CYP2D6 - genetics | Furosemide - pharmacokinetics | Genotype | Ramipril - pharmacokinetics | Hydrochlorothiazide - administration & dosage | Antihypertensive Agents - pharmacokinetics | Digoxin - pharmacokinetics | Warfarin - pharmacokinetics | Benzopyrans - administration & dosage | Digoxin - administration & dosage | Benzopyrans - pharmacokinetics | Fluoxetine - administration & dosage | Cytochrome P-450 CYP2D6 - metabolism | Losartan - administration & dosage | Dosage and administration | Research | Drug interactions | Hypertension | Prescription drugs | Genetics | Index Medicus | Cytochrome | Drugs | Warfarin | Fluoxetine | Cytochrome P450 | Hydrochlorothiazide | digoxin | furosemide | Drug interaction | Heart diseases | CYP2D6 protein | Genotypes
Journal Article
International Journal of Clinical Pharmacology and Therapeutics, ISSN 0946-1965, 01/2015, Volume 53, Issue 1, pp. 41 - 53
Objective: Drug-drug interactions between canagliflozin, a sodium glucose co-transporter 2 inhibitor approved for the management of type-2 diabetes mellitus,... 
Warfarin | Oral contraceptive | Canagliflozin | Digoxin | Drug-drug interaction | LEVONORGESTREL | MANAGEMENT | VOLUNTEERS | PHARMACODYNAMICS | digoxin | warfarin | P-GLYCOPROTEIN | TRANSPORT | THERAPY | METABOLISM | canagliflozin | PHARMACOLOGY & PHARMACY | drug-drug interaction | oral contraceptive | EMPAGLIFLOZIN | Ethinyl Estradiol - blood | Anticoagulants - administration & dosage | Ethinyl Estradiol - pharmacokinetics | Thiophenes - adverse effects | Area Under Curve | Contraceptives, Oral, Combined - pharmacokinetics | Humans | Middle Aged | Half-Life | Male | Metabolic Clearance Rate | Thiophenes - administration & dosage | Healthy Volunteers | Warfarin - administration & dosage | Young Adult | Drug Dosage Calculations | Drug Interactions | Polypharmacy | Hypoglycemic Agents - administration & dosage | Levonorgestrel - pharmacokinetics | Adult | Female | Ethinyl Estradiol - administration & dosage | Contraceptives, Oral, Combined - administration & dosage | Digoxin - blood | Glucosides - adverse effects | Drug Administration Schedule | Risk Assessment | Sodium-Glucose Transporter 2 - metabolism | Cardiotonic Agents - pharmacokinetics | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Anticoagulants - blood | Digoxin - pharmacokinetics | Warfarin - pharmacokinetics | Cross-Over Studies | International Normalized Ratio | Cardiotonic Agents - administration & dosage | Blood Coagulation - drug effects | Digoxin - administration & dosage | Glucosides - administration & dosage | Cardiotonic Agents - blood | Levonorgestrel - administration & dosage | Levonorgestrel - blood | Warfarin - blood | Anticoagulants - pharmacokinetics | Hypoglycemic Agents - adverse effects | Contraceptives, Oral, Combined - blood
Journal Article
JAMA, ISSN 0098-7484, 01/2009, Volume 301, Issue 4, pp. 383 - 392
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2010, Volume 56, Issue 25, pp. 2090 - 2100
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 04/2014, Volume 54, Issue 4, pp. 422 - 431
Journal Article
Drug Safety, ISSN 0114-5916, 9/2017, Volume 40, Issue 9, pp. 835 - 840
Digoxin is commonly prescribed to elderly patients with heart failure and atrial fibrillation, and macrolide antibiotics markedly increase the risk of digoxin... 
Medicine & Public Health | Drug Safety and Pharmacovigilance | Pharmacology/Toxicology | CLARITHROMYCIN | MANAGEMENT | HEART-FAILURE | GUIDELINES | CARDIAC-ARRHYTHMIA | AZITHROMYCIN | ATRIAL-FIBRILLATION | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | INHIBITION | INCREASED MORTALITY | PHARMACOLOGY & PHARMACY | UPDATE | TOXICOLOGY | Digoxin - adverse effects | Cefuroxime - adverse effects | Humans | Male | Azithromycin - administration & dosage | Case-Control Studies | Drug Interactions | Aged, 80 and over | Clarithromycin - administration & dosage | Female | Anti-Bacterial Agents - adverse effects | Cefuroxime - administration & dosage | Death, Sudden - epidemiology | Macrolides - administration & dosage | Atrial Fibrillation - drug therapy | Clarithromycin - adverse effects | Risk Factors | Erythromycin - administration & dosage | Heart Failure - drug therapy | Azithromycin - adverse effects | Erythromycin - adverse effects | Macrolides - adverse effects | Cardiotonic Agents - administration & dosage | Digoxin - administration & dosage | Aged | Anti-Bacterial Agents - administration & dosage | Ontario | Macrolide antibiotics | Usage | Dosage and administration | Sudden death | Risk factors | Elderly people | Heart | Cardiac arrhythmia | Clarithromycin | Digoxin | Toxicity | Azithromycin | Risk | Population studies | Confidence intervals | Cefuroxime | Fibrillation | Safety engineering | Population | Heart diseases | Heart failure | Statistical analysis | Risk groups | Mortality | Erythromycin | Patients | Studies | Prescription drugs | Antibiotics | Death | Health risk assessment | Elderly | Geriatrics
Journal Article