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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism | Index Medicus
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 2270 - 2270
Drugs that mirror the cellular effects of starvation mimics are considered promising therapeutics for common metabolic disorders, such as obesity, liver... 
LOOP-HELIX PROTEIN | REGULATOR | ACTIVATED PROTEIN-KINASE | LIPID-METABOLISM | MULTIDISCIPLINARY SCIENCES | CALCIUM | CALCINEURIN | RECEPTOR | AUTOPHAGY | ENERGY-METABOLISM | LYSOSOMAL BIOGENESIS | Biguanides - pharmacology | Calcium - metabolism | Caloric Restriction | Longevity - drug effects | Humans | Metabolic Syndrome - metabolism | Autophagy - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - agonists | Autophagosomes - drug effects | Lysosomes - metabolism | Liver - drug effects | Diet, High-Fat | Lactams - pharmacology | Lysosomes - drug effects | Starvation | Caenorhabditis elegans - metabolism | Fatty Liver - metabolism | Liver - metabolism | Enzyme Inhibitors - pharmacology | Mitochondria - metabolism | Autophagosomes - metabolism | Mitochondria - drug effects | Digoxin - pharmacology | Animals | Caenorhabditis elegans - drug effects | High-Throughput Screening Assays | Lipid Metabolism - drug effects | Mice | HeLa Cells | Drugs | Animal models | Digoxin | Calcium | Biodegradability | Liver | Disorders | Autophagy | Nanoparticles | Dietary restrictions | Mitochondria | Fatty liver | Biocompatibility | Lipid metabolism | Biodegradation | Metabolic diseases | Lead compounds | Metabolism | Steatosis | Mode of action | Life span | Nematodes | Aging (natural) | Metabolic disorders | Nanotechnology | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2017, Volume 45, Issue 7, pp. 755 - 764
To assess drug-drug interaction (DDI) potential for the three directacting antiviral (3D) regimen of ombitasvir, dasabuvir, and paritaprevir, in vitro studies... 
METABOLISM | PHARMACOKINETICS | INTERACTION PROFILE | TRANSPORTERS | DIGOXIN | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | INHIBITOR | DISPOSITION | P-GLYCOPROTEIN | RITONAVIR | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 Enzyme Inhibitors - metabolism | Male | Antiviral Agents - metabolism | Macrocyclic Compounds - pharmacology | Carbamates - metabolism | Uracil - pharmacology | HEK293 Cells | Female | Membrane Transport Proteins - metabolism | Ritonavir - pharmacology | Carbamates - pharmacology | Hepacivirus - drug effects | Cell Line | Antiviral Agents - pharmacology | Anilides - metabolism | Macrocyclic Compounds - metabolism | Sulfonamides - pharmacology | Ritonavir - metabolism | Anilides - pharmacology | Drug Interactions - physiology | Sulfonamides - metabolism | Uracil - metabolism | Uracil - analogs & derivatives | Plasma | Ritonavir | Viruses | Hepatitis | Dynamic models | Drug interaction | P-Glycoprotein | Static models | Inducers | Glucuronosyltransferase | Antiviral agents | UDP-glucuronosyltransferase | Drug interactions | Glycoprotein | Substrate inhibition | Breast cancer | Pharmacology | Exposure | Substrates | Organic anion transporting polypeptide | Liability | Inhibitors | Predictions | Hepatitis C virus | Hepatitis C | Transporter | Cancer | Index Medicus
Journal Article
Cancer Letters, ISSN 0304-3835, 04/2015, Volume 359, Issue 1, pp. 107 - 116
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 850 - 17
The capacity of HIV-1 to develop resistance to current drugs calls for innovative strategies to control this infection. We aimed at developing novel inhibitors... 
CANCER-CELLS | GLYCOSIDES | CALCIUM OSCILLATIONS | SODIUM-PUMP | NA,K-ATPASE | MULTIDISCIPLINARY SCIENCES | GROWTH | NA+/K+-ATPASE | DRUG-RESISTANCE | CARDIOTONIC STEROIDS | PROTEIN-KINASES | Cardiac Glycosides - pharmacology | Leukocytes, Mononuclear - metabolism | Gene Expression Regulation, Viral - drug effects | Sodium-Potassium-Exchanging ATPase - genetics | Humans | Serine-Arginine Splicing Factors - metabolism | Leukocytes, Mononuclear - virology | gag Gene Products, Human Immunodeficiency Virus - metabolism | HIV Infections - pathology | RNA Interference | RNA, Viral - metabolism | gag Gene Products, Human Immunodeficiency Virus - genetics | HIV-1 - metabolism | Virus Replication - drug effects | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | HIV-1 - drug effects | Digoxin - chemistry | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | HIV-1 - genetics | Digoxin - pharmacology | Sodium-Potassium-Exchanging ATPase - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Cardiac Glycosides - chemistry | Leukocytes, Mononuclear - cytology | HeLa Cells | HIV Infections - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Heart | Calcium (intracellular) | Digoxin | Aglycones | Extracellular signal-regulated kinase | Lymphocytes T | Na+/K+-exchanging ATPase | Gene expression | Drug resistance | Tat protein | Replication | RNA processing | Steroid hormones | Regulatory proteins | Index Medicus
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 2011, Volume 43, Issue 4, pp. 297 - 307
While the utility of cryopreserved human hepatocyte suspensions (CHHS) for drug metabolism assays has been established, less is known about the effects of... 
Drug transport | Cryopreserved human hepatocytes | Drug interaction | OATP | Hepatic drug uptake | NTCP | COLLAGEN-SANDWICH CONFIGURATION | CHOLYL-GLYCYLAMIDO-FLUORESCEIN | METABOLIC-CLEARANCE | HEPATIC-UPTAKE | HEPATOBILIARY DISPOSITION | PROTEASE INHIBITORS | ORGANIC CATION TRANSPORTERS | CULTURED RAT HEPATOCYTES | PHARMACOLOGY & PHARMACY | HUMAN LIVER | ANION TRANSPORTER | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Corticosterone - pharmacology | Digoxin - metabolism | Taurocholic Acid - metabolism | Humans | Middle Aged | Male | Organic Cation Transporter 1 - metabolism | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Organic Cation Transport Proteins - antagonists & inhibitors | Biological Transport | Cryopreservation | Organic Anion Transporters, Sodium-Independent - metabolism | Prazosin - pharmacology | Adult | Membrane Transport Proteins - metabolism | 1-Methyl-4-phenylpyridinium - metabolism | Solute Carrier Organic Anion Transporter Family Member 1B3 | Estradiol - metabolism | Organic Cation Transport Proteins - metabolism | RNA, Messenger - genetics | Symporters - metabolism | Estrone - analogs & derivatives | Estrone - metabolism | Adolescent | Organic Cation Transporter 1 - antagonists & inhibitors | Rifampin - pharmacology | Organic Anion Transporters, Sodium-Dependent - metabolism | Messenger RNA | Gastrointestinal agents | Peptides | Digoxin | Corticosterone | Analysis | Drug interactions | Sulfates | Rifampin | Estradiol | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2013, Volume 144, Issue 1, pp. 179 - 191.e4
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, pp. e69394 - e69394
We have reported that the P-gp substrate digoxin required basolateral and apical uptake transport in excess of that allowed by digoxin passive permeability (as... 
MEMBRANE TRANSPORTERS | IN-VITRO | EFFLUX | MULTIDISCIPLINARY SCIENCES | CONFLUENT MONOLAYER | GLYCOPROTEIN | CANDIDATES | PHARMACEUTICAL DRUGS | IDENTIFICATION | CACO-2 CELLS | MDCKII-HMDR1 CELLS | Vinblastine - metabolism | Digoxin - metabolism | Cyclosporine - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Ketoconazole - metabolism | Ketoconazole - pharmacology | Carbamates - metabolism | Madin Darby Canine Kidney Cells | Digoxin - antagonists & inhibitors | Cyclosporine - metabolism | Carbamates - pharmacology | Caco-2 Cells | Quinidine - metabolism | Tetrahydroisoquinolines - pharmacology | Gene Expression | Acridines - metabolism | Loperamide - pharmacology | Quinidine - pharmacology | Sulfonamides - pharmacology | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Cell Membrane Permeability - drug effects | Dogs | Sulfonamides - metabolism | Protein Binding | Loperamide - metabolism | Vinblastine - pharmacology | Kinetics | Loperamide | Permeability | Ketoconazole | Digoxin | Analysis | Monomolecular films | Drugs | Biotechnology | Cyclosporins | Membrane permeability | Biochemistry | Biology | Kinases | MDR1 protein | Inhibition | P-Glycoprotein | Dimerization | Efflux | Enzymes | Vinblastine | Glycoproteins | Metabolism | Substrates | Quinidine | Cell lines | Verapamil | Transport | Amprenavir | Transporter | Cancer | Pharmaceuticals | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2016, Volume 36, Issue 6, pp. 1186 - 1196
OBJECTIVE—Although inhibitors of vascular endothelial growth factor (VEGF) provide benefit for the management of neovascular retinopathies, their use is... 
DIABETIC-RETINOPATHY | ACTIVATION | ANGIOGENESIS | BEVACIZUMAB | ALPHA | retinoic acid receptor | DEGENERATION | interleukin-17 | ganglion cells | retina | DIGOXIN | PERIPHERAL VASCULAR DISEASE | macroglia | CELL-DIFFERENTIATION | HEMATOLOGY | microglia | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Retina - drug effects | Tumor Necrosis Factor-alpha - metabolism | Microglia - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - antagonists & inhibitors | Retina - metabolism | Retinal Neovascularization - immunology | Ependymoglial Cells - metabolism | Retinopathy of Prematurity - immunology | Placenta Growth Factor - metabolism | Retina - immunology | Retinal Neovascularization - metabolism | Vascular Endothelial Growth Factor A - metabolism | Retinal Ganglion Cells - metabolism | Microglia - immunology | Hyperoxia - complications | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Microglia - pathology | Retinal Neovascularization - prevention & control | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Disease Models, Animal | Microglia - drug effects | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | Interleukin-17 - genetics | Retinal Ganglion Cells - immunology | Ependymoglial Cells - drug effects | Ependymoglial Cells - immunology | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Digoxin - pharmacology | Interleukin-17 - metabolism | Animals | Interleukin-17 - antagonists & inhibitors | Signal Transduction - drug effects | Retinopathy of Prematurity - prevention & control | Retinopathy of Prematurity - metabolism | Thiazoles - pharmacology | Retina - pathology | Retinal Ganglion Cells - drug effects | Retinal Neovascularization - pathology | Retinopathy of Prematurity - pathology | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2017, Volume 32, Issue 1, pp. 71 - 87.e7
Journal Article