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Book
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 02/2018, Volume 58, Issue 2, pp. 202 - 211
Rolapitant is a selective and long‐acting neurokinin‐1 receptor antagonist approved in an oral formulation in combination with other antiemetic agents for the... 
neurokinin‐1 (NK‐1) | drug‐drug interactions | P‐glycoprotein (P‐gp) | breast cancer resistance protein (BCRP) | antiemetics | chemotherapy‐induced nausea and vomiting (CINV) | drug-drug interactions | P-glycoprotein (P-gp) | chemotherapy-induced nausea and vomiting (CINV) | neurokinin-1 (NK-1) | CHEMOTHERAPY-INDUCED NAUSEA | EFFICACY | VOMITING CINV | PREVENTION | RECEPTOR ANTAGONIST | HIGHLY EMETOGENIC CHEMOTHERAPY | TRANSPORT | DRUG DEVELOPMENT | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | ABCG2 | Neurokinin-1 Receptor Antagonists - adverse effects | ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism | Administration, Oral | Humans | Middle Aged | Spiro Compounds - administration & dosage | Male | Neurokinin-1 Receptor Antagonists - administration & dosage | Healthy Volunteers | Neoplasm Proteins - metabolism | Spiro Compounds - adverse effects | Digoxin - pharmacokinetics | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Administration, Intravenous | Drug Interactions | Sulfasalazine - pharmacokinetics | Adult | Female | Prevention | Nausea | Pharmacokinetics | Vomiting | Analysis | EKG | Intravenous administration | Digoxin | Toxicity | Glycoprotein | Glycoproteins | Breast cancer | Pharmacology | Substrates | Confidence intervals | Chemotherapy | Neurokinin NK1 receptors | Neurokinin | Sulfasalazine | Adults | P-Glycoprotein | Cancer | Index Medicus
Journal Article
Advances in Therapy, ISSN 0741-238X, 2/2012, Volume 29, Issue 2, pp. 163 - 177
Coronary heart disease, stroke, and peripheral vascular disease are the most common causes of mortality in patients with type 2 diabetes mellitus (T2DM). The... 
dapagliflozin | pharmacodynamics | Rheumatology | simvastatin | sodium glucose co-transporter-2 | Internal Medicine | Oncology | digoxin | warfarin | type 2 diabetes | Medicine & Public Health | pharmacokinetics | valsartan | Cardiology | Pharmacology/Toxicology | Endocrinology | MEDICINE, RESEARCH & EXPERIMENTAL | SELECTIVE SGLT2 INHIBITOR | HEALTHY-SUBJECTS | HUMANS | INADEQUATE GLYCEMIC CONTROL | DIABETES-MELLITUS | POTENT | HYPERGLYCEMIA | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | TYPE-2 | ASSOCIATION | Hypoglycemic Agents - pharmacokinetics | Benzhydryl Compounds | Valsartan | Valine - pharmacokinetics | Humans | Middle Aged | Valine - analogs & derivatives | Male | Glucosides - pharmacokinetics | Antihypertensive Agents - pharmacokinetics | Simvastatin - pharmacokinetics | Anti-Arrhythmia Agents - pharmacokinetics | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Digoxin - pharmacokinetics | Warfarin - pharmacokinetics | Cross-Over Studies | Anticholesteremic Agents - pharmacokinetics | Drug Interactions | Adult | Female | Anticoagulants - pharmacokinetics | Diabetes Mellitus, Type 2 - drug therapy | Tetrazoles - pharmacokinetics | Type 2 diabetes | Warfarin | Digoxin | Simvastatin | Drug interactions | Anticoagulants (Medicine) | Glucose | Dextrose | Antilipemic agents | Cardiac glycosides | Blood circulation disorders | Cardiotonic agents | Cardiac patients | Diabetes | Heart diseases
Journal Article
Journal Article
Journal Article
Antiviral Therapy, ISSN 1359-6535, 2012, Volume 17, Issue 7, pp. 1211 - 1221
Telaprevir is an inhibitor of the HCV NS3/4A protease. When used in combination with pegylated interferon and ribavirin, telaprevir has demonstrated a... 
INFECTIOUS DISEASES | RENAL IMPAIRMENT | PROTEASE INHIBITORS | P-GLYCOPROTEIN | AMLODIPINE | VIROLOGY | HEPATITIS-C VIRUS | METHADONE | ALPRAZOLAM | DIGOXIN | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | RITONAVIR
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
Journal Article
Journal Article