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Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 6/2014, Volume 29, Issue 3, pp. 379 - 387
Abstract Recent advances in microbial genomics, synthetic organic chemistry and X-ray crystallography provided opportunities to identify novel antibacterial... 
carbonic anhydrase | Antibacterial | dihydropteroate synthase | sulfa drug | trimethoprim | dihydrofolate reductase | Trimethoprim | Dihydropteroate synthase | Sulfa drug | Dihydrofolate reductase | Carbonic anhydrase | HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHATE | CHEMISTRY, MEDICINAL | BACTERIUM VIBRIO-CHOLERAE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SULFONAMIDE RESISTANCE | ATMOSPHERIC CO2 | SOIL-MICROORGANISMS | PLASMODIUM-FALCIPARUM | STAPHYLOCOCCUS-AUREUS | HELICOBACTER-PYLORI | ENZYMATIC SYNTHESIS | Trimethoprim - chemical synthesis | Bacterial Proteins - antagonists & inhibitors | Trimethoprim - pharmacology | Tetrahydrofolate Dehydrogenase - chemistry | Antimetabolites - chemical synthesis | Dihydropteroate Synthase - antagonists & inhibitors | Bacteria - drug effects | Bacterial Proteins - chemistry | Enzyme Inhibitors - pharmacology | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrases - chemistry | Enzyme Inhibitors - chemical synthesis | Anti-Bacterial Agents - chemical synthesis | Trimethoprim - analogs & derivatives | Dihydropteroate Synthase - chemistry | Bacteria - enzymology | Anti-Bacterial Agents - pharmacology | Folic Acid Antagonists - chemical synthesis | Sulfanilamides - chemical synthesis | Folic Acid Antagonists - pharmacology | Antimetabolites - pharmacology | Sulfanilamides - pharmacology
Journal Article
Protein Science, ISSN 0961-8368, 12/2017, Volume 26, Issue 12, pp. 2417 - 2425
Journal Article
Journal Article
Journal Article
Journal Article
by Ng, HL and Chen, SY and Chew, EH and Chui, WK
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 06/2016, Volume 115, pp. 63 - 74
The development of multi-targeting drugs is currently being explored as an attractive alternative to combination therapy, especially for the treatment of... 
SYSTEM | CHEMISTRY, MEDICINAL | Antiproliferative activity | Thioredoxin reductase | CANCER-THERAPY | DISCOVERY | BREAST-CANCER | Chalcones | Dihydrotriazines | RESISTANCE | Dihydrofolate reductase | SURFLEX | EXPRESSION
Journal Article
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2009, Volume 47, Issue 6, pp. 752 - 760
Abstract Folate supplementation improves endothelial function in patients with hyperhomocysteinemia. Mechanistic insights into potential benefits of folate on... 
Cardiovascular | Dihydrofolate reductase (DHFR) | Folic acid (FA) | Tetrahydrofolic acid (THF) | Angiotensin II (Ang II) | Nitric oxide (NO [rad]) | Endothelial nitric oxide synthase (eNOS) | Nitric oxide (NO | HOMOCYSTEINE | CARDIAC & CARDIOVASCULAR SYSTEMS | STROKE PREVENTION | Nitric oxide (NO center dot) | CELL BIOLOGY | SYNTHASE | TRIAL | CELLULAR REDOX STATE | THERAPEUTIC TARGETS | CARDIOVASCULAR-DISEASES | B-VITAMINS | CORONARY-ARTERY-DISEASE | FOLATE | Nitric Oxide - biosynthesis | Angiotensin II - pharmacology | Oxidants - pharmacology | Reproducibility of Results | Chromatography, High Pressure Liquid - methods | Folic Acid - pharmacology | Angiotensin II - administration & dosage | Infusion Pumps | Fluorescence | Biological Availability | Biological Assay - methods | Tetrahydrofolate Dehydrogenase - metabolism | Tetrahydrofolates - metabolism | Up-Regulation - drug effects | Animals | Cattle | Protective Agents - pharmacology | Superoxides - metabolism | Mice | Stress, Physiological - drug effects | Buffers | Dietary Supplements | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Nitric oxide | Angiotensin | Tetrahydrofuran | Liquid chromatography | Superoxide | Dihydrofolate reductase | Methotrexate | Ethers | Peptide hormones | Folic acid | Endothelium | angiotensin II (Ang II) | endothelial nitric oxide synthase (eNOS) | dihydrofolate reductase (DHFR) | nitric oxide (NO•)
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2010, Volume 49, Issue 2, pp. 186 - 195
Abstract Heme oxygenase-1 (HO-1) is highly protective in various pathophysiological states such as cardiovascular and neurodegenerative diseases. HO-1-derived... 
Cardiovascular | Peroxynitrite | Human umbilical vein endothelial cells | Hydrogen peroxide | Hemin | Biliverdin | Heme oxygenase-1 | Lipopolysaccharide | Biliverdin reductase | Superoxide | Bilirubin | NADPH OXIDASE | OXIDATIVE STRESS | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MAJOR PHYSIOLOGICAL CYTOPROTECTANT | CELL BIOLOGY | HEART | CARDIOVASCULAR INJURY | CARBON-MONOXIDE | OXYGENASE | DYSFUNCTION | UP-REGULATION | Heme Oxygenase-1 - metabolism | Bilirubin - metabolism | Gene Silencing - drug effects | Reactive Oxygen Species - metabolism | Antioxidants - metabolism | Humans | Gene Knockdown Techniques | Respiratory Burst - drug effects | Cytoprotection - drug effects | Neutrophils - metabolism | Umbilical Veins - cytology | Xanthine Oxidase - metabolism | Angiotensin II - pharmacology | Free Radical Scavengers - metabolism | Neutrophils - drug effects | Biliverdine - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Oxidoreductases Acting on CH-CH Group Donors - metabolism | Tyrosine - metabolism | Endothelial Cells - cytology | Models, Biological | Nitrosation - drug effects | Lipopolysaccharides - pharmacology | Peroxynitrous Acid - metabolism | Leukocytes - drug effects | Endothelial Cells - enzymology | Leukocytes - metabolism | Endothelial Cells - drug effects | Oxidases | Nervous system diseases | Albumin | Endothelium | Antioxidants | Molybdenum compounds | Heterocyclic compounds | Analysis | Heme | Dihydrofolate reductase | Mitogens
Journal Article