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Investigational New Drugs, ISSN 0167-6997, 2/2014, Volume 32, Issue 1, pp. 25 - 36
We recently reported that novel ring-substituted analogs of 3,3′-diindolylmethane (ring-DIMs) have anti-androgenic and growth inhibitory effects in... 
Diindolylmethane derivatives | LNCaP | Oncology | Concentrations | Androgen-dependent | Necrosis | Androgen-independent | Caspase activity | Medicine & Public Health | Intracellular | Pharmacology/Toxicology | PC-3 | Prostate cancer | Apoptosis | PATHWAYS | RECEPTOR | DEATH | ENDOPLASMIC-RETICULUM STRESS | PROAPOPTOTIC GENES | CYTOCHROME-C | IN-VITRO | ONCOLOGY | PHARMACOLOGY & PHARMACY | 1,1-BIS(3'-INDOLYL)-1-(P-SUBSTITUTED PHENYL)METHANES | INDOLE-3-CARBINOL | TUMOR-GROWTH | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Caspase 8 - metabolism | Extracellular Space - drug effects | Male | Receptors, Death Domain - metabolism | Extracellular Space - metabolism | Dihydrotestosterone - pharmacology | Indoles - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Intracellular Space - drug effects | Up-Regulation - genetics | Up-Regulation - drug effects | Androgens - pharmacology | Signal Transduction - drug effects | Intracellular Space - metabolism | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Indoles - therapeutic use | Cell Proliferation - drug effects | Indoles - chemistry | Receptors, Death Domain - genetics | Drugs | Care and treatment | Pharmacology, Experimental | Indole | Structure-activity relationship (Pharmacology) | Research | Properties | Structure-activity relationships | Studies | Androgens | Cancer therapies | Pharmaceutical sciences | Life Sciences | Cellular Biology | Cancer
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2008, Volume 75, Issue 2, pp. 484 - 493
Aldo-keto reductase (AKR) 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase) regulates ligand access to steroid hormone and prostaglandin... 
Prostaglandin metabolism | Inhibitor design | Steroid hormone metabolism | Cancer treatment | NSAIDs | Chemoprevention | cancer treatment | ANDROGEN RECEPTOR | SIGNALING PATHWAYS | INCREASED EXPRESSION | CRYSTAL-STRUCTURE | prostaglandin metabolism | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | PROLIFERATOR-ACTIVATED RECEPTOR | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | chemoprevention | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | ACID-BINDING PROTEIN | CYCLOOXYGENASE-2 INHIBITORS | inhibitor design | PHARMACOLOGY & PHARMACY | steroid hormone metabolism | Indomethacin - analogs & derivatives | Oxidation-Reduction | Humans | Enzyme Inhibitors - pharmacology | Hydroxyprostaglandin Dehydrogenases - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Melatonin - analogs & derivatives | Aldo-Keto Reductase Family 1 Member C3 | 3-Hydroxysteroid Dehydrogenases - metabolism | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Catalysis | Neoplasms, Hormone-Dependent - drug therapy | Melatonin - pharmacology | Phenanthrenes - metabolism | Dihydrotestosterone - metabolism | Enzymes | Care and treatment | Synthetic prostaglandins F | Crystals | Hormones | Organic acids | Heterocyclic compounds | Physiological aspects | Glycols | Hormones, Sex | Indomethacin | Structure | Cancer
Journal Article
The Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 11/2017, Volume 174, p. 161
Prostate cancer growth and progression are mainly dependent on androgens and many current prostate cancer treatment options target the synthesis or function of... 
Statistical analysis | Prostate-specific antigen | Medical treatment | Bioavailability | Cells | Piceatannol | Androgens | Dihydrotestosterone | Cell lines | Resveratrol | Antiandrogens | Mutation | Receptor mechanisms | Prostate cancer | Prostate
Journal Article
Journal Article
Chemical & Pharmaceutical Bulletin, ISSN 0009-2363, 03/2017, Volume 65, Issue 3, p. 253
Avicequinone C (5a), a furanonaphthoquinone isolated from the Thai mangrove Avicennia marina has been shown previously to have interesting steroid 5α-reductase... 
Phosphates | Thin layer chromatography | Dihydrotestosterone | NADPH-diaphorase | Bioassays | Saturation | Keratinocytes | Benzoquinone | NADP | Molecular docking | Reductase | PharmacoPhores
Journal Article
Fertility and Sterility, ISSN 0015-0282, 2009, Volume 92, Issue 1, pp. 217 - 221
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 12, pp. 6448 - 6459
Journal Article