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Science, ISSN 0036-8075, 04/2018, Volume 360, Issue 6387, pp. 449 - 453
Activated immune cells undergo a metabolic switch to aerobic glycolysis akin to the Warburg effect, thereby presenting a potential therapeutic target in... 
INACTIVATION | ACTIVATION | MULTIPLE-SCLEROSIS | PATHWAY | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | EFFECTOR FUNCTION | SUBSETS | T-CELLS | ACID ESTERS | Myeloid Cells - enzymology | Succinates - chemistry | Autoimmune Diseases - enzymology | Humans | Immunosuppressive Agents - therapeutic use | Mice, Inbred C57BL | Glycolysis - drug effects | Citric Acid Cycle | Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - metabolism | Animals | Lymphocytes - immunology | Dimethyl Fumarate - pharmacology | Dimethyl Fumarate - therapeutic use | Myeloid Cells - immunology | Lymphocytes - drug effects | Lymphocytes - enzymology | Myeloid Cells - drug effects | Cysteine - metabolism | Mice | Immunosuppressive Agents - pharmacology | Autoimmune Diseases - drug therapy | Autoimmunity - drug effects | Biological research | Glyceraldehyde 3-phosphate dehydrogenase | Fumaric acid | Physiological aspects | Glycolysis | Research | Biology, Experimental | Dimethyl | Tricarboxylic acid cycle | Enzymes | Cysteine | Multiple sclerosis | Lymphoid cells | Immune response | Psoriasis | Immunomodulation | Therapeutic applications | Glyceraldehyde | Inflammation | Glyceraldehyde 3-phosphate | Metabolism | Immunity | Krebs cycle | Glyceraldehyde-3-phosphate dehydrogenase | Catalysis | Autoimmune diseases | Immune system
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 07/2016, Volume 25, Issue 2, pp. 61 - 77
Aims: This preclinical study was aimed at determining whether pharmacological targeting of transcription factor NRF2, a master controller of many homeostatic... 
Original Research Communications | OXIDATIVE STRESS | IN-VITRO | TRANSCRIPTION FACTOR NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | MPTP MOUSE MODEL | ALPHA-SYNUCLEIN | HEME OXYGENASE-1 | AUTOPHAGY | NF-KAPPA-B | EXPRESSION | NEUROPROTECTION | Immunohistochemistry | NF-E2-Related Factor 2 - agonists | Parkinson Disease - drug therapy | RNA, Messenger - metabolism | Autophagy | Brain - metabolism | Gliosis - pathology | Neuroprotective Agents - pharmacology | Dimethyl Fumarate - pharmacology | NF-E2-Related Factor 2 - genetics | Parkinson Disease - metabolism | Neuroprotective Agents - administration & dosage | Disease Models, Animal | Gene Expression | Gliosis - genetics | Parkinson Disease - pathology | Synucleins - genetics | Gliosis - metabolism | RNA, Messenger - genetics | Drug Repositioning | Synucleins - metabolism | Mice, Knockout | Phenotype | Animals | Mice | Dimethyl Fumarate - administration & dosage | Care and treatment | Parkinson's disease | Research | Gene expression | Dimethyl | Neuroprotection | Brain | Therapy | Oxidative stress | Basal ganglia | Multiple sclerosis | Mesencephalon | Toxicity | Substantia nigra | Parkinsons disease | Innovations | Synuclein | Proteins | Neurotoxicity | Autopsy | Movement disorders | Dopamine receptors | Recombinant | Phenotypes | Dopamine | Wound healing | Neurodegenerative diseases | Pharmacology | Inflammation | Disease control | Ganglia | Lewy bodies | Gliosis | Cell death | Phagocytosis | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0120254
Delayed-release dimethyl fumarate (also known as gastro-resistant dimethyl fumarate), an oral therapeutic containing dimethyl fumarate (DMF) as the active... 
CELLS | OXIDATIVE STRESS | MULTIPLE-SCLEROSIS | PATHWAY | MULTIDISCIPLINARY SCIENCES | CHEMOPREVENTIVE AGENT SULFORAPHANE | HEME OXYGENASE-1 | INDUCTION | CYSTEINE RESIDUES | ACID-ESTERS | PHASE-II ENZYMES | Astrocytes - drug effects | Dimethyl Fumarate - chemistry | Glutathione - metabolism | Humans | Fumarates - chemistry | Intracellular Signaling Peptides and Proteins - metabolism | Protein Transport - drug effects | Gene Expression Regulation - drug effects | Extracellular Space - metabolism | Cell Nucleus - metabolism | Dimethyl Fumarate - pharmacology | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | HEK293 Cells | NF-E2-Related Factor 2 - genetics | Cysteine - metabolism | Cell Nucleus - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Astrocytes - metabolism | Cysteine | Thiols | Dimethylformamide | B cells | Psoriasis | Health aspects | Dimethyl | Oxidative stress | Salts | Multiple sclerosis | Transcription | Downstream effects | Activation | Antioxidants | Proteins | Biological effects | Rodents | Modulation | Sensors | Glutathione | Translocation | Mass spectroscopy | Pharmacology | Economic conditions | Nuclear transport | Neurology | Depletion | Acids | Proteomics | Scientific imaging | Conjugation | Mass spectrometry | Cancer
Journal Article
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2014, Volume 124, Issue 5, pp. 2188 - 2192
Taken orally, the drug dimethyl fumarate (DMF) has been shown to improve functional outcomes for patients with MS; however, it is unclear how DMF mediates a... 
NICOTINIC-ACID | MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS | PLACEBO-CONTROLLED PHASE-3 | ESTERS | GPR109A | CENTRAL-NERVOUS-SYSTEM | MICE | ORAL BG-12 | PSORIASIS | Physiological aspects | Esters | Care and treatment | Cell receptors | Encephalomyelitis | Health aspects | Studies | Spinal cord | Acids | Rodents | Migration | Gene expression | Experiments | Apoptosis
Journal Article
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 06/2015, Volume 16, Issue 6, pp. 13885 - 13907
Multiple sclerosis (MS) is the most common multifocal inflammatory demyelinating disease of the central nervous system (CNS). Due to the progressive... 
Dimethyl fumarate (DMF) | Neuroprotection | Oxidative stress | MAPK | Multiple sclerosis (MS) | Neural stem/progenitor cells (NPCs) | REMITTING MULTIPLE-SCLEROSIS | STEM-CELLS | ANTIOXIDANT RESPONSE ELEMENT | CORTICAL-NEURONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | CENTRAL-NERVOUS-SYSTEM | CHEMOKINE RECEPTORS | PHASE-3 DEFINE | UP-REGULATION | CHEMISTRY, MULTIDISCIPLINARY | ACID ESTERS | Neurons - pathology | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Neuroprotective Agents - pharmacology | Dimethyl Fumarate - pharmacology | Mitogen-Activated Protein Kinase 1 - genetics | Female | NF-E2-Related Factor 2 - genetics | Neurons - metabolism | Neurons - drug effects | Immunosuppressive Agents - pharmacology | Real-Time Polymerase Chain Reaction | Mitogen-Activated Protein Kinase 3 - genetics | Cells, Cultured | Hydrogen Peroxide - pharmacology | Neural Stem Cells - drug effects | Rats | Chick Embryo | Neural Stem Cells - pathology | Rats, Sprague-Dawley | Blotting, Western | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | NF-E2-Related Factor 2 - metabolism | Mitogen-Activated Protein Kinases - genetics | Mice | Oxidative Stress - drug effects | Neural Stem Cells - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Neural networks | Neurons | Stem cells | multiple sclerosis (MS) | dimethyl fumarate (DMF) | neuroprotection | oxidative stress | neural stem/progenitor cells (NPCs)
Journal Article
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2015, Volume 82, pp. 349 - 358
Abstract Background and purpose Edema formation, inflammation and increased blood–brain barrier permeability contribute to poor outcomes after intracerebral... 
Neurology | Phosphorylated nuclear factor erythroid-2 related factor 2 (Nrf2) | Musculo-aponeurotic fibrosarcoma-G | Evans Blue extravasation | Dimethyl fumarate | Inflammation | Intracerebral hemorrhage | Casein kinase 2 | Evans blue extravasation | OXIDATIVE STRESS | ACTIVATION | RAT | INJURY | BLOOD-BRAIN-BARRIER | NEUROBLASTOMA-CELLS | NEUROSCIENCES | PHASE | DEGRADATION | ACID-ESTERS | Male | Neuroimmunomodulation - physiology | Brain Edema - enzymology | Neuroprotective Agents - pharmacology | Dimethyl Fumarate - pharmacology | Acrylates - pharmacology | Phosphorylation - drug effects | MafG Transcription Factor - metabolism | MafG Transcription Factor - genetics | Repressor Proteins - metabolism | Disease Models, Animal | Cerebral Hemorrhage - drug therapy | Microglia - drug effects | Casein Kinase II - antagonists & inhibitors | Microglia - enzymology | Repressor Proteins - genetics | Blood-Brain Barrier - drug effects | Collagenases | Intercellular Adhesion Molecule-1 - metabolism | Animals | Blood-Brain Barrier - enzymology | NF-E2-Related Factor 2 - metabolism | Cerebral Hemorrhage - enzymology | Brain Edema - drug therapy | Mice | Protein Kinase Inhibitors - pharmacology | Casein Kinase II - metabolism | Neuroimmunomodulation - drug effects | Permeability | Casein | Sarcoma | Fumaric acid | Acrylic acid | Health aspects
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 33, pp. 28017 - 28026
Dimethyl fumarate (DMF) is an effective novel treatment for multiple sclerosis in clinical trials. A reduction of IFN-gamma-producing CD4(+) T cells is... 
TRANSCRIPTIONAL ACTIVATION | MULTIPLE-SCLEROSIS | PHOSPHORYLATION | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | GENE-EXPRESSION | INDUCTION | T-BET | P65 | INNATE IMMUNITY | Dendritic Cells - immunology | Th1 Cells - immunology | MAP Kinase Signaling System - immunology | Th1 Cells - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Th17 Cells - metabolism | Transcription Factor RelA - immunology | Th17 Cells - cytology | Phosphorylation - immunology | B7-1 Antigen - biosynthesis | Phosphorylation - drug effects | B7-2 Antigen - immunology | Dimethyl Fumarate | Immunosuppressive Agents - pharmacology | Interleukin-6 - metabolism | Dendritic Cells - metabolism | Mitogen-Activated Protein Kinase 3 - immunology | B7-1 Antigen - immunology | Cells, Cultured | Histocompatibility Antigens Class II - biosynthesis | Interleukin-12 - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - immunology | Cell Differentiation - immunology | Animals | B7-2 Antigen - biosynthesis | Histocompatibility Antigens Class II - immunology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Transcription Factor RelA - metabolism | Cell Differentiation - drug effects | Fumarates - pharmacology | Interleukin-12 - immunology | Interleukin-6 - immunology | Th17 Cells - immunology | Dendritic Cells - cytology | Mice | Th1 Cells - cytology | Multiple Sclerosis | MAP Kinases (MAPKs) | Immunology | Dendritic Cells | Antigen Presentation | NF-Kappa B (NF-KB) | Cytokine
Journal Article