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Investigational new drugs, ISSN 0167-6997, 2015, Volume 33, Issue 1, pp. 201 - 214
Background This phase I/II study determined the maximal tolerable dose, dose limiting toxicities, antitumor activity, the pharmacokinetics and pharmacodynamics... 
NAMI-A | Ruthenium | Phase I | Medicine & Public Health | Gemcitabine | Non-small cell lung cancer | Oncology | Phase II | Pharmacology/Toxicology | Clinical study | TRANS-IMIDAZOLEDIMETHYLSULFOXIDE-TETRACHLORORUTHENATE | DNA-BINDING | METASTASIS | CHEMICAL-STABILITY | TUMORS | PLATINUM COMPLEXES | INHIBITION | LIQUID-CHROMATOGRAPHY | ONCOLOGY | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | CYTOTOXICITY | Lung Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Ruthenium - administration & dosage | Deoxycytidine - pharmacokinetics | Ruthenium - adverse effects | Adult | Deoxycytidine - adverse effects | Dimethyl Sulfoxide - administration & dosage | Female | Ruthenium - blood | Dimethyl Sulfoxide - adverse effects | Organometallic Compounds - adverse effects | Deoxycytidine - administration & dosage | Carcinoma, Non-Small-Cell Lung - metabolism | Organometallic Compounds - pharmacokinetics | Treatment Outcome | Ruthenium - pharmacokinetics | Maximum Tolerated Dose | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Dimethyl Sulfoxide - analogs & derivatives | Deoxycytidine - analogs & derivatives | Dimethyl Sulfoxide - pharmacokinetics | Organometallic Compounds - administration & dosage | Complications and side effects | Dosage and administration | Research | Lung cancer, Non-small cell | Drug therapy | Studies | Clinical trials | Lung cancer | Pharmaceutical sciences | Clinical outcomes | Index Medicus
Journal Article
Journal Article
Dalton transactions (Cambridge, England : 2003), ISSN 1477-9226, 10/2015, Volume 44, Issue 40, pp. 17482 - 17493
The ruthenium anticancer compound NAMI-A, imidazolium [trans-RuCl4(1H-imidazole)(DMSO-S)], is currently undergoing advanced clinical evaluation. As with other... 
Electron Spin Resonance Spectroscopy | Dimethyl Sulfoxide - chemistry | Humans | Protein Binding | Alanine - chemistry | Ligands | Organometallic Compounds - chemistry | Cysteine - chemistry | Dimethyl Sulfoxide - analogs & derivatives | Antineoplastic Agents - chemistry | Buffers | Serum Albumin - chemistry
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2007, Volume 50, Issue 9, pp. 2185 - 2193
Journal Article
Journal Article