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diosgenin - pharmacology (381) 381
diosgenin (376) 376
index medicus (335) 335
animals (328) 328
humans (292) 292
diosgenin - analogs & derivatives (224) 224
pharmacology & pharmacy (207) 207
male (189) 189
apoptosis (179) 179
rats (166) 166
mice (142) 142
cell line, tumor (125) 125
chemistry, medicinal (122) 122
apoptosis - drug effects (121) 121
biochemistry & molecular biology (103) 103
diosgenin - chemistry (102) 102
saponins - pharmacology (98) 98
saponins (97) 97
cell proliferation - drug effects (81) 81
dioscin (81) 81
cancer (75) 75
expression (75) 75
dose-response relationship, drug (74) 74
female (73) 73
plant extracts - pharmacology (70) 70
diosgenin - therapeutic use (68) 68
antineoplastic agents - pharmacology (67) 67
progesterone (67) 67
rats, wistar (66) 66
analysis (65) 65
activation (61) 61
dioscorea - chemistry (60) 60
plant sciences (60) 60
rats, sprague-dawley (58) 58
cell survival - drug effects (55) 55
oxidative stress (55) 55
antineoplastic agents, phytogenic - pharmacology (52) 52
signal transduction - drug effects (51) 51
integrative & complementary medicine (49) 49
molecular structure (48) 48
inhibition (46) 46
cells (42) 42
inflammation (42) 42
saponins - chemistry (42) 42
oncology (41) 41
steroidal saponins (41) 41
diosgenin - administration & dosage (40) 40
cytotoxicity (39) 39
in-vitro (38) 38
research (38) 38
disease models, animal (37) 37
nf-kappa-b (37) 37
phytotherapy (37) 37
cycle arrest (36) 36
diosgenin - isolation & purification (36) 36
care and treatment (35) 35
cell line (35) 35
down-regulation (35) 35
health aspects (35) 35
cells, cultured (34) 34
proteins (34) 34
structure-activity relationship (34) 34
cell cycle (33) 33
chemistry, applied (33) 33
growth (33) 33
mitochondria (33) 33
oxidative stress - drug effects (33) 33
saponin (33) 33
toxicology (33) 33
cell biology (32) 32
diosgenin - metabolism (32) 32
antineoplastic agents - chemistry (31) 31
antioxidants (31) 31
cancer cells (31) 31
reactive oxygen species - metabolism (31) 31
drug screening assays, antitumor (30) 30
induction (30) 30
liver - metabolism (30) 30
plant extracts - chemistry (30) 30
saponins - isolation & purification (30) 30
anti-inflammatory agents - pharmacology (29) 29
caspase 3 - metabolism (29) 29
cell cycle - drug effects (29) 29
cholesterol - metabolism (29) 29
diosgenin - analysis (29) 29
food science & technology (29) 29
nf-kappa b - metabolism (29) 29
signal transduction (29) 29
chemistry, multidisciplinary (28) 28
gene expression (28) 28
liver (28) 28
medicine, research & experimental (28) 28
blotting, western (27) 27
cholesterol (27) 27
drugs, chinese herbal - pharmacology (27) 27
pathways (27) 27
life sciences (26) 26
liver - drug effects (26) 26
mice, inbred balb c (26) 26
phosphorylation (26) 26
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Chinese Journal of Natural Medicines, ISSN 1875-5364, 08/2015, Volume 13, Issue 8, pp. 578 - 587
Journal Article
SCIENCE, ISSN 0036-8075, 11/2015, Volume 350, Issue 6262, pp. S66 - S69
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 8, pp. 1306 - 1313
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is the most important limiting factor for treatment efficiency... 
lung cancer | epithelial–mesenchymal transition | polyphyllin I | erlotinib | acquired resistance | interleukin-6 | Epithelial–mesenchymal transition | Acquired resistance | Erlotinib | Polyphyllin I | Lung cancer | Interleukin-6 | TARGETED THERAPY | ACTIVATION | ACQUIRED-RESISTANCE | SENSITIVITY | DRUG-RESISTANCE | D INDUCES APOPTOSIS | EGFR INHIBITORS | PHARMACOLOGY & PHARMACY | epithelial-mesenchymal transition | EXPRESSION | Lung Neoplasms - drug therapy | Melanthiaceae - chemistry | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Humans | ErbB Receptors - genetics | Epithelial-Mesenchymal Transition - drug effects | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Rhizome - chemistry | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Diosgenin - therapeutic use | Interleukin-6 - metabolism | STAT3 Transcription Factor - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Diosgenin - analogs & derivatives | Diosgenin - pharmacology | ErbB Receptors - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - genetics | Adenocarcinoma - drug therapy | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Erlotinib Hydrochloride - pharmacology | Cell Line, Tumor | Erlotinib Hydrochloride - therapeutic use | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Drug Resistance, Neoplasm - drug effects
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e65164
Objective: The present study was designed to examine the anticancer effect of Traditional Chinese Medicine of polyphyllin I (PPI) and evodiamine (EVO) on... 
THYMIDYLATE SYNTHASE GENE | DRUG RESPONSE ASSAY | CANCER PATIENTS | LUNG-CANCER | APOPTOSIS | CELLS | GROWTH-INHIBITION | MESSENGER-RNA EXPRESSION | MULTIDISCIPLINARY SCIENCES | PROTEIN EXPRESSION | MITOTIC ARREST | Confidence Intervals | Antineoplastic Combined Chemotherapy Protocols - chemistry | Humans | Middle Aged | Male | Stomach Neoplasms - pathology | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Fluorouracil - therapeutic use | Female | Diosgenin - therapeutic use | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Genes, Neoplasm - genetics | Platinum - pharmacology | Quinazolines - chemistry | Camptothecin - analogs & derivatives | Stomach Neoplasms - genetics | Diosgenin - analogs & derivatives | Diosgenin - pharmacology | Platinum - therapeutic use | Camptothecin - therapeutic use | RNA, Messenger - genetics | Diosgenin - chemistry | Stomach Neoplasms - drug therapy | Drug Synergism | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Quinazolines - therapeutic use | Fluorouracil - pharmacology | Quinazolines - pharmacology | Camptothecin - pharmacology | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Care and treatment | RNA | Gastrointestinal diseases | Genes | Gene expression | Formaldehyde | Cancer | Tumors | Correlation | Molecular structure | Lung cancer | Metastasis | Paraffin | Tissues | Cancer therapies | Stomach cancer | Medical schools | Molecular weight | Anticancer properties | Platinum | Surgery | Inhibition | Sensitivity analysis | DNA topoisomerase | Traditional Chinese medicine | Breast cancer | Thymidylate synthase | Patients | Polymerase chain reaction | Medicine | Irinotecan | Sensitivity | Chemotherapy | ERCC1 protein | Protein expression
Journal Article
FEBS Letters, ISSN 0014-5793, 2007, Volume 581, Issue 30, pp. 5735 - 5742
Journal Article
Journal of Food Science, ISSN 0022-1147, 04/2015, Volume 80, Issue 4, pp. H857 - H868
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2015, Volume 99, pp. 67 - 81
Journal Article
Journal Article
Toxicology, ISSN 0300-483X, 2017, Volume 378, pp. 53 - 64
Journal Article
Journal Article