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Cancer letters, ISSN 0304-3835, 2013, Volume 332, Issue 2, pp. 295 - 303
Journal Article
Drugs, ISSN 0012-6667, 11/2015, Volume 75, Issue 17, pp. 1993 - 2016
Through years of evolutionary selection pressures, organisms have developed potent toxins that coincidentally have marked antineoplastic activity. These... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | IMMUNOTOXIN RFB4(DSFV)-PE38 BL22 | PEGYLATED LIPOSOMAL DOXORUBICIN | EPOTHILONE-B ANALOG | DRUG-RESISTANT PHENOTYPE | GEMTUZUMAB OZOGAMICIN | PHASE-I TRIAL | METASTATIC BREAST-CANCER | ERIBULIN MESYLATE E7389 | PHARMACOLOGY & PHARMACY | TOXICOLOGY | ANTI-MESOTHELIN IMMUNOTOXIN | CHRONIC MYELOID-LEUKEMIA | Dioxoles - therapeutic use | Diphtheria Toxin - pharmacology | Recombinant Fusion Proteins - pharmacology | Furans - pharmacology | Humans | Recombinant Fusion Proteins - therapeutic use | Interleukin-2 - therapeutic use | Epothilones - pharmacology | Drug Discovery - methods | Antineoplastic Agents - therapeutic use | Biological Products - pharmacology | Epothilones - therapeutic use | Harringtonines - therapeutic use | Furans - therapeutic use | TOR Serine-Threonine Kinases - antagonists & inhibitors | Diphtheria Toxin - therapeutic use | Immunoconjugates - pharmacology | Cytochalasins - pharmacology | Dioxoles - pharmacology | Immunoconjugates - therapeutic use | Antineoplastic Agents - pharmacology | Ketones - therapeutic use | Cytochalasins - therapeutic use | Biological Products - therapeutic use | Ketones - pharmacology | Tetrahydroisoquinolines - pharmacology | Tetrahydroisoquinolines - therapeutic use | Withanolides - pharmacology | Harringtonines - pharmacology | Interleukin-2 - pharmacology | Withanolides - therapeutic use | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2008, Volume 154, Issue 5, pp. 1094 - 1103
Background and purpose: We investigated the mechanisms underlying the pruritogenic response induced by trypsin in mice, to assess the relevance of neurogenic... 
neuropeptides | Trypsin | PAR‐2 | TRPV1 | mast cells | scratching behaviour | PAR-2 | Neuropeptides | Mast cells | Scratching behaviour | PROTEINASE-ACTIVATED RECEPTOR-2 | NAFAMOSTAT MESILATE | HUMAN SKIN | PRURITUS | HUMAN KERATINOCYTES | ITCH | PAIN | IN-VIVO | HISTAMINE H-4 | PHARMACOLOGY & PHARMACY | trypsin | MAST-CELL TRYPTASE | Receptor, PAR-2 - metabolism | Male | Peptide Fragments - pharmacology | Antipruritics - pharmacology | Receptors, Calcitonin Gene-Related Peptide - metabolism | Quinolines - pharmacology | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Cromolyn Sodium - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Neurogenic Inflammation - chemically induced | Bradykinin Receptor Antagonists | Dioxoles - pharmacology | Behavior, Animal - drug effects | Pruritus - chemically induced | Disease Models, Animal | Injections, Intradermal | Pyrazoles - pharmacology | Reproducibility of Results | Plant Proteins - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Calcitonin Gene-Related Peptide - pharmacology | Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors | p-Methoxy-N-methylphenethylamine - pharmacology | Celecoxib | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mast Cells - drug effects | Trypsin - administration & dosage | TRPV Cation Channels - genetics | Mice, Knockout | Neurogenic Inflammation - prevention & control | Pruritus - metabolism | Animals | Receptors, Bradykinin - metabolism | Signal Transduction - drug effects | Nerve Fibers, Unmyelinated - metabolism | Anilides - pharmacology | Cyclooxygenase 2 - metabolism | Neurogenic Inflammation - metabolism | Pruritus - prevention & control | Mice | Oligopeptides - pharmacology | Cell Degranulation - drug effects | Index Medicus | Research Papers
Journal Article
Journal Article
Breast cancer research : BCR, ISSN 1465-542X, 2013, Volume 15, Issue 6, pp. R106 - R106
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2018, Volume 23, Issue 3, p. 555
Sauchinone, an active lignan isolated from the aerial parts of Saururus chinensis (Saururaceae), exhibits anti-inflammatory, anti-obesity, anti-hyperglycemic,... 
Saururus chinensis | Herb-drug interaction | CYP450 | Metabolic inhibition | Sauchinone | Human liver microsome | Docking | sauchinone | BIOCHEMISTRY & MOLECULAR BIOLOGY | herb-drug interaction | INTERACTIONS FOCUS | PRESCRIBED DRUGS | HERBAL MEDICINES | CHEMISTRY, MULTIDISCIPLINARY | docking | IN-VITRO | INHIBITION | PHARMACOKINETICS | STRUCTURAL BASIS | human liver microsome | METABOLIC ENZYMES | BINDING | DRUG-DRUG INTERACTIONS | metabolic inhibition | Plant Extracts - pharmacology | Humans | Chlorzoxazone - chemistry | Benzopyrans - chemistry | Cytochrome P-450 CYP3A - chemistry | Dioxoles - pharmacology | Anti-Inflammatory Agents - isolation & purification | Cytochrome P-450 Enzyme Inhibitors - chemistry | Microsomes, Liver - enzymology | Binding Sites | Anti-Inflammatory Agents - pharmacology | Plant Extracts - isolation & purification | Saururaceae - chemistry | Benzopyrans - isolation & purification | Microsomes, Liver - chemistry | Dioxoles - chemistry | Ticlopidine - analogs & derivatives | Hypoglycemic Agents - pharmacology | Hypoglycemic Agents - isolation & purification | Anti-Obesity Agents - chemistry | Cytochrome P-450 CYP3A - metabolism | Mice | Molecular Docking Simulation | Kinetics | Anti-Obesity Agents - pharmacology | Cytochrome P-450 CYP2B6 - chemistry | Cytochrome P-450 Enzyme Inhibitors - isolation & purification | Plant Extracts - chemistry | Ticlopidine - pharmacology | Ticlopidine - chemistry | Cytochrome P-450 CYP2E1 - metabolism | Cytochrome P-450 CYP2B6 - metabolism | Microsomes, Liver - drug effects | Cyclobutanes - pharmacology | Protein Interaction Domains and Motifs | Benzopyrans - pharmacology | Cytochrome P-450 CYP2E1 - chemistry | Catalytic Domain | Dioxoles - isolation & purification | Protein Structure, Secondary | Plant Components, Aerial - chemistry | Cytochrome P-450 CYP2C19 - chemistry | Hypoglycemic Agents - chemistry | Anti-Obesity Agents - isolation & purification | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Chlorzoxazone - pharmacology | Herb-Drug Interactions | Protein Binding | Clopidogrel | Cytochrome P-450 CYP2C19 - metabolism | Cyclobutanes - chemistry | Cytochrome | Herbs | Drugs | Liver | Drug interactions | Amino acids | Inflammation | Sibutramine | Metabolism | Microsomes | Molecular docking | Steatosis | Chlorzoxazone | Fatty liver | Mouse devices | Computer applications | Cytochromes | In vivo methods and tests | Drug interaction | Inhibition | Enzyme kinetics
Journal Article
Psychopharmacology, ISSN 0033-3158, 6/2014, Volume 231, Issue 11, pp. 2291 - 2298
α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor stimulation has been proposed to be a common neural mechanism of metabotropic glutamate... 
Neurosciences | AMPA receptor | Biomedicine | Ketamine | Serotonin | Metabotropic glutamate 2/3 receptor antagonist | Depression | Pharmacology/Toxicology | Psychiatry | 5-HT1A receptor | Novelty-suppressed feeding test | 5-HT1Areceptor | ANTIDEPRESSANT | Novelty-suppressedfeedingtest | RESISTANT MAJOR DEPRESSION | 5-HT1A RECEPTORS | PSYCHIATRY | INVOLVEMENT | RELEASE | NEUROSCIENCES | PREFRONTAL CORTEX | MGS0039 | ANIMAL-MODELS | PHARMACOLOGY & PHARMACY | MICE | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Receptors, Metabotropic Glutamate - metabolism | Amino Acids - pharmacology | Quinoxalines - pharmacology | Piperidines - pharmacology | Dioxoles - pharmacology | Antidepressive Agents - pharmacology | Ritanserin - pharmacology | Fenclonine - pharmacology | Receptors, AMPA - metabolism | Tryptophan Hydroxylase - metabolism | Xanthenes - pharmacology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Serotonin 5-HT2 Receptor Antagonists - pharmacology | Piperazines - pharmacology | Feeding Behavior - physiology | Feeding Behavior - drug effects | Neuropsychological Tests | Animals | Pyridines - pharmacology | Ketamine - pharmacology | Tryptophan Hydroxylase - antagonists & inhibitors | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Receptors, AMPA - antagonists & inhibitors | Neurons | Amino acids
Journal Article
Cell stem cell, ISSN 1934-5909, 2009, Volume 5, Issue 5, pp. 491 - 503
The combined activity of three transcription factors can reprogram adult cells into induced pluripotent stem cells (iPSCs). However, the transgenic methods... 
STEMCELL | PLURIPOTENT STEM-CELLS | OCT4 | POTENT | MOUSE | HUMAN FIBROBLASTS | GENERATION | INDUCTION | DIFFERENTIATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY
Journal Article