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Psychopharmacology, ISSN 0033-3158, 6/2014, Volume 231, Issue 11, pp. 2291 - 2298
α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor stimulation has been proposed to be a common neural mechanism of metabotropic glutamate... 
Neurosciences | AMPA receptor | Biomedicine | Ketamine | Serotonin | Metabotropic glutamate 2/3 receptor antagonist | Depression | Pharmacology/Toxicology | Psychiatry | 5-HT1A receptor | Novelty-suppressed feeding test | 5-HT1Areceptor | ANTIDEPRESSANT | Novelty-suppressedfeedingtest | RESISTANT MAJOR DEPRESSION | 5-HT1A RECEPTORS | PSYCHIATRY | INVOLVEMENT | RELEASE | NEUROSCIENCES | PREFRONTAL CORTEX | MGS0039 | ANIMAL-MODELS | PHARMACOLOGY & PHARMACY | MICE | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Receptors, Metabotropic Glutamate - metabolism | Amino Acids - pharmacology | Quinoxalines - pharmacology | Piperidines - pharmacology | Dioxoles - pharmacology | Antidepressive Agents - pharmacology | Ritanserin - pharmacology | Fenclonine - pharmacology | Receptors, AMPA - metabolism | Tryptophan Hydroxylase - metabolism | Xanthenes - pharmacology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Serotonin 5-HT2 Receptor Antagonists - pharmacology | Piperazines - pharmacology | Feeding Behavior - physiology | Feeding Behavior - drug effects | Neuropsychological Tests | Animals | Pyridines - pharmacology | Ketamine - pharmacology | Tryptophan Hydroxylase - antagonists & inhibitors | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Receptors, AMPA - antagonists & inhibitors | Neurons | Amino acids | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2008, Volume 154, Issue 5, pp. 1094 - 1103
Background and purpose: We investigated the mechanisms underlying the pruritogenic response induced by trypsin in mice, to assess the relevance of neurogenic... 
neuropeptides | Trypsin | PAR‐2 | TRPV1 | mast cells | scratching behaviour | PAR-2 | Neuropeptides | Mast cells | Scratching behaviour | PROTEINASE-ACTIVATED RECEPTOR-2 | NAFAMOSTAT MESILATE | HUMAN SKIN | PRURITUS | HUMAN KERATINOCYTES | ITCH | PAIN | IN-VIVO | HISTAMINE H-4 | PHARMACOLOGY & PHARMACY | trypsin | MAST-CELL TRYPTASE | Receptor, PAR-2 - metabolism | Male | Peptide Fragments - pharmacology | Antipruritics - pharmacology | Receptors, Calcitonin Gene-Related Peptide - metabolism | Quinolines - pharmacology | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Cromolyn Sodium - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Neurogenic Inflammation - chemically induced | Bradykinin Receptor Antagonists | Dioxoles - pharmacology | Behavior, Animal - drug effects | Pruritus - chemically induced | Disease Models, Animal | Injections, Intradermal | Pyrazoles - pharmacology | Reproducibility of Results | Plant Proteins - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Calcitonin Gene-Related Peptide - pharmacology | Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors | p-Methoxy-N-methylphenethylamine - pharmacology | Celecoxib | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mast Cells - drug effects | Trypsin - administration & dosage | TRPV Cation Channels - genetics | Mice, Knockout | Neurogenic Inflammation - prevention & control | Pruritus - metabolism | Animals | Receptors, Bradykinin - metabolism | Signal Transduction - drug effects | Nerve Fibers, Unmyelinated - metabolism | Anilides - pharmacology | Cyclooxygenase 2 - metabolism | Neurogenic Inflammation - metabolism | Pruritus - prevention & control | Mice | Oligopeptides - pharmacology | Cell Degranulation - drug effects | Index Medicus | Research Papers
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2017, Volume 27, Issue 2, pp. 176 - 179
(−)-Cubebin (CUB), isolated from seeds of , was used as starting material to obtain the derivatives (−)-hinokinin (HK) and (−)-O-benzyl cubebin (OBZ). Using... 
Anti-inflammatory activity | (−)-Hinokinin | Piper cubeba | (−)-Cubebin | (−)-O-benzylcubebin | CHEMISTRY, MEDICINAL | APPROXIMATION | (-)-Cubebin | LEAVES | CHEMISTRY, ORGANIC | (-)-Hinokinin | SWISS-MODEL | DENSITY | ZANTHOXYLUM-NARANJILLO | (-)-0-benzylcubebin | LIGNANS | ELECTROSTATICS | Rats, Wistar | Furans - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Benzodioxoles - administration & dosage | Cyclooxygenase 2 Inhibitors - chemistry | Dioxoles - chemical synthesis | Lignans - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyproheptadine - pharmacology | Polysorbates - pharmacology | Dextrans - pharmacology | Dioxoles - administration & dosage | Furans - chemistry | Computer Simulation | Dioxoles - pharmacology | 4-Butyrolactone - chemistry | Benzodioxoles - chemistry | Lignans - chemical synthesis | Rutaceae - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Benzodioxoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Dinoprostone - pharmacology | Catalytic Domain | Cyclooxygenase 2 Inhibitors - pharmacology | Lignans - chemistry | Cyclooxygenase 2 - chemistry | Cyclooxygenase 2 Inhibitors - administration & dosage | 4-Butyrolactone - pharmacology | 4-Butyrolactone - chemical synthesis | Dioxoles - chemistry | Indomethacin - pharmacology | Lignans - isolation & purification | Lignans - administration & dosage | Animals | 4-Butyrolactone - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Ligands | Mice | Molecular Docking Simulation | 4-Butyrolactone - analogs & derivatives | Edema - chemically induced | Furans - chemical synthesis | Benzodioxoles - pharmacology | Furans - administration & dosage | Index Medicus
Journal Article
Psychopharmacology, ISSN 0033-3158, 9/2016, Volume 233, Issue 17, pp. 3125 - 3134
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2010, Volume 30, Issue 4, pp. 749 - 757
OBJECTIVE—Animal and clinical studies have suggested that polyphenols in fruits, red wine, and tea may delay the development of atherosclerosis through their... 
Endothelial dysfunction | Soluble P-selectin | Oxidative stress | Polyphenol | Inflammation | Endothelin-1 | polyphenol | endothelial dysfunction | soluble P-selectin | inflammation | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | BLACK TEA CONSUMPTION | SMOOTH-MUSCLE-CELLS | HEME OXYGENASE-1 | RED WINE | endothelin-1 | HEMATOLOGY | E-DEFICIENT MICE | NF-KAPPA-B | oxidative stress | CORONARY-ARTERY-DISEASE | Inflammation - pathology | Heme Oxygenase-1 - metabolism | Apolipoproteins E - deficiency | Cholesterol - blood | Endothelium, Vascular - drug effects | Male | Aorta - metabolism | F2-Isoprostanes - metabolism | Lignans - pharmacology | Aortic Diseases - metabolism | Inflammation - metabolism | Leukotriene B4 - metabolism | Aortic Diseases - prevention & control | Dioxoles - pharmacology | Polyphenols | Anti-Inflammatory Agents - administration & dosage | Disease Models, Animal | Phenols - pharmacology | Biomarkers - metabolism | Atherosclerosis - pathology | Anti-Inflammatory Agents - pharmacology | Atherosclerosis - physiopathology | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Diet | Endothelium, Vascular - metabolism | Inflammation - prevention & control | Mice | Oxidative Stress - drug effects | Biflavonoids - pharmacology | Chlorogenic Acid - pharmacology | Nitrates - urine | Superoxides - metabolism | Flavonoids - administration & dosage | Flavonoids - pharmacology | Membrane Proteins - metabolism | Aorta - physiopathology | Nitric Oxide Synthase Type III - metabolism | Catechin - pharmacology | Fatty Acids - metabolism | Nitrites - urine | Aorta - drug effects | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Aortic Diseases - physiopathology | Animals | Quercetin - pharmacology | Apolipoproteins E - genetics | Endothelin-1 - urine | P-Selectin - blood | Phenols - administration & dosage | Nitric Oxide - metabolism | Atherosclerosis - prevention & control | Inflammation - physiopathology | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 2009, Volume 57, Issue 4, pp. 356 - 368
To date, it has been thought that cannabinoid receptors in CNS are primarily of the CB1R subtype, with CB2R expressed only in glia and peripheral tissues.... 
Entorhinal | GABA | Inhibition | Cannabinoid | IPSC | MOUSE-BRAIN | ENDOGENOUS CANNABINOIDS | CEREBELLAR PURKINJE-CELLS | PHARMACOLOGICAL CHARACTERIZATION | NEUROSCIENCES | SELECTIVE LIGANDS | IN-VITRO | NETWORK OSCILLATIONS | DEPOLARIZATION-INDUCED SUPPRESSION | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | RAT ENTORHINAL CORTEX | Cannabinoid Receptor Modulators - pharmacology | Rats, Wistar | Receptor, Cannabinoid, CB2 - agonists | gamma-Aminobutyric Acid - metabolism | Benzofurans - administration & dosage | Benzofurans - pharmacology | Male | Quinolones - pharmacology | Hippocampus - drug effects | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Indoles - administration & dosage | Receptor, Cannabinoid, CB1 - agonists | Dioxoles - administration & dosage | Neurons - physiology | Dioxoles - pharmacology | Indoles - pharmacology | Synaptic Transmission - drug effects | Neurons - drug effects | Endocannabinoids | Synapses - drug effects | Cannabinoids - administration & dosage | Synapses - physiology | Rats | Entorhinal Cortex - drug effects | Arachidonic Acids - pharmacology | Cannabinoids - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Glycerides - pharmacology | Quinolones - administration & dosage | Animals | Central Nervous System Agents - administration & dosage | Central Nervous System Agents - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Hippocampus - physiology | In Vitro Techniques | Neural Inhibition - drug effects | Entorhinal Cortex - physiology | RNA | Analysis | Index Medicus
Journal Article
Journal Article
Breast Cancer Research, ISSN 1465-5411, 11/2013, Volume 15, Issue 6, pp. R106 - R106
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 3, p. 555
Sauchinone, an active lignan isolated from the aerial parts of Saururus chinensis (Saururaceae), exhibits anti-inflammatory, anti-obesity, anti-hyperglycemic,... 
Saururus chinensis | Herb-drug interaction | CYP450 | Metabolic inhibition | Sauchinone | Human liver microsome | Docking | sauchinone | BIOCHEMISTRY & MOLECULAR BIOLOGY | herb-drug interaction | INTERACTIONS FOCUS | PRESCRIBED DRUGS | HERBAL MEDICINES | CHEMISTRY, MULTIDISCIPLINARY | docking | IN-VITRO | INHIBITION | PHARMACOKINETICS | STRUCTURAL BASIS | human liver microsome | METABOLIC ENZYMES | BINDING | DRUG-DRUG INTERACTIONS | metabolic inhibition | Plant Extracts - pharmacology | Humans | Chlorzoxazone - chemistry | Benzopyrans - chemistry | Cytochrome P-450 CYP3A - chemistry | Dioxoles - pharmacology | Anti-Inflammatory Agents - isolation & purification | Cytochrome P-450 Enzyme Inhibitors - chemistry | Microsomes, Liver - enzymology | Binding Sites | Anti-Inflammatory Agents - pharmacology | Plant Extracts - isolation & purification | Saururaceae - chemistry | Benzopyrans - isolation & purification | Microsomes, Liver - chemistry | Dioxoles - chemistry | Ticlopidine - analogs & derivatives | Hypoglycemic Agents - pharmacology | Hypoglycemic Agents - isolation & purification | Anti-Obesity Agents - chemistry | Cytochrome P-450 CYP3A - metabolism | Mice | Molecular Docking Simulation | Kinetics | Anti-Obesity Agents - pharmacology | Cytochrome P-450 CYP2B6 - chemistry | Cytochrome P-450 Enzyme Inhibitors - isolation & purification | Plant Extracts - chemistry | Ticlopidine - pharmacology | Ticlopidine - chemistry | Cytochrome P-450 CYP2E1 - metabolism | Cytochrome P-450 CYP2B6 - metabolism | Microsomes, Liver - drug effects | Cyclobutanes - pharmacology | Protein Interaction Domains and Motifs | Benzopyrans - pharmacology | Cytochrome P-450 CYP2E1 - chemistry | Catalytic Domain | Dioxoles - isolation & purification | Protein Structure, Secondary | Plant Components, Aerial - chemistry | Cytochrome P-450 CYP2C19 - chemistry | Hypoglycemic Agents - chemistry | Anti-Obesity Agents - isolation & purification | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Chlorzoxazone - pharmacology | Herb-Drug Interactions | Protein Binding | Clopidogrel | Cytochrome P-450 CYP2C19 - metabolism | Cyclobutanes - chemistry | Cytochrome | Herbs | Drugs | Liver | Drug interactions | Amino acids | Inflammation | Sibutramine | Metabolism | Microsomes | Steatosis | Chlorzoxazone | Fatty liver | Mouse devices | Computer applications | Cytochromes | In vivo methods and tests | Drug interaction | Inhibition | Enzyme kinetics | Index Medicus
Journal Article