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Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 17 - 30
and mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate... 
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 04/2018, Volume 1417, Issue 1, pp. 104 - 115
Cancer immunotherapy involving blockade of immune checkpoint molecules, such as CTLA‐4 and PD‐1, has shown remarkable clinical success across several types of... 
regulatory T cells | OX40 | CTLA‐4 | PD‐1 | PD‐L1 | PD-l1 | CTLA-4 | Regulatory T cells | PD-1 | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | INDUCTION | SUPPRESSION | TUMOR-IMMUNITY | GROWTH-FACTOR-BETA | MELANOMA | PD-L1 | IMMUNE TOLERANCE | NIVOLUMAB | CARCINOMA | SELF-TOLERANCE | Glucocorticoid-Induced TNFR-Related Protein - antagonists & inhibitors | Immunotherapy - methods | T-Lymphocytes, Regulatory - classification | Interleukin-2 Receptor alpha Subunit - antagonists & inhibitors | Receptors, CCR4 - immunology | HSP70 Heat-Shock Proteins - antagonists & inhibitors | Humans | Antibodies, Monoclonal - therapeutic use | Vascular Endothelial Growth Factor A - immunology | Vascular Endothelial Growth Factor A - antagonists & inhibitors | CTLA-4 Antigen - immunology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, OX40 - immunology | Receptors, CCR4 - antagonists & inhibitors | T-Lymphocytes, Regulatory - immunology | Models, Immunological | Neoplasms - therapy | Neoplasms - immunology | Transforming Growth Factor beta - antagonists & inhibitors | Glucocorticoid-Induced TNFR-Related Protein - immunology | CTLA-4 Antigen - antagonists & inhibitors | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Interleukin-2 Receptor alpha Subunit - immunology | Receptors, OX40 - antagonists & inhibitors | Development and progression | Care and treatment | Drug therapy | T cells | Immunotherapy | Cancer | Immunoregulation | Medical treatment | Medical services | Homeostasis | Immunosurveillance | Lymphocytes T | Immunity | Patients | Molecular chains | Anticancer properties | CD4 antigen | Inhibitors | Immune checkpoint | Lymphocytes | Foxp3 protein | Antitumor activity | Tumors
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 06/2015, Volume 12, Issue 6, pp. 319 - 334
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2017, Volume 74, pp. 55 - 72
Abstract Recent success in cancer immunotherapy (anti-CTLA-4, anti-PD1/PD-L1) has confirmed the hypothesis that the immune system can control many cancers... 
Hematology, Oncology and Palliative Medicine | Molecular biology | Clinical development | Immuno-oncology | Novel antibodies | OX40 | NATURAL-KILLER-CELLS | SOLID TUMORS | CD4(+) T-CELLS | CANCER-IMMUNOTHERAPY | LUNG-CANCER | THERAPY | NK CELLS | ONCOLOGY | PHASE-I TRIAL | MONOCLONAL-ANTIBODIES | T-Lymphocyte Subsets - immunology | Immunotherapy - methods | Humans | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | B7 Antigens - immunology | Inducible T-Cell Co-Stimulator Protein - agonists | Glucocorticoid-Induced TNFR-Related Protein - drug effects | OX40 Ligand - agonists | Hepatitis A Virus Cellular Receptor 2 - antagonists & inhibitors | Lymphocyte Activation - immunology | Neoplasms - therapy | Immunity, Cellular - physiology | Killer Cells, Natural - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - agonists | Cytokines - immunology | T-Lymphocytes, Cytotoxic - immunology | Antibodies, Monoclonal, Humanized - therapeutic use | CD40 Antigens - agonists | Antigens, CD - drug effects | B7 Antigens - antagonists & inhibitors | B-Lymphocytes - immunology | Neoplasms - immunology | Major Histocompatibility Complex - immunology | CTLA-4 Antigen - antagonists & inhibitors | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Receptors, KIR - antagonists & inhibitors | Drugs | Chemotherapy | Cell death | Immunotherapy | Monoclonal antibodies | Control systems | T cells | Cancer
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 08/2013, Volume 38, Issue 9, pp. 1609 - 1616
We have previously demonstrated that lipopolysaccharide (LPS) induces depressive-like behavior by activating indoleamine 2,3 dioxygenase (IDO; O'Connor et al,... 
AMPA receptor | depression | lipopolysaccharide | NMDA receptor | inflammation | ketamine | BACILLUS-CALMETTE-GUERIN | PSYCHIATRY | MACROPHAGES | INDOLEAMINE 2,3-DIOXYGENASE | INDUCTION | NEUROSCIENCES | HIPPOCAMPUS | QUINOLINIC ACID | SICKNESS | IMMUNE ACTIVATION | PHARMACOLOGY & PHARMACY | BRAIN | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Body Weight - drug effects | Motor Activity - drug effects | Male | Ketamine - antagonists & inhibitors | Lipopolysaccharides - antagonists & inhibitors | Brain - metabolism | Quinoxalines - pharmacology | Depression - drug therapy | Drug Interactions | Liver - drug effects | Depression - chemically induced | Immobility Response, Tonic - drug effects | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - biosynthesis | Ketamine - therapeutic use | Cytokines - metabolism | Drug Administration Schedule | Food Preferences - drug effects | Liver - metabolism | Mice, Inbred C57BL | Excitatory Amino Acid Antagonists - pharmacology | Antidepressive Agents - therapeutic use | Brain - drug effects | Eating - drug effects | Animals | Signal Transduction - drug effects | Mice | Ketamine - pharmacology | Receptors, AMPA - antagonists & inhibitors | Antidepressants | biological psychiatry | animal models | behavioral science | bipolar | unipolar | Original
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2013, Volume 437, Issue 3, pp. 368 - 373
Journal Article
Biochemical Journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 505 - 512
The tandem PHD (plant homeodomain) fingers of the CHD4 (chromodomain helicase DNA-binding protein 4) ATPase are epigenetic readers that bind either unmodified... 
Chromodomain helicase DNA-binding protein 4 (CHD4) | Plant homeodomain (PHD) | Inhibitor | Calixarene | Histone | Methylation | COMPLEX | PROTEIN | DEACETYLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HP1 CHROMO DOMAIN | SELECTIVE RECOGNITION | METHYLATED LYSINE | H3 | chromodomain helicase DNA-binding protein 4 (CHD4) | plant homeodomain (PHD) | DISCOVERY | FLUORESCENT | inhibitor | methylation | HETEROCHROMATIN | histone | calixarene | Indicators and Reagents - chemical synthesis | Hypoxia-Inducible Factor-Proline Dioxygenases - chemistry | Autoantigens - metabolism | Homeodomain Proteins - metabolism | Humans | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors | Autoantigens - genetics | Chromatin Assembly and Disassembly - drug effects | Protein Subunits - metabolism | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | Mi-2 Nucleosome Remodeling and Deacetylase Complex - antagonists & inhibitors | Calixarenes - chemistry | Drug Design | HEK293 Cells | Indicators and Reagents - pharmacology | Epigenesis, Genetic - drug effects | Lysine - metabolism | Indicators and Reagents - chemistry | Histones - antagonists & inhibitors | Peptide Fragments - genetics | Protein Subunits - genetics | Recombinant Proteins - metabolism | Lysine - analogs & derivatives | Peptide Fragments - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Protein Interaction Domains and Motifs - drug effects | Calixarenes - pharmacology | Hypoxia-Inducible Factor-Proline Dioxygenases - genetics | Models, Molecular | Recombinant Proteins - chemistry | Calixarenes - chemical synthesis | Autoantigens - chemistry | Homeodomain Proteins - chemistry | Homeodomain Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Peptide Fragments - chemistry | Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism | Peptide Fragments - antagonists & inhibitors | Homeodomain Proteins - antagonists & inhibitors | Mi-2 Nucleosome Remodeling and Deacetylase Complex - chemistry | Protein Processing, Post-Translational | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Histones - metabolism | Chromosomal Proteins, Non-Histone - chemistry | Index Medicus
Journal Article
International Journal of Oncology, ISSN 1019-6439, 6/2016, Volume 48, Issue 6, pp. 2303 - 2309
Journal Article
EMBO reports, ISSN 1469-221X, 05/2011, Volume 12, Issue 5, pp. 463 - 469
Journal Article