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Journal of Neuroscience, ISSN 0270-6474, 08/2012, Volume 32, Issue 33, pp. 11356 - 11364
Journal Article
Pain, ISSN 0304-3959, 2005, Volume 117, Issue 1, pp. 171 - 181
Protein kinase C (PKC) is able to phosphorylate several cellular components that serve as key regulatory components in signal transduction pathways of... 
Nociception | Protein kinase C | Substance P | Phorbol ester | MAP kinase | Mice | Glutamate | phorbol ester | PRIMARY AFFERENT NEURONS | INFLAMMATORY HYPERALGESIA | nociception | VANILLOID RECEPTOR | NECROSIS-FACTOR-ALPHA | RAT SENSORY NEURONS | mice | NEUROSCIENCES | CLINICAL NEUROLOGY | NERVE GROWTH-FACTOR | IN-VITRO | SCIATIC-NERVE | ANESTHESIOLOGY | substance P | UP-REGULATION | protein kinase C | glutamate | Bradykinin - analogs & derivatives | Analgesics - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Capsaicin - pharmacology | Nociceptors - physiology | Tetradecanoylphorbol Acetate - analogs & derivatives | Male | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Pain - chemically induced | Dose-Response Relationship, Drug | Salicylates - pharmacology | Adrenergic beta-Antagonists - pharmacology | Propranolol - pharmacology | Drug Interactions | Pain - enzymology | Time Factors | Pain - drug therapy | Protein Kinase C - metabolism | Sympatholytics - pharmacology | Behavior, Animal - drug effects | Indoles - pharmacology | Bradykinin - pharmacology | Blotting, Western - methods | Protein Kinase C - physiology | Calcitonin Gene-Related Peptide - pharmacology | Dipeptides - pharmacology | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Chelating Agents - pharmacology | Enzyme Activation - drug effects | Antibodies - pharmacology | Pain Measurement - methods | Animals | Egtazic Acid - pharmacology | Ruthenium Red - pharmacology | Dizocilpine Maleate - pharmacology | Excitatory Amino Acid Antagonists | Guanethidine - pharmacology | Nociceptors - drug effects | Methyl aspartate | Nerve growth factor | Cell research | Protein kinases | Index Medicus
Journal Article
Psychopharmacology, ISSN 0033-3158, 12/2008, Volume 201, Issue 3, pp. 443 - 458
Fluoxetine has relatively high affinity for Gq/11 protein-coupled 5-HT2 receptors. Part of these receptors in brain are on astrocytes, where fluoxetine causes... 
Neurosciences | Biomedicine | Serotonin | Astrocytes | Fluoxetine | EGFR transactivation | fosB | c-fos | Pharmacology/Toxicology | Psychiatry | ERK | 5-HT 2B receptor | receptor | C-fos | FosB | 5-HT | SIGNALING PATHWAYS | PSYCHIATRY | TYROSINE KINASE | PHARMACOLOGICAL CHARACTERIZATION | CELL-PROLIFERATION | 5-HT2B receptor | NEUROSCIENCES | SEROTONIN REUPTAKE INHIBITORS | MESSENGER-RNA | TISSUE DISTRIBUTION | MECHANICAL-STRESS | CULTURED ASTROCYTES | PHARMACOLOGY & PHARMACY | R-FLUOXETINE | Receptor, Epidermal Growth Factor - genetics | Up-Regulation | Phosphorylation | Transcriptional Activation - genetics | Nitriles - pharmacology | Calcium - metabolism | Maleimides - pharmacology | Substrate Specificity | Extracellular Signal-Regulated MAP Kinases - metabolism | Quinazolines | Calcium - chemistry | Receptor, Serotonin, 5-HT2B - physiology | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Receptor, Epidermal Growth Factor - metabolism | Piperidines - pharmacology | Receptor, Serotonin, 5-HT2B - drug effects | Urea - analogs & derivatives | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Proto-Oncogene Proteins c-fos - antagonists & inhibitors | Astrocytes - drug effects | Fluoxetine - pharmacology | Butadienes - pharmacology | Gene Expression | Signal Transduction | Dipeptides - pharmacology | RNA, Messenger - genetics | Cells, Cultured | Proto-Oncogene Proteins c-fos - metabolism | Antidepressive Agents, Second-Generation - pharmacology | Protein Kinase C - antagonists & inhibitors | Tyrphostins - pharmacology | Chelating Agents - pharmacology | Antidepressive Agents, Second-Generation - antagonists & inhibitors | Fluoxetine - antagonists & inhibitors | Astrocytes - physiology | Animals | Egtazic Acid - pharmacology | Aminopyridines - pharmacology | Proto-Oncogene Proteins c-fos - genetics | Mice | Urea - pharmacology | Brain | Neurotransmitters | Antidepressants | Psychopharmacology | Cells | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 11810 - 11819
gamma-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production of Alzheimer disease-related amyloid-beta (A beta) peptides. The... 
TARGET | PROTEIN | PATTERN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSMEMBRANE DOMAIN | INHIBITORS | BINDING-SITES | EXPRESSION | FAILURE | PRESENILIN-1 | Pyridines - chemistry | Receptors, Notch - metabolism | Humans | Receptor, EphA4 - metabolism | Pyrimidines - chemistry | Brain - metabolism | Alanine - analogs & derivatives | Dibenzazepines - pharmacology | Drug Interactions | Azepines - chemistry | Piperidines - pharmacology | Protein Processing, Post-Translational - drug effects | Pyrans - chemistry | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Female | Pyrans - pharmacology | Alanine - pharmacology | Carbamates - pharmacology | Binding, Competitive | Guinea Pigs | Amyloid beta-Peptides - biosynthesis | Dipeptides - pharmacology | Mice, Inbred C57BL | Rats | Imidazoles - pharmacology | Pyrimidines - pharmacology | Receptor, EphB2 - metabolism | Sulfonamides - pharmacology | Azepines - pharmacology | Brain - drug effects | Sulindac - analogs & derivatives | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell-Free System | Protein Binding | Mice | Pyridines - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Flurbiprofen - pharmacology | Sulindac - pharmacology | Index Medicus | Neurodegenerative Diseases | Secretases | Neurobiology | Intramembrane Proteolysis | Amyloid | Pharmacology | Alzheimer Disease
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2014, Volume 58, Issue 2, pp. 722 - 733
Journal Article
Circulation Research, ISSN 0009-7330, 11/2004, Volume 95, Issue 10, pp. 989 - 997
Stimulation of α1-adrenoceptors induces proliferation of vascular smooth muscle cells (SMCs) and contributes to arterial remodeling. Although activation of... 
Vascular smooth muscle cell proliferation | Signal transduction | α-adrenergic receptor | Reactive oxygen species | Metalloproteinase | ADVENTITIAL FIBROBLASTS | CARDIAC & CARDIOVASCULAR SYSTEMS | signal transduction | HB-EGF | metalloproteinase | PROTEIN-COUPLED RECEPTORS | ANGIOTENSIN-II | CELL REPLICATION | vascular smooth muscle cell proliferation | MATRIX METALLOPROTEINASES | IN-VITRO | SIGNALING PATHWAY | RAT CAROTID-ARTERY | reactive oxygen species | BALLOON INJURY | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | alpha-adrenergic receptor | Glycine - analogs & derivatives | MAP Kinase Signaling System - physiology | MAP Kinase Kinase 2 - physiology | Nitriles - pharmacology | Adrenergic alpha-1 Receptor Agonists | Receptor, Epidermal Growth Factor - drug effects | MAP Kinase Kinase 1 - physiology | Quinazolines | Phenylephrine - pharmacology | Thrombin - pharmacology | Protein Processing, Post-Translational - drug effects | Cell Division | Flavonoids - pharmacology | Phosphorylation - drug effects | Benzopyrans - pharmacology | Myocytes, Smooth Muscle - drug effects | Receptor, Epidermal Growth Factor - physiology | Hydroxamic Acids - pharmacology | Myocytes, Smooth Muscle - cytology | Aorta, Thoracic - pathology | Organ Culture Techniques | Receptors, Adrenergic, alpha-1 - physiology | Butadienes - pharmacology | Mitogen-Activated Protein Kinase 1 - physiology | Myocytes, Smooth Muscle - enzymology | Dipeptides - pharmacology | Rats | Aorta, Thoracic - injuries | Imidazoles - pharmacology | Tyrphostins - pharmacology | Muscle, Smooth, Vascular - cytology | Anthracenes - pharmacology | Mitogen-Activated Protein Kinase 3 - physiology | Bacterial Proteins - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Glycine - pharmacology | Catheterization - adverse effects | Pyridines - pharmacology | Index Medicus
Journal Article
Vascular Pharmacology, ISSN 1537-1891, 2017, Volume 90, pp. 36 - 43
Abstract Aim The neuropeptide calcitonin gene-related peptide (CGRP) is found in afferent sensory nerve fibers innervating the resistance arteries and plays a... 
Cardiovascular | Brain | Schild plot | Binding affinity | CGRP receptor | Gepants | Mesenteric arteries | AMYLIN RECEPTORS | GENE-RELATED PEPTIDE | N-MC CELLS | HUMAN SUBCUTANEOUS ARTERIES | MIGRAINE | CORONARY-ARTERIES | POTENT | PHARMACOLOGY & PHARMACY | CGRP RECEPTOR ANTAGONISTS | CEREBRAL-ARTERIES | BIBN4096BS | Myography | Muscle, Smooth, Vascular - metabolism | Humans | Male | Mesenteric Arteries - drug effects | Receptors, Calcitonin Gene-Related Peptide - metabolism | Cerebral Arteries - drug effects | Dose-Response Relationship, Drug | Piperidines - pharmacology | Vasodilator Agents - metabolism | Aged, 80 and over | Female | Radioligand Assay | Calcitonin Gene-Related Peptide - metabolism | Muscle, Smooth, Vascular - drug effects | Binding, Competitive | Calcitonin Gene-Related Peptide Receptor Antagonists | Vasodilator Agents - pharmacology | Calcitonin Gene-Related Peptide - pharmacology | Endothelial Cells - metabolism | Dipeptides - pharmacology | Receptor Activity-Modifying Protein 1 - metabolism | Imidazoles - pharmacology | Calcitonin Receptor-Like Protein - metabolism | Mesenteric Arteries - metabolism | Rats, Sprague-Dawley | Cerebellum - blood supply | Azepines - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Cerebral Arteries - metabolism | Protein Binding | Ligands | Aged | Pyridines - pharmacology | Vasodilation - drug effects | In Vitro Techniques | Quinazolines - pharmacology | Sus scrofa | Spiro Compounds - pharmacology | Endothelial Cells - drug effects | Arteries | Peptides | Migraine | Binding | Immunohistochemistry | Headache | Membranes | Muscles | Neuropeptides | Smooth muscle | Pharmacology | Hormones | Receptor activity modifying proteins | Vasodilation | Endothelial cells | Bleeding | Membrane separation | Calcitonin gene-related peptide | Receptors | Calcitonin | Sensory neurons | Affinity | Index Medicus
Journal Article
Molecules, ISSN 1420-3049, 01/2017, Volume 22, Issue 1, pp. 114 - 114
The potential role of non-antibiotic medicinal products in the treatment of multidrug-resistant Gram-negative bacteria has recently been investigated. It is... 
Drugs | Efflux | Efflux pump inhibitor | MDR | Non-antibiotics | Gram-negative bacteria | Medicinal products | PA βN | Quinolones | medicinal products | INFECTIONS | non-antibiotics | drugs | ESCHERICHIA-COLI | CHEMISTRY, ORGANIC | PREVALENCE | efflux | ACINETOBACTER-BAUMANNII | efflux pump inhibitor | ANTIBACTERIAL ACTIVITY | PSEUDOMONAS-AERUGINOSA | quinolones | ARG-BETA-NAPHTHYLAMIDE | DRUG EFFLUX | PAN | MULTIDRUG-RESISTANCE | ANTIMICROBIAL ACTIVITY | Klebsiella pneumoniae - drug effects | Magnesium Sulfate - pharmacology | Ticlopidine - pharmacology | Atorvastatin Calcium - pharmacology | Escherichia coli - drug effects | Pseudomonas aeruginosa - growth & development | Quinolones - pharmacology | Nicergoline - pharmacology | Microbial Sensitivity Tests | Pseudomonas aeruginosa - metabolism | Escherichia coli - metabolism | Escherichia coli - growth & development | Genes, MDR - drug effects | Klebsiella pneumoniae - metabolism | Salmonella - metabolism | Dipeptides - pharmacology | Acyclovir - pharmacology | Salmonella - drug effects | Pseudomonas aeruginosa - drug effects | Alendronate - pharmacology | Klebsiella pneumoniae - growth & development | Salmonella - growth & development | Anti-Bacterial Agents - pharmacology | Famotidine - pharmacology | Amitriptyline - pharmacology | Drug Resistance, Multiple, Bacterial - genetics | Drug Resistance, Multiple, Bacterial - drug effects | Drug Combinations | Antibiotics | Multidrug resistance | Index Medicus | PAβN
Journal Article
Breast Cancer Research, ISSN 1465-5411, 11/2013, Volume 15, Issue 6, pp. R106 - R106
Journal Article
Science Translational Medicine, ISSN 1946-6234, 04/2016, Volume 8, Issue 334, pp. 334ra51 - 334ra51
Journal Article
Journal of Neurophysiology, ISSN 0022-3077, 09/2009, Volume 102, Issue 3, pp. 1443 - 1450
Journal Article