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Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2005, Volume 48, Issue 1, pp. 141 - 151
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 09/2011, Volume 13, Issue 9, pp. 775 - 783
Inhibition of dipeptidyl peptidase‐4 (DPP‐4) by vildagliptin prevents degradation of glucagon‐like peptide‐1 (GLP‐1) and reduces glycaemia in patients with... 
islet function | hypoglycaemia | glucagon‐like peptide‐1 | dipeptidyl peptidase‐4 | type 2 diabetes mellitus | glucose‐dependent insulinotropic polypeptide | insulin resistance | Glucagon-like peptide-1 | Glucose-dependent insulinotropic polypeptide | Hypoglycaemia | Insulin resistance | Type 2 diabetes mellitus | Islet function | Dipeptidyl peptidase-4 | POSTPRANDIAL GLYCEMIA | PERFUSED RAT PANCREAS | glucagon-like peptide-1 | DIPEPTIDYL-PEPTIDASE-4 INHIBITOR | ANTIHYPERGLYCEMIC PROPERTIES | glucose-dependent insulinotropic polypeptide | BETA-CELL FUNCTION | IMPROVES GLYCEMIC CONTROL | dipeptidyl peptidase-4 | IV INHIBITOR | ENDOCRINOLOGY & METABOLISM | TYPE-2 DIABETES-MELLITUS | Dipeptidyl Peptidase 4 - drug effects | Glucagon-Like Peptide 1 - drug effects | Adamantane - pharmacology | Nitriles - pharmacology | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Glucagon-Like Peptide 1 - physiology | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Dipeptidyl Peptidase 4 - physiology | Diabetes Mellitus, Type 2 - physiopathology | Adamantane - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Adamantane - analogs & derivatives | Nitriles - therapeutic use | Type 2 diabetes | Enzymes | Glucose metabolism | Glucagon | Analysis | Physiological aspects | Triglycerides | Glucose | Dextrose
Journal Article
British Journal of Cancer, ISSN 0007-0920, 04/2017, Volume 116, Issue 9, pp. 1126 - 1134
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2011, Volume 19, Issue 16, pp. 4953 - 4970
Synthesis, inhibition of dipeptidyl peptidase IV (DPP-4) inhibitory activity of new isoquinolone ( ) are described. The design, synthesis, and... 
Anti-diabetic effects | Isoquinolone | Dipeptidyl peptidase IV (DPP-4) | CHEMISTRY, MEDICINAL | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN-SECRETION | RATS | CHEMISTRY, ORGANIC | IMPROVED GLUCOSE-TOLERANCE | IN-VITRO | HORMONE | GLUCAGON-LIKE PEPTIDE-1 | DEGRADATION | MICE | THIAZOLIDIDE | Dipeptidyl Peptidase 4 - drug effects | Rats, Wistar | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Quinolones - pharmacology | Structure-Activity Relationship | Molecular Targeted Therapy | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - antagonists & inhibitors | Isoquinolines - pharmacology | Peptides - metabolism | Quinolones - chemistry | Hypoglycemic Agents - administration & dosage | Quinolones - chemical synthesis | Quinolones - therapeutic use | Drug Design | Female | Dipeptidyl Peptidase 4 - analysis | Caco-2 Cells | Hypoglycemic Agents - therapeutic use | Glucose Tolerance Test | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - drug effects | Administration, Oral | Rats | Blood Glucose | Dipeptidyl-Peptidase IV Inhibitors - chemistry | Hypoglycemic Agents - chemistry | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Hypoglycemic Agents - pharmacology | Dipeptidyl-Peptidase IV Inhibitors - chemical synthesis | Quinolones - administration & dosage | Animals | Isoquinolines - chemical synthesis | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - analysis | Hypoglycemic Agents - chemical synthesis | Isoquinolines - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Isoquinolines - administration & dosage
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2006, Volume 28, Issue 1, pp. 55 - 72
Journal Article
Journal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2016, Volume 153, Issue 3, pp. 713 - 724.e4
Journal Article