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European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2019, Volume 180, pp. 509 - 523
Journal Article
by Li, Y and Yang, L and Dong, L and Yang, ZW and Zhang, J and Zhang, SL and Niu, MJ and Xia, JW and Gong, Y and Zhu, N and Zhang, XJ and Zhang, YY and Wei, XM and Zhang, YZ and Zhang, P and Li, SQ
ACTA PHARMACOLOGICA SINICA, ISSN 1671-4083, 10/2019, Volume 40, Issue 10, pp. 1322 - 1333
Abnormal wound healing by pulmonary artery smooth muscle cells (PASMCs) promotes vascular remodeling in hypoxia-induced pulmonary hypertension (HPH).... 
I kappa B kinase | RAPAMYCIN | MOLECULAR-DYNAMICS | pulmonary hypertension | DOCKING | CHEMISTRY, MULTIDISCIPLINARY | pulmonary artery smooth muscle cells | DISCOVERY | DPP4 | SMOOTH-MUSCLE | NF-kappa B | sitagliptin | INHIBITION | INFLAMMATION | PHARMACOLOGY & PHARMACY | mTORC1 | Dipeptidyl Peptidase 4 - metabolism | Sitagliptin Phosphate - pharmacology | TOR Serine-Threonine Kinases - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Male | NF-kappa B - metabolism | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Pulmonary Artery - metabolism | HEK293 Cells | Myocytes, Smooth Muscle - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Myocytes, Smooth Muscle - metabolism | Wound Healing - drug effects | Disease Models, Animal | Sitagliptin Phosphate - administration & dosage | Cell Survival - drug effects | Cell Hypoxia - drug effects | NF-kappa B - antagonists & inhibitors | Administration, Oral | Cells, Cultured | Computational Biology | Rats | Pulmonary Artery - drug effects | Rats, Sprague-Dawley | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Animals | Signal Transduction - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Pulmonary Artery - pathology | TOR protein | Phosphorylation | Immunoprecipitation | Transcription | Crosstalk | Smooth muscle | AKT protein | Activation | Remodeling | Kinases | Molecular docking | Inhibition | Bioinformatics | Hypertension | NF-κB protein | Immunoglobulins | Wound healing | Peptidase | Pulmonary arteries | Muscles | Mass spectroscopy | Rapamycin | Pulmonary artery | Pulmonary hypertension | Signaling | Inhibitors | Hypoxia | Mass spectrometry
Journal Article
Journal Article
Cardiovascular Toxicology, ISSN 1530-7905, 2018, Volume 19, Issue 3, pp. 244 - 254
This study investigated vildagliptin-induced vasodilation and its related mechanisms using phenylephrine induced precontracted rabbit aortic rings.... 
channel | Vildagliptin | Aortic smooth muscle | SERCA pump | Voltage-dependent K | CALCIUM-ATPASE | CARDIAC & CARDIOVASCULAR SYSTEMS | DEATH | Voltage-dependent K+ channel | ENDOTHELIUM | DISEASE | TOXICOLOGY | TYPE-2 | EXPRESSION | K+ CHANNELS | MODULATION | Rabbits | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Vasodilator Agents - pharmacology | Signal Transduction | Potassium Channels, Voltage-Gated - agonists | Male | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Aorta, Thoracic - enzymology | Animals | Potassium Channels, Voltage-Gated - metabolism | Vildagliptin - pharmacology | Aorta, Thoracic - drug effects | Enzyme Activation | Vasodilation - drug effects | Muscle, Smooth, Vascular - enzymology | Muscle, Smooth, Vascular - drug effects | Medical colleges | Dendritic cells | Dilatation | Vasodilators | Blood vessels | Hypoglycemic agents | Protein kinases | Adenosine triphosphatase | Biomedical engineering | Endothelium | Protein kinase A | Protein kinase G | Smooth muscle | Activation | Potassium conductance | Kinases | Guanylate cyclase | Channels | Vasodilation | Ca2+-transporting ATPase | Potassium channels (calcium-gated) | Proteins | Thapsigargin | Cascades | Phenylephrine | Aorta | Potassium channels (voltage-gated) | Pretreatment | Glibenclamide | Diabetes mellitus | Muscles | Potassium channels | Cyclopiazonic acid | Resistance | Inhibitors | Calcium conductance | Nitric oxide | Conductance | Endoplasmic reticulum | Calcium (reticular) | Calcium ions
Journal Article
Journal Article
Journal Article