X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (114) 114
animals (99) 99
index medicus (78) 78
male (58) 58
dipeptidyl-peptidases and tripeptidyl-peptidases (56) 56
neuronal ceroid-lipofuscinoses - genetics (55) 55
aminopeptidases (54) 54
dipeptidyl-peptidases and tripeptidyl-peptidases - metabolism (53) 53
female (53) 53
serine proteases (49) 49
dipeptidyl-peptidases and tripeptidyl-peptidases - genetics (48) 48
mice (44) 44
aminopeptidases - genetics (38) 38
mutation (38) 38
serine proteases - genetics (36) 36
biochemistry & molecular biology (35) 35
child (30) 30
enzymes (30) 30
rats (30) 30
dipeptidyl-peptidases and tripeptidyl-peptidases - deficiency (29) 29
genetics & heredity (29) 29
neuronal ceroid-lipofuscinosis (29) 29
aminopeptidases - metabolism (27) 27
child, preschool (27) 27
batten-disease (26) 26
serine proteases - metabolism (26) 26
cell biology (25) 25
mutations (25) 25
neuronal ceroid lipofuscinosis (25) 25
neurons (25) 25
gene (24) 24
neuronal ceroid-lipofuscinoses - enzymology (24) 24
mice, knockout (23) 23
neuronal ceroid-lipofuscinoses - pathology (22) 22
peptide hydrolases - genetics (22) 22
disease models, animal (21) 21
genetic aspects (21) 21
proteins (21) 21
research (21) 21
endopeptidases - metabolism (20) 20
neurosciences (20) 20
dipeptidyl peptidase 4 (19) 19
endopeptidases - genetics (19) 19
molecular sequence data (19) 19
tripeptidyl-peptidase-i (19) 19
adult (18) 18
amino acid sequence (18) 18
neuronal ceroid-lipofuscinoses - metabolism (18) 18
disease (17) 17
endopeptidases (17) 17
medicine, research & experimental (17) 17
mouse model (17) 17
protein (17) 17
phenotype (16) 16
proteases (16) 16
adolescent (15) 15
analysis (15) 15
apoptosis (15) 15
article (15) 15
cln2 (15) 15
endopeptidases - deficiency (15) 15
expression (15) 15
infant (15) 15
membrane proteins - genetics (15) 15
neuronal ceroid-lipofuscinoses - diagnosis (15) 15
diagnosis (14) 14
lysosomes - enzymology (14) 14
neuronal ceroid-lipofuscinoses - physiopathology (14) 14
research article (14) 14
batten disease (13) 13
cells, cultured (13) 13
multidisciplinary sciences (13) 13
rats, inbred f344 (13) 13
aminopeptidases - deficiency (12) 12
clinical neurology (12) 12
gene expression (12) 12
brain (11) 11
brain - pathology (11) 11
cell line (11) 11
enzyme replacement therapy (11) 11
lysosomes - metabolism (11) 11
medicine (11) 11
mice, inbred c57bl (11) 11
neurodegeneration (11) 11
neuronal ceroid-lipofuscinoses - therapy (11) 11
peptidase (11) 11
physiological aspects (11) 11
base sequence (10) 10
cd26 (10) 10
dipeptidyl-peptidases and tripeptidyl-peptidases - antagonists & inhibitors (10) 10
dipeptidyl-peptidases and tripeptidyl-peptidases - chemistry (10) 10
disease progression (10) 10
pathology (10) 10
serine proteases - deficiency (10) 10
subunit-c (10) 10
age of onset (9) 9
biochemistry (9) 9
children (9) 9
cho cells (9) 9
deficiency (9) 9
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Blood, ISSN 0006-4971, 01/2015, Volume 125, Issue 5, pp. 753 - 761
Autoimmune cytopenia is a frequent manifestation of primary immunodeficiencies. Two siblings presented with Evans syndrome, viral infections, and progressive... 
B-CELLS | EFFECTOR | TPPII | COMPLEX | PHENOTYPE | SUBSETS | SENESCENCE | MUTATIONS | GIANT PROTEASE | HEMATOLOGY | EXHAUSTION | Immunologic Deficiency Syndromes - pathology | Frameshift Mutation | Perforin - genetics | Humans | Aminopeptidases - immunology | Child, Preschool | Male | Anemia, Hemolytic, Autoimmune - genetics | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - deficiency | Thrombocytopenia - complications | Thrombocytopenia - genetics | Aging - immunology | Anemia, Hemolytic, Autoimmune - pathology | T-Lymphocytes - metabolism | Base Sequence | Serine Endopeptidases - genetics | Serine Endopeptidases - immunology | CD8-Positive T-Lymphocytes - metabolism | Perforin - immunology | Immunologic Deficiency Syndromes - immunology | Child | Fibroblasts - metabolism | Gene Expression | Serine Endopeptidases - deficiency | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - immunology | Thrombocytopenia - immunology | Aminopeptidases - deficiency | Fibroblasts - pathology | Thrombocytopenia - pathology | Mice, Knockout | Anemia, Hemolytic, Autoimmune - immunology | Fibroblasts - immunology | T-Lymphocytes - immunology | Consanguinity | Mice | CD8-Positive T-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - pathology | Molecular Sequence Data | T-Box Domain Proteins - immunology | Female | T-Lymphocytes - pathology | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics | Siblings | Aminopeptidases - genetics | Immunologic Deficiency Syndromes - complications | Anemia, Hemolytic, Autoimmune - complications | T-Box Domain Proteins - genetics | Animals | Immunologic Deficiency Syndromes - genetics | Apoptosis | Plenary Paper | 100
Journal Article
Journal Article
Journal Article
Brain, ISSN 0006-8950, 2013, Volume 136, Issue 5, pp. 1488 - 1507
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e78378
Dipeptidyl Peptidase (DPP) 4 and related dipeptidyl peptidases are emerging as current and potential therapeutic targets. DPP9 is an intracellular protease... 
LOCALIZATION | APOPTOSIS | DPP-IV | INHIBITION | GENE | MULTIDISCIPLINARY SCIENCES | CELL-ADHESION | MICE | SUBSTANCE-P | FIBROBLAST ACTIVATION PROTEIN | EXPRESSION | Animals, Newborn - abnormalities | Animals, Newborn - metabolism | Fibroblasts - enzymology | Gene Expression | Animals, Newborn - genetics | Liver - enzymology | Embryo, Mammalian | Mice, Transgenic - genetics | Male | Enzyme Assays | Mice, Transgenic - metabolism | Mice, Transgenic - abnormalities | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - deficiency | Gene Knock-In Techniques | Founder Effect | Homozygote | Point Mutation | Animals | Female | Heterozygote | Mice | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics | Amino Acid Substitution | Crosses, Genetic | Type 2 diabetes | Infants (Newborn) | Gene mutations | Proteases | Patient outcomes | Amino acids | Infants | B cells | Health aspects | Neonates | Peptides | Weaning | Serine | Body weight | Leukemia | Antigen processing | Homeostasis | Neuropeptides | Biology | Lethality | Birth | Kinases | Inactivation | Medical schools | Proteins | SUMO protein | Epidermal growth factor | Enzymatic activity | Rodents | Gender aspects | Fibroblasts | Localization | Genotypes | Medical research | Enzymes | Antigens | Alanine | Peptidase | Deactivation | Therapeutic applications | Sex differences | Embryo fibroblasts | Embryos | Peptidases | Signaling | Point mutation | Mutation | Cancer | Apoptosis
Journal Article
Experimental Eye Research, ISSN 0014-4835, 08/2014, Volume 125, pp. 164 - 172
Journal Article
Molecular Therapy, ISSN 1525-0016, 07/2017, Volume 25, Issue 7, pp. 1531 - 1543
We have investigated delivery of protein therapeutics from the bloodstream into the brain using a mouse model of late-infantile neuronal ceroid lipofuscinosis... 
blood brain barrier | intravenous | enzyme replacement therapy | tripeptidyl peptidase 1 | MEDICINE, RESEARCH & EXPERIMENTAL | WHEAT-GERM-AGGLUTININ | HORSERADISH-PEROXIDASE | LYSOSOMAL-ENZYME | TRANSPORT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ADSORPTIVE TRANSCYTOSIS | MOUSE MODEL | I ACTIVITY | GENETICS & HEREDITY | MANNOSE 6-PHOSPHATE RECEPTOR | POLYCATIONS | NEURONAL CEROID-LIPOFUSCINOSIS | Neuronal Ceroid-Lipofuscinoses - enzymology | Serine Proteases - genetics | Injections, Intravenous | Humans | Peptides - pharmacokinetics | Brain - enzymology | Infant | Apolipoproteins E - pharmacokinetics | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - deficiency | Neuronal Ceroid-Lipofuscinoses - pathology | Drug Carriers | Endocytosis | Neuronal Ceroid-Lipofuscinoses - genetics | Serine Proteases - deficiency | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics | Disease Models, Animal | Amino Acid Sequence | Neuronal Ceroid-Lipofuscinoses - therapy | Aminopeptidases - genetics | Peptides - chemistry | Endothelial Cells - metabolism | Gene Expression Regulation | Treatment Outcome | Aminopeptidases - deficiency | Blood-Brain Barrier - drug effects | Apolipoproteins E - chemistry | Blood-Brain Barrier - metabolism | Brain - drug effects | Enzyme Replacement Therapy - methods | Animals | Survival Analysis | Brain - pathology | Mice | Endothelial Cells - pathology | Endothelial Cells - drug effects | Animal models | Intravenous administration | Disease | Peptides | Toxicity | Liver | Experiments | Proteins | Blood-brain barrier | Apolipoprotein E | Neuronal ceroid lipofuscinosis | Drug dosages | Enzymes | Peptidase | Kidneys | Biotin | Grants | Endothelial cells | Studies | Brain research | Life span | Morphology | Scientific imaging | Mass spectrometry | Cancer | Original
Journal Article
Acta neuropathologica communications, ISSN 2051-5960, 10/2017, Volume 5, Issue 1, pp. 74 - 21
The neuronal ceroid lipofuscinoses (NCLs or Batten disease) are a group of inherited, fatal neurodegenerative disorders of childhood. In these disorders, glial... 
CLN3 disease | Neuronal ceroid lipofuscinosis | Juvenile batten disease | Astrocyte and microglial dysfunction | Neuron-glial interactions | THALAMOCORTICAL SYSTEM | COLONY-STIMULATING FACTORS | NECROSIS-FACTOR-ALPHA | NEUROSCIENCES | IN-VITRO | EPILEPTIFORM ACTIVITY | MOUSE MODEL | NITRIC-OXIDE | CENTRAL-NERVOUS-SYSTEM | BATTEN-DISEASE | METHYL-D-ASPARTATE | Serine Proteases - genetics | Neurons - pathology | Glutathione - metabolism | Neuroglia - pathology | Coculture Techniques | Humans | Male | Neuronal Ceroid-Lipofuscinoses - physiopathology | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - deficiency | Cell Movement - physiology | Neuronal Ceroid-Lipofuscinoses - pathology | Young Adult | Neurons - physiology | Adult | Female | Serine Proteases - deficiency | Child | Cell Survival - physiology | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics | Aminopeptidases - genetics | Cytoskeleton - pathology | Brain - physiopathology | Mice, Inbred C57BL | Cells, Cultured | Molecular Chaperones - genetics | Neuroglia - physiology | Mice, Transgenic | Aminopeptidases - deficiency | Membrane Glycoproteins - genetics | Animals | Brain - pathology | Cytoskeleton - metabolism | Membrane Glycoproteins - deficiency | Medical research | Nervous system diseases | Neurons | Medicine, Experimental | Genetic aspects | Glutamate | Mitogens | Signal transduction | Pathology | Disease | Cytokines | Neurodegeneration | Pathogenesis | Rodents | Mutation
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/1999, Volume 96, Issue 15, pp. 8627 - 8632
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2007, Volume 120, Issue 2, pp. 403 - 408
Journal Article