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Chemical Research in Toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a... 
ACYL GLUCURONIDES | CHEMISTRY, MEDICINAL | PROTEIN | RAT | REACTIVE METABOLITES | TIENILIC ACID | HEPATIC-NECROSIS | BIOACTIVATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | TOXICOLOGY | HUMAN URINE | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
Journal Article
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2005, Volume 353, Issue 2, pp. 334 - 344
In mammals, histamine action is terminated through metabolic inactivation by histamine N-methyltransferase (HNMT) and diamine oxidase. In addition to three... 
amodiaquine | tacrine | metoprine | diphenhydramine | HNMT inhibitors | Amodiaquine | Metoprine | Diphenhydramine | Tacrine | MONOAMINE-OXIDASE | H-3 RECEPTOR | BRAIN HISTAMINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAST-CELLS | ESCHERICHIA-COLI | LOCOMOTOR-ACTIVITY | DEFICIENT MICE | RAT-BRAIN | Folic Acid Antagonists - chemistry | Histamine N-Methyltransferase - chemistry | Histamine N-Methyltransferase - metabolism | Humans | Cholinesterase Inhibitors - chemistry | Crystallography, X-Ray | Amodiaquine - chemistry | Pyrimethamine - metabolism | Amodiaquine - metabolism | Histamine H1 Antagonists - metabolism | Cholinesterase Inhibitors - metabolism | Diphenhydramine - metabolism | Pyrimethamine - analogs & derivatives | Molecular Structure | Tacrine - chemistry | Pyrimethamine - chemistry | Tacrine - metabolism | Antimalarials - metabolism | Models, Molecular | Diphenhydramine - chemistry | Animals | Folic Acid Antagonists - metabolism | Antimalarials - chemistry | Protein Conformation | Histamine N-Methyltransferase - antagonists & inhibitors | Histamine H1 Antagonists - chemistry | Oxidases | Histamine | Permeability | Cholinesterase inhibitors | Alzheimer's disease | STIMULATION | PERMEABILITY | BASIC BIOLOGICAL SCIENCES | CELL PROLIFERATION | national synchrotron light source | INACTIVATION | CONTRACTION | AROMATICS | GASTRIC ACID | HISTAMINE | REGULATIONS | SECRETION | PROTEINS | RESIDUES | MUSCLES | MAMMALS
Journal Article
The AAPS Journal, ISSN 1550-7416, 4/2013, Volume 15, Issue 2, pp. 299 - 307
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 05/2013, Volume 114, Issue 5, pp. 1009 - 1019
Histamine, a major mediator present in mast cells that is released into the extracellular milieu upon degranulation, is well known to possess a wide range of... 
SYNERGISTIC ACTION | BASIC FIBROBLAST GROWTH FACTOR | HISTAMINE | ANGIOGENESIS | histamine | synergistic action | angiogenesis | basic fibroblast growth factor | PROTEIN-KINASE-C | ACTIVATION | ARTERY ENDOTHELIAL-CELLS | CYCLOOXYGENASE-2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | FIBROBLAST-GROWTH-FACTOR | NECROSIS-FACTOR-ALPHA | CANCER | CELL BIOLOGY | INHIBITION | INFLAMMATION | EXPRESSION | Neovascularization, Physiologic - drug effects | Vascular Endothelial Growth Factor A - biosynthesis | Human Umbilical Vein Endothelial Cells - drug effects | Histamine - pharmacology | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Fibroblast Growth Factor 2 - pharmacology | Rats | Male | NF-kappa B - metabolism | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Receptors, Histamine H1 - metabolism | Animals | Human Umbilical Vein Endothelial Cells - enzymology | Receptors, Vascular Endothelial Growth Factor - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | Nitric Oxide Synthase - metabolism | Phosphorylation - drug effects | In Vitro Techniques | Mitogen-Activated Protein Kinases - metabolism | COX-2 inhibitors | Histamine | Analysis | Nitric oxide | Cimetidine | Physiological aspects | Fibroblast growth factors | Diphenhydramine | Indomethacin | Vascular endothelial growth factor | Mitogens
Journal Article
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 07/2013, Volume 49, Issue 4, pp. 767 - 772
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2008, Volume 106, Issue 1, pp. 147 - 157
The pattern of activation of dopamine (DA) neurotransmission in the nucleus accumbens (NAc) of rats produced by H1 histamine antagonists which have behavioral... 
histamine H1 antagonists | cocaine | dopamine | chlorpheniramine | diphenhydramine | nucleus accumbens shell | Histamine H1 antagonists | Chlorpheniramine | Cocaine | Dopamine | Nucleus accumbens shell | Diphenhydramine | HISTAMINE H-1 ANTAGONISTS | EXTRACELLULAR DOPAMINE | RECEPTOR BLOCKADE | RHESUS-MONKEYS | PLACE PREFERENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | NEUROSCIENCES | NUCLEUS-ACCUMBENS | LOCAL-ANESTHETICS | MESOLIMBIC DOPAMINE TRANSMISSION | Diphenhydramine - pharmacology | Dopamine Plasma Membrane Transport Proteins - metabolism | Synaptosomes - drug effects | Central Nervous System Stimulants - pharmacology | Synaptic Transmission - physiology | Dopamine Uptake Inhibitors - agonists | Dopamine Plasma Membrane Transport Proteins - drug effects | Stereoisomerism | Nucleus Accumbens - metabolism | Male | Dopamine Agonists - adverse effects | Synaptosomes - metabolism | Cocaine - agonists | Serotonin Plasma Membrane Transport Proteins - drug effects | Central Nervous System Stimulants - adverse effects | Histamine H1 Antagonists - pharmacology | Triprolidine - adverse effects | Synaptic Transmission - drug effects | Chlorpheniramine - adverse effects | Dopamine - metabolism | Dopamine Agonists - pharmacology | Substance-Related Disorders - metabolism | Presynaptic Terminals - drug effects | Rats | Rats, Sprague-Dawley | Substance-Related Disorders - physiopathology | Triprolidine - pharmacology | Diphenhydramine - adverse effects | Histamine H1 Antagonists - adverse effects | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Presynaptic Terminals - metabolism | Chlorpheniramine - pharmacology | Reward | Nucleus Accumbens - drug effects | Antihistamines | Neurology | Histamine | Neurotransmitters | Rodents | Comparative studies | Biochemistry | Index Medicus | Nucleus Accumbens shell
Journal Article
Journal Article