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Journal Article
Nature, ISSN 0028-0836, 09/2011, Volume 477, Issue 7366, pp. 616 - 622
Journal Article
Biochimie, ISSN 0300-9084, 10/2014, Volume 105, pp. 110 - 118
Journal Article
Carbohydrate Research, ISSN 0008-6215, 12/2012, Volume 364, pp. 22 - 27
Journal Article
FEBS Letters, ISSN 0014-5793, 2003, Volume 541, Issue 1, pp. 115 - 120
The last enzyme (LytB) of the methylerythritol phosphate pathway for isoprenoid biosynthesis catalyzes the reduction of ( E )‐4‐hydroxy‐3‐methylbut‐2‐enyl... 
2- C-Methyl- D-erythritol 4-phosphate pathway | Isoprenoid | Isopentenyl diphosphate | ( E)-4-Hydroxy-3-methylbut-2-enyl diphosphate | Dimethylallyl diphosphate | LytB | EPR, electron paramagnetic resonance | HMBPP | erythritol 4-phosphate pathway | erythritol 4-phosphate | 4-Hydroxy-3-methylbut-2-enyl diphosphate | IPP, isopentenyl diphosphate | MEP, 2 | Methyl | DAF, 5-deazaflavin (10-methyl-5-deazaisoalloxazine) | DMAPP, dimethylallyl diphosphate | ME, 2 | erythritol | (E)-4-Hydroxy-3-methylbut-2-enyl diphosphate | 2-C-Methyl-D-erythritol 4-phosphate pathway | IRON-SULFUR PROTEINS | 2-C-methyl-D-erythritol 4-phosphate pathway | CONVERSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | QUANTITATION | LYASE ACTIVATING ENZYME | isopentenyl diphosphate | (E)-4-hydroxy-3-methylbut-2-enyl diphosphate | CELL BIOLOGY | SYNTHASE | BIOPHYSICS | CLUSTERS | HIGHER-PLANTS | 2-C-METHYL-D-ERYTHRITOL | PYROPHOSPHATE | dimethylallyl diphosphate | isoprenoid | NONMEVALONATE PATHWAY | Diphosphates - metabolism | Escherichia coli - enzymology | Electron Spin Resonance Spectroscopy | Erythritol - analogs & derivatives | Models, Chemical | Oxidoreductases - metabolism | Polyisoprenyl Phosphate Sugars - biosynthesis | Escherichia coli Proteins - metabolism | Iron-Sulfur Proteins - chemistry | Organophosphorus Compounds - metabolism | Oxidoreductases - chemistry | Sugar Phosphates - metabolism | Hemiterpenes | Erythritol - metabolism | Iron-Sulfur Proteins - metabolism | Escherichia coli Proteins - chemistry | NADH, NADPH Oxidoreductases - metabolism | isoprenoids | LytB protein | diphosphate reductase | methylerythritol phosphate | Index Medicus
Journal Article
International Journal of Psychophysiology, ISSN 0167-8760, 10/2018, Volume 131, p. S28
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 24, pp. 10022 - 10027
Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS), resulting in decreased... 
Enzymes | Yeasts | Electronic structure | Molecular structure | Terpenoids | Diphosphonates | Ligands | Biosynthesis | Diphosphates | Binding sites | Undecaprenyl diphosphate synthase | Geranylgeranyl diphosphate synthase | X-ray structure | Cell wall | FARNESYL DIPHOSPHATE SYNTHASE | POTENTIAL ROUTE | INHIBITION | MECHANISM | ISOPRENOID BIOSYNTHESIS | STRUCTURAL BASIS | NITROGEN-CONTAINING BISPHOSPHONATES | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GERANYLGERANYL PYROPHOSPHATE SYNTHASE | DRUGS | Diphosphates - metabolism | Polyisoprenyl Phosphates - chemistry | Sesquiterpenes - metabolism | Models, Chemical | Stereoisomerism | Alkyl and Aryl Transferases - antagonists & inhibitors | Substrate Specificity | Crystallography, X-Ray | Isoenzymes - chemistry | Isoenzymes - metabolism | Transferases - metabolism | Farnesyltranstransferase - antagonists & inhibitors | Molecular Structure | Transferases - antagonists & inhibitors | Diterpenes - metabolism | Binding Sites | Dimerization | Diterpenes - chemistry | Alkyl and Aryl Transferases - chemistry | Sesquiterpenes - chemistry | Protein Structure, Secondary | Models, Molecular | Transferases - chemistry | Diphosphonates - metabolism | Polyisoprenyl Phosphates - metabolism | Farnesyltranstransferase - chemistry | Diphosphates - chemistry | Diphosphonates - chemistry | Hydrophobic and Hydrophilic Interactions | Saccharomyces cerevisiae - enzymology | Isoenzymes - antagonists & inhibitors | Usage | Research | X-ray spectroscopy | Plant cell walls | Guanosine triphosphatase | Biochemistry | Inhibitor drugs | Drug therapy | Index Medicus | Biological Sciences | undecaprenyl diphosphate synthase | x-ray structure | geranylgeranyl diphosphate synthase | cell wall
Journal Article
Science, ISSN 0036-8075, 2013, Volume 342, Issue 6163, pp. 1235 - 1239
Journal Article
Acta Crystallographica Section F, ISSN 2053-230X, 06/2018, Volume 74, Issue 6, pp. 373 - 384
Nucleoside diphosphate kinases (NDKs) are implicated in a wide variety of cellular functions owing to their enzymatic conversion of NDP to NTP. NDK from... 
structural genomics | protein structure | Lyme disease | bacterial metabolism | Borrelia burgdorferi | protein crystallization | nucleoside diphosphate kinase | Seattle Structural Genomics Center for Infectious Disease | LYME-DISEASE SPIROCHETE | PROTEIN-PRODUCTION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | X-RAY-STRUCTURE | BIOCHEMICAL RESEARCH METHODS | CRYSTALLOGRAPHY | IDENTIFICATION | DICTYOSTELIUM | INFECTIOUS-DISEASE | TRANSPOSON MUTAGENESIS | BIOPHYSICS | LINEAR PLASMID-25 | GENOMICS CENTER | Adenosine Diphosphate - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Nucleoside-Diphosphate Kinase - metabolism | Adenosine Diphosphate - chemistry | Vanadates - chemistry | Mice, Inbred C3H | Vanadates - metabolism | Borrelia burgdorferi - enzymology | Animals | Nucleoside-Diphosphate Kinase - chemistry | Borrelia burgdorferi - genetics | Female | Mice | Adenosine Diphosphate - metabolism | Binding Sites | Nucleoside-Diphosphate Kinase - genetics | Data banks | Quaternary | Crystallization | Infections | Kinases | ADP | Mutants | Vanadate | Proteins | Infectious diseases | Infectivity | Vanadates | Nucleosides | Ligands | Catalysis | Inhibition | Phosphohistidine | Nucleoside-diphosphate kinase | Protein structure | Structural analysis | Recombinant | Structure-function relationships | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2002, Volume 99, Issue 3, pp. 1158 - 1163
Isopentenyl diphosphate and dimethylallyl diphosphate serve as the universal precursors for the biosynthesis of terpenes. Although their biosynthesis by means... 
Enzymes | Chemical equilibrium | Biological Sciences | Metabolites | Plasmids | Terpenoids | Atoms | Biosynthesis | Biochemistry | Diphosphates | Terpenes | Biosynthesis of isoprenoids | Isopentenyl diphosphate | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate | Dimethylallyl diphosphate | PRECURSOR | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | THIAMIN | 4-(CYTIDINE 5'-DIPHOSPHO)-2-C-METHYL-D-ERYTHRITOL | biosynthesis of isoprenoids | ENZYME | GENE | ISOPRENOID BIOSYNTHESIS | 5-PHOSPHATE | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate isopentenyl diphosphate | dimethylallyl diphosphate | ISOPENTENYL-DIPHOSPHATE ISOMERASE | Recombinant Proteins - metabolism | Promoter Regions, Genetic | Magnetic Resonance Spectroscopy | Operon | Bacterial Proteins - genetics | Oligodeoxyribonucleotides - chemistry | Enterobacteriaceae - genetics | Molecular Sequence Data | Mevalonic Acid - metabolism | Escherichia coli Proteins | Terpenes - metabolism | Escherichia coli - genetics | Base Sequence | Escherichia coli - metabolism | Bacterial Proteins - metabolism | Oxidoreductases | Mycobacterium tuberculosis - genetics | Physiological aspects | Genetic research | Analysis | Proteins | Phosphates | Metabolism | Genes | ispH gene | mevalonic acid | lytB gene | terpenes | isopentenyl diphosphate | Index Medicus | biosynthesis of isoprenoids‖1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate‖isopentenyl diphosphate‖dimethylallyl diphosphate
Journal Article