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1. Full Text Pharmacokinetics/Pharmacodynamics of Bisphosphonates: Use for Optimisation of Intermittent Therapy for Osteoporosis
by Cremers, Serge C.L.M and Pillai, Goonaseelan Colin and Papapoulos, Socrates E
2005, Volume 44, Issue 6, 20
Alendronic acid | Osteoporosis | Etidronic acid | Risedronic acid | Olpadronic acid | Zoledronic acid | Ibandronic acid | Tiludronic acid | Bisphosphonates | Pamidronic acid | Research and development | Clodronic acid | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Animals | Osteoporosis - metabolism | Humans | Diphosphonates - pharmacokinetics | Diphosphonates - therapeutic use | Osteoporosis - drug therapy | Clinical Trials as Topic | Index Medicus
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2. Full Text Bone metastasis targeting: A novel approach to reach bone using Zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel
by Ramanlal Chaudhari, Kiran and Kumar, Abhinesh and Megraj Khandelwal, Vinoth Kumar and Ukawala, Mukesh and Manjappa, Arehalli S and Mishra, Anil Kumar and Monkkonen, Jukka and Ramachandra Murthy, Rayasa S
Journal of controlled release, ISSN 0168-3659, 03/2012, Volume 158, Issue 3, pp. 470 - 478
Nanoparticles | Zoledronic acid | Bone targeting | Bisphosphonates | Docetaxel | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Humans | Drug Carriers - administration & dosage | Imidazoles - administration & dosage | Antineoplastic Agents - administration & dosage | Imidazoles - pharmacokinetics | Lactic Acid - pharmacokinetics | Neoplasm Metastasis | Antineoplastic Agents - pharmacokinetics | Bone Neoplasms - drug therapy | Lactic Acid - administration & dosage | Polyglycolic Acid - administration & dosage | Bone Density Conservation Agents - pharmacokinetics | Cell Line | Diphosphonates - pharmacokinetics | Polyethylene Glycols - pharmacokinetics | Diphosphonates - administration & dosage | Bone Density Conservation Agents - administration & dosage | Polyethylene Glycols - administration & dosage | Taxoids - pharmacokinetics | Taxoids - administration & dosage | Animals | Polyglycolic Acid - pharmacokinetics | Cell Line, Tumor | Drug Carriers - pharmacokinetics | Mice | Nanoparticles - administration & dosage | Drugs | Phosphates | Antimitotic agents | Drug delivery systems | Phosphonates | Metastasis | Antineoplastic agents | Vehicles | Index Medicus
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3. The Role of phosphonates in living systems
by Hilderbrand, Richard L., 1946
1983, 1, ISBN 0849357241, Volume 1, 207
Metabolism | Physiological effect | Phosphonates | Phosphonic acids | Complementary & Alternative Medicine | Phosphonic acids-Metabolism | Phosphonic acids-Physiological effect | Phosphonates-Physiological effect | Phosphonates-Metabolism
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4. Full Text Design, Synthesis, and Pharmacokinetics of a Bone-Targeting Dual-Action Prodrug for the Treatment of Osteoporosis
by Xie, Haibo and Chen, Gang and Young, Robert N
Journal of medicinal chemistry, ISSN 0022-2623, 08/2017, Volume 60, Issue 16, pp. 7012 - 7028
Alendronate - analogs & derivatives | Alendronate - chemical synthesis | Humans | Osteoporosis - drug therapy | Tritium | Prodrugs - metabolism | Bone and Bones - metabolism | Diphosphonates - chemical synthesis | Drug Design | Female | Dipeptides - chemical synthesis | Dipeptides - metabolism | Bone Density Conservation Agents - metabolism | Receptors, Prostaglandin E, EP4 Subtype - agonists | Dipeptides - pharmacology | Drug Stability | Bone Resorption - drug therapy | Diphosphonates - metabolism | Bone Density Conservation Agents - chemical synthesis | Rats, Sprague-Dawley | Bone Density Conservation Agents - pharmacology | Alendronate - metabolism | Animals | Cathepsin K - metabolism | Alendronate - pharmacology | Prodrugs - chemical synthesis | Prodrugs - pharmacology | Diphosphonates - pharmacology | Index Medicus
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5. Full Text Pharmacokinetics and Tolerability of Minodronic Acid Tablets in Healthy Chinese Subjects and Food and Age Effects on the Pharmacokinetics
by Zhou, Ying, MS and He, Xiaomeng, MD and Li, Huqun, MD and Ni, Yang, MS and Xu, Mingzhen, MS and Sattar, Haseeb, PharmD and Chen, Hui, MD and Li, Weiyong, MD, PhD
Clinical therapeutics, ISSN 0149-2918, 2015, Volume 37, Issue 4, pp. 869 - 876
Internal Medicine | Medical Education | pharmacokinetics | minodronic acid | Chinese subjects | age | food | tolerability | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Tablets | Administration, Oral | Area Under Curve | Food-Drug Interactions | Humans | Imidazoles - adverse effects | Middle Aged | Diphosphonates - pharmacokinetics | Imidazoles - administration & dosage | Biological Availability | Male | Diphosphonates - administration & dosage | Imidazoles - pharmacokinetics | Young Adult | Asian Continental Ancestry Group | Chromatography, Liquid | Adult | Female | Aged | Diphosphonates - adverse effects | Tandem Mass Spectrometry - methods | Osteoporosis | Studies | Body mass index | Statistical analysis | Fractures | Acids | Values | Calcification | Blood pressure | Drug therapy | Drug dosages | Apoptosis | Food | Index Medicus
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6. Full Text Bisphosphonates: Pharmacokinetics, bioavailability, mechanisms of action, clinical applications in children, and effects on tooth development
by Soares, Ana Prates and do Espírito Santo, Renan Fernandes and Line, Sérgio Roberto Peres and Pinto, Maria das Graças Farias and Santos, Pablo de Moura and Toralles, Maria Betânia Pereira and do Espírito Santo, Alexandre Ribeiro
Environmental toxicology and pharmacology, ISSN 1382-6689, 2016, Volume 42, pp. 212 - 217
Emergency | Odontogenesis | Dentin | Dental enamel | Tooth | Bisphosphonates | Pharmacology & Pharmacy | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Dental Physiological Phenomena - drug effects | Humans | Bone Density Conservation Agents - therapeutic use | Diphosphonates - therapeutic use | Diphosphonates - metabolism | Bone Density Conservation Agents - metabolism | Diphosphonates - pharmacology | Bone Density Conservation Agents - pharmacology | Osteoporosis | Metastasis | Pregnant women | Pharmacy | Phosphonates | Index Medicus
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7. Full Text Pharmacokinetics and Pharmacodynamics of Zoledronic Acid in Cancer Patients with Bone Metastases
by Chen, Tianling and Berenson, James and Vescio, Robert and Swift, Regina and Gilchick, Alicia and Goodin, Susan and LoRusso, Patricia and Ma, Peiming and Ravera, Christina and Deckert, Fabienne and Schran, Horst and Seaman, John and Skerjanec, Andrej
Journal of clinical pharmacology, ISSN 0091-2700, 11/2002, Volume 42, Issue 11, pp. 1228 - 1236
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Area Under Curve | Humans | Middle Aged | Bone Neoplasms - secondary | Male | Imidazoles - pharmacokinetics | Bone Neoplasms - metabolism | Dose-Response Relationship, Drug | Time Factors | Antineoplastic Agents - adverse effects | Adult | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Bone Neoplasms - drug therapy | Diphosphonates - adverse effects | Drug Administration Schedule | Imidazoles - adverse effects | Diphosphonates - pharmacokinetics | Imidazoles - pharmacology | Zoledronic Acid | Models, Biological | Aged | Infusions, Intravenous | Diphosphonates - pharmacology | Index Medicus
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8. Full Text Mechanism of Action, Pharmacokinetic and Pharmacodynamic Profile, and Clinical Applications of Nitrogen-containing Bisphosphonates
by Kimmel, D.B
11/2007, Volume 86, Issue 11, 12
Osteoporosis | Bone metastasis | Osteoclast | Bone remodeling | Half-life | Farnesyl pyrophosphase synthase | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Bone Density Conservation Agents - pharmacokinetics | Humans | Bone Density Conservation Agents - therapeutic use | Bone Neoplasms - secondary | Diphosphonates - pharmacokinetics | Half-Life | Nitrogen | Bone Remodeling - drug effects | Osteoporosis, Postmenopausal - drug therapy | Bone Density Conservation Agents - pharmacology | Geranyltranstransferase - antagonists & inhibitors | Multiple Myeloma - drug therapy | Bone and Bones - metabolism | Diphosphonates - chemistry | Diphosphonates - therapeutic use | Female | Hypercalcemia - drug therapy | Molecular Structure | Bone Neoplasms - drug therapy | Diphosphonates - pharmacology | Osteoclasts - drug effects | Bone Density Conservation Agents - chemistry | Index Medicus | Dentistry
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9. Full Text Ibandronate: A Clinical Pharmacological and Pharmacokinetic Update
by Barrett, Joanne and Worth, Eric and Bauss, Frieder and Epstein, Solomon
Journal of clinical pharmacology, ISSN 0091-2700, 09/2004, Volume 44, Issue 9, pp. 951 - 965
drug interactions | Ibandronate | pharmacodynamics | tolerability | pharmacokinetics | bisphosphonates | postmenopausal osteoporosis | Pharmacodynamics | Drug interactions | Tolerability | Pharmacokinetics | Postmenopausal osteoporosis | Bisphosphonates | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Injections, Intravenous | Humans | Diphosphonates - pharmacokinetics | Biological Availability | Osteoporosis - drug therapy | Diphosphonates - administration & dosage | Intestinal Absorption | Dose-Response Relationship, Drug | Tissue Distribution | Biotransformation | Diphosphonates - chemistry | Diphosphonates - adverse effects | Diphosphonates - pharmacology | Index Medicus
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