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Investigative ophthalmology & visual science, ISSN 0146-0404, 11/2018, Volume 59, Issue 14, pp. DES151 - DES156
Mucins, which play important roles on the ocular surface in wettability, lubrication, and barrier function, are classified into two categories: secreted mucins... 
Goblet cell | Rebamipide | Osaka study | Diquafosol | MUC5AC | REBAMIPIDE INCREASES | goblet cell | rebamipide | HUMAN CORNEAL | BARRIER FUNCTION | SODIUM HYALURONATE | LACRIMAL GLAND | DIQUAFOSOL OPHTHALMIC SOLUTION | VISUAL FUNCTION | diquafosol | GENE-EXPRESSION | OPHTHALMOLOGY | CONJUNCTIVAL GOBLET CELLS | DRY EYE DISEASE
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 01/2019, Volume 60, Issue 1, pp. 255 - 264
PURPOSE. Exposure to airborne particulate matter can induce ocular surface damage and inflammation. We evaluated the effects of a topical mucin secretagogue on... 
Mucin secretagogue | Air pollution | Carbon black | Particulate matter | Ocular surface damage | ocular surface damage | CELLS | SODIUM | AMBIENT LEVELS | carbon black | DIQUAFOSOL OPHTHALMIC SOLUTION | 3-PERCENT DIQUAFOSOL | EYE | particulate matter | AIR-POLLUTION | mucin secretagogue | OPHTHALMOLOGY | DIESEL EXHAUST | air pollution | 0.1-PERCENT
Journal Article
Clinical Ophthalmology, ISSN 1177-5483, 05/2016, Volume 2016, Issue Issue 1, pp. 879 - 886
Hideki Miyake,1 Yuri Kawano,2 Hiroshi Tanaka,2 Akihiro Iwata,3 Takahiro Imanaka,1 Masatsugu Nakamura1 1Ophthalmic Disease Area Strategy Department, 2Clinical... 
tear | Schirmer | multicenter | diquafosol | dry eye
Journal Article
Drug Discovery Today, ISSN 1359-6446, 08/2019, Volume 24, Issue 8, pp. 1427 - 1432
The underlying mechanisms of dry eye are thought to be part of a vicious circle involving a hyperosmolarity-triggered inflammatory cascade, resulting in loss... 
OCULAR SURFACE | REBAMIPIDE INCREASES | MUCIN-LIKE GLYCOPROTEIN | SOLUTION 5.0-PERCENT | INTEGRIN ANTAGONIST | P2Y AGONIST | SJOGRENS-SYNDROME | SODIUM HYALURONATE | PHARMACOLOGY & PHARMACY | DIQUAFOSOL OPHTHALMIC SOLUTION | GROWTH-FACTOR-I | Eye diseases | Inflammation
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 11/2018, Volume 59, Issue 14, pp. DES64 - DES70
Measurement of tear film breakup time (TBUT) has become a standard diagnostic procedure in the dry eye clinic. Short TBUT-type dry eye is characterized by TBUT... 
Tear film | Break-up time | Subjective symptoms | DEFINITION | VISUAL-DISPLAY TERMINALS | OPTICAL-QUALITY | CLASSIFICATION | SYMPTOMS | UP TIME | DIQUAFOSOL OPHTHALMIC SOLUTION | tear film | PAIN | break-up time | DISEASE | OPHTHALMOLOGY | ASSOCIATION | subjective symptoms
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 11/2018, Volume 59, Issue 14, pp. DES157 - DES162
Many studies have revealed that transmembrane mucins, large glycoproteins with heavily glycosylated glycans, are essential for maintaining ocular surface... 
MUC1 | MUC16 | Glycocalyx barrier | Transmembrane mucins | Diquafosol | Rebamipide | Galectin-3 | MUC4 | MUCIN EXPRESSION | rebamipide | HUMAN CORNEAL | SJOGRENS-SYNDROME | SODIUM HYALURONATE | GOBLET CELL-DENSITY | CONJUNCTIVAL EPITHELIA | transmembrane mucins | diquafosol | GENE-EXPRESSION | OPHTHALMOLOGY | glycocalyx barrier | galectin-3
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 06/2018, Volume 59, Issue 7, pp. 3104 - 3114
PURPOSE. A topical mucolytic agent, N-acetylcysteine (NAC), has been used to create an animal model without the intestinal mucus layer. In this study, we... 
Goblet cell | MUC1 | MUC16 | Dry eye | MUC5AC | Ocular surface damage | N-acetylcysteine | ocular surface damage | MANAGEMENT | goblet cell | ACETYLCYSTEINE | dry eye | DIQUAFOSOL | CORNEAL | CONJUNCTIVAL | PATHOGENESIS | MOUSE MODEL | OPHTHALMOLOGY | RABBIT | EXPRESSION | PARTICULATE MATTER
Journal Article
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 11/2018, Volume 59, Issue 14, pp. DES13 - DES22
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 11/2018, Volume 59, Issue 14, pp. DES29 - DES35
Dry eye (DE) causes irregularity of the ocular surface and reduces the quality of vision. An intact, regular tear film is essential for high-quality retinal... 
Tear film | Tear breakup time | Visual function | Functional visual acuity | Dry eye | functional visual acuity | CONTRAST SENSITIVITY | dry eye | DIQUAFOSOL TETRASODIUM | tear breakup time | MEASUREMENT SYSTEM | ARTIFICIAL TEARS | tear film | HIGHER-ORDER ABERRATIONS | OPHTHALMOLOGY | CORNEAL SURFACE REGULARITY | PUNCTAL OCCLUSION | BREAK-UP TIME | visual function | DRY EYE SYNDROME
Journal Article
Korean journal of ophthalmology : KJO, ISSN 1011-8942, 08/2019, Volume 33, Issue 4, pp. 343 - 352
To evaluate the efficacy and safety of cyclosporine nanoemulsion 0.05% compared to cyclosporine emulsion 0.05% and diquafosol sodium 3%. This was a... 
Dry eye syndromes | Cyclosporine | Original | Diquafosol | Nanotechnology | 안과학
Journal Article
by Jun, I and Choi, S and Lee, G and Choi, YJ and Lee, HK and Kim, EK and Seo, KY and Kim, TI
SCIENTIFIC REPORTS, ISSN 2045-2322, 09/2019, Volume 9, Issue 1, pp. 12659 - 9
Dry eye disease (DED) after cataract surgery has become a critical concern, and various therapeutic options have been developed. Recently, preservative-free... 
TOPICAL DIQUAFOSOL | OCULAR SURFACE | OPHTHALMIC SOLUTION | SODIUM | MULTICENTER | INTERNATIONAL WORKSHOP | EFFICACY | SAFETY | MULTIDISCIPLINARY SCIENCES | MEIBOMIAN GLAND DYSFUNCTION | TEAR-FILM | Cataracts | Cornea | Preservatives | Surgery | Eye diseases | Eye surgery | Patients
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 11/2018, Volume 59, Issue 14, pp. DES109 - DES115
Post-LASIK dry eye is the most common postoperative dry eye after ophthalmic surgeries. The clinical signs of post-LASIK dry eye include positive vital... 
Dry eyes | Corneal nerve | LASIK | OCULAR SURFACE | INCISION LENTICULE EXTRACTION | OPHTHALMIC SOLUTION | IN-SITU KERATOMILEUSIS | TEAR FUNCTIONS | SODIUM HYALURONATE | PHOTOREFRACTIVE KERATECTOMY | DIQUAFOSOL TETRASODIUM | CORNEAL SENSATION | REINNERVATION | corneal nerve | OPHTHALMOLOGY | dry eyes
Journal Article