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1. Full Text Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study
by Laetsch, Theodore W and DuBois, Steven G and Mascarenhas, Leo and Turpin, Brian and Federman, Noah and Albert, Catherine M and Nagasubramanian, Ramamoorthy and Davis, Jessica L and Rudzinski, Erin and Feraco, Angela M and Tuch, Brian B and Ebata, Kevin T and Reynolds, Mark and Smith, Steven and Cruickshank, Scott and Cox, Michael C and Pappo, Alberto S and Hawkins, Douglas S
The Lancet Oncology, ISSN 1470-2045, 05/2018, Volume 19, Issue 5, pp. 705 - 714
Gene fusions involving , or (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective small-molecule... 
ONCOLOGY | INFANTILE FIBROSARCOMA | MOLECULAR-DETECTION | RESPONSE ASSESSMENT | ACQUIRED-RESISTANCE | CONGENITAL FIBROSARCOMA | QUALITY-OF-LIFE | KINASE INHIBITOR LOXO-101 | TROPOMYOSIN | SOFT-TISSUE SARCOMA | MESOBLASTIC NEPHROMA | Age Factors | Discoidin Domain Receptor 2 - antagonists & inhibitors | United States | Humans | Receptor, trkA - antagonists & inhibitors | Child, Preschool | Infant | Male | Receptor, trkB - genetics | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Young Adult | Membrane Glycoproteins - antagonists & inhibitors | Neoplasms - genetics | Time Factors | Antineoplastic Agents - adverse effects | Receptor, trkB - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Biomarkers, Tumor - antagonists & inhibitors | Child | Discoidin Domain Receptor 2 - genetics | Pyrazoles - adverse effects | Drug Administration Schedule | Administration, Oral | Pyrimidines - administration & dosage | Gene Fusion | Treatment Outcome | Membrane Glycoproteins - genetics | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Pyrazoles - administration & dosage | Receptor Protein-Tyrosine Kinases - genetics | Adolescent | Pyrimidines - adverse effects | Receptor, trkA - genetics | Biomarkers, Tumor - genetics | Neoplasms - pathology | Genetic research | Pediatrics | Analysis
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2. Full Text TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis
by Grither, Whitney R and Divine, Laura M and Meller, Eric H and Wilke, Daniel J and Desai, Riva A and Loza, Andrew J and Zhao, Peinan and Lohrey, Anne and Longmore, Gregory D and Fuh, Katherine C
Oncogene, ISSN 0950-9232, 03/2018, Volume 37, Issue 13, pp. 1714 - 1729
The mesenchymal gene program has been shown to promote the metastatic progression of ovarian cancer; however, specific proteins induced by this program that... 
MATRIX | ACTIVATION | COLLAGEN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL METASTASIS | FIBROBLASTS | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | INVASION | ONCOLOGY | GENETICS & HEREDITY | FIBRONECTIN | UP-REGULATION | CARCINOMA | Neoplasm Invasiveness | Humans | Cells, Cultured | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Up-Regulation - genetics | Biomarkers, Tumor - physiology | Ovarian Neoplasms - mortality | Epithelial-Mesenchymal Transition - genetics | Cell Movement - genetics | Ovarian Neoplasms - genetics | Neoplasm Metastasis | Animals | Mice, Nude | Twist-Related Protein 1 - physiology | Female | Mice | Mice, Inbred BALB C | Nuclear Proteins - physiology | Neoplasm Staging | Discoidin Domain Receptor 2 - genetics | Tyrosine | Enzymes | Phenotypes | Mesenchyme | Tumor cells | Invasiveness | Genes | Metastasis | Tumor cell lines | Patients | Fibronectin | Ovarian cancer | Metastases | Collagen | Protein-tyrosine kinase receptors | Extracellular matrix | Protein-tyrosine kinase | Cell migration | Tumors
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3. Full Text Inhibition of tumor–microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain
by Grither, Whitney R and Longmore, Gregory D
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2018, Volume 115, Issue 33, pp. E7786 - E7794
The action of the collagen binding receptor tyrosine kinase (RTK) discoidin domain receptor 2 (DDR2) in both tumor and tumor stromal cells has been established... 
Allosteric inhibition | Metastasis | DDR2 | allosteric inhibition | LIGAND-BINDING | COLLAGEN | MECHANISM | BREAST-CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | DISCOVERY | LUNG-CANCER | RECEPTOR TYROSINE KINASES | metastasis | THERAPEUTIC TARGET | ACTINOMYCIN-D | CARCINOMA | Fibroblasts - enzymology | Discoidin Domain Receptor 2 - antagonists & inhibitors | Humans | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Breast Neoplasms - enzymology | Protein Kinase Inhibitors - chemistry | Tumor Microenvironment - genetics | Female | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Discoidin Domain Receptor 2 - genetics | Allosteric Regulation - drug effects | Tumor Microenvironment - drug effects | Allosteric Regulation - genetics | Discoidin Domain Receptor 2 - metabolism | Mice, Transgenic | Signal Transduction - genetics | Antineoplastic Agents - chemistry | Fibroblasts - pathology | Breast Neoplasms - drug therapy | Animals | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Neoplasm Invasiveness - genetics | Biological Sciences | PNAS Plus
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4. Full Text The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK–JNK Signaling Pathway in Axon Regeneration
by Hisamoto, Naoki and Nagamori, Yuki and Shimizu, Tatsuhiro and Pastuhov, Strahil I and Matsumoto, Kunihiro
PLoS Genetics, ISSN 1553-7390, 12/2016, Volume 12, Issue 12, p. e1006475
The ability of specific neurons to regenerate their axons after injury is governed by cell-intrinsic regeneration pathways. However, the signaling pathways... 
GUIDE AXONS | NEURONS | TYROSINE KINASES | CAENORHABDITIS-ELEGANS | COLLAGEN | GENETICS & HEREDITY | Discoidin Domain - genetics | Nerve Regeneration - genetics | Caenorhabditis elegans - growth & development | Signal Transduction | Caenorhabditis elegans - genetics | Discoidin Domain Receptor 2 - metabolism | Axons - metabolism | Caenorhabditis elegans Proteins - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Animals | Receptor Protein-Tyrosine Kinases - genetics | Adaptor Proteins, Signal Transducing - genetics | Neurons - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Caenorhabditis elegans Proteins - genetics | Discoidin Domain Receptor 2 - genetics | Proteins | Phosphorylation | Mutagenesis | Funding | Neurons | Collagen | Nematodes | Science | Nervous system | Mutation | Kinases | Growth factors
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5. Full Text Discoidin Domain Receptor 2 as a Potential Therapeutic Target for Development of Disease-Modifying Osteoarthritis Drugs
by Manning, Lauren B and Li, Yefu and Chickmagalur, Nithya S and Li, Xiaolong and Xu, Lin
American Journal of Pathology, The, ISSN 0002-9440, 2016, Volume 186, Issue 11, pp. 3000 - 3010
Osteoarthritis (OA) is the most common form of arthritis disorders, but the identification of therapeutic targets to effectively prevent OA has been... 
Pathology | ACTIVATION | INHIBITION | INCREASED EXPRESSION | CHONDROCYTES | ARTICULAR-CARTILAGE | ATTENUATION | MODEL | COLLAGENASE-3 | PATHOLOGY | PROGRESSION | DDR2 | Matrix Metalloproteinase 13 - genetics | Mice, Inbred C57BL | Discoidin Domain Receptor 2 - metabolism | Male | Mice, Transgenic | Aggrecans - genetics | Matrix Metalloproteinase 13 - metabolism | Cartilage, Articular - pathology | Animals | Knee Joint | Cartilage, Articular - metabolism | Osteoarthritis, Knee - pathology | Menisci, Tibial - surgery | Female | Mice | Discoidin Domain Receptor 2 - genetics | Osteoarthritis, Knee - drug therapy | Osteoarthritis, Knee - metabolism | Disease Models, Animal
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6. Full Text Functional analysis of Discoidin domain receptor 2 mutation and expression in squamous cell lung cancer
by Kobayashi-Watanabe, Naomi and Sato, Akemi and Watanabe, Tatsuro and Abe, Tomonori and Nakashima, Chiho and Sueoka, Eisaburo and Kimura, Shinya and Sueoka-Aragane, Naoko
Lung Cancer, ISSN 0169-5002, 2017, Volume 110, pp. 35 - 41
Highlights • Endogenous DDR2 protein expression levels were high in 29% of lung SQCC patients. • A DDR2 mutation (T681I) identified in a lung SQCC clinical... 
Hematology, Oncology and Palliative Medicine | Pulmonary/Respiratory | Overexpression | Mutation | MMP-1 | DDR2 | Lung squamous cell carcinoma | INVASION | ONCOLOGY | RESPIRATORY SYSTEM | REGISTRY | Immunohistochemistry | Lung Neoplasms - genetics | Gene Expression | Phosphorylation | Cell Proliferation | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Discoidin Domain Receptor 2 - metabolism | Lung Neoplasms - pathology | Male | Cell Movement - genetics | Animals | Proto-Oncogene Proteins c-jun - metabolism | Alleles | Cell Line, Tumor | Mice | Matrix Metalloproteinase 1 - metabolism | Discoidin Domain Receptor 2 - genetics | Disease Models, Animal | Memory (Computers) | RNA | Lung cancer | Analysis | Respiratory agents | Genetic aspects | Metastasis | Animal experimentation | Squamous cell carcinoma | Development and progression
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7. Full Text NTRK3 kinase fusions in Spitz tumours
by Yeh, Iwei and Tee, Meng Kian and Botton, Thomas and Shain, A Hunter and Sparatta, Alyssa J and Gagnon, Alexander and Vemula, Swapna S and Garrido, Maria C and Nakamaru, Kenji and Isoyama, Takeshi and McCalmont, Timothy H and LeBoit, Philip E and Bastian, Boris C
The Journal of Pathology, ISSN 0022-3417, 11/2016, Volume 240, Issue 3, pp. 282 - 290
Oncogenic fusions in TRK family receptor tyrosine kinases have been identified in several cancers and can serve as therapeutic targets. We identified... 
kinase inhibitor | genetics | NTRK3 fusion | spitzoid melanoma | melanoma | Spitz naevus | Spitz tumour | atypical Spitz tumour | oncogene | READ ALIGNMENT | LANDSCAPE | CONGENITAL FIBROSARCOMA | PATHOLOGY | REARRANGEMENTS | CANCER | UVEAL MELANOMA | ONCOLOGY | ETV6-NTRK3 GENE FUSION | MUTATIONS | SEQUENCING DATA | BURROWS-WHEELER TRANSFORM | Proto-Oncogene Proteins c-ets - genetics | Humans | Child, Preschool | Melanoma - enzymology | Myosin Heavy Chains - genetics | Male | Phosphatidylinositol 3-Kinases - metabolism | Nevus, Epithelioid and Spindle Cell - pathology | Molecular Motor Proteins - genetics | Myosin Heavy Chains - metabolism | Skin Neoplasms - enzymology | Melanoma - genetics | Oncogene Fusion | Nevus, Epithelioid and Spindle Cell - genetics | Adult | Female | Molecular Motor Proteins - metabolism | Proto-Oncogene Proteins c-ets - metabolism | Nevus, Epithelioid and Spindle Cell - enzymology | Child | Discoidin Domain Receptor 2 - genetics | Repressor Proteins - metabolism | Skin Neoplasms - pathology | Myosin Type V - metabolism | Discoidin Domain Receptor 2 - metabolism | Repressor Proteins - genetics | Melanoma - pathology | Sequence Analysis, DNA | Phosphatidylinositol 3-Kinases - genetics | Myosin Type V - genetics | Sequence Analysis, RNA | Comparative Genomic Hybridization | Skin Neoplasms - genetics | Adolescent | Mitogen-Activated Protein Kinases - genetics | Aged | Mitogen-Activated Protein Kinases - metabolism | Tumors | Spitz nevus
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8. Full Text Functional analyses of mutations in receptor tyrosine kinase genes in Non-Small cell lung cancer: Double-Edged Sword of DDR2
by Terashima, Masato and Togashi, Yosuke and Sato, Katsuaki and Mizuuchi, Hiroshi and Sakai, Kazuko and Suda, Kenichi and Nakamura, Yu and Banno, Eri and Hayashi, Hidetoshi and De Velasco, Marco A and Fujita, Yoshihiko and Tomida, Shuta and Mitsudomi, Tetsuya and Nishio, Kazuto
Clinical Cancer Research, ISSN 1078-0432, 07/2016, Volume 22, Issue 14, pp. 3663 - 3671
Purpose: This study investigated whether mutations of receptor tyrosine kinase (RTK) genes detected using next-generation sequencing (NGS) are suitable... 
GEFITINIB | FIBRILLAR COLLAGEN | METASTASIS | ONCOLOGY | ADENOCARCINOMA | CRIZOTINIB | PROLIFERATION | CBL | TUMOR-GROWTH | CHEMOTHERAPY | NEGATIVE REGULATOR | Lung Neoplasms - genetics | A549 Cells | Cell Line | NIH 3T3 Cells | Receptor, Epidermal Growth Factor - genetics | Cell Proliferation - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Mutation - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cell Line, Tumor | Mice | Discoidin Domain Receptor 2 - genetics
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9. Full Text Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy
by Church, Alanna J and Calicchio, Monica L and Nardi, Valentina and Skalova, Alena and Pinto, Andre and Dillon, Deborah A and Gomez-Fernandez, Carmen R and Manoj, Namitha and Haimes, Josh D and Stahl, Joshua A and Dela Cruz, Filemon S and Tannenbaum-Dvir, Sarah and Glade-Bender, Julia L and Kung, Andrew L and Dubois, Steven G and Kozakewich, Harry P and Janeway, Katherine A and Perez-Atayde, Antonio R and Harris, Marian H
Modern Pathology, ISSN 0893-3952, 03/2018, Volume 31, Issue 3, pp. 463 - 473
Infantile fibrosarcoma and congenital mesoblastic nephroma are tumors of infancy traditionally associated with the ETV6-NTRK3 gene fusion. However, a number of... 
TRANSCRIPTS | DIAGNOSIS | ANALOG SECRETORY CARCINOMA | MOLECULAR-DETECTION | ETV6-NTRK3 GENE FUSION | PATHOLOGY | IDENTIFICATION | CHEMOTHERAPY | FEATURES | Kidney Neoplasms - genetics | Nephroma, Mesoblastic - diagnosis | Genetic Testing | Microtubule-Associated Proteins - genetics | Proto-Oncogene Proteins c-ets - genetics | Humans | Middle Aged | Child, Preschool | Infant | Male | Kidney Neoplasms - diagnosis | Kidney Neoplasms - congenital | Serine Endopeptidases - genetics | Aged, 80 and over | Cell Cycle Proteins - genetics | Adult | Female | Discoidin Domain Receptor 2 - genetics | Infant, Newborn | Fibrosarcoma - diagnosis | Repressor Proteins - genetics | In Situ Hybridization, Fluorescence | Fibrosarcoma - genetics | Breast Neoplasms - genetics | Sequence Analysis, RNA | Nephroma, Mesoblastic - genetics | Oncogene Proteins, Fusion - genetics | Adolescent | Carcinoma - genetics | Neoplasm Recurrence, Local - genetics | Aged | Nephroma, Mesoblastic - congenital | Breast carcinoma | NTRK3 gene | Case reports | Fibrosarcoma | Ribonucleic acid--RNA | Gene fusion | Tumors
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10. Full Text Recurrent, Activating Variants in the Receptor Tyrosine Kinase DDR2 Cause Warburg-Cinotti Syndrome
by Xu, Linda and Jensen, Hanne and Johnston, Jennifer J and Di Maria, Emilio and Kloth, Katja and Cristea, Ileana and Sapp, Julie C and Darling, Thomas N and Huryn, Laryssa A and Tranebjærg, Lisbeth and Cinotti, Elisa and Kubisch, Christian and Rødahl, Eyvind and Bruland, Ove and Biesecker, Leslie G and Houge, Gunnar and Bredrup, Cecilie
The American Journal of Human Genetics, ISSN 0002-9297, 12/2018, Volume 103, Issue 6, pp. 976 - 983
We have investigated a distinct disorder with progressive corneal neovascularization, keloid formation, chronic skin ulcers, wasting of subcutaneous tissue,... 
contractures | corneal neovascularization | acro-osteolysis | chronic skin ulcers | keloid formation | lipodystrophy | DDR2 | DISCOIDIN | OVERGROWTH | DEFICIENCY | MUTATION | GENETICS & HEREDITY | Amino Acid Sequence | Humans | Middle Aged | Child, Preschool | Signal Transduction - genetics | Sequence Alignment | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Connective Tissue Diseases - drug therapy | Protein Kinase Inhibitors - therapeutic use | Fibroblasts - drug effects | Adult | Female | Collagen - genetics | Connective Tissue Diseases - genetics | Child | Discoidin Domain Receptor 2 - genetics | Care and treatment | Phosphorylation | Development and progression | Cellular signal transduction | Research | Neovascularization | Muscular dystrophy | Report
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11. Full Text Identification of NTRK3 Fusions in Childhood Melanocytic Neoplasms
by Wang, Lu and Busam, Klaus J and Benayed, Ryma and Cimera, Robert and Wang, Jiajing and Denley, Ryan and Rao, Mamta and Aryeequaye, Ruth and Mullaney, Kerry and Cao, Long and Ladanyi, Marc and Hameed, Meera
Journal of Molecular Diagnostics, The, ISSN 1525-1578, 2017, Volume 19, Issue 3, pp. 387 - 396
Spitzoid neoplasms are a distinct group of melanocytic tumors. Genetically, they lack mutations in common melanoma-associated oncogenes. Recent studies have... 
Pathology | GENOMIC LANDSCAPE | MELANOMA | ANALOG SECRETORY CARCINOMA | ETV6-NTRK3 GENE FUSION | HYBRIDIZATION | PROTEIN-TYROSINE KINASE | COLORECTAL-CARCINOMA | PATHOLOGY | REARRANGEMENTS | TROPOMYOSIN | FIBROSARCOMA | Humans | Myosin Heavy Chains - genetics | Sequence Analysis, DNA | Gene Fusion - genetics | Myosin Type V - genetics | Receptor, trkC - genetics | Receptor Protein-Tyrosine Kinases - genetics | Melanoma - genetics | Oncogene Proteins, Fusion - genetics | Proto-Oncogene Proteins B-raf - genetics | High-Throughput Nucleotide Sequencing | Oncogene Fusion - genetics | Mutation | Discoidin Domain Receptor 2 - genetics | Proto-Oncogene Proteins c-ret - genetics | Regular
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12. Full Text Prevalence of mutations in discoidin domain-containing receptor tyrosine kinase 2 (DDR2) in squamous cell lung cancers in Korean patients
by Lee, Mi-Sook and Jung, Eun Ah and An, Sung Bin and Kim, Yu Jin and Oh, Doo-Yi and Song, Ji-Young and Um, Sang-Won and Han, Joungho and Choi, Yoon-La
Cancer Research and Treatment, ISSN 1598-2998, 2017, Volume 49, Issue 4, pp. 1065 - 1076
Purpose The discoidin domain-containing receptor tyrosine kinase 2 (DDR2) is known to contain mutations in a small subset of patients with squamous cell... 
Squamous cell carcinoma | Somatic mutations | Discoidin domain receptor 2 | Lung neoplasms | ALK | NETWORKS | DASATINIB | AMPLIFICATION | THERAPY | ONCOLOGY | GENES | RESISTANCE | CARCINOMA | REGULATES PROLIFERATION | Immunohistochemistry | Prevalence | Exons | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Tomography, X-Ray Computed | Neoplasm Metastasis | Aged, 80 and over | Female | Republic of Korea - epidemiology | Discoidin Domain Receptor 2 - genetics | Lung Neoplasms - genetics | Cell Line | Carcinoma, Squamous Cell - epidemiology | Gene Frequency | Tumor Burden | Sequence Analysis, DNA | Animals | Lung Neoplasms - epidemiology | Alleles | Aged | Mice | Mutation | Lung Neoplasms - diagnosis | Neoplasm Staging | Original
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13. Full Text Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations
by Oczko-Wojciechowska, Malgorzata and Swierniak, Michal and Krajewska, Jolanta and Kowalska, Malgorzata and Kowal, Monika and Stokowy, Tomasz and Wojtas, Bartosz and Rusinek, Dagmara and Pawlaczek, Agnieszka and Czarniecka, Agnieszka and Szpak-Ulczok, Sylwia and Gawlik, Tomasz and Chmielik, Ewa and Tyszkiewicz, Tomasz and Nikiel, Barbara and Lange, Dariusz and Jarzab, Michal and Wiench, Malgorzata and Jarzab, Barbara
Scientific Reports, ISSN 2045-2322, 02/2017, Volume 7, Issue 1, p. 42074
Medullary thyroid cancer (MTC) can be caused by germline mutations of the RET proto-oncogene or occurs as a sporadic form. It is well known that RET mutations... 
BREAST-CANCER | GENOTYPE-PHENOTYPE CORRELATIONS | DISEASE PHENOTYPE | MULTIDISCIPLINARY SCIENCES | CELL NEUROENDOCRINE CARCINOMA | KINASE | FOLLOW-UP | SOMATIC RAS MUTATIONS | ENDOCRINE NEOPLASIA TYPE-2 | EXPRESSION PROFILES | PROTOONCOGENE | Membrane Proteins - genetics | Humans | Middle Aged | Nerve Tissue Proteins - analysis | Carcinoma, Neuroendocrine - genetics | Male | Gene Expression Profiling | Nerve Tissue Proteins - genetics | Membrane Proteins - analysis | Discoidin Domain Receptor 2 - analysis | Thyroid Neoplasms - genetics | Carcinoma, Neuroendocrine - pathology | Dual-Specificity Phosphatases - genetics | Adult | Female | Aged | Mutation | Discoidin Domain Receptor 2 - genetics | Dual-Specificity Phosphatases - analysis | Proto-Oncogene Proteins c-ret - genetics | Thyroid Neoplasms - pathology | Tyrosine | Cysteine | Papillary thyroid cancer | Gene expression | Kinases | Thyroid cancer | Ret protein | Point mutation | Cell cycle | Localization | Thyroid | Tumors
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14. Full Text Identification of NTRK fusions in pediatric mesenchymal tumors
by Pavlick, Dean and Schrock, Alexa B and Malicki, Denise and Stephens, Philip J and Kuo, Dennis J and Ahn, Hyunah and Turpin, Brian and Allen, Justin M and Rosenzweig, Mark and Badizadegan, Kamran and Ross, Jeffrey S and Miller, Vincent A and Wong, Victor and Ali, Siraj M
Pediatric Blood & Cancer, ISSN 1545-5009, 08/2017, Volume 64, Issue 8, p. n/a
Background NTRK fusions are known oncogenic drivers and have recently been effectively targeted by investigational agents in adults. We sought to assess the... 
IMT | mesoblastic nephroma | sarcoma | kinase fusion | NTRK1–3 | IFS | ALK | INFANTILE FIBROSARCOMA | KINASE INHIBITOR LOXO-101 | REARRANGEMENTS | LUNG-CANCER | THERAPY | ONCOLOGY | ETV6-NTRK3 GENE FUSION | PEDIATRICS | NTRK1-3 | INFLAMMATORY MYOFIBROBLASTIC TUMORS | HEMATOLOGY | CARCINOMA | ROS1 | Humans | Child, Preschool | In Situ Hybridization, Fluorescence | Infant | Male | Gene Expression Profiling | Young Adult | Oncogene Proteins, Fusion - genetics | Adolescent | Receptor, trkA - genetics | Female | Discoidin Domain Receptor 2 - genetics | Infant, Newborn | Soft Tissue Neoplasms - genetics | Pediatrics | Sarcoma | Drug approval | Stem cells | Drugs | Profiling | Mesenchyme | Fibrosarcoma | Inflammation | Patients | Adults | Children | Diagnosis | Low frequencies | Tumors
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