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The Lancet Oncology, ISSN 1470-2045, 05/2018, Volume 19, Issue 5, pp. 705 - 714
Gene fusions involving , or (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective small-molecule... 
ONCOLOGY | INFANTILE FIBROSARCOMA | MOLECULAR-DETECTION | RESPONSE ASSESSMENT | ACQUIRED-RESISTANCE | CONGENITAL FIBROSARCOMA | QUALITY-OF-LIFE | KINASE INHIBITOR LOXO-101 | TROPOMYOSIN | SOFT-TISSUE SARCOMA | MESOBLASTIC NEPHROMA | Age Factors | Discoidin Domain Receptor 2 - antagonists & inhibitors | United States | Humans | Receptor, trkA - antagonists & inhibitors | Child, Preschool | Infant | Male | Receptor, trkB - genetics | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Young Adult | Membrane Glycoproteins - antagonists & inhibitors | Neoplasms - genetics | Time Factors | Antineoplastic Agents - adverse effects | Receptor, trkB - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Biomarkers, Tumor - antagonists & inhibitors | Child | Discoidin Domain Receptor 2 - genetics | Pyrazoles - adverse effects | Drug Administration Schedule | Administration, Oral | Pyrimidines - administration & dosage | Gene Fusion | Treatment Outcome | Membrane Glycoproteins - genetics | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Pyrazoles - administration & dosage | Receptor Protein-Tyrosine Kinases - genetics | Adolescent | Pyrimidines - adverse effects | Receptor, trkA - genetics | Biomarkers, Tumor - genetics | Neoplasms - pathology | Genetic research | Pediatrics | Analysis
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2018, Volume 115, Issue 33, pp. E7786 - E7794
Journal Article
Journal Article
The Journal of Pathology, ISSN 0022-3417, 11/2016, Volume 240, Issue 3, pp. 282 - 290
Oncogenic fusions in TRK family receptor tyrosine kinases have been identified in several cancers and can serve as therapeutic targets. We identified... 
kinase inhibitor | genetics | NTRK3 fusion | spitzoid melanoma | melanoma | Spitz naevus | Spitz tumour | atypical Spitz tumour | oncogene | READ ALIGNMENT | LANDSCAPE | CONGENITAL FIBROSARCOMA | PATHOLOGY | REARRANGEMENTS | CANCER | UVEAL MELANOMA | ONCOLOGY | ETV6-NTRK3 GENE FUSION | MUTATIONS | SEQUENCING DATA | BURROWS-WHEELER TRANSFORM | Proto-Oncogene Proteins c-ets - genetics | Humans | Child, Preschool | Melanoma - enzymology | Myosin Heavy Chains - genetics | Male | Phosphatidylinositol 3-Kinases - metabolism | Nevus, Epithelioid and Spindle Cell - pathology | Molecular Motor Proteins - genetics | Myosin Heavy Chains - metabolism | Skin Neoplasms - enzymology | Melanoma - genetics | Oncogene Fusion | Nevus, Epithelioid and Spindle Cell - genetics | Adult | Female | Molecular Motor Proteins - metabolism | Proto-Oncogene Proteins c-ets - metabolism | Nevus, Epithelioid and Spindle Cell - enzymology | Child | Discoidin Domain Receptor 2 - genetics | Repressor Proteins - metabolism | Skin Neoplasms - pathology | Myosin Type V - metabolism | Discoidin Domain Receptor 2 - metabolism | Repressor Proteins - genetics | Melanoma - pathology | Sequence Analysis, DNA | Phosphatidylinositol 3-Kinases - genetics | Myosin Type V - genetics | Sequence Analysis, RNA | Comparative Genomic Hybridization | Skin Neoplasms - genetics | Adolescent | Mitogen-Activated Protein Kinases - genetics | Aged | Mitogen-Activated Protein Kinases - metabolism | Tumors | Spitz nevus
Journal Article
Modern Pathology, ISSN 0893-3952, 03/2018, Volume 31, Issue 3, pp. 463 - 473
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2017, Volume 7, Issue 1, p. 42074
Journal Article