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Matrix Biology, ISSN 0945-053X, 01/2011, Volume 30, Issue 1, pp. 16 - 26
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 06/2014, Volume 426, Issue 13, pp. 2457 - 2470
The discoidin domain receptors (DDRs), DDR1 and DDR2, form a unique subfamily of receptor tyrosine kinases that are activated by the binding of triple-helical... 
crystallography | gleevec | drug design | phosphorylation | oncology | CHRONIC MYELOGENOUS LEUKEMIA | LUNG FIBROSIS | DISCOIDIN DOMAIN RECEPTOR-1 | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTAL-STRUCTURES | CELL-SURVIVAL | CANCER | CHRONIC MYELOID-LEUKEMIA | IMATINIB | STI-571 INHIBITION | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Molecular Sequence Data | Pyridazines - pharmacology | Discoidin Domain Receptors | Protein Kinase Inhibitors - chemistry | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Receptors, Collagen - genetics | Benzamides - pharmacology | Binding Sites | Receptors, Collagen - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Proto-Oncogene Proteins c-abl - genetics | Protein Structure, Secondary | Receptors, Mitogen - antagonists & inhibitors | Proto-Oncogene Proteins c-abl - chemistry | Models, Molecular | Imidazoles - pharmacology | Discoidin Domain Receptor 1 | Pyrimidines - pharmacology | Receptors, Mitogen - chemistry | Imatinib Mesylate | Piperazines - pharmacology | Receptors, Collagen - antagonists & inhibitors | Sequence Homology, Amino Acid | Receptor Protein-Tyrosine Kinases - genetics | Protein Kinase Inhibitors - pharmacology | Receptor Protein-Tyrosine Kinases - chemistry | Receptors, Mitogen - genetics | Memory (Computers) | Collagen | Atherosclerosis | Crystals | Development and progression | Drug resistance | Structure | Phosphotransferases | Index Medicus | CML, chronic myeloid leukemia | KID, kinase insert domain | A-loop, activation loop | ITC, isothermal titration calorimetry | TCEP, tris(2-carboxyethyl)phosphine | DDR, discoidin domain receptor | TKI, tyrosine kinase inhibitor | RTKs, receptor tyrosine kinases | TrkB, tropomyosin-related kinase B | IGF1R, insulin-like growth factor 1 receptor
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 04/2016, Volume 27, Issue 8, pp. 1262 - 1271
Streams of migratory cells are initiated by the formation of tandem pairs of cells connected head to tail to which other cells subsequently adhere. The... 
Biomechanical Phenomena | Cell Adhesion Molecules - genetics | Discoidins - metabolism | Dictyostelium - genetics | Dictyostelium - cytology | Discoidins - genetics | Cell Adhesion | Cell Adhesion Molecules - metabolism | Cell Movement - physiology | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2008, Volume 599, Issue 1, pp. 44 - 53
Journal Article
Journal Article
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 03/2017, Volume 89, Issue 3, pp. 420 - 427
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2013, Volume 454, Issue 3, pp. 501 - 513
Collagen is an important extracellular matrix component that directs many fundamental cellular processes including differentiation, proliferation and motility.... 
Cell signalling | Discoidin domain receptor | Phosphoproteomics | Mass spectrometry | Collagen | Lung cancer | phosphoproteomics | MIGRATION | ACTIVATION | FIBRILLAR COLLAGEN | INCREASED EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | collagen | TYROSINE KINASES | lung cancer | discoidin domain receptor | CELLULAR SIGNALING NETWORKS | cell signalling | BINDING SITES | mass spectrometry | EXTRACELLULAR-MATRIX | PROTEOMIC ANALYSIS | DISCOIDIN DOMAIN RECEPTORS | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Phosphorylation | Carcinoma, Squamous Cell - genetics | Humans | Molecular Sequence Data | Mutation, Missense | Phosphoproteins - metabolism | Tandem Mass Spectrometry | Discoidin Domain Receptors | HEK293 Cells | src-Family Kinases - metabolism | Lung Neoplasms - genetics | Amino Acid Sequence | Carcinoma, Squamous Cell - enzymology | Collagen Type I - metabolism | Lung Neoplasms - enzymology | Signal Transduction | Receptors, Mitogen - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Receptors, Collagen - metabolism | Receptor Protein-Tyrosine Kinases - genetics | Proteomics | Protein Processing, Post-Translational | Cluster Analysis | Receptors, Mitogen - genetics | Index Medicus | IMAC, immobilized metal-ion-affinity chromatography | CDK1, cyclin-dependent kinase 1 | mAb, monoclonal antibody | HEK, human embryonic kidney | PLCL2, phospholipase C-like 2 | DDR, discoidin domain receptor | PIK3C2A, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2α | KD, kinase domain | TEAB, triethylammonium bicarbonate | ERK, extracellular-signal-regulated kinase | HRP, horseradish peroxidase | SCC, squamous cell carcinoma | DYRK1A, dual-specificity tyrosine-phosphorylation-regulated kinase 1A | RFB, radiometric filter binding | SHP-2, Src homology 2 domain-containing protein tyrosine phosphatase 2 | TDA, template-directed assembly | GO, Gene Ontology | EGFR, epidermal growth factor receptor | MCAM, multiple clustering analysis methodology | SRM, selective reaction monitoring | SHIP-2, SH2 (Src homology 2)-domain-containing inositol phosphatase 2 | DMEM, Dulbecco’s modified Eagle’s medium | EV, empty vector | NCK1, non-catalytic region of tyrosine kinase adaptor protein 1 | IL, interleukin | RTK, receptor tyrosine kinase | TFA, trifluoroacetic acid
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2016, Volume 291, Issue 44, pp. 23208 - 23223
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 8, pp. 2841 - 2849
Discoidin domain receptor 1 (DDR1) is a collagen receptor that mediates cell communication with the extracellular matrix (ECM). Aberrant expression and... 
BREAST-CANCER CELLS | BASAL-LIKE | OBESITY | CLAUDIN-LOW | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE | TYROSINE KINASES | MESENCHYMAL TRANSITION | EXPRESSION | PROGRESSION | Neoplasm Transplantation | Breast Neoplasms - immunology | Stromal Cells - pathology | Humans | Neoplasm Invasiveness - prevention & control | Discoidin Domain Receptor 1 - genetics | Adipose Tissue - immunology | Neoplasm Proteins - metabolism | Breast Neoplasms - metabolism | Adipose Tissue - metabolism | Neoplasm Invasiveness - pathology | Stromal Cells - drug effects | Female | Discoidin Domain Receptor 1 - metabolism | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Tumor Microenvironment - drug effects | Mice, Inbred C57BL | Neoplasm Invasiveness - immunology | Stromal Cells - metabolism | Adipose Tissue - pathology | Antibodies, Neutralizing - pharmacology | Stromal Cells - immunology | Breast Neoplasms - drug therapy | Transplantation, Isogeneic | Mice, Knockout | Cell Movement - drug effects | Collagen - metabolism | Animals | Tumor Burden - drug effects | Breast Neoplasms - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Adipose Tissue - drug effects | Index Medicus | cytokine | DDR1 | breast cancer | IL-6 | Cell Biology | stromal–vascular fraction | discoidin domain receptor 1 | cancer biology | adipose stromal cells | mammary tumor | cell invasion | tumor microenvironment | tumor cell biology | extracellular matrix
Journal Article
Blood, ISSN 0006-4971, 12/2007, Volume 110, Issue 12, pp. 4055 - 4063
The BCR-ABL tyrosine kinase inhibitor imatinib represents the current frontline therapy in chronic myeloid leukemia. Because many patients develop imatinib... 
CHRONIC MYELOGENOUS LEUKEMIA | SELECTIVE INHIBITOR | DISCOIDIN DOMAIN RECEPTOR-1 | TYROSINE KINASE | PROTEIN-KINASE | CRYSTAL-STRUCTURE | DRUG DISCOVERY | INTRACELLULAR TARGETS | AFFINITY-CHROMATOGRAPHY | HEMATOLOGY | CHRONIC MYELOID-LEUKEMIA | Protein-Tyrosine Kinases - metabolism | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Piperazines - chemistry | Thiazoles - therapeutic use | Neoplasm Proteins - metabolism | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Fusion Proteins, bcr-abl | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Dasatinib | Quinone Reductases - metabolism | Piperazines - therapeutic use | Discoidin Domain Receptor 1 | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Imatinib Mesylate | Piperazines - pharmacology | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Quinone Reductases - antagonists & inhibitors | K562 Cells | Proteomics | Thiazoles - chemistry | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Benzamides | Drug Screening Assays, Antitumor | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
Journal Article