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dna - metabolism (375) 375
biochemistry & molecular biology (302) 302
base sequence (253) 253
distamycin (243) 243
distamycins - pharmacology (221) 221
animals (211) 211
binding sites (203) 203
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base composition (37) 37
deoxyribonuclease i - metabolism (37) 37
binding, competitive (36) 36
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substrate specificity (35) 35
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Current Medicinal Chemistry, ISSN 0929-8673, 2001, Volume 8, Issue 5, pp. 533 - 544
Recent work on a number of different classes of anticancer agents that alkylate DNA in the minor groove is reviewed. There has been much work with nitrogen... 
CHEMISTRY, MEDICINAL | DUOCARMYCIN SA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO TRANSCRIPTION | NITROGEN-MUSTARD | ANTITUMOR-ACTIVITY | BENZOIC-ACID MUSTARD | INTERSTRAND CROSS-LINKING | SEQUENCE PREFERENTIAL ALKYLATION | DIRECTED ANILINE MUSTARDS | BIOLOGICAL-ACTIVITY | PHARMACOLOGY & PHARMACY | SECO-CBI-TMI | Anthramycin - metabolism | Distamycins - metabolism | Antibiotics, Antineoplastic - pharmacology | Alkylating Agents - pharmacology | Humans | Cyclohexenes | Benzofurans - pharmacology | Structure-Activity Relationship | Nitrogen Mustard Compounds - chemistry | Netropsin - metabolism | Benzofurans - chemistry | Alkylating Agents - metabolism | Indoles - metabolism | Antibiotics, Antineoplastic - chemistry | Indoles - pharmacology | Cyclohexanecarboxylic Acids - metabolism | Chlorambucil - metabolism | DNA - drug effects | Bisbenzimidazole - metabolism | Chlorambucil - chemistry | Pyrroles - metabolism | Nitrogen Mustard Compounds - pharmacology | Bisbenzimidazole - chemistry | DNA - metabolism | Alkylating Agents - chemistry | Netropsin - analogs & derivatives | Anthramycin - pharmacology | Distamycins - chemistry | DNA - chemistry | Animals | Netropsin - chemistry | Cyclohexanecarboxylic Acids - pharmacology | Nitrogen Mustard Compounds - metabolism | Pyrroles - chemistry | Anthramycin - chemistry | Antibiotics, Antineoplastic - metabolism | Indoles - chemistry | Cyclohexanecarboxylic Acids - chemistry | Benzofurans - metabolism
Journal Article
Oncogene, ISSN 0950-9232, 01/2010, Volume 29, Issue 2, pp. 273 - 284
Cellular senescence guards against cancer and modulates aging; however, the underlying mechanisms remain poorly understood. Here, we show that genotoxic drugs... 
5-bromo-2'-deoxyuridine | Cytokines | Interleukins | JAK/STAT signaling | Cellular senescence | Distamycin A | TUMOR SUPPRESSION | DNA-DAMAGE RESPONSE | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | distamycin A | INDUCTION | ONCOGENE-INDUCED SENESCENCE | 5-bromo-2 '-deoxyuridine | CANCER | interleukins | CELL BIOLOGY | cellular senescence | HELA-CELLS | ONCOLOGY | PATHWAY | PML PROTEIN | GENETICS & HEREDITY | cytokines | STRESS | Interleukin-8 - genetics | Humans | Cellular Senescence - drug effects | Distamycins - pharmacology | Interleukins - metabolism | Interleukins - genetics | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | RNA Interference | Janus Kinase 1 - genetics | Interleukin-10 - metabolism | Interferons - genetics | Interleukin-8 - metabolism | Cytokines - genetics | Interleukin-6 - metabolism | Cytokines - metabolism | Interleukin-6 - genetics | Reverse Transcriptase Polymerase Chain Reaction | STAT1 Transcription Factor - genetics | Blotting, Western | Drug Synergism | Bromodeoxyuridine - pharmacology | Signal Transduction - drug effects | Interleukin-10 - genetics | Cell Line, Tumor | Interferons - metabolism | HeLa Cells | Chemotherapy | Aging | Genetic aspects | Research | Drug therapy | Health aspects | Cells | Cancer | Signal transduction | Oncology | Gene expression | Cell cycle
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 12/2000, Volume 28, Issue 24, pp. 4856 - 4864
Mechanisms of DNA oxidation by copper complexes of 3-Clip-Phen and its conjugate with a distamycin analogue, in the presence of a reductant and air, were... 
NUCLEASE ACTIVITY | STRANDED-DNA | CHEMICAL NUCLEASES | REPAIR | ABASIC SITES | PHENANTHROLINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLEOMYCIN | LIGAND CLIP-PHEN | DAMAGE | MINOR-GROOVE
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 5, pp. 1863 - 1868
Many cancer therapeutics target DNA and exert cytotoxicity through the induction of DNA damage and inhibition of transcription. We report that a DNA minor... 
Cell culture techniques | RNA | DNA | DNA damage | Genes | Cytotoxicity | Heterologous transplantation | Tumors | Vehicles | Apoptosis | Minor groove binder | Small molecule transcription inhibitor | ChIP-Seq | RNA-POLYMERASE-II | ANDROGEN RECEPTOR | PY-IM POLYAMIDES | DNA MINOR-GROOVE | minor groove binder | HAIRPIN POLYAMIDES | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | MEDIATED GENE-EXPRESSION | LIGHT-INDUCED APOPTOSIS | INDUCED UBIQUITINATION | DISTAMYCIN-A | small molecule transcription inhibitor | Prostatic Neoplasms - metabolism | Transcription, Genetic - drug effects | Humans | Imidazoles - chemistry | Immunoblotting | Male | RNA Polymerase II - metabolism | Protein Subunits - metabolism | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Time Factors | Antineoplastic Agents - pharmacology | Prostatic Neoplasms - prevention & control | Prostatic Neoplasms - pathology | RNA Polymerase II - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Nylons - chemistry | Antineoplastic Agents - chemistry | Mice, SCID | Interleukin Receptor Common gamma Subunit - genetics | Nylons - pharmacology | Mice, Knockout | Interleukin Receptor Common gamma Subunit - deficiency | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Pyrroles - chemistry | Mice, Inbred NOD | Mice | Protein Subunits - antagonists & inhibitors | Nylons - metabolism | Care and treatment | Polyamides | Genetic aspects | Research | Properties | Prostate cancer | RNA polymerases | Methods | Cancer | Cell culture | DNA polymerase | Toxicity | Index Medicus | Biological Sciences
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 5, p. e10656
Background: The architectural transcription factor High Mobility Group-A1 (HMGA1) binds to the minor groove of AT-rich DNA and forms transcription factor... 
ADHESION MOLECULE | MOBILITY GROUP-I(Y) PROTEIN | NITRIC-OXIDE SYNTHASE | ENDOTHELIAL-CELLS | IN-VIVO | BIOLOGY | NECROSIS-FACTOR-ALPHA | NF-KAPPA-B | MINOR-GROOVE-BINDING | IFN-BETA GENE | RESPIRATORY-DISTRESS-SYNDROME | Inflammation - pathology | Neutrophils - cytology | Liver - pathology | Endotoxemia - prevention & control | P-Selectin - metabolism | Humans | Endotoxins | Male | NF-kappa B - metabolism | Endotoxemia - pathology | Distamycins - pharmacology | Inflammation - complications | Inflammation - metabolism | Liver - drug effects | Cattle | Protein Binding - drug effects | Lung - metabolism | Neutrophils - metabolism | Promoter Regions, Genetic | Lung - pathology | Cytokines - metabolism | Endothelial Cells - metabolism | Endotoxemia - drug therapy | Liver - metabolism | Mice, Inbred C57BL | Neutrophils - drug effects | HMGA1a Protein - metabolism | P-Selectin - genetics | AT Rich Sequence | Distamycins - therapeutic use | Animals | Endothelial Cells - cytology | Endotoxemia - complications | Lung - drug effects | Cell Communication - drug effects | Mice | Endothelial Cells - drug effects | Acute respiratory distress syndrome | Chromosomal proteins | Genes | Liver | Genetic aspects | Inflammation | Genetic transcription | DNA binding proteins | DNA-ligand interactions | Drugs | Transcription factors | Biomedical research | Critical care | Inflammatory response | Biochemistry | Medical schools | Borides | Transfection | Rodents | Enhanceosomes | Attenuation | Tumor necrosis factor-TNF | Inhibition | Deoxyribonucleic acid--DNA | Endotoxemia | NF-κB protein | Cytokines | Nucleotide sequence | Neutrophils | Antimicrobial agents | Gene expression | Distamycin | Magnesium compounds | Endothelial cells | Medicine | E-selectin | High mobility group proteins | Insects | Microscopy | Lungs | Womens health | Sepsis | In vivo methods and tests | Binding sites | P-selectin | Conformation | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Nucleic acids research, ISSN 1362-4962, 11/2001, Volume 29, Issue 21, pp. 103 - 103
  The interactions of self-complementary oligonucleotides with a group of metal-mediated DNA-binding drugs, including chromomycin A3, mithramycin and the novel... 
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 2001, Volume 8, Issue 5, pp. 475 - 508
Journal Article
Journal Article
Antiviral Research, ISSN 0166-3542, 2011, Volume 91, Issue 2, pp. 177 - 186
Human papillomavirus (HPV) causes cervical cancer and other hyperproliferative diseases. There currently are no approved antiviral drugs for HPV that directly... 
Papillomavirus | Polyamide | Episome | Antiviral | Cervical cancer | VIRAL LIFE-CYCLE | DNA MINOR-GROOVE | HUMAN-PAPILLOMAVIRUS TYPE-16 | SOLID-PHASE SYNTHESIS | CERVICAL-CANCER | KERATINOCYTE CELL-LINE | BINDING PROTEIN | EPITHELIAL DIFFERENTIATION | NUCLEAR-LOCALIZATION | VIROLOGY | LINKED POLYAMIDES | PHARMACOLOGY & PHARMACY | Immunohistochemistry | Humans | Human papillomavirus 16 - drug effects | Distamycins - pharmacology | Viral Load | Antiviral Agents - chemistry | Human papillomavirus 18 - metabolism | Plasmids - drug effects | Inhibitory Concentration 50 | Female | Bromodeoxyuridine - metabolism | Human papillomavirus 18 - genetics | Binding Sites | Antiviral Agents - pharmacology | DNA, Viral - metabolism | Nylons - chemistry | Human papillomavirus 31 - drug effects | Uterine Cervical Neoplasms - drug therapy | Nylons - pharmacology | Plasmids - metabolism | Human papillomavirus 16 - metabolism | Pyrroles - pharmacology | Human papillomavirus 31 - metabolism | Human papillomavirus 18 - drug effects | Replication Origin | Human papillomavirus 31 - genetics | Cell Line, Tumor | Papillomavirus Infections - drug therapy | DNA, Viral - genetics | Human papillomavirus 16 - genetics | Microbial Sensitivity Tests - methods | Antiviral agents | Care and treatment | Polyamides | DNA | DNA synthesis | Papillomavirus infections | Cancer | Index Medicus | papillomavirus | polyamide | episome | cervical cancer | antiviral
Journal Article