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Science, ISSN 0036-8075, 10/2010, Volume 330, Issue 6000, pp. 70 - 74
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of Taxol and its... 
Enzymes | Cellular metabolism | Terpenoids | Chemical engineering | Bioreactors | Plasmids | REPORTS | Operons | Biosynthesis | Indoles | Streams | YEAST | CYTOCHROME-P450 | TAXADIENE | CELLS | MULTIDISCIPLINARY SCIENCES | CONSTRUCTION | BIOSYNTHETIC GENES | STEP | OXYGENASES | LYCOPENE PRODUCTION | TERPENOIDS | Metabolomics | NADPH-Ferrihemoprotein Reductase - genetics | Erythritol - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Taxoids - metabolism | Organophosphorus Compounds - metabolism | Recombinant Fusion Proteins - metabolism | Farnesyltranstransferase - metabolism | Escherichia coli K12 - metabolism | Hemiterpenes - metabolism | Indoles - metabolism | Terpenes - metabolism | Erythritol - metabolism | Isomerases - genetics | Diterpenes - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Paclitaxel - biosynthesis | Oxidation-Reduction | Fermentation | Taxus - enzymology | Metabolic Networks and Pathways - genetics | Genetic Engineering | Sugar Phosphates - metabolism | Farnesyltranstransferase - genetics | Cytochrome P-450 Enzyme System - genetics | Isomerases - metabolism | Escherichia coli K12 - genetics | Alkenes - metabolism | Escherichia coli K12 - enzymology | Physiological aspects | Research | Health aspects | Escherichia coli | Biological transport | Biochemistry | Pharmacology | E coli
Journal Article
Cardiovascular Research, ISSN 0008-6363, 12/2011, Volume 92, Issue 3, pp. 504 - 513
Aims Activation of transient receptor potential vanilloid type-1 (TRPV1) channels may affect lipid storage and the cellular inflammatory response. Now, we... 
Transient receptor potential vanilloid type-1 | Capsaicin | Vascular smooth muscle cells | Atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | DEPENDENT PROTEIN-KINASE | RECEPTOR | MECHANISMS | DEFICIENT MICE | CHOLESTEROL EFFLUX | CALCINEURIN | SMOOTH-MUSCLE-CELLS | CHANNELS | EXPRESSION | Immunohistochemistry | Dietary Fats - metabolism | Muscle, Smooth, Vascular - metabolism | Calcium - metabolism | Capsaicin - pharmacology | Atherosclerosis - genetics | Aorta - metabolism | RNA, Messenger - metabolism | Apolipoproteins E - metabolism | Aortic Diseases - metabolism | TRPV Cation Channels - deficiency | Dose-Response Relationship, Drug | TRPV Cation Channels - metabolism | Time Factors | Dietary Fats - administration & dosage | Polymerase Chain Reaction | ATP-Binding Cassette Transporters - metabolism | Aortic Diseases - prevention & control | ATP Binding Cassette Transporter 1 | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Aortic Diseases - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Diterpenes - pharmacology | Atherosclerosis - pathology | Tumor Suppressor Proteins - metabolism | Aorta - drug effects | Mice, Inbred C57BL | TRPV Cation Channels - agonists | Cells, Cultured | Receptors, LDL - metabolism | Atherosclerosis - metabolism | Blotting, Western | TRPV Cation Channels - genetics | Mice, Knockout | Aortic Diseases - genetics | Animals | Apolipoproteins E - genetics | Lipid Metabolism - drug effects | Mice | Atherosclerosis - prevention & control | Calcineurin - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2011, Volume 6, Issue 10, p. e26214
Ecological performance is all about timing and the endogenous clock that allows the entrainment of rhythms and anticipation of fitness-determining events is... 
CIRCADIAN CLOCK | MOLECULAR-INTERACTIONS | ARABIDOPSIS ROOTS | INSECT HERBIVORES | BIOLOGY | GENE-EXPRESSION | MANDUCA-SEXTA LEPIDOPTERA | TYROSINE DECARBOXYLASE | JASMONIC ACID | AMINO-ACID CONTENT | DITERPENE GLYCOSIDES | Disaccharides - metabolism | Plant Roots - genetics | Manduca - metabolism | RNA, Messenger - metabolism | Plant Roots - drug effects | Plant Roots - physiology | Plant Leaves - drug effects | Tobacco - physiology | Phenylalanine - metabolism | Plant Roots - metabolism | Tobacco - metabolism | Larva - metabolism | RNA, Messenger - genetics | Circadian Rhythm - genetics | Tobacco - drug effects | Herbivory | Fatty Acids, Unsaturated - metabolism | Organ Specificity | Polyamines - metabolism | Oxylipins - metabolism | Tyrosine - metabolism | Animals | Plant Leaves - genetics | Plant Leaves - metabolism | Genes, Plant - genetics | Glycosides - metabolism | Tobacco - genetics | Cyclopentanes - metabolism | Mechanical Phenomena | Plant Leaves - physiology | Metabolites | Animal behavior | Analysis | Physiological aspects | Liquid chromatography | Mass spectrometry | Health aspects | Larvae | Roots | Tissues | Accumulation | Leaves | Entrainment | Drought | Jasmonic acid | Tyrosine | Tyramine | Stresses | Plants (botany) | Computer simulation | Phenylalanine | Mass spectroscopy | Ions | Rhythms | Circadian rhythm | Metabolism | Diurnal | Tobacco | Acids | Insects | Herbivores | Fitness
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2009, Volume 106, Issue 26, pp. 10865 - 10870
We identified a cis-prenyltransferase gene, neryl diphosphate synthase 1 (NDPS1). that is expressed in cultivated tomato (Solanum lycopersicum) cultivar M82... 
Enzymes | Sesquiterpenes | Genes | Monoterpenes | Trichomes | Biosynthesis | Diphosphates | Plants | Terpenes | Chromosomes | Terpene synthases | Specialized metabolism | Plant biochemistry | Cis-prenyltransferases | Biochemical diversity | ARABIDOPSIS-THALIANA | plant biochemistry | SAGE SALVIA-OFFICINALIS | MULTIDISCIPLINARY SCIENCES | DOLICHOL BIOSYNTHESIS | specialized metabolism | cis-prenyltransferases | terpene synthases | PYROPHOSPHATE SYNTHETASE | biochemical diversity | LYCOPERSICON-ESCULENTUM | CIS-PRENYLTRANSFERASE | CDNA ISOLATION | SESQUITERPENE BIOSYNTHESIS | KEY ENZYME | BACTERIAL EXPRESSION | Diphosphates - metabolism | Polyisoprenyl Phosphates - chemistry | Gas Chromatography-Mass Spectrometry | Alkyl and Aryl Transferases - metabolism | DNA, Complementary - genetics | Molecular Sequence Data | Substrate Specificity | Lycopersicon esculentum - enzymology | Organophosphorus Compounds - metabolism | Plant Epidermis - metabolism | Hemiterpenes - metabolism | Dimethylallyltranstransferase - genetics | Alkyl and Aryl Transferases - genetics | Cloning, Molecular | Gene Expression Regulation, Plant | Lycopersicon esculentum - genetics | Molecular Structure | Plant Proteins - metabolism | Diterpenes - metabolism | Plant Epidermis - enzymology | Diterpenes - chemistry | Hemiterpenes - chemistry | Lycopersicon esculentum - metabolism | Gene Library | Organophosphorus Compounds - chemistry | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Polyisoprenyl Phosphates - metabolism | Sequence Analysis, DNA | Diphosphates - chemistry | Plant Proteins - genetics | Monoterpenes - metabolism | Dimethylallyltranstransferase - metabolism | Monoterpenes - analysis | Monoterpenes - chemistry | DNA, Complementary - chemistry | Kinetics | Tomatoes | Chemical properties | Research | Pyrophosphates | Biological Sciences
Journal Article
Plant Physiology, ISSN 0032-0889, 3/2014, Volume 164, Issue 3, pp. 1222 - 1236
Journal Article
New Phytologist, ISSN 0028-646X, 2016, Volume 209, Issue 2, pp. 679 - 690
Journal Article
Medicinal Research Reviews, ISSN 0198-6325, 09/2008, Volume 28, Issue 5, pp. 746 - 772
Medicinal plants have been traditionally used for treating liver diseases since centuries. Several leads from plant sources have been found as potential... 
phyllanthin | picroside | silymarin | neoandrographolide | kutkoside | hepatoprotective | glycyrrhizin | andrographolide | curcumin | hypophyllanthin | Glycyrrhizin | Hepatoprotective | Kutkoside | Silymarin | Phyllanthin | Neoandrographolide | Curcumin | Andrographolide | Hypophyllanthin | Picroside | CLEOME-VISCOSA SEEDS | ANDROGRAPHIS-PANICULATA NEES | CHEMISTRY, MEDICINAL | RAT HEPATOCYTES | INDUCED HEPATIC DAMAGE | neoandrogapholide | INDUCED LIVER-INJURY | CYTOCHROME-P450 2E1 EXPRESSION | PHYLLANTHUS-AMARUS | CURCUMA-LONGA | PHARMACOLOGY & PHARMACY | CARBON-TETRACHLORIDE | INDUCED HEPATOTOXICITY | Silymarin - toxicity | Plant Extracts - toxicity | Diterpenes - toxicity | Plant Extracts - pharmacology | Humans | Protective Agents - chemistry | Curcumin - metabolism | Silymarin - chemistry | Lignans - pharmacology | Plant Extracts - metabolism | Glycyrrhizic Acid - pharmacology | Liver - drug effects | Glucosides - chemistry | Cinnamates - chemistry | Phytotherapy | Diterpenes - pharmacology | Glucosides - toxicity | Liver - metabolism | Curcumin - pharmacology | Lignans - metabolism | Plants | Cinnamates - pharmacology | Glucosides - metabolism | Tetrahydronaphthalenes - metabolism | Tetrahydronaphthalenes - pharmacology | Liver Diseases - drug therapy | Glycyrrhizic Acid - toxicity | Plant Extracts - therapeutic use | Curcumin - chemistry | Tetrahydronaphthalenes - toxicity | Protective Agents - metabolism | Protective Agents - therapeutic use | Lignans - toxicity | Protective Agents - pharmacology | Cinnamates - metabolism | Cinnamates - toxicity | Silymarin - metabolism | Silymarin - pharmacology | Diterpenes - metabolism | Diterpenes - chemistry | Glucosides - pharmacology | Cytokines - metabolism | Lignans - chemistry | Glycyrrhizic Acid - chemistry | Glycyrrhizic Acid - metabolism | Animals | Curcumin - toxicity | Tetrahydronaphthalenes - chemistry | Liver Diseases - metabolism | Protective Agents - toxicity
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 141, Issue 4, pp. 1346 - 1358
Background & Aims The neuropeptides calcitonin gene-related peptide (CGRP) and substance P, and calcium channels, which control their release from extrinsic... 
Gastroenterology and Hepatology | Immune System | 4-HNE | Inflammatory Bowel Diseases | Nervous | GENE-RELATED PEPTIDE | ION-CHANNEL TRPA1 | GASTROINTESTINAL-TRACT | DORSAL-ROOT GANGLIA | IRRITANT RECEPTOR TRPA1 | SLOW-TRANSIT CONSTIPATION | PIG MYENTERIC PLEXUS | SENSORY NEURONS | RAT EXPERIMENTAL COLITIS | SODIUM-INDUCED COLITIS | GASTROENTEROLOGY & HEPATOLOGY | Dextran Sulfate | Calcium Channels - metabolism | Calcium - metabolism | Colitis - genetics | Humans | Colon - drug effects | Colitis - pathology | Colon - innervation | Trinitrobenzenesulfonic Acid | Aldehydes - metabolism | Transient Receptor Potential Channels - deficiency | TRPV Cation Channels - metabolism | Transfection | Colitis - chemically induced | HEK293 Cells | Inflammation Mediators - metabolism | Transient Receptor Potential Channels - metabolism | Calcitonin Gene-Related Peptide - metabolism | Calcium Channels - genetics | Disease Models, Animal | Diterpenes - pharmacology | Colon - pathology | Calcitonin Gene-Related Peptide - genetics | Nerve Tissue Proteins - genetics | Colon - metabolism | TRPV Cation Channels - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Patch-Clamp Techniques | Animals | Substance P - deficiency | Membrane Potentials | Transient Receptor Potential Channels - genetics | Substance P - genetics | TRPA1 Cation Channel | Colitis - metabolism | Substance P - metabolism | Mice | Mutation | Lipid Peroxidation | Ganglia, Spinal - metabolism | Cysteine | Calcium channels | Neurons | Analysis | Gastrointestinal diseases | Neuropeptides | Colitis | Cystine
Journal Article