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Science (American Association for the Advancement of Science), ISSN 1095-9203, 09/2010, Volume 330, Issue 6000, pp. 70 - 74
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of Taxol and its... 
Enzymes | Cellular metabolism | Terpenoids | Chemical engineering | Bioreactors | Plasmids | REPORTS | Operons | Biosynthesis | Indoles | Streams | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Metabolomics | NADPH-Ferrihemoprotein Reductase - genetics | Erythritol - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Taxoids - metabolism | Organophosphorus Compounds - metabolism | Recombinant Fusion Proteins - metabolism | Farnesyltranstransferase - metabolism | Escherichia coli K12 - metabolism | Hemiterpenes - metabolism | Indoles - metabolism | Terpenes - metabolism | Erythritol - metabolism | Isomerases - genetics | Diterpenes - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Paclitaxel - biosynthesis | Oxidation-Reduction | Fermentation | Taxus - enzymology | Metabolic Networks and Pathways - genetics | Genetic Engineering | Sugar Phosphates - metabolism | Farnesyltranstransferase - genetics | Cytochrome P-450 Enzyme System - genetics | Isomerases - metabolism | Escherichia coli K12 - genetics | Alkenes - metabolism | Escherichia coli K12 - enzymology | Physiological aspects | Research | Health aspects | Escherichia coli | Biological transport | Biochemistry | Pharmacology | E coli | Drugs | Pathways | Searching | Taxol | Modules | Modular | Pacific yew | Optimization | Index Medicus
Journal Article
Plant physiology (Bethesda), ISSN 0032-0889, 3/2014, Volume 164, Issue 3, pp. 1222 - 1236
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 06/2009, Volume 106, Issue 26, pp. 10865 - 10870
We identified a cis-prenyltransferase gene, neryl diphosphate synthase 1 (NDPS1). that is expressed in cultivated tomato (Solanum lycopersicum) cultivar M82... 
Enzymes | Sesquiterpenes | Genes | Monoterpenes | Trichomes | Biosynthesis | Diphosphates | Plants | Terpenes | Chromosomes | Terpene synthases | Specialized metabolism | Plant biochemistry | Cis-prenyltransferases | Biochemical diversity | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Diphosphates - metabolism | Polyisoprenyl Phosphates - chemistry | Gas Chromatography-Mass Spectrometry | Alkyl and Aryl Transferases - metabolism | DNA, Complementary - genetics | Molecular Sequence Data | Substrate Specificity | Lycopersicon esculentum - enzymology | Organophosphorus Compounds - metabolism | Plant Epidermis - metabolism | Hemiterpenes - metabolism | Dimethylallyltranstransferase - genetics | Alkyl and Aryl Transferases - genetics | Cloning, Molecular | Gene Expression Regulation, Plant | Lycopersicon esculentum - genetics | Molecular Structure | Plant Proteins - metabolism | Diterpenes - metabolism | Plant Epidermis - enzymology | Diterpenes - chemistry | Hemiterpenes - chemistry | Lycopersicon esculentum - metabolism | Gene Library | Organophosphorus Compounds - chemistry | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Polyisoprenyl Phosphates - metabolism | Sequence Analysis, DNA | Diphosphates - chemistry | Plant Proteins - genetics | Monoterpenes - metabolism | Dimethylallyltranstransferase - metabolism | Monoterpenes - analysis | Monoterpenes - chemistry | DNA, Complementary - chemistry | Kinetics | Tomatoes | Chemical properties | Research | Pyrophosphates | Ribonucleic acid--RNA | Index Medicus | specialized metabolism | Biological Sciences | cis-prenyltransferases | terpene synthases | plant biochemistry | biochemical diversity
Journal Article
Plant biotechnology journal, ISSN 1467-7644, 09/2017, Volume 15, Issue 9, pp. 1105 - 1119
Journal Article
Molecular neurobiology, ISSN 0893-7648, 10/2016, Volume 53, Issue 8, pp. 5640 - 5651
Netrin-1 is a neuronal guidance molecule implicated in the development of spinal cord neurons and cortical neurons. In the adult spinal cord, UNC5H (repulsive... 
Axon growth | Neurology | Postherpetic neuralgia | Neurosciences | Biomedicine | Netrin-1 | Neurobiology | TRPV1 receptor | Cell Biology | Neuropathic pain | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Oligodendroglia - metabolism | Posterior Horn Cells - drug effects | Posterior Horn Cells - metabolism | Gene Silencing - drug effects | Spinal Cord - drug effects | Spinal Cord - metabolism | Diterpenes - toxicity | Humans | Neuralgia - metabolism | Myelin Sheath - drug effects | Male | DCC Receptor - metabolism | RNA, Messenger - metabolism | Hyperalgesia - pathology | Myelin Sheath - metabolism | Lentivirus - metabolism | Oligodendroglia - drug effects | Spinal Cord - pathology | Neurons, Afferent - pathology | Neurogenesis - drug effects | Biomarkers - metabolism | Netrin-1 - genetics | Neurons, Afferent - drug effects | Hyperalgesia - metabolism | RNA, Messenger - genetics | Receptors, Cell Surface - metabolism | Down-Regulation - drug effects | Rats, Sprague-Dawley | Up-Regulation - drug effects | Animals | Cell Line, Tumor | Neurons, Afferent - metabolism | Netrin-1 - metabolism | RNA, Small Interfering - metabolism | Yuan (China) | Nervous system diseases | Neurons | Analysis | Colorectal cancer | Cellular signal transduction | Neurophysiology | Signal transduction | Peripheral neuropathy | Index Medicus
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, pp. e0151397 - e0151397
Synaptic loss induced by beta-amyloid (Aβ) plays a critical role in the pathophysiology of Alzheimer's disease (AD), but the mechanisms underlying this process... 
Disks Large Homolog 4 Protein | Humans | Male | Dendritic Spines - metabolism | Hippocampus - drug effects | Alzheimer Disease - pathology | Diterpenes, Kaurane - therapeutic use | Synapses - metabolism | Dendritic Spines - drug effects | Amyloid beta-Peptides | Brain-Derived Neurotrophic Factor - metabolism | Membrane Proteins - metabolism | Synaptophysin - metabolism | Diterpenes, Kaurane - pharmacology | Synapses - drug effects | Mice, Inbred C57BL | Cognition Disorders - pathology | Alzheimer Disease - drug therapy | Hippocampus - pathology | Mitochondria - metabolism | Mitochondria - drug effects | Cognition Disorders - drug therapy | Hippocampus - metabolism | Animals | Signal Transduction - drug effects | Dendritic Spines - pathology | Cyclic AMP Response Element-Binding Protein - metabolism | Guanylate Kinases - metabolism | Receptor, trkB - metabolism | Brain | Neurosciences | Laboratories | Neuropathology | Spine | Pathogenesis | Memory | Cognitive ability | Medical schools | Dendritic spines | Signal transduction | Mitochondria | Rodents | Synaptosomes | Alzheimer's disease | Medical research | Synaptophysin | Immunoglobulins | Neurodegenerative diseases | Cyclic AMP response element-binding protein | Latency | Medicine | Pathology | Neurology | Signaling | Brain-derived neurotrophic factor | Hospitals | Morphology | β-Amyloid | Mice | TrkB receptors | In vivo methods and tests | Postsynaptic density proteins | Alzheimers disease | Hippocampus | Binding sites | Dendritic structure | Animal cognition | Index Medicus
Journal Article